The Resolved Asteroid Program - Size, shape, and pole of (52) Europa

With the adaptive optics (AO) system on the 10 m Keck-II telescope, we acquired a high quality set of 84 images at 14 epochs of asteroid (52) Europa on 2005 January 20. The epochs covered its rotation period and, by following its changing shape and orientation on the plane of sky, we obtained its triaxial ellipsoid dimensions and spin pole location. An independent determination from images at three epochs obtained in 2007 is in good agreement with these results. By combining these two data sets, along with a single epoch data set obtained in 2003, we have derived a global fit for (52) Europa of diameters (379x330x249) +/- (16x8x10) km, yielding a volume-equivalent spherical-diameter of 315 +/- 7 km, and a rotational pole within 7 deg of [RA; Dec] = [257,+12] in an Equatorial J2000 reference frame (ECJ2000: 255,+35). Using the average of all mass determinations available forEuropa, we derive a density of 1.5 +/- 0.4, typical of C-type asteroids. Comparing our images with the shape model of Michalowski et al. (A&A 416, 2004), derived from optical lightcurves, illustrates excellent agreement, although several edge features visible in the images are not rendered by the model. We therefore derived a complete 3-D description of Europa's shape using the KOALA algorithm by combining our imaging epochs with 4 stellar occultations and 49 lightcurves. We use this 3-D shape model to assess these departures from ellipsoidal shape. Flat facets (possible giant craters) appear to be less distinct on (52) Europa than on other C-types that have been imaged in detail. We show that fewer giant craters, or smaller craters, is consistent with its expected impact history. Overall, asteroid (52) Europa is still well modeled as a smooth triaxial ellipsoid with dimensions constrained by observations obtained over several apparitions.Comment: Accepted for publication in Icaru

Interploidy Hybridization In Sympatric Zones: The Formation Of Epidendrum Fulgens × e. Puniceoluteum Hybrids (epidendroideae, Orchidaceae)

Interspecific hybridization is a primary cause of extensive morphological and chromosomal variation and plays an important role in plant species diversification. However, the role of interploidal hybridization in the formation of hybrid swarms is less clear. Epidendrum encompasses wide variation in chromosome number and lacks strong premating barriers, making the genus a good model for clarifying the role of chromosomes in postzygotic barriers in interploidal hybrids. In this sense, hybrids from the interploidal sympatric zone between E. fulgens (2n = 2x = 24) and E. puniceoluteum (2n = 4x = 56) were analyzed using cytogenetic techniques to elucidate the formation and establishment of interploidal hybrids. Hybrids were not a uniform group: two chromosome numbers were observed, with the variation being a consequence of severe hybrid meiotic abnormalities and backcrossing with E. puniceoluteum. The hybrids were triploids (2n = 3x = 38 and 40) and despite the occurrence of enormous meiotic problems associated with triploidy, the hybrids were able to backcross, producing successful hybrid individuals with broad ecological distributions. In spite of the nonpolyploidization of the hybrid, its formation is a long-term evolutionary process rather than a product of a recent disturbance, and considering other sympatric zones in Epidendrum, these events could be recurrent. © 2013 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd.31138243837Aagaard, S.M.D., Såstad, S.M., Greilhuber, J., Moen, A., A secondary hybrid zone between diploid Dactylorhiza incarnata ssp. cruenta and allotetraploid