Propagation of Policies in Rich Data Flows

Governing the life cycle of data on the web is a challenging issue for organisations and users. Data is distributed under certain policies that determine what actions are allowed and in which circumstances. Assessing what policies propagate to the output of a process is one crucial problem. Having a description of policies and data flow steps implies a huge number of propagation rules to be specified and computed (number of policies times number of actions). In this paper we provide a method to obtain an abstraction that allows to reduce the number of rules significantly. We use the Datanode ontology, a hierarchical organisation of the possible relations between data objects, to compact the knowledge base to a set of more abstract rules. After giving a definition of Policy Propagation Rule, we show (1) a methodology to abstract policy propagation rules based on an ontology, (2) how effective this methodology is when using the Datanode ontology, (3) how this ontology can evolve in order to better represent the behaviour of policy propagation rules

Positivity Constraints for Spin-Dependent Parton Distributions

We derive new positivity constraints on the spin-dependent structure functions of the nucleon. These model independent results reduce conside\-rably their domain of allowed values, in particular for the chiral-odd parton distribution $h_1 (x)$.Comment: 8 pages,CPT-94/P.3059,LaTex,3 fig available on cpt.univ-mrs.fr directory pub/preprints/94/fundamental-interactions/94-P.305

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: A multicenter study

The increase of proinflammatory cytokines in vaginal secretions may serve as a surrogate marker of unwanted inflammatory reaction to microbicide products topically applied for the prevention of sexually transmitted diseases, including HIV-1. Interleukin (IL)-1β and IL-6 have been proposed as indicators of inflammation and increased risk of HIV-1 transmission; however, the lack of information regarding detection platforms optimal for vaginal fluids and interlaboratory variation limit their use for microbicide evaluation and other clinical applications. This study examines fluid matrix variants relevant to vaginal sampling techniques and proposes a model for interlaboratory comparisons across current cytokine detection technologies. IL-1β and IL-6 standards were measured by 12 laboratories in four countries, using 14 immunoassays and four detection platforms based on absorbance, chemiluminescence, electrochemiluminescence, and fluorescence. International reference preparations of cytokines with defined biological activity were spiked into (1) a defined medium simulating the composition of human vaginal fluid at pH 4.5 and 7.2, (2) physiologic salt solutions (phosphate-buffered saline and saline) commonly used for vaginal lavage sampling in clinical studies of cytokines, and (3) human blood serum. Assays were assessed for reproducibility, linearity, accuracy, and significantly detectable fold difference in cytokine level. Factors with significant impact on cytokine recovery were determined by Kruskal−Wallis analysis of variance with Dunn’s multiple comparison test and multiple regression models. All assays showed acceptable intra-assay reproducibility; however, most were associated with significant interlaboratory variation. The smallest reliably detectable cytokine differences (P < 0.05) derived from pooled interlaboratory data varied from 1.5- to 26-fold depending on assay, cytokine, and matrix type. IL-6 but not IL-1β determinations were lower in both saline and phosphate-buffered saline as compared to vaginal fluid matrix, with no significant effect of pH. The (electro)chemiluminescence-based assays were most discriminative and consistently detected <2-fold differences within each matrix type. The Luminex-based assays were less discriminative with lower reproducibility between laboratories. These results suggest the need for uniform vaginal sampling techniques and a better understanding of immunoassay platform differences and cross-validation before the biological significance of cytokine variations can be validated in clinical trials. This investigation provides the first standardized analytic approach for assessing differences in mucosal cytokine levels and may improve strategies for monitoring immune responses at the vaginal mucosal interface

A Study of the Radiative Ke3 Decay and Search for Direct Photon Emission with the KLOE Detector

We present a measurement of the ratio R = \Gamma(\keg;\Estar>30\mev,\qstar>20^\circ)$/$\Gamma(\kegf)$and a first measurement of the direct emission contribution in KL semileptonic decays. The measurement is done at the DAFNE phi-factory selecting phi->KL KS decays with the KLOE detector. We use 328 pb^{-1}$ of data corresponding to about 3.5 million Ke3(g) events and about 9000 radiative events. Our result is R=(924 +/- 23(stat) +/-16(syst)10^{-5} for the branching ratio and X=-2.3 +/- 1.3(stat) +/- 1.4(syst) for the parameter describing direct emission.Comment: 8 pages, 7 figure

An architecture for establishing legal semantic workflows in the context of integrated law enforcement

