181 research outputs found
A construction of multiwavelets
AbstractA class of r-regular multiwavelets, depending on the smoothness of the multiwavelet functions, is introduced with the appropriate notation and definitions. Oscillation properties of orthonormal systems are obtained in Lemma 1 and Corollary 1 without assuming any vanishing moments for the scaling functions, and in Theorem 1 the existence of r-regular multiwavelets in L2(Rn) is established. In Theorem 2, a particular r-regular multiresolution analysis for multiwavelets is obtained from an r-regular multiresolution analysis for uniwavelets. In Theorem 3, an r-regular multiresolution analysis of split-type multiwavelets, which are perhaps the simplest multiwavelets, is easily obtained by using an r-regular multiresolution analysis for uniwavelets and a (2n β 1)-fold regular multiresolution analysis for uniwavelets. For some split-type multiwavelets, the support or width of the wavelets is shorter than the support or width of the scaling functions without loss of regularity nor of vanishing moments. Examples of split-type multiwavelets in L2(R) are constructed and illustrated by means of figures. Symmetry and antisymmetry are preserved in the case of infinite support
Convolution Theorems for Clifford Fourier Transform and Properties
The non-commutativity of the Clifford multiplication gives different aspects from the classical Fourier analysis.We establish main properties of convolution theorems for the Clifford Fourier transform. Some properties of these generalized convolutionsare extensions of the corresponding convolution theorems of the classical Fourier transform.DOI : http://dx.doi.org/10.22342/jims.20.2.143.125-14
Smooth tight frame wavelets and image microanalyis in the fourier domain
AbstractGeneral results on microlocal analysis and tight frames in R2 are summarized. To perform microlocal analysis of tempered distributions, orthogonal multiwavelets, whose Fourier transforms consist of characteristic functions of squares or sectors of annuli, are constructed in the Fourier domain and are shown to satisfy a multiresolution analysis with several choices of scaling functions. To have good localization in both the x and Fourier domains, redundant smooth tight wavelet frames, with frame bounds equal to one, called Parseval wavelet frames, are obtained in the Fourier domain by properly tapering the above characteristic functions. These nonorthogonal frame wavelets can be generated by two-scale equations from a multiresolution analysis. A natural formulation of the problem is by means of pseudodifferential operators. Singularities, which are added to smooth images, can be localized in position and direction by means of the frame coefficients of the filtered images computed in the Fourier domain. Using Plancherel's theorem, the frame expansion of the filtered images is obtained in the x domain. Subtracting this expansion from the scarred images restores the original images
Nanoelectromechanical coupling in fullerene peapods probed via resonant electrical transport experiments
Fullerene peapods, that is carbon nanotubes encapsulating fullerene
molecules, can offer enhanced functionality with respect to empty nanotubes.
However, the present incomplete understanding of how a nanotube is affected by
entrapped fullerenes is an obstacle for peapods to reach their full potential
in nanoscale electronic applications. Here, we investigate the effect of C60
fullerenes on electron transport via peapod quantum dots. Compared to empty
nanotubes, we find an abnormal temperature dependence of Coulomb blockade
oscillations, indicating the presence of a nanoelectromechanical coupling
between electronic states of the nanotube and mechanical vibrations of the
fullerenes. This provides a method to detect the C60 presence and to probe the
interplay between electrical and mechanical excitations in peapods, which thus
emerge as a new class of nanoelectromechanical systems.Comment: 7 pages, 3 figures. Published in Nature Communications. Free online
access to the published version until Sept 30th, 2010, see
http://www.nature.com/ncomms/journal/v1/n4/abs/ncomms1034.htm
Discrete structure of ultrathin dielectric films and their surface optical properties
The boundary problem of linear classical optics about the interaction of
electromagnetic radiation with a thin dielectric film has been solved under
explicit consideration of its discrete structure. The main attention has been
paid to the investigation of the near-zone optical response of dielectrics. The
laws of reflection and refraction for discrete structures in the case of a
regular atomic distribution are studied and the structure of evanescent
harmonics induced by an external plane wave near the surface is investigated in
details. It is shown by means of analytical and numerical calculations that due
to the existence of the evanescent harmonics the laws of reflection and
refraction at the distances from the surface less than two interatomic
distances are principally different from the Fresnel laws. From the practical
point of view the results of this work might be useful for the near-field
optical microscopy of ultrahigh resolution.Comment: 25 pages, 16 figures, LaTeX2.09, to be published in Phys.Rev.
Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia
Bruton's tyrosine kinase (BTK) is a cytoplasmic protein found in all hematopoietic cell lineages except for T cells. BTK mediates signalling downstream of a number of receptors. Pharmacological targeting of BTK using ibrutinib (previously PCI-32765) has recently shown encouraging clinical activity in a range of lymphoid malignancies. This study reports for the first time that ibrutinib inhibits blast proliferation from human acute myeloid leukaemia (AML) and that treatment with ibrutinib significantly augmented cytotoxic activities of standard AML chemotherapy cytarabine or daunorubicin. Here we describe that BTK is constitutively phosphorylated in the majority of AML samples tested, with BTK phosphorylation correlating highly with the cell's cytotoxic sensitivity towards ibrutinib. BTK targeted RNAi knock-down reduced colony forming capacity of primary AML blasts and proliferation of AML cell lines. We showed ibrutinib binds at nanomolar range to BTK. Furthermore, we also showed ibrutinib's anti-proliferative effects in AML are mediated via an inhibitory effect on downstream nuclear factor-ΞΊB (NF-ΞΊB) survival pathways. Moreover, ibrutinib inhibited AML cell adhesion to bone marrow stroma. Furthermore, these effects of ibrutinib in AML were seen at comparable concentrations efficacious in chronic lymphocytic leukemia (CLL). These results provide a biologic rationale for clinical evaluation of BTK inhibition in AML patients
Low CD4/CD8 T-Cell Ratio Associated with Inflammatory Arthropathy in Human T-Cell Leukemia Virus Type I Tax Transgenic Mice
Human T-cell leukemia virus type I (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATL) as well as inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A transgenic mouse that expresses HTLV-1 Tax also develops T-cell leukemia/lymphoma and an inflammatory arthropathy that resembles rheumatoid arthritis. The aim of this study was to identify the primary T-cell subsets involved in the development of arthropathy in Tax transgenic mice. mRNA was strong in the spleen and joints of arthropathic mice, with a 40-fold increase compared with healthy transgenic mice.Our findings reveal that Tax transgenic mice develop rheumatoid-like arthritis with proliferating synovial cells in the joints; however, the proportion of different splenic T-cell subsets in these mice was completely different from other commonly used animal models of rheumatoid arthritis. The crucial T-cell subsets in arthropathic Tax transgenic mice appear to resemble those in HAM/TSP patients rather than those in rheumatoid arthritis patients
Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells
BACKGROUND: Lung fluid balance in the healthy lung is dependent upon finely regulated vectorial transport of ions across the alveolar epithelium. Classically, the cellular locus of the major ion transport processes has been widely accepted to be the alveolar type II cell. Although evidence is now emerging to suggest that the alveolar type I cell might significantly contribute to the overall ion and fluid homeostasis of the lung, direct assessment of functional ion channels in type I cells has remained elusive. METHODS: Here we describe a development of a lung slice preparation that has allowed positive identification of alveolar type I cells within an intact and viable alveolar epithelium using living cell immunohistochemistry. RESULTS: This technique has allowed, for the first time, single ion channels of identified alveolar type I cells to be recorded using the cell-attached configuration of the patch-clamp technique. CONCLUSION: This exciting new development should facilitate the ascription of function to alveolar type I cells and allow us to integrate this cell type into the general model of alveolar ion and fluid balance in health and disease
Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies
There is increasing evidence of a systemic inflammatory response associated with malignancy, which may have an impact on both drug disposition and resistance to cytotoxic therapy. The impact of inflammation on drug disposition was studied in mice bearing a number of common tumour xenografts. C57BL/6 mice were inoculated with tumour xenografts. Hepatic expressions of Cyp3a and drug transporters were analysed at the mRNA, protein and functional levels (Cyp3a only). Circulating serum cytokines and the hepatic expression of acute phase proteins (APPs) were measured. Intratumoral levels of multidrug resistance genes were determined. Tumour xenografts elicited an inflammatory response that coincided with repression in hepatic Cyp3a11 activity and the expression of a number of hepatic drug transporters. With tumour growth, a progressive reduction in hepatic Cyp3a11 mRNA expression was seen. Conversely, an increase in the hepatic APP expression and circulating interleukin (IL)-6 levels was observed. Furthermore, a correlation was seen between increased intratumoral expression of the multidrug resistance gene, Mdr1a, and levels of circulating IL-6. Malignancy results in reduced hepatic drug disposition that correlates with an associated inflammatory response. Reduction of inflammation may improve the clinical outcome for patients receiving chemotherapeutic agents that undergo hepatic metabolism
- β¦