First ERTS-1 results in southeastern France: Geology, sedimentology, pollution at sea

Results obtained by four ERTS projects in southeastern France are summarized. With regard to geology, ERTS photos of Western Alps are very useful for tectonic interpretation because large features are clearly visible on these photographs even though they are often hidden by small complicated structures if studied on large scale documents. The 18-day repetition coverage was not obtained, and time-varying sedimentological surveys were impossible. Nevertheless, it was possible to delineate the variations of the shorelines in the Rhone Delta for a period covering the least 8,000 years. Some instances of industries discharging pollutant products at sea were detected, as well as very large anomalies of unknown origin. Some examples of coherent optical processing have been made in order to bring out tectonic features in the Alps mountains

A spinal organ of proprioception for integrated motor action feedback

Proprioception is essential for behavior and provides a sense of our body movements in physical space. Proprioceptor organs are thought to be only in the periphery. Whether the central nervous system can intrinsically sense its own movement remains unclear. Here we identify a segmental organ of proprioception in the adult zebrafish spinal cord, which is embedded by intraspinal mechanosensory neurons expressing Piezo2 channels. These cells are late-born, inhibitory, commissural neurons with unique molecular and physiological profiles reflecting a dual sensory and motor function. The central proprioceptive organ locally detects lateral body movements during locomotion and provides direct inhibitory feedback onto rhythm-generating interneurons responsible for the central motor program. This dynamically aligns central pattern generation with movement outcome for efficient locomotion. Our results demonstrate that a central proprioceptive organ monitors self-movement using hybrid neurons that merge sensory and motor entities into a unified network

Plaidoyer pour une sylviculture du Pin d'Alep par les techniciens de terrain

Constatant qu'ils gèrent une forêt où le Pin d'Alep tient une place prédominante, les auteurs proposent d'en améliorer la sylviculture. Ils évoquent les modes de traitement qu'impose l'état des peuplements : la futaie régulière devant être traitée en priorité, la futaie d'aspect jardiné et les peuplements mélangés qui sont les plus délicats à aménager. Après avoir examiné les difficultés rencontrées dans ces aménagements, les auteurs concluent que le mode de sylviculture le plus approprié est la futaie régulière par parquets de 0,5 à 4 ha

Radioactive Phosphorylation of Alcohols to Monitor Biocatalytic Diels-Alder Reactions

Nature has efficiently adopted phosphorylation for numerous biological key processes, spanning from cell signaling to energy storage and transmission. For the bioorganic chemist the number of possible ways to attach a single phosphate for radioactive labeling is surprisingly small. Here we describe a very simple and fast one-pot synthesis to phosphorylate an alcohol with phosphoric acid using trichloroacetonitrile as activating agent. Using this procedure, we efficiently attached the radioactive phosphorus isotope 32P to an anthracene diene, which is a substrate for the Diels-Alderase ribozyme—an RNA sequence that catalyzes the eponymous reaction. We used the 32P-substrate for the measurement of RNA-catalyzed reaction kinetics of several dye-labeled ribozyme variants for which precise optical activity determination (UV/vis, fluorescence) failed due to interference of the attached dyes. The reaction kinetics were analyzed by thin-layer chromatographic separation of the 32P-labeled reaction components and densitometric analysis of the substrate and product radioactivities, thereby allowing iterative optimization of the dye positions for future single-molecule studies. The phosphorylation strategy with trichloroacetonitrile may be applicable for labeling numerous other compounds that contain alcoholic hydroxyl groups

European stakeholders’ visions and needs for stormwater in future urban drainage systems

Transitioning urban drainage systems to serve water-smart societies requires the involvement of different disciplines and stakeholders. However, stakeholders have different visions and needs from the transitioning process (e.g in terms of financing, policy adaptation and system management) these also vary between regions and countries. Identifying such different needs for stakeholders is necessary to propose practical adaptation strategies. Therefore, evidence of needs as reflected in policy papers and legislation in seven European countries was collected. Knowledgeable individuals in the urban drainage community were asked about their visions. Results show that whilst there is consensus on the challenges, visions on how to transition are diverse, indicating that more interaction between the different stakeholder groups is required to develop consensus. Additionally, organisational and legislative structures often slow down the necessary change processes

Natural parenting : back to basics in infant care

Peer reviewe

Étude par résonance magnétique du sel de seignette irradié

Pas de Résumé disponibl

A GraspxELS approach for the job-shop with a web services paradigm packaging

International audienc

Malignes neuroleptisches Syndrom nach 30-jähriger Behandlung mit Clozapin: Eine seltene Differenzialdiagnose auf der Intensivstation

Das maligne neuroleptische Syndrom (MNS) ist eine seltene, aber potenziell letale, unerwünschte Nebenwirkung der Behandlung mit konventionellen und atypischen Neuroleptika. Wir berichten über einen 62-jährigen Patienten, der sich nach 30-jähriger unauffälliger Behandlung mit Clozapin plötzlich mit subfebrilen Temperaturen, Muskelrigidität, Stupor, Leukozytose und massiver Rhabdomyolyse präsentierte. Die Clozapinmedikation wurde wegen des Verdachtes auf das Vorliegen eines MNS sistiert. Nach Abklingen der akuten Symptomatik wurde die Clozapintherapie nach 14 Tagen wieder aufgenommen, was am darauf folgenden Tag zu erneuter, diesmal abgeschwächter Symptomatik mit subfebrilen Temperaturen, generalisierter Katatonie, Leukozytose und erhöhter Serum-Kreatinkinase führte. Die Therapie mit Clozapin wurde in Annahme eines diesmal schwächer ausgeprägten, wahrscheinlich beginnenden MNS definitiv sistiert und auf eine Monotherapie mit Benzodiazepinen umgestellt, was auch nach 1 Monat zur Symptomfreiheit führte. Die Latenzzeit von 30 Jahren zwischen Therapiebeginn mit Clozapin und der Manifestation eines MNS ist die längste in der Literatur beschriebene Periode. Die Differenzialdiagnose des MNS ist, wie der vorliegende Fall beweist, daher nicht immer trivial und wird diskutiert. = The neuroleptic malignant syndrome (NMS) is a rare, but potentially lethal side effect of conventional and atypical antipsychotic drugs. We present a 62 years old male patient who was admitted to our institution because of sudden onset of mild hyperthermia, muscle rigidity, stupor, leucocytosis and massive rhabdomyolysis after 30 years uneventful treatment with clozapine. The medication with clozapine was suspended because of the suspicion of NMS. When the acute symptoms were abated, the treatment with clozapine was resumed again after 14 days. The very next day, the patient suffered again from raised body core temperature, leucocytosis, elevated serum creatine kinase and new catatonia. The therapy with clozapine was stopped definitively and benzodiazepines were administered assuming a relapse of an alleviated, probably reconvening NMS. Under the treatment with benzodiazepines the patient was free of symptoms even after 1 month. To our knowledge, the latency of 30 years between the beginning of the treatment with clozapine and the onset of NMS is the longest period in the literature. According to our case, the differential diagnosis of NMS is not always trivial and is therefore discussed