Factors Affecting the Impulse Purchase Intentions for Luxury Pret

The purpose of this study is to examine the effect of advertising cues, attitude, perceived price, and subjective norms on the impulse purchase intentions in the context of fashion pret. This study incorporated survey method for data collection and the 386 personally administered questionnaire were distributed among visitors from three high customer traffic malls in the provincial capital of the Province Punjab Lahore. However, 272 responses were used in SPSS 25 and Smart PLS-3 for data analysis. The result found that advertising cues, customer attitude, perceived price and subjective norms showed significantly positive impact on the impulse purchase intentions in the context of fashion pret. Further, this study offers contribution towards brand managers and advertisers particularly in the field of fashion industry. Policy makers may also find important references from this study to develop policy guidelines. Moreover, this study discussed some limitations while performing this research. Finally, this article offers future research suggestions for further development in this area.

Genetic Analysis of Consanguineous Pakistani Families with Congenital Stationary Night Blindness

Introduction: Congenital stationary night blindness (CSNB) is a rare, largely nonprogressive, inherited retinal disorder that can be clinically classified on the basis of fundus and electroretinogram abnormalities. Methods: We analyzed four large consanguineous families from the Southern Punjab region of Pakistan including multiple individuals affected with CSNB. Exome sequencing was performed in probands of all four families; Sanger sequencing was performed in additional members to test co-segregation of the variants identified. Results: We identified two novel and likely pathogenic variants in two pedigrees, namely, NM_002905.4:c.668A>C (p.Gln223Pro) in RDH5 and NM_022567.2:c.908del (p.Gly303ValfsTer45) in NYX. In the two other families, the variants NM_002905.4:c.319G>C (p.Gly107Arg) in RDH5 and NM_000541.5:c.874C>T (p.Arg292Ter) in SAG were identified. These latter mutations have been reported previously, but not in the Pakistani population. Conclusions: Our findings expand the mutational spectrum of CSNB, in particular within the population of Southern Punjab

Consequences of diverse use of nitrogen sources on grain yield, grain quality and growth attributes of hybrid maize (Zea mays L.)

A two year field experiment was conducted to check the consequences of diverse use of nitrogen sources on grain yield, grain quality and growth attributes of hybrid maize (Zea mays L.) at the Agronomic Research Area, University of Agriculture, Faisalabad during Autumn 2008 and 2009. Experiments were laid out in a randomized complete block design with factorial arrangement comprising 3 replications with a net plot size of 3 × 5 m. Treatment comprised two hybrids: that is, H1 (Pioneer-30Y87) and H2 (Pioneer-31R88) with combination of six nitrogen sources S0 : Control (0) kg N ha-1, S1: Urea (50%) + Poultry manure (50%), S2: Urea (50%) + Farm Yard Manure (50%) , S3: Urea (50%) + Pressmud of sugarcane manure (50%), S4: Urea (50%) + Compost (50%), S5: Urea (50%) + (PM+FYM+PMS+ Compost) 50% . Results of grain yield (t ha-1), grain protein content (%) grain oil content (%), leaf area index, leaf area duration, dry matter accumulation, crop growth rate and net assimilation rate was found to be significant during 2008 and 2009. It was concluded that hybrid maize H1 (Pioneer - 30Y87) produced better grain yield (6.14 t ha-1) during 2008 when nitrogen sources S1: Urea (50%) + Poultry manure (50%) was applied in combination as compared to grain yield (6.0 t ha-1) in hybrid H2 (Pioneer -31R88) during 2009. Growth and quality attributes also performed better in 2008 as compared to 2009 at nitrogen sources S1: Urea (50%) + Poultry manure (50%).Key words: Nitrogen sources, hybrid maize, yield, growth, quality

Substitution of a single non-coding nucleotide upstream of TMEM216 causes non-syndromic retinitis pigmentosa and is associated with reduced TMEM216 expression.

Genome analysis of individuals affected by retinitis pigmentosa (RP) identified two rare nucleotide substitutions at the same genomic location on chromosome 11 (g.61392563 [GRCh38]), 69 base pairs upstream of the start codon of the ciliopathy gene TMEM216 (c.-69G>A, c.-69G>T [GenBank: NM_001173991.3]), in individuals of South Asian and African ancestry, respectively. Genotypes included 71 homozygotes and 3 mixed heterozygotes in trans with a predicted loss-of-function allele. Haplotype analysis showed single-nucleotide variants (SNVs) common across families, suggesting ancestral alleles within the two distinct ethnic populations. Clinical phenotype analysis of 62 available individuals from 49 families indicated a similar clinical presentation with night blindness in the first decade and progressive peripheral field loss thereafter. No evident systemic ciliopathy features were noted. Functional characterization of these variants by luciferase reporter gene assay showed reduced promotor activity. Nanopore sequencing confirmed the lower transcription of the TMEM216 c.-69G>T allele in blood-derived RNA from a heterozygous carrier, and reduced expression was further recapitulated by qPCR, using both leukocytes-derived RNA of c.-69G>T homozygotes and total RNA from genome-edited hTERT-RPE1 cells carrying homozygous TMEM216 c.-69G>A. In conclusion, these variants explain a significant proportion of unsolved cases, specifically in individuals of African ancestry, suggesting that reduced TMEM216 expression might lead to abnormal ciliogenesis and photoreceptor degeneration

