1,525 research outputs found
DERECHO Y POLÍTICAS AMBIENTALES EN LA REGIÓN DE MURCIA
DERECHO Y POLÍTICAS AMBIENTALES EN LA REGIÓN DE MURCI
Derecho y políticas ambientales en la Región de Murcia (Segundo semestre 2017)
Derecho y políticas ambientales en la Región de Murcia (Segundo semestre 2017
New properties of a bioinspired pyridine benzimidazole compound as a novel differential staining agent for endoplasmic reticulum and Golgi apparatus in fluorescence live cell imaging
Indexación: Scopus.In this study, we explored new properties of the bioinspired pyridine benzimidazole compound B2 (2,4-di-tert-butyl-6-(3H-imidazo[4,5-c]pyridine-2-yl)phenol) regarding its potential use as a differential biomarker. For that, we performed 1D 1HNMR (TOCSY), UV-Vis absorption spectra in different organic solvents, voltammetry profile (including a scan-rate study), and TD-DFT calculations that including NBO analyses, to provide valuable information about B2 structure and luminescence. In our study, we found that the B2 structure is highly stable, where the presence of an intramolecular hydrogen bond (IHB) seems to have a crucial role in the stability of luminescence, and its emission can be assigned as fluorescence. In fact, we found that the relatively large Stokes Shift observed for B2 (around 175 nm) may be attributed to the stability of the B2 geometry and the strength of its IHB. On the other hand, we determined that B2 is biocompatible by cytotoxicity experiments in HeLa cells, an epithelial cell line. Furthermore, in cellular assays we found that B2 could be internalized by passive diffusion in absence of artificial permeabilization at short incubation times (15 min to 30 min). Fluorescence microscopy studies confirmed that B2 accumulates in the endoplasmic reticulum (ER) and Golgi apparatus, two organelles involved in the secretory pathway. Finally, we determined that B2 exhibited no noticeable blinking or bleaching after 1 h of continuous exposure. Thus, B2 provides a biocompatible, rapid, simple, and efficient way to fluorescently label particular organelles, producing similar results to that obtained with other well-established but more complex methods. © 2018 Llancalahuen, Fuentes, Carreño, Zúñiga, Páez-Hernández, Gacitúa, Polanco, Preite, Arratia-Pérez and Otero.https://www.frontiersin.org/articles/10.3389/fchem.2018.00345/ful
El nuevo régimen de la reutilización de las aguas depuradas: en especial las novedades en el nuevo Plan Hidrológico de la demarcación del Segura
La reutilización de las aguas depuradas constituye una práctica adecuada para incrementar la disponibilidad del recurso. Sin embargo, las implicaciones sanitarias que pudiera conllevar hacen necesario la instauración de un marco jurídico que otorgue seguridad a los diferentes sectores implicados. La incorporación de las aguas regeneradas a la gestión integral del dominio público hidráulico implica, a su vez, su consideración en los nuevos planes hidrológicos recientemente aprobados. En la Demarcación Hidrográfica del Segura, donde el recurso se encuentra sometido a una intensa presión por los actuales y potenciales usuarios, la reutilización puede representar un relevante recurso adicional
A disaster risk management performance index
The Risk Management Index, RMI, proposed in this paper, brings together a group of indicators that measure risk management performance and effectiveness. These indicators reflect the organizational, development, capacity and institutional actions taken to reduce vulnerability and losses in a given area, to prepare for crisis and to recover efficiently from disasters. This index is designed to
assess risk management performance. It provides a quantitative measure of management based on predefined qualitative targets or benchmarks that risk management efforts should aim to achieve. The design of the RMI involved establishing a scale of achievement levels or determining the distance between current conditions and an objective threshold or conditions in a reference country, sub-national region, or city. The proposed RMI is constructed by quantifying four public policies, each of which is described by six indicators. The mentioned policies include the identification of risk, risk reduction, disaster management, and governance and financial
protection. Risk identification comprises the individual perception, social representation and objective assessment; risk reduction involves the prevention and mitigation; disaster management comprises response and recovery; and, governance and financial protection policy is related to institutionalization and risk transfer. Results at the urban, national and sub-national levels, which illustrate the application of the RMI in those scales, are finally given
La custodia del territorio como instrumento complementario para la protección de los espacios naturales
La presente nota analiza la evolución normativa de la custodia del territorio como estrategia complementaria de protección de los espacios naturales caracterizada por las notas de participación y voluntariedad y que goza de una creciente vitalidad y posibilidades de futuro. En especial, se trata de subrayar la evolución de los mecanismos de protección que, si bien descansaban en el ejercicio unilateral de potestades administrativas, de modo creciente se orientan a estrategias acordadas con los sectores interesados y afectados, como modo de conseguir mayor apoyo social y colaboración de los particulares en la consecución de los fines de interés general, en este caso, la utilización racional de los recursos naturales, la garantía del derecho a disfrutar de un medio ambiente adecuado y el más cabal cumplimiento de los deberes de protección
Urban Seismic Risk Evaluation: A Holistic Approach
Risk has been defined, for management purposes, as the potential economic, social and environmental consequences of hazardous events that may occur in a specified period of time. However, in the past, the concept of risk has been defined in a fragmentary way in many cases, according to each scientific discipline involved in its appraisal. From the perspective of this article, risk requires a multidisciplinary evaluation that takes into account not only the expected physical damage, the number and type of casualties or economic losses, but also the conditions related to social fragility and lack of resilience conditions, which favour the second order effects (indirect effects) when a hazard event strikes an urban centre. The proposed general method of urban risk evaluation is multi hazard and holistic, that is, an integrated and comprehensive approach to guide decision-making. The evaluation of the potential physical damage (hard approach) as the result of the convolution of hazard and physical vulnerability of buildings and infrastructure is the first step of this method. Subsequently, a set of social context conditions that aggravate the physical effects are also considered (soft approach). In the method here proposed, the holistic risk evaluation is based on urban risk indicators. According to this procedure, a physical risk index is obtained, for each unit of analysis, from existing loss scenarios, whereas the total risk index is obtained by factoring the former index by an impact factor or aggravating coefficient, based on variables associated with the socioeconomic conditions of each unit of analysis. Finally, the proposed method is applied in its single hazard form to the holistic seismic risk evaluation for the cities of Bogota (Colombia) and Barcelona (Spain)
Computational Tool for Post-Earthquake Evaluation of Damage in Buildings
A method and a computational tool oriented to assist the damage and safety evaluation of buildings after strong earthquakes is described in this article. The input of the model is the subjective and incomplete information on the building state, obtained by inspectors which are possibly not expert professionals of the field of building safety. The damage levels of the structural components are usually described by linguistic qualifications which can be adequately processed by computational intelligence techniques based on neuro-fuzzy systems what facilitate the complex and urgent tasks of engineering decision-making on the building occupancy after a seismic disaster. The hybrid neuro-fuzzy system used is based on a special three-layer feedforward artificial neural network and fuzzy rule bases and is an effective
tool during the emergency response phase providing decisions about safety, habitability, and reparability of the buildings. Examples of application of the computer program are given for two different building classes
Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome
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