Building and exploiting a Digital Twin for the management of drinking water distribution networks

[EN] Digital Twins (DTs) are starting to be exploited to improve the management of water distribution systems (WDSs) and, in the future, they will be crucial for decision making. In this paper, the authors propose several requirements that a DT of a water distribution system should accomplish. Developing a DT is a challenge, and a continuous process of adjustments and learning is required. Due to the advantages of having a DT of the WDS always available, during the last years a strategy to build and maintain a DT of the water distribution network of Valencia (Spain) and its Metropolitan Area (1.6 million inhabitants) was developed. This is one of the first DTs built of a water utility, being currently in operation. The great benefits of their use in the daily operation of the system ensure that they will begin to be usual in the most advanced smart cities.Conejos Fuertes, P.; Martínez Alzamora, F.; Hervás-Carot, M.; Alonso Campos, JC. (2020). Building and exploiting a Digital Twin for the management of drinking water distribution networks. Urban Water Journal. 17(8):704-713. https://doi.org/10.1080/1573062X.2020.1771382S704713178Chacón Ramírez, E., Albarrán, J. C., & Cruz Salazar, L. A. (2019). The Control of Water Distribution Systems as a Holonic System. Studies in Computational Intelligence, 352-365. doi:10.1007/978-3-030-27477-1_27Grieves, M., et al. 2015. Virtually Intelligent Product Systems: Digital and Physical Twins. In Complex Systems Engineering: Theory and Practice, edited by S. Flumerfelt, et al., 175–200. American Institute of Aeronautics and Astronautics.Hatchett, S., J. Uber, D. Boccelli, T. Haxton, R. Janke, A. Kramer, A. Matracia, and S. Panguluri. 2011. “Real-Time Distribution System Modeling: Development, Application, and Insights.” Urban Water Management: Challenges and Oppurtunities - 11thInternational Conference on Computing and Control for the Water Industry, CCWI 2011 July.Kartakis, S., Abraham, E., & McCann, J. A. (2015). WaterBox. Proceedings of the 1st ACM International Workshop on Cyber-Physical Systems for Smart Water Networks. doi:10.1145/2738935.2738939Lin, J., Sedigh, S., & Miller, A. (2009). Towards Integrated Simulation of Cyber-Physical Systems: A Case Study on Intelligent Water Distribution. 2009 Eighth IEEE International Conference on Dependable, Autonomic and Secure Computing. doi:10.1109/dasc.2009.140Qi, Q., & Tao, F. (2018). Digital Twin and Big Data Towards Smart Manufacturing and Industry 4.0: 360 Degree Comparison. IEEE Access, 6, 3585-3593. doi:10.1109/access.2018.2793265Alac, M. (2008). Working with Brain Scans. Social Studies of Science, 38(4), 483-508. doi:10.1177/0306312708089715Shi, Y., Xu, J., & Du, W. (2019). Discussion on the New Operation Management Mode of Hydraulic Engineering Based on the Digital Twin Technique. Journal of Physics: Conference Series, 1168, 022044. doi:10.1088/1742-6596/1168/2/022044Tao, F., Zhang, H., Liu, A., & Nee, A. Y. C. (2019). Digital Twin in Industry: State-of-the-Art. IEEE Transactions on Industrial Informatics, 15(4), 2405-2415. doi:10.1109/tii.2018.2873186Tao, F., Cheng, J., Qi, Q., Zhang, M., Zhang, H., & Sui, F. (2017). Digital twin-driven product design, manufacturing and service with big data. The International Journal of Advanced Manufacturing Technology, 94(9-12), 3563-3576. doi:10.1007/s00170-017-0233-1Tao, F., & Qi, Q. (2019). Make more digital twins. Nature, 573(7775), 490-491. doi:10.1038/d41586-019-02849-1Uber, J., S. Hatchett, S. Hooper, D. Boccelli, H. Woo, and R. Janke. 2014. Water Utility Case Study of Real-Time Network Hydaulic and Water Qualilty Modeling Using EPANET-RTX Libraries. EPA 6007R-14/350 Report. Cincinnati, Ohio: Environmental Protection Agency.Wang, Z., Song, H., Watkins, D. W., Ong, K. G., Xue, P., Yang, Q., & Shi, X. (2015). Cyber-physical systems for water sustainability: challenges and opportunities. IEEE Communications Magazine, 53(5), 216-222. doi:10.1109/mcom.2015.710566