D. lapponica (Orchidaceae) (2005) Heredity, 94, pp. 488-496Abbott, R., Albach, D., Ansell, S., Arntzen, J.W., Baird, S.J.E., Bierne, N., Hybridization and speciation (2013) J. Evol. Biol., 26, pp. 229-246Alexander, M.P., A versatile stain for pollen fungi, yeast and bacteria (1980) Stain Technol., 55, pp. 13-18Almeida, A.M., Figueiredo, R.A., Ants visit nectaries of Epidendrum denticulatum (Orchidaceae) in a Brazilian rainforest: effects on herbivory and pollination (2003) Braz. J. Biol., 63, pp. 551-558Arnold, M.L., Ballerini, E.S., Brothers, A.N., Hybrid fitness, adaptation and evolutionary diversification: lessons learned from Louisiana Irises (2012) Heredity, 108, pp. 159-166. , Nature Publishing GroupAyres, M., Jr Ayres, M., Ayres, D.L., Santos, A.A.S., (2007) BioEstat. V. 5, , Sociedade Civil Mamirauá, BrazilBellusci, F., Pellegrino, G., Palermo, A.M., Musacchio, A., Crossing barriers between the unrewarding Mediterranean orchids Serapias vomeracea and Serapias cordigera (2010) Plant Species Biol., 25, pp. 68-76Blumenschein, A., Número de cromossomas de algumas espécies de orquídeas (1960) Publicações Científicas da Universidade de São Paulo, 1, pp. 45-50Bomblies, K., Lempe, J., Epple, P., Warthmann, N., Lanz, C., Dangl, J.L., Autoimmune response as a mechanism for a Dobzhansky-Muller-type incompatibility syndrome in plants (2007) PLoS Biol., 5, pp. e236Buerkle, C.A., Morris, R.J., Asmussen, M.A., Rieseberg, L.H., The likelihood of homoploid hybrid speciation (2000) Heredity, 84 (PART 4), pp. 441-451Buggs, R.J.A., Soltis, P.S., Soltis, D.E., Does hybridization between divergent progenitors drive whole-genome duplication? (2009) Mol. Ecol., 18, pp. 3334-3339Buggs, R.J.A., Renny-Byfield, S., Chester, M., Jordon-Thaden, I.E., Viccini, L.F., Chamala, S., Next-generation sequencing and genome evolution in allopolyploids (2012) Am. J. Bot., 99, pp. 372-382Chapman, M.A., Abbott, R.J., Introgression of fitness genes across a ploidy barrier (2010) New Phytol., 186, pp. 63-71Chapman, M.A., Burke, J.M., Genetic divergence and hybrid speciation (2007) Evolution, 61, pp. 1773-1780Chase, C.D., Cytoplasmic male sterility: a window to the world of plant mitochondrial-nuclear interactions (2007) Trends Genet., 23, pp. 81-90Chester, M., Leitch, A.R., Soltis, P.S., Soltis, D.E., Review of the application of modern cytogenetic methods (FISH/GISH) to the study of reticulation (polyploidy/hybridisation) (2010) Genes, 1, pp. 166-192Chester, M., Gallagher, J.P., Symonds, V.V., Cruz da Silva, A.V., Mavrodiev, E.V., Leitch, A.R., Extensive chromosomal variation in a recently formed natural allopolyploid species, Tragopogon miscellus (Asteraceae) (2012) Proc. Natl Acad. Sci. USA, 109, pp. 1176-1181Clarkson, J.J., Lim, K.Y., Kovarik, A., Chase, M.W., Knapp, S., Leitch, A.R., Long-term genome diploidization in allopolyploid Nicotiana section Repandae (Solanaceae) (2005) New Phytol., 168, pp. 241-252Coyne, J.A., Orr, H.A., (2004) Speciation, , 1st ed. Sinauer, Sunderland, MACozzolino, S., Emerico, S.D., Widmer, A., Evidence for reproductive isolate selection in Mediterranean orchids: karyotype differences compensate for the lack of pollinator specificity (2004) Proc. Biol. Sci., 271, pp. S259-S262Da Conceição, L.P., De Oliveira, A.L.P.C., Barbosa, L.V., Characterization of the species Epidendrum cinnabarinum Salzm. (Epidendroideae: Orchidaceae) occurring in dunas do Abaeté-Salvador, Ba-Brasil (2006) Cytologia, 71, pp. 125-129De Hert, K., Jacquemyn, H., Van Glabeke, S., Roldán-Ruiz, I., Vandepitte, K., Leus, L., Patterns of hybridization between diploid and derived allotetraploid species of Dactylorhiza (Orchidaceae) co-occurring in Belgium (2011) Am. J. Bot., 