Anthropogenic impact on a protected area, Rio Doce Park

This study aimed to assess the anthropogenic activities at Rio Doce Park, Minas Gerais, Brazil, from ethnopharmacological surveys in Timóteo and Marliéria, which are located around the park. Interviews were conducted with previously identified, key informants, 15 in Timóteo and 10 in Marliéria. Two respondents collected medicinal plants in the forest of the park (from a few trees) but kept the same vulnerability of the use of their barks. Among the 141 surveyed botanical terms, we identified 95 species of 44 different botanical families. On the basis of statistical analyses, the 12 most used species were selected by respondents considering their therapeutic purposes and also obtaining the purpose of the use and dosage, among others. The knowledge about the use of medicinal plants has been maintained through generations but away from the formal health system and a sustainable management plan to encourage the preservation of the park

Fixed-Dose Artesunate-Amodiaquine Combination vs Chloroquine for Treatment of Uncomplicated Blood Stage P. vivax Infection in the Brazilian Amazon: An Open-Label Randomized, Controlled Trial

BACKGROUND: Despite increasing evidence of the development of Plasmodium vivax chloroquine (CQ) resistance, there have been no trials comparing its efficacy with that of artemisinin-based combination therapies (ACTs) in Latin America. METHODS: This randomized controlled trial compared the antischizontocidal efficacy and safety of a 3-day supervised treatment of the fixed-dose combination artesunate-amodiaquine Winthrop(R) (ASAQ) versus CQ for treatment of uncomplicated P. vivax infection in Manaus, Brazil. Patients were followed for 42 days. Primary endpoints were adequate clinical and parasitological responses (ACPR) rates at day 28. Genotype-adjustment was performed. RESULTS: From 2012 to 2013, 380 patients were enrolled. In the per-protocol (PP) analysis, adjusted-ACPR was achieved in 100% (165/165) and 93.6% (161/172) of patients in the ASAQ and CQ arm (difference 6.4%, 95% CI 2.7%; 10.1%) at day 28 and in 97.4% (151/155) and 77.7% (129/166), respectively (difference 19.7%, 95% CI 12.9%; 26.5%), at day 42. Apart from ITT D28 assessment, superiority of ASAQ on ACPR was demonstrated. ASAQ presented faster clearance of parasitaemia and fever. Based on CQ blood level measurements, CQ resistance prevalence was estimated at 11.5% (95% CI: 7.5-17.3) up to day 42. At least one emergent adverse event (AE) was recorded for 79/190 (41x6%) in the ASAQ group and for 85/190 (44x7%) in the CQ group. Both treatments had similar safety profiles. CONCLUSIONS: ASAQ exhibited high efficacy against CQ resistant P. vivax and is an adequate alternative in the study area. Studies with an efficacious comparator, longer follow-up and genotype-adjustment can improve CQR characterization

Educomunicação e suas áreas de intervenção: Novos paradigmas para o diálogo intercultural

oai:omp.abpeducom.org.br:publicationFormat/1O material aqui divulgado representa, em essência, a contribuição do VII Encontro Brasileiro de Educomunicação ao V Global MIL Week, da UNESCO, ocorrido na ECA/USP, entre 3 e 5 de novembro de 2016. Estamos diante de um conjunto de 104 papers executivos, com uma média de entre 7 e 10 páginas, cada um. Com este rico e abundante material, chegamos ao sétimo e-book publicado pela ABPEducom, em seus seis primeiros anos de existência. A especificidade desta obra é a de trazer as “Áreas de Intervenção” do campo da Educomunicação, colocando-as a serviço de uma meta essencial ao agir educomunicativo: o diálogo intercultural, trabalhado na linha do tema geral do evento internacional: Media and Information Literacy: New Paradigms for Intercultural Dialogue

Wastewater-Based Epidemiology (WBE) and Viral Detection in Polluted Surface Water: A Valuable Tool for COVID-19 Surveillance—A Brief Review

SARS-CoV-2 is the causative agent of the current COVID-19 pandemic. Disease clinical manifestations range from asymptomatic to severe multiple organ damage. SARS-CoV-2 uses ACE2 as a cellular receptor, which is abundantly expressed in the small intestine, allowing viral replication in the gastrointestinal tract. Viral RNA has been detected in the stool of COVID-19 patients and viable viruses had been isolated in some of these samples. Thus, a putative role of SARS-CoV-2 fecal-oral transmission has been argued. SARS-CoV-2 is shed in human excreta and further disposed in the sewerage or in the environment, in poor basic sanitation settings. Wastewater-based epidemiology (WBE) is a valuable population level approach for monitoring viral pathogens and has been successfully used in different contexts. This review summarizes the current global experience on SARS-CoV-2 WBE in distinct continents and viral detection in polluted surface water. The advantages and concerns of this strategy for SARS-CoV-2 surveillance are discussed. Outcomes suggest that WBE is a valuable early warning alert and a helpful complementary surveillance tool to subside public health response, to tailor containment and mitigation measures and to determine target populations for testing. In poor sanitation settings, contaminated rivers could be alternatively used as a source for environmental surveillance

Synergy in ethnopharmacological data collection methods employed for communities adjacent to urban forest

Several ethnopharmacological techniques used for sampling and data collection cannot be used as they are for different areas and cultural groups. This study combined and adapted reported ethnopharmacological research techniques for sampling and data collection of medicinal plants in forests adjacent to urban areas, and evaluated their potential applicability. The areas considered in this study included the neighborhoods adjacent to the Botanical Garden of the Federal University of Juiz de Fora, MG, Brazil. Application of combined ethnopharmacological research techniques ensured a practical strategy and reliability in the collected data. Preliminary interviews with 303 questionnaires constituted the general sampling of the population, and interviews with eleven people knowledgeable of medicinal plants constituted specific sampling. Using the two techniques, it was possible to identify sixty species, which are stored in the CESJ Herbarium. Given the lack of specific ethnopharmacological research tools in the context of multi-cultural urban communities located adjacent to forest areas that require preservation, this study shows that the synergistic use of techniques provides more reliable and reproducible data. The combined use of these techniques provides safety and simplifies the tools for future use in similar studies