8,763 research outputs found
Spectral properties of incommensurate charge-density wave systems
The concept of frustrated phase separation is applied to investigate its
consequences for the electronic structure of the high T_c cuprates. The
resulting incommensurate charge density wave (CDW) scattering is most effective
in creating local gaps in k-space when the scattering vector connects states
with equal energy. Starting from an open Fermi surface we find that the
resulting CDW is oriented along the (10)- and (or) (01)-direction which allows
for a purely one-dimensional or a two-dimensional ``eggbox type'' charge
modulation. In both cases the van Hove singularities are substantially
enhanced, and the spectral weight of Fermi surface states near the M-points,
tends to be suppressed. Remarkably, a leading edge gap arises near these
points, which, in the eggbox case, leaves finite arcs of the Fermi surface
gapless. We discuss our results with repect to possible consequences for
photoemission experiments
Nitric oxide and hydrogen sulfide: the gasotransmitter paradigm of the vascular system.
There are several reviews on NO and hydrogen sulfide (H2 S) and their role in vascular diseases in the current relevant literature. The aim of this review is to discuss, within the limits of present knowledge, the interconnection between these two gasotransmitters in vascular function. In particular, the review focuses on the role played by the balance between the NO and H2 S pathways in either physiological or pathological conditions. The distinction between physiology and pathology has been made in order to dissect the molecular basis of this crosstalk, highlighting how and if this balance varies, depending upon the vascular status. Perspectives and possible novel therapeutic approaches are also discussed
Role of prucalopride in treatment of chronic constipation and recurrent functional obstructionina patient with steinert myotonic dystrophy
Palindromic Length of Words with Many Periodic Palindromes
The palindromic length of a finite word is the minimal
number of palindromes whose concatenation is equal to . In 2013, Frid,
Puzynina, and Zamboni conjectured that: If is an infinite word and is
an integer such that for every factor of then
is ultimately periodic.
Suppose that is an infinite word and is an integer such
for every factor of . Let be the set
of all factors of that have more than
palindromic prefixes. We show that is an infinite set and we show
that for each positive integer there are palindromes and a word such that is a factor of and is nonempty. Note
that is a periodic word and is a palindrome for each . These results justify the following question: What is the palindromic
length of a concatenation of a suffix of and a periodic word with
"many" periodic palindromes?
It is known that ,
where and are nonempty words. The main result of our article shows that
if are palindromes, is nonempty, is a nonempty suffix of ,
is the minimal period of , and is a positive integer
with then
Different approaches for assessing sperm function
Different approaches can be used to assess sperm function in different conditions, i.e. sperm storage, freezing-thawing or activation by induction of capacitation and acrosome reaction. In this review we will focus on the assays routinely performed in our laboratories, giving a literature support to critically analyse different approaches. In fact, researchers usually tend to look for the \u201cone shot\u201c parameter that could explain itself a specific process; it is our conviction that a multiparametric approach is still more valid, as some changes in sperm function are very complex and could be explained only by operating in different ways. Sperm motility, the most evident sperm characteristic, should be assessed by computer-aided sperm analysers that permit an objective evaluation of the motility and its kinematic parameters. Commercial and open source instruments are available and could be profitably used together with specific statistical approaches. The use of microscopy, and particularly fluorescent microscopy, could be a very useful tool to assess different parameters in sperm cells both by fluorophores that give indication of a determined function, and by immunolocalization of proteins, that permits the discover of new features or to explain particular sperm functions. The same substrates could be used also in flow cytometry: the difference is that it permits to study wider sperm populations (and their sub-population distribution). Flow cytometry is undergoing a very wide use in spermatology and technical and experimental rigor is needed to obtain reliable results. Metabolic assessment of sperm features, particularly energetic supply, ATP formation and other enzyme activities, could represent a very important challenge to acquire new information and complete/integrate those derived from other techniques. Finally, functional assays such as oocyte binding and in vitro fertilization, represent a very strong tool to assess sperm function in vitro, as they could evidence the functional intactness of some pathways
Interleukin-1beta tear concentration in glaucomatous and ocular hypertensive patients treated with preservative-free nonselective beta-blockers
PURPOSE: To evaluate the ocular surface inflammatory response to the presence of preservatives in nonselective
beta-blocker eyedrops.
DESIGN: Prospective, crossover, single-masked, randomized
clinical study. METHODS: STUDY POPULATION: Twenty primary open angle glaucoma or ocular hypertensive patients were divided in two groups, one treated with preservative-free timolol 0.5% (group 1) and the other with preserved timolol 0.5% (group 2) eyedrops. After 60 days of therapy and 3 more weeks of washout, the two groups switched to the other therapy. PROCEDURE: At each visit,basal tear samples were collected from the inferior conjunctival fornix for the determination of interleukin (IL)-1 tear concentrations by an enzyme-linked immunosorbent assay. Intraocular pressure measurement, conjunctival
hyperemia, superficial punctate keratitis, and tear film breakup time were evaluated. MAIN OUTCOME MEASURE: IL-1 concentration in tears following the use of preserved eyedrops.
