Sequentially dinormal ditopological texture spaces and dimetrizability

AbstractThe authors extend the bitopological notion of sequential normality to ditopological texture spaces, and use this notion to state and prove a (pseudo-)dimetrizability theorem

A broadband multilevel fast multipole algorithm with incomplete-leaf tree structures for multiscale electromagnetic problems

An efficient, broadband, and accurate multilevel fast multipole algorithm (MLFMA) is proposed to solve a wide range of multiscale electromagnetic problems with orders of magnitude differences in the mesh sizes. Given a maximum RWG population threshold, only overcrowded boxes are recursively bisected into smaller ones, which leads to novel incomplete-leaf tree structures. Simulations reveal that, for surface discretizations possessing highly overmeshed local regions, the proposed method presents a more efficient and/or accurate results than the conventional MLFMA. The key feature of such a population-based clustering scenario is that the error is controllable, and hence, regardless of the number of levels, the efficiency can be optimized based on the population threshold. Numerical examples are provided to demonstrate the superior efficiency and accuracy of the proposed algorithm in comparison to the conventional MLFMA. © 2016 European Association of Antennas and Propagation

Bovine Colostrum and Its Potential for Human Health and Nutrition

Colostrum is the first milk produced post-partum by mammals and is compositionally distinct from mature milk. Bovine colostrum has a long history of consumption by humans, and there have been a number of studies investigating its potential for applications in human nutrition and health. Extensive characterization of the constituent fractions has identified a wealth of potentially bioactive molecules, their potential for shaping neonatal development, and the potential for their application beyond the neonatal period. Proteins, fats, glycans, minerals, and vitamins are abundant in colostrum, and advances in dairy processing technologies have enabled the advancement of bovine colostrum from relative limitations of a fresh and unprocessed food to a variety of potential applications. In these forms, clinical studies have examined bovine colostrumas having the substantial potential to improve human health. This review discusses the macro-and micronutrient composition of colostrum as well as describing well-characterized bioactives found in bovine colostrum and their potential for human health. Current gaps in knowledge are also identified and future directions are considered in order to elevate the potential for bovine colostrum as a component of a healthy diet for a variety of relevant human populations

Ion mobility-tandem mass spectrometry of mucin-type O-glycans

The dense O-glycosylation of mucins plays an important role in the defensive properties of the mucus hydrogel. Aberrant glycosylation is often correlated with inflammation and pathology such as COPD, cancer, and Crohn’s disease. The inherent complexity of glycans and the diversity in the O-core structure constitute fundamental challenges for the analysis of mucin-type O-glycans. Due to coexistence of multiple isomers, multidimensional workflows such as LC-MS are required. To separate the highly polar carbohydrates, porous graphitized carbon is often used as a stationary phase. However, LC-MS workflows are time-consuming and lack reproducibility. Here we present a rapid alternative for separating and identifying O-glycans released from mucins based on trapped ion mobility mass spectrometry. Compared to established LC-MS, the acquisition time is reduced from an hour to two minutes. To test the validity, the developed workflow was applied to sputum samples from cystic fibrosis patients to map O-glycosylation features associated with disease