Substitution of a single non-coding nucleotide upstream of TMEM216 causes non-syndromic retinitis pigmentosa and is associated with reduced TMEM216 expression

Genome analysis of individuals affected by retinitis pigmentosa (RP) identified two rare nucleotide substitutions at the same genomic location on chromosome 11 (g.61392563 [GRCh38]), 69 base pairs upstream of the start codon of the ciliopathy gene TMEM216 (c.-69G>A, c.-69G>T [GenBank: NM_001173991.3]), in individuals of South Asian and African ancestry, respectively. Genotypes included 71 homozygotes and 3 mixed heterozygotes in trans with a predicted loss-of-function allele. Haplotype analysis showed single-nucleotide variants (SNVs) common across families, suggesting ancestral alleles within the two distinct ethnic populations. Clinical phenotype analysis of 62 available individuals from 49 families indicated a similar clinical presentation with night blindness in the first decade and progressive peripheral field loss thereafter. No evident systemic ciliopathy features were noted. Functional characterization of these variants by luciferase reporter gene assay showed reduced promotor activity. Nanopore sequencing confirmed the lower transcription of the TMEM216 c.-69G>T allele in blood-derived RNA from a heterozygous carrier, and reduced expression was further recapitulated by qPCR, using both leukocytes-derived RNA of c.-69G>T homozygotes and total RNA from genome-edited hTERT-RPE1 cells carrying homozygous TMEM216 c.-69G>A. In conclusion, these variants explain a significant proportion of unsolved cases, specifically in individuals of African ancestry, suggesting that reduced TMEM216 expression might lead to abnormal ciliogenesis and photoreceptor degeneration

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Investigating the effect of Cd-Mn co-doped nano-sized BiFeO3 on its physical properties

This work deals with the investigation of different effects on the structural, magnetic, electronic and dielectric properties of Cd and Mn doped Bi0.75Cd0.25Fe1−xMnxO3 multiferroic samples by taking fixed ratios of Cd and varying the Mn ratio with values of x = 0.0, 0.5, 0.10 and 0.15. Cd-Mn doped samples were synthesized chemically using a microemulsion method. All the samples were finally sintered at 700 °C for 2 h to obtain the single phase perovskites structure of BiFeO3 materials. The synthesized samples were characterized by different techniques, such as X-ray diffractometry (XRD), Scanning Electron Microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), LCR meter and magnetic properties using VSM. XRD results confirm BFO is a perovskite structure having crystallite size in the range of 24–54 nm. XRD results also reveal observed structural distortion due to doping of Cd at the A-site and Mn at the B-site of BFO. SEM results depict that, as the substitution of Cd-Mn increases in BFO, grain size decreases up to 30 nm. FTIR spectra showed prominent absorption bands at 555 cm−1 and 445 cm−1 corresponding to the stretching vibrations of the metal ions complexes at site A and site B, respectively. Variation of dielectric constant (ɛ′) and loss tangent (tan δ) at room temperature in the range of 1 MHz to 3 GHz have been investigated. Results reveal that with Cd-Mn co doping a slight decrease in dielectric constant have been observed. Magnetic properties of Cd-Mn doped pure BFO samples have been studied at 300 K. Results reveal that undoped BiFeO3 exhibits weak ferromagnetic ordering due to the canting of its spin. Increase in magnetization and decrease in coercivity is a clear indication that a material can be used in high density recording media and memory devices. Keywords: Nanoparticles, Cd-Mn doped BiFeO3, FESEM, XANES, Magnetic propertie

First-principles calculations to investigate structural, electronic, optical, and magnetic properties of a scintillating double perovskite halide (Cs2LiCeCl6)

In this study, the investigations of structural, electronic, optical, and magnetic properties of a scintillating double perovskite halide (Cs2LiCeCl6) by using the full-potential linearized augmented plane wave (FP-LAPW) method in the framework of density functional theory (DFT) is reported. The optimized lattice constant (a0) is fully consistent with the experimental results, and the ground state optimized energy confirms the cubic (Fm 3¯ m space group) stability of the compound. The electronic band structures and densities of states are analyzed within approximations of PBE-GGA and TB-mBJ to have precise and accurate results. In the spin-up channel the metallic behavior of the compound is confirmed, while in the spin-down channel there is a band gap of 3.83 eV with an indirect nature from Γ-X, so clarifying its behavior towards semiconductors and thus overall making the compound to be half-metallic, and hence, it is clear that the material exhibit spin polarization. The ferromagnetic behavior is verified by the asymmetric density of states in both spin channels and the optimized energy volume curve in spin-polarized calculations. The optical parameters are computed and it is found that the compound Cs2LiCeCl6 possesses high optical conductivity, absorption coefficient and compared in both approximations and analyzed in the energy range of (0–20) eV and hence predict the applications of this material in high-frequency ultraviolet devices and also for particle detection