RESULTS: IL-1 tear concentrations increased significantly in both groups, compared with baseline values,during preserved timolol therapy. There were no statistically significant changes in hyperemia and superficial punctate keratitis throughout the study in either group.A statistically significant breakup time reduction was observed in both groups after 30 days and after 60 days of preserved therapy.
CONCLUSION: The use of preservatives in timolol 0.5% eyedrops leads to tear film instability and ocular surface inflammatory changes documented by a reduction of breakup time and an increase of IL-1 tear concentrations.Preservative-free beta-blockers are preferable for long-term hypotensive therapy to prevent ocular surface inflammation
Long-term prediction of adherence to continuous positive air pressure therapy for the treatment of moderate/severe obstructive sleep apnea syndrome
BACKGROUND: Continuous positive airway pressure (CPAP) therapy is a highly effective treatment for obstructive sleep apnea syndrome (OSAS). However, poor adherence is a limiting factor, and a significant proportion of patients are unable to tolerate CPAP. The aim of this study was to determine predictors of long-term non-compliance with CPAP.
METHODS: CPAP treatment was prescribed to all consecutive patients with moderate or severe OSAS (AHI ≥15 events/h) (n = 295) who underwent a full-night CPAP titration study at home between February 1, 2002 and December 1, 2016. Adherence was defined as CPAP use for at least 4 h per night and five days per week. Subjects had periodical follow-up visits including clinical and biochemical evaluation and assessment of adherence to CPAP.
RESULTS: Median follow-up observation was 74.8 (24.2/110.9) months. The percentage of OSAS patients adhering to CPAP was 41.4% (42.3% in males and 37.0% in females), and prevalence was significantly higher in severe OSAS than in moderate (51.8% vs. 22.1%; p < 0.001; respectively). At multivariate analysis, lower severity of OSAS (HR = 0.66; CI 95 0.46-0.94) p < 0.023), cigarette smoking (HR = 1.72; CI 95 1.13-2.61); p = 0.011), and previous cardiovascular events (HR = 1.95; CI 95 1.03-3.70; p = 0.04) were the only independent predictors of long-term non-adherence to CPAP after controlling for age, gender, and metabolic syndrome.
CONCLUSIONS: In our cohort of patients with moderate/severe OSAS who were prescribed CPAP therapy, long-term compliance to treatment was present in less than half of the patients. Adherence was positively associated with OSAS severity and negatively associated with cigarette smoking and previous cardiovascular events at baseline
Interleukin-1beta tear concentration in glaucomatous and ocular hypertensive patients treated with preservative-free nonselective beta-blockers
PURPOSE: To evaluate the ocular surface inflammatory response to the presence of preservatives in nonselective
beta-blocker eyedrops.
DESIGN: Prospective, crossover, single-masked, randomized
clinical study. METHODS: STUDY POPULATION: Twenty primary open angle glaucoma or ocular hypertensive patients were divided in two groups, one treated with preservative-free timolol 0.5% (group 1) and the other with preserved timolol 0.5% (group 2) eyedrops. After 60 days of therapy and 3 more weeks of washout, the two groups switched to the other therapy. PROCEDURE: At each visit,basal tear samples were collected from the inferior conjunctival fornix for the determination of interleukin (IL)-1 tear concentrations by an enzyme-linked immunosorbent assay. Intraocular pressure measurement, conjunctival
hyperemia, superficial punctate keratitis, and tear film breakup time were evaluated. MAIN OUTCOME MEASURE: IL-1 concentration in tears following the use of preserved eyedrops.
RESULTS: IL-1 tear concentrations increased significantly in both groups, compared with baseline values,during preserved timolol therapy. There were no statistically significant changes in hyperemia and superficial punctate keratitis throughout the study in either group.A statistically significant breakup time reduction was observed in both groups after 30 days and after 60 days of preserved therapy.
CONCLUSION: The use of preservatives in timolol 0.5% eyedrops leads to tear film instability and ocular surface inflammatory changes documented by a reduction of breakup time and an increase of IL-1 tear concentrations.Preservative-free beta-blockers are preferable for long-term hypotensive therapy to prevent ocular surface inflammation
Asymmetric Hydrogenation vs Transfer Hydrogenation in the Reduction of Cyclic Imines
A comparison between the two most common reduction approaches for obtaining chiral amines, asymmetric hydrogenation (AH) versus asymmetric transfer hydrogenation (ATH), was accomplished by using iridium complexes based on atropoisomeric diphosphines and cyclic diamines as ligands respectively. Seven substrates, different in electronic and steric properties, were screened applying both reduction methods. For AH the best results in terms of enantioselectivity (e.e. up to 64%) were obtained by using [Ir(COD)(TetraMe-BITIOP)]Cl in the presence of DCDMH as additive. ATH was carried out with [IrCp*(CAMPY)Cl]Cl as catalyst, allowing the obtainment of the products with appreciable e.e. (up to 76%)
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