Low temperature laser scanning microscopy of a superconducting radio-frequency cavity

An apparatus was developed to obtain, for the first time, 2D maps of the surface resistance of the inner surface of an operating superconducting radio-frequency niobium cavity by a low-temperature laser scanning microscopy technique. This allows identifying non-uniformities of the surface resistance with a spatial resolution of about one order of magnitude better than with earlier methods and surface resistance resolution of ~ 1 micro-Ohm at 3.3 GHz. A signal-to-noise ratio of about 10 dB was obtained with 240 mW laser power and 1 Hz modulation frequency. The various components of the apparatus, the experimental procedure and results are discussed in detail in this contribution.Comment: 19 pages, 17 figures, submitted to Rev. Sci. Instru

Fabrication, Tuning, Treatment and Testing of Two 3.5 Cell Photo-Injector Cavities for the ELBE Linac

As part of a CRADA (Cooperative Research and Development Agreement) between Helmholtz-Zentrum Dresden-Rossendorf (HZDR) and Thomas Jefferson Lab National Accelerator Facility (TJNAF) we have fabricated and tested two 1.3 GHz 3.5 cell photo-injector cavities from polycrystalline RRR niobium and large grain RRR niobium, respectively. The cavity with the better performance will replace the presently used injector cavity in the ELBE linac. The cavities have been fabricated and pre-tuned at TJNAF, while the more sophisticated final field tuning, the adjustment of the external couplings and the field profile measurement of transverse electric modes for RF focusing was done at HZDR. The following standard surface treatment and the vertical test was carried out at TJNAF's production facilities. A major challenge turned out to be the rinsing of the cathode cell, which has small opening (O-slash10mm) to receive the cathode stalk. Another unexpected problem encountered after etching, since large visible defects appeared in the least accessible cathode cell. This contribution reports about our experiences, initial results and the on-going diagnostic work to understand and fix the problems

Effect of Interleukin-1 Blockade With Anakinra on Leukocyte Count in Patients With ST-Segment Elevation Acute Myocardial Infarction

Leukocytosis is a common finding in patients with ST elevation myocardial infarction (STEMI) and portends a poor prognosis. Interleukin 1-β regulates leukopoiesis and pre-clinical studies suggest that anakinra (recombinant human interleukin-1 [IL-1] receptor antagonist) suppresses leukocytosis in myocardial infarction. However, the effect of IL-1 blockade with anakinra on leukocyte count in patients with STEMI is unknown. We reviewed the white blood cell (WBC) and differential count of 99 patients enrolled in a clinical trial of anakinra (n = 64) versus placebo (n = 35) for 14 days after STEMI. A complete blood cell count with differential count were obtained at admission, and after 72 h, 14 days and 3 months. After 72 h from treatment, anakinra compared to placebo led to a statistically significant greater percent reduction in total WBC count (− 35% [− 48 to − 24] vs. − 21% [− 34 to − 10], P = 0.008), absolute neutrophil count (− 48% [− 60 to − 22] vs. − 27% [− 46 to − 5], P = 0.004) and to an increase in absolute eosinophil count (+ 50% [0 to + 100] vs. 0% [− 50 to + 62], P = 0.022). These changes persisted while on treatment at 14 days and were no longer apparent at 3 months after treatment discontinuation. We found that in patients with STEMI IL-1 blockade with anakinra accelerates resolution of leukocytosis and neutrophilia. This modulation may represent one of the mechanisms by which IL-1 blockade improves clinical outcomes

Interleukin‐1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST‐Segment–Elevation Myocardial Infarction