Examining the impact of dry climates temperature on citrus fruit internal ripening

[EN] High temperatures alter the ripening process of citrus fruit, affecting quality, flavor, harvest time and marketing period. For example, citrus fruits ripen faster and are sweeter in tropical hot-humid climates than in Mediterranean warm-dry climates due to higher sugar accumulation and organic acid catabolism. Considering that: 1) over 60 % of the world's citrus exports come from countries with warm Mediterranean climates, and 2) the Mediterranean region is warming 20 % faster than the global average, the citrus industry will face significant challenges in the coming years. The range of high temperatures and the timing at which they determine sugar and acid content in dry climates have not been studied under field conditions. Therefore, a study was undertaken over 6 years to determine the relationship between high temperature and citrus ripening in two dry macroclimates, hot (Arid, in Morocco) and warm (Mediterranean, in Spain), and 5 microclimates of the Mediterranean region. Heat stress in these dry climates correlates with changes in fruit quality (lower juice and sugar content, and higher organic acids), depending on the maximum temperature threshold and the time of onset and duration of heat. In the arid climate, the heat stress threshold was found to be a significant number of days above 35 degrees C. This was particularly important at the beginning of summer (July in the northern hemisphere). However, in the current Mediterranean climate of Spain, the percentage of summer days above 35 degrees C is still low indicating that other microclimatic conditions are involved in determining fruit quality. In particular, an increase in the number of days with temperatures between 27 degrees C and 33 degrees C in late summer and early autumn was found to correlate with reduced citric acid concentration. Microclimate did not determine sucrose, fructose, and glucose concentrations.Mesejo Conejos, C.; Martinez Fuentes, A.; Reig, C.; El-Otmani, M.; Agustí Fonfría, M. (2024). Examining the impact of dry climates temperature on citrus fruit internal ripening. Scientia Horticulturae. 337. https://doi.org/10.1016/j.scienta.2024.11350133

Cultural dynamism and business vitality in medium-sized cities—evidence and proposals for sustainable development

This work uses tools recently designed to conduct analyses and proposals around the cultural development of medium-sized cities. The Cultural and Creative Cities Monitor model, or CCCM, is first applied to the 81 cities in Spain with between 50, 000 and 100, 000 inhabitants. We also refer to the UNESCO Culture/2030 Indicators, specifically indicator 8 (Cultural companies), to in-vestigate whether cultural dynamism is related to business vitality in those cities. Our observation of the 29 CCCM indicators and the C3 index, which synthesizes cultural performance, is explained, and these data are complemented with cultural business data (on assets, benefits, and jobs) from a sample of 13, 204 firms. The C3 index values reveal significant differences in the cultural and creative performance of the selected cities according to their location (metropolitan or non-metropolitan) and their administrative rank. Moreover, when comparing the C3 index with the indicators on business activity, evidence indicates a clear positive relationship between cultural dynamism and firm vitality. These results support the contribution of culture to the sustainable development of me-dium-sized Spanish cities and further establish the suitability of the tools used to assist cities in designing appropriate cultural policies