98, pp. 946-955De hert, K., Jacquemyn, H., Van Glabeke, S., Roldán-Ruiz, I., Vandepitte, K., Leus, L., Reproductive isolation and hybridization in sympatric populations of three Dactylorhiza species (Orchidaceae) with different ploidy levels (2012) Ann. Bot., 109, pp. 709-720Dressler, R.L., Will the real Epidendrum ibaguense please stand up? (1989) Am. Orchid Soc. Bull., 58, pp. 796-800Dunsterville, G.C., Orchids of Venezuela-Epidendrum elongatum (1979) Am. Orchid Soc. Bull., 48, pp. 447-454Erilova, A., Brownfield, L., Exner, V., Rosa, M., Twell, D., Mittelsten Scheid, O., Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis (2009) PLoS Genet., 5, pp. e1000663Felix, L.P., Guerra, M., Variation in chromosome number and the basic number of subfamily Epidendroideae (Orchidaceae) (2010) Bot. J. Linn. Soc., 163, pp. 234-278Ferreira, M.E., Grattapaglia, D., (1998) Introdução ao uso de marcadores moleculares em análise genética, , 3rd ed. Embrapa-Cenargen, BrasíliaFlatberg, K.I., Thingsgaard, K., Såstad, S.M., Interploidal gene flow and introgression in bryophytes: Sphagnum girgensohnii × S. russowii, a case of spontaneous neotriploidy (2006) J. Bryol., 28, pp. 27-37Flatscher, R., Frajman, B., Schönswetter, P., Paun, O., Environmental heterogeneity and phenotypic divergence: can heritable epigenetic variation aid speciation? (2012) Genet. Res. Int., 2012, p. 698421Guerra, M., O uso do Giemsa na citogenética vegetal - comparaão entre a coloração simples e o bandeamento (1983) Ciência e Cultura, 35, pp. 190-193Hágsater, E., Soto-Arenas, M.A., Epidendrum L (2005) Genera Orchidacearum, pp. 236-251. , A. M. Pridgeon, P. J. Cribb, M. W. Chase, F. N. Rasmussen, eds. Vol. 4. Oxford Univ. Press, Oxford, U.KHarder, L.D., Johnson, S.D., Function and evolution of aggregated pollen in angiosperms (2008) Int. J. Plant Sci., 169, pp. 59-78He, J.H., Shahid, M.Q., Li, Y.J., Guo, H.B., Cheng, X.A., Liu, X.D., Allelic interaction of F1 pollen sterility loci and abnormal chromosome behaviour caused pollen sterility in intersubspecific autotetraploid rice hybrids (2011) J. Exp. Bot., 62, pp. 4433-4445Heslop-Harrison, J., Microsporogenesis in some triploid dactylorchid hybrids (1953) Ann. Bot., 17, pp. 539-549Heslop-harrison, J.S.P., On the hybridization of the common spotted orchid, Dactylorchis fuchsii (Druce) Vermln., with the marsh orchids, D. praetermissa (Druce) Vermln. and D. purpurella (T. and T. A. Steph.) Vermln (1957) Proc. Linn. Soc. Lond., 167, pp. 176-185Husband, B.C., Ozimec, B., Martin, S.L., Pollock, L., Mating consequences of polyploid evolution in flowering plants: current trends and insights from synthetic polyploids (2008) Int. J. Plant Sci., 169, pp. 195-206Jiang, J., Gill, B.S., Current status and the future of fluorescence in situ hybridization (FISH) in plant genome research (2006) Genome, 1068, pp. 1057-1068Jiao, Y., Chanderbali, S., Landherr, L., Ralph, P.E., Wickett, N.J., Ayyampalayam, S., Ancestral polyploidy in seed plants and angiosperms (2011) Nature, 473, pp. 97-102Johnston, S.A., Den Nijs, T.P.M., Peloquin, S.J., Hanneman, R.E., The significance of genic balance to endosperm development in interspecific crosses (1980) Theor. Appl. Genet., 57, pp. 5-9Johnston, J.A., Wesselingh, R.A., Bouck, A.C., Donovan, L.A., Arnold, M.L., Intimately linked or hardly speaking? The relationship between genotype and environmental gradients in a Louisiana Iris hybrid population (2001) Mol. Ecol., 10, pp. 673-681Jorgensen, M.H., Ehrich, D., Schmickl, R., Koch, M.A., Brysting, A.K., Interspecific and interploidal gene flow in Central European Arabidopsis (Brassicaceae) (2011) BMC Evol. Biol., 11, p. 346. , BioMed Central