144 research outputs found
Crossing Over from Attractive to Repulsive Interactions in a Tunneling Bosonic Josephson Junction
We explore the interplay between tunneling and interatomic interactions in
the dynamics of a bosonic Josephson junction. We tune the scattering length of
an atomic K Bose-Einstein condensate confined in a double-well trap to
investigate regimes inaccessible to other superconducting or superfluid
systems. In the limit of small-amplitude oscillations, we study the transition
from Rabi to plasma oscillations by crossing over from attractive to repulsive
interatomic interactions. We observe a critical slowing down in the oscillation
frequency by increasing the strength of an attractive interaction up to the
point of a quantum phase transition. With sufficiently large initial
oscillation amplitude and repulsive interactions the system enters the
macroscopic quantum self-trapping regime, where we observe coherent undamped
oscillations with a self-sustained average imbalance of the relative well
population. The exquisite agreement between theory and experiments enables the
observation of a broad range of many body coherent dynamical regimes driven by
tunable tunneling energy, interactions and external forces, with applications
spanning from atomtronics to quantum metrology.Comment: 10 pages, 8 figures, supplemental materials are include
Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats
Rationale
Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in behaviours related to salient, reward-paired cues.
Objectives
Here, we used designer receptors exclusively activated by designer drugs (DREADDs) to investigate the role of parafascicular (Pf) thalamic inputs to the dorsomedial striatum (DMS) using the five-choice serial reaction time task (5CSRTT) in rats.
Methods
The 5CSRTT requires sustained attention in order to detect spatially and temporally distributed visual cues and provides measures of inhibitory control related to impulsivity (premature responses) and compulsivity (perseverative responses). Rats underwent bilateral Pf injections of the DREADD vector, AAV2-CaMKIIa-HA-hM4D(Gi)-IRES-mCitrine. The DREADD agonist, clozapine N-oxide (CNO; 1 μl bilateral; 3 μM) or vehicle, was injected into DMS 1 h before behavioural testing. Task parameters were manipulated to increase attention load or reduce stimulus predictability respectively.
Results
We found that inhibition of the Pf-DMS projection significantly increased perseverative responses when stimulus predictability was reduced but had no effect on premature responses or response accuracy, even under increased attentional load. Control experiments showed no effects on locomotor activity in an open field.
Conclusions
These results complement previous lesion work in which the DMS and orbitofrontal cortex were similarly implicated in perseverative responses and suggest a specific role for thalamostriatal inputs in inhibitory control
Bose-Einstein Condensate in Weak 3d Isotropic Speckle Disorder
The effect of a weak three-dimensional (3d) isotropic laser speckle disorder
on various thermodynamic properties of a dilute Bose gas is considered at zero
temperature. First, we summarize the derivation of the autocorrelation function
of laser speckles in 1d and 2d following the seminal work of Goodman. The goal
of this discussion is to show that a Gaussian approximation of this function,
proposed in some recent papers, is inconsistent with the general background of
laser speckle theory. Then we propose a possible experimental realization for
an isotropic 3d laser speckle potential and derive its corresponding
autocorrelation function. Using a Fourier transform of that function, we
calculate both condensate depletion and sound velocity of a Bose-Einstein
condensate as disorder ensemble averages of such a weak laser speckle potential
within a perturbative solution of the Gross-Pitaevskii equation. By doing so,
we reproduce the expression of the normalfluid density obtained earlier within
the treatment of Landau. This physically transparent derivation shows that
condensate particles, which are scattered by disorder, form a gas of
quasiparticles which is responsible for the normalfluid component
Long-Term Memory for Pavlovian Fear Conditioning Requires Dopamine in the Nucleus Accumbens and Basolateral Amygdala
The neurotransmitter dopamine (DA) is essential for learning in a Pavlovian fear conditioning paradigm known as fear-potentiated startle (FPS). Mice lacking the ability to synthesize DA fail to learn the association between the conditioned stimulus and the fear-inducing footshock. Previously, we demonstrated that restoration of DA synthesis to neurons of the ventral tegmental area (VTA) was sufficient to restore FPS. Here, we used a target-selective viral restoration approach to determine which mesocorticolimbic brain regions receiving DA signaling from the VTA require DA for FPS. We demonstrate that restoration of DA synthesis to both the basolateral amygdala (BLA) and nucleus accumbens (NAc) is required for long-term memory of FPS. These data provide crucial insight into the dopamine-dependent circuitry involved in the formation of fear-related memory
Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex
Rationale: Trace conditioning may provide a behavioural model suitable to examine the maintenance of ‘on line’ information and its underlying neural substrates.
Objectives: Experiment la was run to establish trace conditioning in a shortened procedure which would be suitable to test the effects of dopamine (DA) D1 receptor agents administered by microinjection directly into the brain. Experiment lb examined the effects of the DA D1 agonist SKF81297 and the DA D1 antagonist SCH23390 following systemic administration in pre-trained animals. Experiment 2 went on to test the effects of systemically administered SKF81297 on the acquisition of trace conditioning. In experiment 3, SKF81297 was administered directly in prelimbic (PL) and infralimbic (IL) sub-regions of medial prefrontal cortex (mPFC) to compare the role of different mPFC sub-regions.
Results: Whilst treatment with SCH23390 impaired motor responding and/or motivation, SKF81297 had relatively little effect in the pre-trained animals tested in experiment 1b. However, systemic SKF81297 depressed the acquisition function at the 2-s trace interval in experiment 2. Similarly, in experiment 3, SKF81297 (0.1 μg in 1.0 μl) microinjected into either PL or IL mPFC impaired appetitive conditioning at the 2-s trace interval.
Conclusions: Impaired trace conditioning under SKF81297 is likely to be mediated in part (but not exclusively) within the IL and PL mPFC sub-regions. The finding that trace conditioning was impaired rather than enhanced under SKF81297 provides further evidence for the inverse U-function which has been suggested to be characteristic of mPFC DA function
Influence of Dopaminergically Mediated Reward on Somatosensory Decision-Making
This pharmacological fMRI study shows that during reward-based sensory decision-making, dopamine is crucially involved in reward-related modulation of human primary sensory cortex
The elusive Heisenberg limit in quantum enhanced metrology
We provide efficient and intuitive tools for deriving bounds on achievable
precision in quantum enhanced metrology based on the geometry of quantum
channels and semi-definite programming. We show that when decoherence is taken
into account, the maximal possible quantum enhancement amounts generically to a
constant factor rather than quadratic improvement. We apply these tools to
derive bounds for models of decoherence relevant for metrological applications
including: dephasing,depolarization, spontaneous emission and photon loss.Comment: 10 pages, 4 figures, presentation imporved, implementation of the
semi-definite program finding the precision bounds adde
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