AUP’S ROLE IN EVANGELISM AS EXPERIENCED BY THE STUDENTS

The Adventist University of the Philippines (AUP) is celebrating its centennial anniversary this academic year. In  its 100 years of existence providing quality education not only to Filipino citizens but also to other nationalities from over 60 countries, AUP has been doing its role in soul-winning, being one of the functions of Adventist  education. In fact, Adventist education’s primary role is to lead the youth in finding a saving relationship with Jesus Christ, thus this qualitative phenomenological study was conducted to find out how AUP has performed such function. The participants of the study were eight AUP students, four undergraduates and four graduates who were all converted and baptized in AUP. One of the participants, a graduate student, was baptized in his country in Senegal but did not feel any change in his life after baptism and only did he find true relationship with Jesus in AUP so he decided to be rebaptized here. Data were gathered through semi- structured interviews. The audio-recorded interviews were transcribed and analyzed. Eight themes emerged as to how the study participants found a saving relationship with Jesus in AUP: encouragement  and close relationships in small groups, Week of Prayer touching messages, devotions in classes, Bible study with friends, ways of worship in SDA specifically in AUP including music, influence of faculty and guardians, participation in the Voice of Youth (VOY) and beautiful landscape or nature of AUP that draws students close to the Creator and Savior. These results show the significance of AUP in terms of its role in winning souls and these may serve as basis in further designing and strengthening of spiritual enrichment programs