LtdKoukalova, B., Moraes, A.P., Renny-Byfield, S., Matyasek, R., Leitch, A.R., Kovarik, A., Fall and rise of satellite repeats in allopolyploids of Nicotiana over c. 5 million years (2010) New Phytol., 186, pp. 148-160Leitch, A.R., Leitch, I.J., Genomic plasticity and the diversity of polyploid plants (2008) Science, 320, pp. 481-483Leitch, I.J., Hanson, L., Lim, K.Y., Kovarik, A., Chase, M.W., Clarkson, J.J., The ups and downs of genome size evolution in polyploid species of Nicotiana (Solanaceae) (2008) Ann. Bot., 101, pp. 805-814Levin, D.A., (2002) The role of chromosomal change in plant evolution, , Oxford Univ. Press, NYLexer, C., Widmer, A., The genic view of plant speciation: recent progress and emerging questions (2008) Philos. Trans. R. Soc. Lond. B Biol. Sci., 363, pp. 3023-3036Lim, K.Y., Matyasek, R., Kovarik, A., Leitch, A.R., Biological relevance of polyploidy: ecology to genomics genome evolution in allotetraploid Nicotiana (2004) Biol. J. Linn. Soc., 82, pp. 599-606Lord, R.M., Richards, A.J., A hybrid swarm between the diploid (1977) Watsonia, 11, pp. 205-210Markova, M., Vyskot, B., New horizons of genomic in situ hybridization (2009) Cytogenet. Genome Res., 126, pp. 368-375Markova, M., Michu, E., Vyskot, B., Janousek, B., Zluvova, J., An interspecific hybrid as a tool to study phylogenetic relationships in plants using the GISH technique (2007) Chromosome Res., 15, pp. 1051-1059Marques, I., Feliner, G.N., Draper Munt, D., Martins-Loução, M.A., Aguilar, J.F., Unraveling cryptic reticulate relationships and the origin of orphan hybrid disjunct populations in Narcissus (2010) Evolution, 64, pp. 2353-2368Martin, F.N., Staining and observing pollen tubes in the style by means of fluorescence (1959) Stain Technol., 34, p. 125Mayr, E., (1942) Systematics and the origin of species, , 1st ed. Columbia Univ. Press, NYMoccia, M.D., Widmer, A., Cozzolino, S., The strength of reproductive isolation in two hybridizing food-deceptive orchid species (2007) Mol. Ecol., 16, pp. 2855-2866Moraes, A.P., Guerra, M., Cytological differentiation between the two subgenomes of the tetraploid Emilia fosbergii Nicolson and its relationship with E. sonchifolia (L.) DC. (Asteraceae) (2010) Plant Syst. Evol., 287, pp. 113-118Palma-Silva, C., Wendt, T., Pinheiro, F., Barbara, T., Fay, M.F., Cozzolino, S., Sympatric bromeliad species (Pitcairnia spp.) facilitate tests of mechanisms involved in species cohesion and reproductive isolation in Neotropical inselbergs (2011) Mol. Ecol., 20, pp. 3185-3201Pansarin, E.R., Amaral, M.C.E., Reproductive biology and pollination mechanisms of Epidendrum secundum (Orchidaceae). Floral variation: a consequence of natural hybridization? (2008) Plant Biol., 10, pp. 211-219Paun, O., Forest, F., Fay, M.F., Chase, M.W., Hybrid speciation in angiosperms: parental divergence drives ploidy (2009) New Phytol., 182, pp. 507-518Paun, O., Bateman, R.M., Fay, M.F., Hedrén, M., Civeyrel, L., Chase, M.W., Stable epigenetic effects impact adaptation in allopolyploid orchids (Dactylorhiza: Orchidaceae) (2010) Mol. Biol. Evol., 27, pp. 2465-2473Paun, O., Bateman, R.M., Fay, M.F., Luna, J.A., Moat, J., Hedrén, M., Altered gene expression and ecological divergence in sibling allopolyploids of Dactylorhiza (Orchidaceae) (2011) BMC Evol. Biol., 11, p. 113. , BioMed Central LtdPaun, O., Forest, F., Fay, M.F., Chase, M.W., Parental divergence and hybrid speciation in angiosperms revisited (2011) Taxon, 60, pp. 1241-1244Pedrosa, A., Sandal, N., Stougaard, J., Schweizer, D., Bachmair, A., Chromosomal map of the model legume Lotus japonicus (2002) Genetics, 161, pp. 1661-1672Petit, C., Bretagnolle, F., Felber, F., Evolutionary consequences of diploid-polyploid hybrid