Background ST‐segment–elevation myocardial infarction is associated with an intense acute inflammatory response and risk of heart failure. We tested whether interleukin‐1 blockade with anakinra significantly reduced the area under the curve for hsCRP (high sensitivity C‐reactive protein) levels during the first 14 days in patients with ST‐segment–elevation myocardial infarction (VCUART3 [Virginia Commonwealth University Anakinra Remodeling Trial 3]). Methods and Results We conducted a randomized, placebo‐controlled, double‐blind, clinical trial in 99 patients with ST‐segment–elevation myocardial infarction in which patients were assigned to 2 weeks treatment with anakinra once daily (N=33), anakinra twice daily (N=31), or placebo (N=35). hsCRP area under the curve was significantly lower in patients receiving anakinra versus placebo (median, 67 [interquartile range, 39–120] versus 214 [interquartile range, 131–394] mg·day/L; P\u3c0.001), without significant differences between the anakinra arms. No significant differences were found between anakinra and placebo groups in the interval changes in left ventricular end‐systolic volume (median, 1.4 [interquartile range, −9.8 to 9.8] versus −3.9 [interquartile range, −15.4 to 1.4] mL; P=0.21) or left ventricular ejection fraction (median, 3.9% [interquartile range, −1.6% to 10.2%] versus 2.7% [interquartile range, −1.8% to 9.3%]; P=0.61) at 12 months. The incidence of death or new‐onset heart failure or of death and hospitalization for heart failure was significantly lower with anakinra versus placebo (9.4% versus 25.7% [P=0.046] and 0% versus 11.4% [P=0.011], respectively), without difference between the anakinra arms. The incidence of serious infection was not different between anakinra and placebo groups (14% versus 14%; P=0.98). Injection site reactions occurred more frequently in patients receiving anakinra (22%) versus placebo (3%; P=0.016). Conclusions In patients presenting with ST‐segment–elevation myocardial infarction, interleukin‐1 blockade with anakinra significantly reduces the systemic inflammatory response compared with placebo. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT01950299

Obstructed Labor and Caesarean Delivery: The Cost and Benefit of Surgical Intervention

Background: Although advances in the reduction of maternal mortality have been made, up to 273,000 women will die this year from obstetric etiologies. Obstructed labor (OL), most commonly treated with Caesarean delivery, has been identified as a major contributor to global maternal morbidity and mortality. We used economic and epidemiological modeling to estimate the cost per disability-adjusted life-year (DALY) averted and benefit-cost ratio of treating OL with Caesarean delivery for 49 countries identified as providing an insufficient number of Caesarean deliveries to meet demand. Methods and Findings Using publicly available data and explicit economic assumptions, we estimated that the cost per DALY (3,0,0) averted for providing Caesarean delivery for OL ranged widely, from $251 per DALY averted in Madagascar to$3,462 in Oman. The median cost per DALY averted was $304. Benefit-cost ratios also varied, from 0.6 in Zimbabwe to 69.9 in Gabon. The median benefit-cost ratio calculated was 6.0. The main limitation of this study is an assumption that lack of surgical capacity is the main factor responsible for DALYs from OL. Conclusions: Using the World Health Organization's cost-effectiveness standards, investing in Caesarean delivery can be considered “highly cost-effective” for 48 of the 49 countries included in this study. Furthermore, in 46 of the 49 included countries, the benefit-cost ratio was greater than 1.0, implying that investment in Caesarean delivery is a viable economic proposition. While Caesarean delivery alone is not sufficient for combating OL, it is necessary, cost-effective by WHO standards, and ultimately economically favorable in the vast majority of countries included in this study

Electrophysiological evidence of enhanced performance monitoring in recently abstinent alcoholic men