Genetic inhibition of flowering differs between juvenile and adult Citrus trees

[EN] Background and Aims In woody species, the juvenile period maintains the axillary meristems in a vegetative stage, unable to flower, for several years. However, in adult trees, some 1-year-old meristems flower whereas others remain vegetative to ensure a polycarpic growth habit. Both types of trees, therefore, have non-flowering meristems, and we hypothesize that the molecular mechanism regulating flower inhibition in juvenile trees is different from that in adult trees. Methods In adult Citrus trees, the main endogenous factor inhibiting flower induction is the growing fruit. Thus, we studied the expression of the main flowering time, identity and patterning genes of trees with heavy fruit load (not-flowering adult trees) compared to that of 6-month-old trees (not-flowering juvenile trees). Adult trees without fruits (flowering trees) were used as a control. Second, we studied the expression of the same genes in the meristems of 6-month, and 1-, 3-, 5-and 7-year-old juvenile trees compared to 10-year-old flowering trees. Key Results The axillary meristems of juvenile trees are unable to transcribe flowering time and patterning genes during the period of induction, although they are able to transcribe the FLOWERING LOCUS T citrus orthologue (CiFT2) in leaves. By contrast, meristems of not-flowering adult trees are able to transcribe the flowering network genes but fail to achieve the transcription threshold required to flower, due to CiFT2 repression by the fruit. Juvenile meristems progressively achieve gene expression, with age-dependent differences from 6 months to 7 years, FD-like and CsLFY being the last genes to be expressed. Conclusions During the juvenile period the mechanism inhibiting flowering is determined in the immature bud, so that it progressively acquires flowering ability at the gene expression level of the flowering time programme, whereas in the adult tree it is determined in the leaf, where repression of CiFT2 gene expression occurs.We thank Cristina Ferrandiz (IBMCP-UPV, Spain) and Fernando Andres (UMR AGAP, France) for useful comments on the manuscript. We thank D. Westall for her help in editing the manuscript. This work was supported by a grant from the Ministerio de Economia y Competitividad, Spain (RTA2013-0024-C02-02)Muñoz Fambuena, N.; Nicolas-Almansa, M.; Martinez Fuentes, A.; Reig Valor, C.; Iglesias, DJ.; Primo-Millo, E.; Mesejo Conejos, C.... (2019). Genetic inhibition of flowering differs between juvenile and adult Citrus trees. Annals of Botany. 123(3):483-490. https://doi.org/10.1093/aob/mcy179S4834901233Abe, M. (2005). FD, a bZIP Protein Mediating Signals from the Floral Pathway Integrator FT at the Shoot Apex. Science, 309(5737), 1052-1056. doi:10.1126/science.1115983Albani, M. C., & Coupland, G. (2010). Comparative Analysis of Flowering in Annual and Perennial Plants. Plant Development, 323-348. doi:10.1016/s0070-2153(10)91011-9Andrés, F., & Coupland, G. (2012). The genetic basis of flowering responses to seasonal cues. Nature Reviews Genetics, 13(9), 627-639. doi:10.1038/nrg3291Balanzà, V., Martínez-Fernández, I., Sato, S., Yanofsky, M. F., Kaufmann, K., Angenent, G. C., … Ferrándiz, C. (2018). Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway. Nature Communications, 9(1). doi:10.1038/s41467-018-03067-5Bäurle, I., & Dean, C. (2006). The Timing of Developmental Transitions in Plants. Cell, 125(4), 655-664. doi:10.1016/j.cell.2006.05.005Betancourt, M., Sistachs, V., Martínez-Fuentes, A., Mesejo, C., Reig, C., & Agustí, M. (2014). Influence of harvest date on fruit yield and return bloom in ‘Marsh’ grapefruit trees (Citrus paradisiMacf.) grown under a tropical climate. The Journal of Horticultural Science and Biotechnology, 89(4), 435-440. doi:10.1080/14620316.2014.11513103Blázquez, M. A., Ferrándiz, C., Madueño, F., & Parcy, F. (2006). How Floral Meristems are Built. Plant Molecular Biology, 60(6), 855-870. doi:10.1007/s11103-006-0013-zBlümel, M., Dally, N., & Jung, C. (2015). Flowering time regulation in crops — what did we learn from Arabidopsis? Current Opinion in Biotechnology, 32, 121-129. doi:10.1016/j.copbio.2014.11.023Castillo, M.-C., Forment, J., Gadea, J., Carrasco, J. L., Juarez, J., Navarro, L., & Ancillo, G. (2013). Identification of transcription factors potentially involved in the juvenile to adult phase transition in Citrus. Annals of Botany, 112(7), 1371-1381. doi:10.1093/aob/mct211Chica, E. J., & Albrigo, L. G. (2013). Expression of Flower Promoting Genes in Sweet Orange during Floral Inductive Water Deficits. Journal of the American Society for Horticultural Science, 138(2), 88-94. doi:10.21273/jashs.138.2.88Endo, T., Shimada, T., Fujii, H., Kobayashi, Y., Araki, T., & Omura, M. (2005). Ectopic Expression of an FT Homolog from Citrus Confers an Early Flowering Phenotype on Trifoliate Orange (Poncirus trifoliata L. Raf.). Transgenic Research, 14(5), 703-712. doi:10.1007/s11248-005-6632-3Haberman, A., Ackerman, M., Crane, O., Kelner, J.