A previous version of this paper was presented at the Third Workshop on Legal Knowledge and the Semantic Web (LK&SW-2016), EKAW-2016, November 19th, Bologna, ItalyTraditionally the integration of data from multiple sources is done on an ad-hoc basis for each to "silos" that prevent sharing data across different agencies or tasks, and is unable to cope with the modern environment, where workflows, tasks, and priorities frequently change. Operating within the Data to Decision Cooperative Research Centre (D2D CRC), the authors are currently involved in the Integrated Law Enforcement Project, which has the goal of developing a federated data platform that will enable the execution of integrated analytics on data accessed from different external and internal sources, thereby providing effective support to an investigator or analyst working to evaluate evidence and manage lines of inquiries in the investigation. Technical solutions should also operate ethically, in compliance with the law, and subject to good governance principles

A New Measurement of the Radiative Ke3 Branching Ratio and Photon Spectrum

We present a preliminary report on a new measurement of the radiative neutral Ke3 branching ratio and the first study of the photon spectrum in this decay. We find BR(Ke3g, E*_g>30 GeV, Th*_eg>20 deg)/BR(Ke3) = 0.911+-0.009(stat)+0.021-0.010(syst)%. Our measurement of the spectrum is consistent with inner bremsstrahlung only as the source of photons at the 2 sigma level.Comment: 5 pages, 4 figures, proceedings paper from Meson 2000, Cracow, Poland, May 200

Spin Structure of the Proton from Polarized Inclusive Deep-Inelastic Muon-Proton Scattering

We have measured the spin-dependent structure function $g_1^p$ in inclusive deep-inelastic scattering of polarized muons off polarized protons, in the kinematic range $0.003 < x < 0.7$ and $1 GeV^2 < Q^2 < 60 GeV^2$. A next-to-leading order QCD analysis is used to evolve the measured $g_1^p(x,Q^2)$ to a fixed $Q^2_0$. The first moment of $g_1^p$ at $Q^2_0 = 10 GeV^2$ is $\Gamma^p = 0.136\pm 0.013(stat.) \pm 0.009(syst.)\pm 0.005(evol.)$. This result is below the prediction of the Ellis-Jaffe sum rule by more than two standard deviations. The singlet axial charge $a_0$ is found to be $0.28 \pm 0.16$. In the Adler-Bardeen factorization scheme, $\Delta g \simeq 2$ is required to bring $\Delta \Sigma$ in agreement with the Quark-Parton Model. A combined analysis of all available proton and deuteron data confirms the Bjorken sum rule.Comment: 33 pages, 22 figures, uses ReVTex and smc.sty. submitted to Physical Review

Lynx: A knowledge-based AI service platform for content processing, enrichment and analysis for the legal domain

The EU-funded project Lynx focuses on the creation of a knowledge graph for the legal domain (Legal Knowledge Graph, LKG) and its use for the semantic processing, analysis and enrichment of documents from the legal domain. This article describes the use cases covered in the project, the entire developed platform and the semantic analysis services that operate on the documents. © 202

The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition

It has been proposed that ATR kinase senses the completion of DNA replication to initiate the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex prevents a premature entry into G2 from early S-phase independently of ATR/CHK1 kinases. TRESLIN-MTBP acts transiently at pre-replication complexes (preRCs) to initiate origin firing and is released after the subsequent recruitment of CDC45. This dynamic behavior of TRESLIN-MTBP implements a monitoring system that checks the activation of replication forks and senses the rate of origin firing to prevent the entry into G2. This system detects the decline in the number of origins of replication that naturally occurs in very late S, which is the signature that cells use to determine the completion of DNA replication and permit the S/G2 transition. Our work introduces TRESLIN-MTBP as a key player in cell-cycle control independent of canonical checkpoints

Establishing the Maximum Collectivity in Highly Deformed N=Z Nuclei

The lifetimes of the first excited 2^{+} states in the N=Z nuclei ^{80}Zr, ^{78}Y, and ^{76}Sr have been measured using the γ-ray line shape method following population via nucleon-knockout reactions from intermediate-energy rare-isotope beams. The extracted reduced electromagnetic transition strengths yield new information on where the collectivity is maximized and provide evidence for a significant, and as yet unexplained, odd-odd vs even-even staggering in the observed values. The experimental results are analyzed in the context of state-of-the-art nuclear density-functional model calculations