zones in wild species (1999) Trends Ecol. Evol., 14, pp. 306-311Pinheiro, F., Barros, F., Epidendrum puniceoluteum, uma nova espécie de Orchidaceae do litoral brasileiro (2006) Hoehnea, 33, pp. 247-250Pinheiro, F., Cozzolino, S., Epidendrum (Orchidaceae) as a model system for ecological and evolutionary studies in the Neotropics (2013) Taxon, 62, pp. 77-88Pinheiro, F., Koehler, S., Correa, A.M., Salatino, M.L.F., Salatino, A., De Barros, F., Phylogenetic relationships and infrageneric classification of Epidendrum subgenus Amphiglottium (Laeliinae, Orchidaceae) (2009) Plant Syst. Evol., 283, pp. 165-177Pinheiro, F., De Barros, F., Palma-Silva, C., Meyer, D., Fay, M.F., Suzuki, R.M., Hybridization and introgression across different ploidy levels in the Neotropical orchids Epidendrum fulgens and E. puniceoluteum (Orchidaceae) (2010) Mol. Ecol., 19, pp. 3981-3994Presgraves, D.C., Hitchhiking to speciation (2013) PLoS Biol., 11, pp. e1001498Ramsey, J., Schemske, D.W., Pathways, mechanisms, and rates of polyploid formation in flowering plants (1998) Annu. Rev. Ecol. Syst., 29, pp. 467-501Renny-Byfield, S., Kovarik, A., Kelly, L.J., Macas, J., Novak, P., Chase, M.W., Diploidisation and genome size change in allopolyploids is associated with differential dynamics of low and high copy sequences (2013) Plant J., 74, pp. 829-839. , doi: 10.1111/tpj.12168Ricca, M., Szövényi, P., Temsch, E.M., Johnson, M.G., Shaw, A.J., Interploidal hybridization and mating patterns in the Sphagnum subsecundum complex (2011) Mol. Ecol., 20, pp. 3202-3218Rieseberg, L.H., Chromosomal rearrangements and speciation (2001) Trends Ecol. Evol., 16, pp. 351-358Rieseberg, L.H., Blackman, B.K., Speciation genes in plants (2010) Ann. Bot., 106, pp. 439-455Rieseberg, L.H., Willis, J.H., Plant speciation (2007) Science, 317, pp. 910-914Scarano, F.R., Structure, function and floristic relationships of plant communities in stressful habitats marginal to the Brazilian Atlantic Rainforest (2002) Ann. Bot., 90, pp. 517-524Schwarzacher, T., Leitch, A.R., Bennett, M.D., Heslop-harrison, J.S., In situ localization of parental genomes in a wide hybrid (1989) Ann. Bot., 64, pp. 315-324Scopece, G., Widmer, A., Cozzolino, S., Evolution of postzygotic reproductive isolation in a guild of deceptive orchids (2008) Am. Nat., 171, pp. 315-326Scopece, G., Cozzolino, S., Johnson, S.D., Schiestl, F.P., Pollination efficiency and the evolution of specialized deceptive pollination systems (2010) Am. Nat., 175, pp. 98-105Slotte, T., Huang, H., Lascoux, M., Ceplitis, A., Polyploid speciation did not confer instant reproductive isolation in Capsella (Brassicaceae) (2008) Mol. Biol. Evol., 25, pp. 1472-1481Soltis, P.S., Soltis, D.E., The role of hybridization in plant speciation (2009) Annu. Rev. Plant Biol., 60, pp. 561-588Soltis, D.E., Soltis, P.S., Tate, J.A., Advances in the study of polyploidy since plant speciation (2003) New Phytol., 161, pp. 173-191Soltis, D.E., Albert, V.A., Leebens-mack, J., Bell, C.D., Paterson, A.H., Zheng, C., Polyploidy and angiosperm diversification (2009) Am. J. Bot., 96, pp. 336-348Soltis, D.E., Buggs, R.J.A., Doyle, J.J., Soltis, P.S., What we still don't know about polyploidy (2010) New Phytol., 59, pp. 1387-1403Souza, L.G.R., Crosa, O., Speranza, P., Guerra, M., Cytogenetic and molecular evidence suggest multiple origins and geographical parthenogenesis in Nothoscordum gracile (Alliaceae) (2012) Ann. Bot., 109, pp. 987-999Ståhlberg, D., Habitat differentiation, hybridization and gene flow patterns in mixed populations of diploid and autotetraploid Dactylorhiza maculata s.l. (Orchidaceae) (2009) Evol. Ecol., 23, pp. 295-328Stebbins, G.L., (1971) Chromosomal evolution in higher plants, p. 216. , Addison Wesley Publishing, Reading, MATanaka, R., Kamemoto, H., Chromosomes in orchids: counting and numbers (1984) Orchid Biology: Reviews and Perspectives III, pp. 324-410. , - J. Arditti, ed. Cornell University Press, Ithaca, NYTwyford, A.D., Ennos, R.A., Next-generation hybridization and introgression (2012) Heredity, 108, pp. 179-189. , Nature ublishing GroupWanzebock, E.