-J., Costes, E., & Samach, A. (2016). Different flowering response to various fruit loads in apple cultivars correlates with degree of transcript reaccumulation of a TFL1-encoding gene. The Plant Journal, 87(2), 161-173. doi:10.1111/tpj.13190Hanano, S., & Goto, K. (2011). Arabidopsis TERMINAL FLOWER1 Is Involved in the Regulation of Flowering Time and Inflorescence Development through Transcriptional Repression. The Plant Cell, 23(9), 3172-3184. doi:10.1105/tpc.111.088641Mafra, V., Kubo, K. S., Alves-Ferreira, M., Ribeiro-Alves, M., Stuart, R. M., Boava, L. P., … Machado, M. A. (2012). Reference Genes for Accurate Transcript Normalization in Citrus Genotypes under Different Experimental Conditions. PLoS ONE, 7(2), e31263. doi:10.1371/journal.pone.0031263Martínez-Fuentes, A., Mesejo, C., Reig, C., & Agustí, M. (2010). Timing of the inhibitory effect of fruit on return bloom of ‘Valencia’ sweet orange (Citrus sinensis (L.) Osbeck). Journal of the Science of Food and Agriculture, 90(11), 1936-1943. doi:10.1002/jsfa.4038Michaels, S. D., & Amasino, R. M. (1999). FLOWERING LOCUS C Encodes a Novel MADS Domain Protein That Acts as a Repressor of Flowering. The Plant Cell, 11(5), 949-956. doi:10.1105/tpc.11.5.949Muñoz-Fambuena, N., Mesejo, C., Carmen González-Mas, M., Primo-Millo, E., Agustí, M., & Iglesias, D. J. (2011). Fruit regulates seasonal expression of flowering genes in alternate-bearing ‘Moncada’ mandarin. Annals of Botany, 108(3), 511-519. doi:10.1093/aob/mcr164Muñoz-Fambuena, N., Mesejo, C., González-Mas, M. C., Primo-Millo, E., Agustí, M., & Iglesias, D. J. (2012). Fruit load modulates flowering-related gene expression in buds of alternate-bearing ‘Moncada’ mandarin. Annals of Botany, 110(6), 1109-1118. doi:10.1093/aob/mcs190Nishikawa, F., Endo, T., Shimada, T., Fujii, H., Shimizu, T., Omura, M., & Ikoma, Y. (2007). Increased CiFT abundance in the stem correlates with floral induction by low temperature in Satsuma mandarin (Citrus unshiu Marc.). Journal of Experimental Botany, 58(14), 3915-3927. doi:10.1093/jxb/erm246Peña, L., Martín-Trillo, M., Juárez, J., Pina, J. A., Navarro, L., & Martínez-Zapater, J. M. (2001). Constitutive expression of Arabidopsis LEAFY or APETALA1 genes in citrus reduces their generation time. Nature Biotechnology, 19(3), 263-267. doi:10.1038/85719Pillitteri, L. J., Lovatt, C. J., & Walling, L. L. (2004). Isolation and Characterization of a TERMINAL FLOWER Homolog and Its Correlation with Juvenility in Citrus. Plant Physiology, 135(3), 1540-1551. doi:10.1104/pp.103.036178Seo, E., Lee, H., Jeon, J., Park, H., Kim, J., Noh, Y.-S., & Lee, I. (2009). Crosstalk between Cold Response and Flowering in Arabidopsis Is Mediated through the Flowering-Time Gene SOC1 and Its Upstream Negative Regulator FLC. The Plant Cell, 21(10), 3185-3197. doi:10.1105/tpc.108.063883Sgamma, T., Jackson, A., Muleo, R., Thomas, B., & Massiah, A. (2014). TEMPRANILLO is a regulator of juvenility in plants. Scientific Reports, 4(1). doi:10.1038/srep03704Shalom, L., Samuels, S., Zur, N., Shlizerman, L., Zemach, H., Weissberg, M., … Sadka, A. (2012). Alternate Bearing in Citrus: Changes in the Expression of Flowering Control Genes and in Global Gene Expression in ON- versus OFF-Crop Trees. PLoS ONE, 7(10), e46930. doi:10.1371/journal.pone.0046930Shalom, L., Samuels, S., Zur, N., Shlizerman, L., Doron-Faigenboim, A., Blumwald, E., & Sadka, A. (2014). Fruit load induces changes in global gene expression and in abscisic acid (ABA) and indole acetic acid (IAA) homeostasis in citrus buds. Journal of Experimental Botany, 65(12), 3029-3044. doi:10.1093/jxb/eru148Sohn, E. J., Rojas-Pierce, M., Pan, S., Carter, C., Serrano-Mislata, A., Madueno, F., … Raikhel, N. V. (2007). The shoot meristem identity gene TFL1 is involved in flower development and trafficking to the protein storage vacuole. Proceedings of the National Academy of Sciences, 104(47), 18801-18806. doi:10.1073/pnas.0708236104Spiegel-Roy, P., & Goldschmidt, E. E. (1996). The Biology of Citrus. doi:10.1017/cbo9780511600548Sussmilch, F. C., Berbel, A., Hecht, V., Vander Schoor, J. K., Ferrándiz, C., Madueño, F., & Weller, J. L. (2015). Pea VEGETATIVE2 Is an FD Homolog That Is Essential for Flowering and Compound Inflorescence Development. The Plant Cell, 27(4), 1046-1060. doi:10.1105/tpc.115.136150Tan, F.-C., & Swain, S. M. (2007). Functional characterization of AP3, SOC1 and WUS homologues from citrus (Citrus sinensis). Physiologia Plantarum, 131(3), 481-495. doi:10.1111/j.1399-3054.2007.00971.xLeal Valentim, F., Mourik, S. van, Posé, D., Kim, M. C., Schmid, M., van Ham, R. C. H. J., … van Dijk, A. D. J. (2015). A Quantitative and Dynamic Model of the Arabidopsis Flowering Time Gene Regulatory Network. PLOS ONE, 10(2), e0116973. doi:10.1371/journal.pone.0116973Wang, J.-W., Czech, B., & Weigel, D. (2009). miR156-Regulated SPL Transcription Factors Define an Endogenous Flowering Pathway in Arabidopsis thaliana. Cell, 138(4), 738-749. doi:10.1016/j.cell.2009.06.014Weigel, D. (1995). The Genetics of Flower Development: From Floral Induction to Ovule Morphogenesis. 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Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates

Alzheimer’s disease (AD), the most prevalent form of dementia, remains incurable mainly due to our failings in the search for effective pharmacological strategies. Here, we describe the development of targeted multimodal polypeptide-based nanoconjugates as potential AD treatments. Treatment with polypeptide nanoconjugates bearing propargylamine moieties and bisdemethoxycurcumin or genistein afforded neuroprotection and displayed neurotrophic effects, as evidenced by an increase in dendritic density of pyramidal neurons in organotypic hippocampal culture. The additional conjugation of the Angiopep-2 targeting moiety enhanced nanoconjugate passage through the blood-brain barrier and modulated brain distribution with nanoconjugate accumulation in neurogenic areas, including the olfactory bulb. Nanoconjugate treatment effectively reduced neurotoxic amyloid aggregate levels and rescued impairments to olfactory memory and object recognition in APP/PS1 transgenic AD model mice. Overall, this study provides a description of a targeted multimodal polyglutamate-based nanoconjugate with neuroprotective and neurotrophic potential for AD treatment. Copyrigh

A scoring system to detect fixed airflow limitation in smokers from simple easy-to-use parameters

No validated screening method currently exists for Chronic Obstructive Pulmonary Disease (COPD) in smokers. Therefore, we constructed a predictive model with simple parameters that can be applied for COPD screening to detect fixed airflow limitation. This observational cross-sectional study included a random sample of 222 smokers with no previous diagnosis of COPD undertaken in a Spanish region in 2014–2016. The main variable was fixed airflow limitation by spirometry. The secondary variables (COPD factors) were: age, gender, smoking (pack-years and Fagerström test), body mass index, educational level, respiratory symptoms and exacerbations. A points system was developed to predict fixed airflow limitation based on secondary variables. The model was validated internally through bootstrapping, determining discrimination and calibration. The system was then integrated into a mobile application for Android. Fifty-seven patients (25.7%) presented fixed airflow limitation. The points system included as predictors: age, pack-years, Fagerström test and presence of respiratory symptoms. Internal validation of the system was very satisfactory, both in discrimination and calibration. In conclusion, a points system has been constructed to predict fixed airflow limitation in smokers with no previous COPD. This system can be integrated as a screening tool, though it should be externally validated in other geographical regions

Teaching linguistic politeness: a methodological proposal

The aim of this article is to explore theoretical and methodological aspects of the teaching of pragmatics in a second language. Taking as point of departure the pragmatic continuum, which includes pragmalinguistics and sociopragmatics, we focus on the promotion of sociopragmatic knowledge in classroom contexts. More specifically, it is argued that a revised contextual and interactional view of Brown and Levinson¿s (1987) model of linguistic politeness, related to such notions as genre and politeness systems, offers suitable tools of pragmatic description for use in teaching and learning second languages. We start with a brief overview of linguistic politeness from a socio-cognitive framework. Then, we revise the main methodological approaches to the teaching of pragmatic knowledge in general and the specific teaching of linguistic politeness in particular. Finally, we make a methodological proposal for use in foreign language instruction

Assessing sustainability in housing LED urban regeneration : insights from a housing association in Northern England