RATIONALE: Chronic alcoholism is associated with mild to moderate cognitive impairment. Under certain conditions, impairment can be ameliorated by invoking compensatory processes. OBJECTIVE: To identify electrophysiological mechanisms of such compensation that would be required to resolve response conflict. METHODS: 14 abstinent alcoholic men and 14 similarly aged control men performed a variation of the Eriksen flanker task during an electroencephalography (EEG) recording to examine whether alcoholics could achieve and maintain control-level performance and whether EEG markers could identify evidence for the action of compensatory processes in the alcoholics. Monitoring processes engaged following a response were indexed by the correct related negativity (CRN) and error related negativity (ERN), two medial-frontal negative event-related potentials. RESULTS: The alcoholics were able to perform at control levels on accuracy and reaction time (RT). Alcoholics generated larger ERN amplitudes following incorrect responses and larger CRNs following correct responses than controls. Both groups showed evidence of post-error slowing. Larger CRN amplitudes in the alcoholics were related to longer RTs. Also observed in the alcoholics was an association between smaller CRN amplitudes and length of sobriety, suggesting a normalization of monitoring activity with extended abstinence. CONCLUSIONS: To the extent that greater amplitude of these electrophysiological markers of performance monitoring indexes greater resource allocation and performance compensation, the larger amplitudes observed in the alcoholic than control group support the view that elevated performance monitoring enables abstinent alcoholics to overcome response conflict, as was evident in their control-level performance

Highly enantioselective copper(I)-catalyzed conjugate addition of 1,3-diynes to a,b-unsaturated trifluoromethyl ketones