-M., Schofer, C., Schweizer, D., Bachmair, A., Ribosomal transcription units integrated via T-DNA transformation associate with the nucleolus and do not require upstream repeat sequences for activity in Arabidopsis thaliana (1997) Plant J., 11, pp. 1007-1016Widmer, A., Lexer, C., Cozzolino, S., Evolution of reproductive isolation in plants (2009) Heredity, 102, pp. 31-3

Connective tissue anomalies in patients with spontaneous cervical artery dissection.

OBJECTIVE: To investigate the prevalence of connective tissue abnormalities in patients with spontaneous cervical artery dissections (sCeAD). METHODS: We systematically assessed clinically detectable signs of connective tissue aberration in a series of consecutive patients with sCeAD and of age- and sex-matched patients with ischemic stroke unrelated to CeAD (non-CeAD IS) by a standard examination protocol including 68 items, and performed extensive molecular investigation for hereditary connective tissue disorders in all patients with sCeAD. RESULTS: The study group included 84 patients with sCeAD (mean age, 44.5 ± 7.8 years; 66.7% men) and 84 patients with non-CeAD IS. None of the patients with sCeAD met clinical or molecular diagnostic criteria for established hereditary connective tissue disorder. Connective tissue abnormalities were detected more frequently in the group of patients with sCeAD than in the group of those with non-CeAD IS (mean number of pathologic findings, 4.5 ± 3.5 vs 1.9 ± 2.3; p < 0.001). Eighty-one patients (96.4%) in the sCeAD group had at least one detectable sign compared with 55 patients (66.7%) in the group with non-CeAD IS (p < 0.001). Skeletal, ocular, and skin abnormalities, as well as craniofacial dysmorphisms, were the clinical signs more strongly associated with sCeAD. Signs suggesting connective tissue abnormality were also more frequently represented in patients with sCeAD than in patients with traumatic CeAD (28.6%, p < 0.001; mean number of pathologic findings, 1.7 ± 3.7, p = 0.045). CONCLUSIONS: Connective tissue abnormalities are frequent in patients with sCeAD. This reinforces the hypothesis that systemic aberrations of the connective tissue might be implicated in the pathogenesis of the disease

Postępowanie w niewydolności serca u osób starszych

Wstęp: Celem pracy był przegląd aktualnie dost&#234;pnej wiedzy dotyczącej objawów oraz cech klinicznych i post&#234;powania w niewydolności serca (HF) u osób starszych. Metody: Autorzy dokładnie przeszukali kilka źródeł informacji opartych na dowodach naukowych, obejmujących Cochrane Database of Systemic Reviews, Clinical Evidence, wytyczne oparte na dowodach naukowych z National Guidelines Clearinghouse, zaś w bazie MEDLINE sprawdzili takie terminy, jak "niewydolność serca", "osoby starsze" oraz "postępowanie". Wyniki: Różne cechy związane z procesem starzenia mogą predysponowa&#230; osoby starsze do HF i upośledzać ich zdolność do reakcji na uszkodzenie. Inną cechą charakterystyczną u starszych pacjentów jest rosnąca częstość występowania wielu towarzyszących chorób przewlekłych i zespołów geriatrycznych, które mogą wikłać obraz kliniczny i rozwój HF. Kryteria diagnostyczne nie zmieniają się u osób starszych, mimo że rozpoznanie może stanowić wyzwanie z powodu często atypowych objawów i manifestacji