How far do current assessment methods allow the thorough evaluation of sustainable urban regeneration? Would it be useful, to approach the evaluation of the environmental and social impacts of housing regeneration schemes, by making both hidden pitfalls and potentials explicit, and budgeting costs and benefits in the stakeholders’ perspective? The paper aims at answering these questions, by focusing on a case study located in the Manchester area, the City West Housing Trust, a nonprofit housing association. Drawing from extensive fieldwork and including several interviews with key experts from this housing association, the paper first attempts to monetize the environmental and social value of two extant projects – a high-rise housing estate and an environmentally-led program. It then discusses whether and how a stakeholder-oriented approach would allow more engagement of both current and potential funders in the projects at hand. Findings from both the literature and the empirical data that was gathered show how in current housing regeneration processes, room for significant improvements in terms of assessment methods still exist. Findings additionally show that the environmental and social spillovers are largely disregarded because of a gap in the evaluation tools. This may also hinder the potential contributions of further funders in the achievements of higher impacts in terms of sustainability

La infección del tracto urinario como causa principal de ingreso en pacientes cistectomizados

Introducción y objetivos La cistectomía radical con derivación urinaria asociada a linfadenectomía pélvica ampliada continúa siendo el tratamiento de elección en el cáncer vesical musculoinvasivo. Un 64% de los pacientes presentan complicaciones postoperatorias, siendo la infección urinaria responsable en un 20-40% de los casos. El objetivo del presente proyecto es valorar la tasa de infección urinaria como causa de reingreso tras cistectomía, e identificar factores protectores y predisponentes de infección urinaria en nuestro medio. Por último, conocer los resultados obtenidos al aplicar el protocolo de profilaxis antibiótica tras la retirada de los catéteres ureterales. Material y métodos Estudio descriptivo retrospectivo de pacientes cistectomizados en el Servicio de Urología del Hospital Clínico Universitario desde enero de 2012 hasta diciembre de 2018. Desde octubre de 2017, de forma estandarizada, a todo paciente se le aplica un protocolo de prevención de infección del tracto urinario (ITU) tras la retirada de catéteres. Resultados La ITU es responsable del 54, 7% de los reingresos, siendo un 55, 1% de estos por causa de una ITU tras la retirada de los catéteres ureterales. El 9, 5% de los pacientes con profilaxis presenta ITU tras la retirada, frente a un 10, 6% en el grupo de pacientes sin profilaxis. El paciente que reingresa por ITU tras la retirada tiene un tiempo de catéteres medio de 24, 3 ± 7, 2 días, frente a los 24, 5 ± 7, 4 días en el grupo sin ITU (p = 0, 847). Conclusiones El tipo de derivación urinaria empleada no guarda relación con la tasa de infección urinaria. El modelo de regresión no identifica la profilaxis antibiótica, ni tampoco el tiempo de catéteres, como factores independientes de ITU tras la retirada de los catéteres. Introduction and objectives: Radical cystectomy with urinary diversion associated with extended pelvic lymphadenectomy continues to be the treatment of choice in muscle invasive bladder cancer. Sixty-four percent of patients submitted to this procedure present postoperative complications, with urinary infection being responsible in 20-40% of cases. The aim of this project is to assess the rate of urinary infection as a cause of re-admission after cystectomy, and to identify protective and predisposing factors for urinary infection in our environment. Finally, we will evaluate the outcomes after the establishment of a prophylactic antibiotic protocol after removal of ureteral catheters. Material and methods: Retrospective descriptive study of cystectomized patients in the Urology Service of the Hospital Clínico Universitario of Zaragoza, from January 2012 to December 2018. A urinary tract infection (UTI) prevention protocol after catheter removal is established for all patients since October 2017. Results: UTI is responsible for 54.7% of readmissions, with 55.1% of these being due to UTI after removal of ureteral catheters. Of the patients who received with prophylaxis, 9.5% presented UTIs after withdrawal, compared to 10.6% in the group of patients without prophylaxis. The patient who is re-admitted for UTI after withdrawal has a mean catheter time of 24.3 ± 7.2 days, compared to 24.5 ± 7.4 days for patients in the group without UTI (P =.847). Conclusions: The type of urinary diversion performed is not related to the rate of urinary infection. The regression model does not identify antibiotic prophylaxis, nor catheter time, as independent factors of UTI after catheter removal