[EN] The conjugate diynylation of a,b-unsaturated trifluoromethyl ketones is carried out in the presence of a low catalytic load (2.5 mol%) of a copper(I)–MeOBIPHEP complex, triethylamine and a terminal 1,3-diyne. Pre-metalation of the terminal 1,3-diyne with stoichiometric or higher amounts of dialkylzinc reagent is not required. The corresponding internal diynes bearing a propargylic stereogenic center are obtained with good yields and excellent enantioselectivities.Financial support from the Ministerio de Economia y Competitividad (MINECO-Gobierno de Espana) and FEDER (EU) (CTQ2013-47494-P) and from Generalitat Valenciana (ISIC2012/001) is gratefully acknowledged. A.S.-M. thanks the MINECO for a predoctoral grant (FPI program). Access to NMR and MS facilities from the Servei Central de Suport a la Investigacio Experimental (SCSIE)-UV is also acknowledged.Sanz-Marco, A.; Blay, G.; Muñoz Roca, MDC.; Pedro, J. (2015). Highly enantioselective copper(I)-catalyzed conjugate addition of 1,3-diynes to a,b-unsaturated trifluoromethyl ketones. Chemical Communications. (51):8958-8961. https://doi.org/10.1039/C5CC01676BS8958896151Shi Shun, A. L. K., & Tykwinski, R. R. (2006). Synthesis of Naturally Occurring Polyynes. Angewandte Chemie International Edition, 45(7), 1034-1057. doi:10.1002/anie.200502071Modern Acetylene Chemistry, ed. P. J. Stang and F. Diederich, VCH, Weinheim, 1995Sindhu, K. S., & Anilkumar, G. (2014). Recent advances and applications of Glaser coupling employing greener protocols. RSC Adv., 4(53), 27867-27887. doi:10.1039/c4ra02416hJung, H.-J., Min, B.-S., Park, J.-Y., Kim, Y.-H., Lee, H.-K., & Bae, K.-H. (2002). Gymnasterkoreaynes A−F, Cytotoxic Polyacetylenes fromGymnasterkoraiensis. Journal of Natural Products, 65(6), 897-901. doi:10.1021/np0104018Mayer, S. F., Steinreiber, A., Orru, R. V. A., & Faber, K. (2002). Chemoenzymatic Asymmetric Total Syntheses of Antitumor Agents (3R,9R,10R)- and (3S,9R,10R)-Panaxytriol and (R)- and (S)-Falcarinol fromPanaxginsengUsing an Enantioconvergent Enzyme-Triggered Cascade Reaction. The Journal of Organic Chemistry, 67(26), 9115-9121. doi:10.1021/jo020073wSatoh, Y., Satoh, M., Isobe, K., Mohri, K., Yoshida, Y., & Fujimoto, Y. (2007). Studies on Panax Acetylenes: Absolute Structure of a New Panax Acetylene, and Inhibitory Effects of Related Acetylenes on the Growth of L-1210 Cells. CHEMICAL & PHARMACEUTICAL BULLETIN, 55(4), 561-564. doi:10.1248/cpb.55.561McLaughlin, N. P., Butler, E., Evans, P., Brunton, N. P., Koidis, A., & Rai, D. K. (2010). A short synthesis of (+) and (−)-falcarinol. Tetrahedron, 66(51), 9681-9687. doi:10.1016/j.tet.2010.10.049Shin, D., Yang, J.-E., Lee, S. B., & Nho, C. W. (2010). SAR studies of gymnasterkoreayne derivatives with cancer chemopreventive activities. Bioorganic & Medicinal Chemistry Letters, 20(24), 7549-7552. doi:10.1016/j.bmcl.2010.07.066Nielsen, M. B., & Diederich, F. (2005). Conjugated Oligoenynes Based on the Diethynylethene Unit. Chemical Reviews, 105(5), 1837-1868. doi:10.1021/cr9903353Wan, W. B., Brand, S. C., Pak, J. J., & Haley, M. M. (2000). Synthesis of Expanded Graphdiyne Substructures. Chemistry - A European Journal, 6(11), 2044-2052. doi:10.1002/1521-3765(20000602)6:113.0.co;2-yWest, K., Wang, C., Batsanov, A. S., & Bryce, M. R. (2008). Carbon-rich molecules: synthesis and isolation of aryl/heteroaryl terminal bis(butadiynes) (HCC–CC–Ar–CC–CCH) and their applications in the synthesis of oligo(arylenebutadiynylene) molecular wires. Organic & Biomolecular Chemistry, 6(11), 1934. doi:10.1039/b802968gYu, D.