klinicznej, a choroby towarzyszące mogą naśladować lub wikłać obraz kliniczny. Farmakoterapia nie różni się znacząco od tej zalecanej u młodszych pacjentów i w dużym stopniu pozostaje empiryczna, ponieważ zwykle wyklucza się osoby starsze oraz osoby z chorobami współistniejącymi z prób klinicznych. Programy postępowania mogą potencjalnie przyczynią się do zmniejszenia chorobowości i śmiertelności pacjentów z HF. Wnioski: Niewydolność serca jest najczęstszą przyczyną hospitalizacji i rehospitalizacji osób starszych. Wykazuje ona szczególne cechy u starszych pacjentów i jest zwykle powikłana chorobami towarzyszącymi, stanowiąc na całym świecie ogromne obciążenie finansowe. Pomimo to osoby starsze zwykle wykluczano z prób klinicznych i dlatego postępowanie w dużym stopniu pozostaje empiryczne i oparte na dowodach naukowych dotyczących osób z młodszych grup wiekowych

Good prognosis for pericarditis with and without myocardial involvement: Results from a multicenter, prospective cohort study

Background The natural history of myopericarditis/perimyocarditis is poorly known, and recently published studies have presented contrasting data on their outcomes. The aim of the present article is to assess the prognosis of myopericarditis/perimyocarditis in a multicenter, prospective cohort study. Methods and Results A total of 486 patients (median age, 39 years; range, 18-83 years; 300 men) with acute pericarditis or a myopericardial inflammatory syndrome (myopericarditis/perimyocarditis; 85% idiopathic, 11% connective tissue disease or inflammatory bowel disease, 5% infective) were prospectively evaluated from January 2007 to December 2011. The diagnosis of acute pericarditis was based on the presence of 2 of 4 clinical criteria (chest pain, pericardial rubs, widespread ST-segment elevation or PR depression, and new or worsening pericardial effusion). Myopericardial inflammatory involvement was suspected with atypical ECG changes for pericarditis, arrhythmias, and cardiac troponin elevation or new or worsening ventricular dysfunction on echocardiography and confirmed by cardiac magnetic resonance. After a median follow-up of 36 months, normalization of left ventricular function was achieved in >90% of patients with myopericarditis/perimyocarditis. No deaths were recorded, as well as evolution to heart failure or symptomatic left ventricular dysfunction. Recurrences (mainly as recurrent pericarditis) were the most common complication during follow-up and were recorded more frequently in patients with acute pericarditis (32%) than in those with myopericarditis (11%) or perimyocarditis (12%; P<0.001). Troponin elevation was not associated with an increase in complications. Conclusions The outcome of myopericardial inflammatory syndromes is good. Unlike acute coronary syndromes, troponin elevation is not a negative prognostic marker in this setting

A focus on selected perspectives of the NUMEN project

The use of double charge exchange reactions is discussed in view of their application to extract information that may be helpful to determinate the nuclear matrix elements entering in the expression of neutrinoless double beta decay half-life. The strategy adopted in the experimental campaigns performed at INFN - Laboratori Nazionali del Sud and in the analysis methods within the NUMEN project is briefly described, emphasizing the advantages of the multi-channel approach to nuclear reaction data analysis. An overview on the research and development activities on the MAGNEX magnetic spectrometer is also given, with a focus on the chosen technological solutions for the focal plane detector which will guarantee the performances at high-rate conditions