-G., de Azambuja, F., Gensch, T., Daniliuc, C. G., & Glorius, F. (2014). The CH Activation/1,3-Diyne Strategy: Highly Selective Direct Synthesis of Diverse Bisheterocycles by RhIIICatalysis. Angewandte Chemie International Edition, 53(36), 9650-9654. doi:10.1002/anie.201403782Lee, N.-K., Yun, S. Y., Mamidipalli, P., Salzman, R. M., Lee, D., Zhou, T., & Xia, Y. (2014). Hydroarylation of Arynes Catalyzed by Silver for Biaryl Synthesis. Journal of the American Chemical Society, 136(11), 4363-4368. doi:10.1021/ja500292xYun, S. Y., Wang, K.-P., Lee, N.-K., Mamidipalli, P., & Lee, D. (2013). Alkane C–H Insertion by Aryne Intermediates with a Silver Catalyst. Journal of the American Chemical Society, 135(12), 4668-4671. doi:10.1021/ja400477rHuang, G., Xie, K., Lee, D., & Xia, Y. (2012). Reactivity of Alkynyl Metal Carbenoids: DFT Study on the Pt-Catalyzed Cyclopropanation of Propargyl Ester Containing 1,3-Diynes. Organic Letters, 14(15), 3850-3853. doi:10.1021/ol301497vGupta, S., Agarwal, P. K., Saifuddin, M., & Kundu, B. (2011). Hydro-amination/-amidation of 1,3-diynes with indoles/azoles/amides under modified Ullmann conditions: stereo- and regio-selective synthesis of N-alkenynes via N–H bond activation. Tetrahedron Letters, 52(44), 5752-5757. doi:10.1016/j.tetlet.2011.08.079Cho, E. J., Kim, M., & Lee, D. (2006). Reactivity and Selectivity of 1,3-Diyn-6-enes in Electrophilic Transition Metal-Catalyzed Reactions. Organic Letters, 8(23), 5413-5416. doi:10.1021/ol062335cTrost, B. M., & Weiss, A. H. (2009). The Enantioselective Addition of Alkyne Nucleophiles to Carbonyl Groups. Advanced Synthesis & Catalysis, 351(7-8), 963-983. doi:10.1002/adsc.200800776Blay, G., Monleon, A., & Pedro, J. (2009). Recent Developments in Asymmetric Alkynylation of Imines. Current Organic Chemistry, 13(15), 1498-1539. doi:10.2174/138527209789177734Knöpfel, T. F., Zarotti, P., Ichikawa, T., & Carreira, E. M. (2005). Catalytic, Enantioselective, Conjugate Alkyne Addition. Journal of the American Chemical Society, 127(27), 9682-9683. doi:10.1021/ja052411rYazaki, R., Kumagai, N., & Shibasaki, M. (2010). Direct Catalytic Asymmetric Conjugate Addition of Terminal Alkynes to α,β-Unsaturated Thioamides. Journal of the American Chemical Society, 132(30), 10275-10277. doi:10.1021/ja105141xYazaki, R., Kumagai, N., & Shibasaki, M. (2011). Enantioselective Synthesis of a GPR40 Agonist AMG 837 via Catalytic Asymmetric Conjugate Addition of Terminal Alkyne to α,β-Unsaturated Thioamide. Organic Letters, 13(5), 952-955. doi:10.1021/ol102998wSanz-Marco, A., García-Ortiz, A., Blay, G., & Pedro, J. R. (2014). Catalytic asymmetric conjugate addition of terminal alkynes to β-trifluoromethyl α,β-enones. Chem. Commun., 50(18), 2275-2278. doi:10.1039/c3cc48508kSanz-Marco, A., García-Ortiz, A., Blay, G., Fernández, I., & Pedro, J. R. (2013). Highly Enantioselective Copper(I)-Catalyzed Conjugate Addition of Terminal Alkynes to 1,1-Difluoro-1-(phenylsulfonyl)-3-en-2-ones: New Ester/Amide Surrogates in Asymmetric Catalysis. Chemistry - A European Journal, 20(3), 668-672. doi:10.1002/chem.201303920Nishimura, T., Guo, X.-X., Uchiyama, N., Katoh, T., & Hayashi, T. (2008). Steric Tuning of Silylacetylenes and Chiral Phosphine Ligands for Rhodium-Catalyzed Asymmetric Conjugate Alkynylation of Enones. Journal of the American Chemical Society, 130(5), 1576-1577. doi:10.1021/ja710540sNishimura, T., Sawano, T., & Hayashi, T. (2009). Asymmetric Synthesis of β-Alkynyl Aldehydes by Rhodium-Catalyzed Conjugate Alkynylation. Angewandte Chemie International Edition, 48(43), 8057-8059. doi:10.1002/anie.200904486Fillion, E., & Zorzitto, A. K. (2009). Enantioselective Rhodium-Catalyzed Conjugate Alkynylation of 5-Benzylidene Meldrum’s Acids with TMS-acetylene. Journal of the American Chemical Society, 131(41), 14608-14609. doi:10.1021/ja905336pBlay, G., Cardona, L., Pedro, J. R., & Sanz-Marco, A. (2012). Enantioselective Zinc-Mediated Conjugate Addition of Terminal Alkynes to Enones. Chemistry - A European Journal, 18(41), 12966-12969. doi:10.1002/chem.201201765Blay, G., Muñoz, M. C., Pedro, J. R., & Sanz-Marco, A. (2013). Enantioselective Synthesis of 4-Substituted Dihydrocoumarins through a Zinc Bis(hydroxyamide)-Catalyzed Conjugate Addition of Terminal Alkynes. Advanced Synthesis & Catalysis, 355(6), 1071-1076. doi:10.1002/adsc.201201120Cui, S., Walker, S. D., Woo, J. C. S., Borths, C. J., Mukherjee, H., Chen, M. J., & Faul, M. M. (2010). Practical Asymmetric Conjugate Alkynylation of Meldrum’s Acid-Derived Acceptors: Access to Chiral β-Alkynyl Acids. Journal of the American Chemical Society, 132(2), 436-437. doi:10.1021/ja909105sKwak, Y.-S., & Corey, E. J. (2004). Catalytic Enantioselective Conjugate Addition of Trimethylsilylacetylene to 2-Cyclohexen-1-one. Organic Letters, 6(19), 3385-3388. doi:10.1021/ol048623vLarionov, O. V., & Corey, E. J. (2010). Ni(II)-Catalyzed Enantioselective Conjugate Addition of Acetylenes to α,β-Enones. Organic Letters, 12(2), 300-302. doi:10.1021/ol902643wReber, S., Knöpfel, T. F., & Carreira, E. M. (2003). Enantioselective total synthesis of (R)-strongylodiols A and B. Tetrahedron, 59(35), 6813-6817. doi:10.1016/s0040-4020(03)00905-0Trost, B. M., Chan, V. S., & Yamamoto, D. (2010). Enantioselective ProPhenol-Catalyzed Addition of 1,3-Diynes to Aldehydes to Generate Synthetically Versatile Building Blocks and Diyne Natural Products. Journal of the American Chemical Society, 132(14), 5186-5192. doi:10.1021/ja910656bTurlington, M., Du, Y., Ostrum, S. G., Santosh, V., Wren, K., Lin, T., … Pu, L. (2011). From Highly Enantioselective Catalytic Reaction of 1,3-Diynes with Aldehydes to Facile Asymmetric Synthesis of Polycyclic Compounds. Journal of the American Chemical Society, 133(30), 11780-11794. doi:10.1021/ja204289qGraham, E. R., & Tykwinski, R. R. (2011). Chiral Propargyl Alcohols via the Enantioselective Addition of Terminal Di- and Triynes to Aldehydes. The Journal of Organic Chemistry, 76(16), 6574-6583. doi:10.1021/jo2008719Zheng, B., Li, S.-N., Mao, J.-Y., Wang, B., Bian, Q.-H., Liu, S.-Z., … Wang, M. (2012). Highly Enantioselective Addition of 1,3-Diynes to Aldehydes Catalyzed by a Zinc-Amino Alcohol Complex. Chemistry - A European Journal, 18(30), 9208-9211. doi:10.1002/chem.201200728Liu, T.-L., Ma, H., Zhang, F.-G., Zheng, Y., Nie, J., & Ma, J.-A. (2011). Catalytic enantioselective addition of terminal 1,3-diynes to aromatic ketones: facile access to chiral nonracemic tertiary alcohols. Chemical Communications, 47(48), 12873. doi:10.1039/c1cc15968bLiu, T.-L., Zhang, H.-X., Zheng, Y., Yao, Q., & Ma, J.-A. (2012). Catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines: access to chiral diynylated carbinamines. Chemical Communications, 48(100), 12234. doi:10.1039/c2cc37290hZhang, F.-G., Ma, H., Zheng, Y., & Ma, J.-A. (2012). Zinc-mediated enantioselective addition of terminal 1,3-diynes to N-arylimines of trifluoropyruvates. Tetrahedron, 68(37), 7663-7669. doi:10.1016/j.tet.2012.05.086Zhang, F.-G., Ma, H., Nie, J., Zheng, Y., Gao, Q., & Ma, J.-A. (2012). Enantioselective Diynylation of Cyclic N-Acyl Ketimines: Access to Chiral Trifluoromethylated Tertiary Carbinamines. Advanced Synthesis & Catalysis, 354(8), 1422-1428. doi:10.1002/adsc.201100926Nie, J., Guo, H.-C., Cahard, D., & Ma, J.-A. (2011). Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates. Chemical Reviews, 111(2), 455-529. doi:10.1021/cr100166aCahard, D., Xu, X., Couve-Bonnaire, S., & Pannecoucke, X. (2010). Fluorine & chirality: how to create a nonracemic stereogenic carbon–fluorine centre? Chem. Soc. Rev., 39(2), 558-568. doi:10.1039/b909566gKirk, K. L. (2008). Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments. Organic Process Research & Development, 12(2), 305-321. doi:10.1021/op700134jMa, J.-A., & Cahard, D. (2008). Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions. Chemical Reviews, 108(9), PR1-PR43. doi:10.1021/cr800221vPurser, S., Moore, P. R., Swallow, S., & Gouverneur, V. (2008). Fluorine in medicinal chemistry. Chem. Soc. Rev., 37(2), 320-330. doi:10.1039/b610213cMorrill, L. C., Smith, S. M., Slawin, A. M. Z., & Smith, A. D. (2014). Isothiourea-Mediated Asymmetric Functionalization of 3-Alkenoic Acids. The Journal of Organic Chemistry, 79(4), 1640-1655. doi:10.1021/jo402591vYeh, P.-P., Daniels, D. S. B., Cordes, D. B., Slawin, A. M. Z., & Smith, A. D. (2014). Isothiourea-Mediated One-Pot Synthesis of Trifluoromethyl Substituted 2-Pyrones. Organic Letters, 16(3), 964-967. doi:10.1021/ol403697hMorrill, L. C., Douglas, J., Lebl, T., Slawin, A. M. Z., Fox, D. J., & Smith, A. D. (2013). Isothiourea-mediated asymmetric Michael-lactonisation of trifluoromethylenones: a synthetic and mechanistic study. Chemical Science, 4(11), 4146. doi:10.1039/c3sc51791hPei, Z., Zheng, Y., Nie, J., & Ma, J.-A. (2010). Chiral Brønsted acid-catalyzed regio- and enantioselective arylation of α,β-unsaturated trifluoromethyl ketones. Tetrahedron Letters, 51(35), 4658-4661. doi:10.1016/j.tetlet.2010.06.132Sasaki, S., Yamauchi, T., & Higashiyama, K. (2010). Dy(OTf)3/Pybox-catalyzed enantioselective Friedel–Crafts alkylation of indoles with α,β-unsaturated trifluoromethyl ketones. Tetrahedron Letters, 51(17), 2326-2328. doi:10.1016/j.tetlet.2010.02.121Li, P., Chai, Z., Zhao, S.-L., Yang, Y.-Q., Wang, H.-F., Zheng, C.-W., … Zhu, S.-Z. (2009). Highly enantio- and diastereoselective synthesis of α-trifluoromethyldihydropyrans using a novel bifunctional piperazine-thiourea catalyst. Chemical Communications, (47), 7369. doi:10.1039/b915210eZheng, C., Li, Y., Yang, Y., Wang, H., Cui, H., Zhang, J., & Zhao, G. (2009). Highly Efficient Asymmetric Epoxidation of Electron-Deficient α,β-Enones and Related Applications to Organic Synthesis. Advanced Synthesis & Catalysis, 351(10), 1685-1691. doi:10.1002/adsc.200900041Zhang, G.-W., Meng, W., Ma, H., Nie, J., Zhang, W.-Q., & Ma, J.-A. (2011). Catalytic Enantioselective Alkynylation of Trifluoromethyl Ketones: Pronounced Metal Fluoride Effects and Implications of Zinc-to-Titanium Transmetallation. Angewandte Chemie International Edition, 50(15), 3538-3542. doi:10.1002/anie.201007341Liu, Z.-J., & Liu, J.-T. (2008). Asymmetric synthesis of either diastereomer of trifluoromethylated allylic amines by the selective reduction of trifluoromethyl α,β-unsaturated N-tert-butanesulfinyl ketoimines. Chemical Communications, (41), 5233. doi:10.1039/b810459jWang, X.-J., Zhao, Y., & Liu, J.-T. (2007). Regiospecific Organocatalytic Asymmetric Aldol Reaction of Methyl Ketones and α,β-Unsaturated Trifluoromethyl Ketones. Organic Letters, 9(7), 1343-1345. doi:10.1021/ol070217zNenajdenko, V. G., Smolko, K. I., & Balenkova, E. S. (2001). Enantioselective reduction of α,β-unsaturated ketones bearing the trifluoromethyl group. Tetrahedron: Asymmetry, 12(9), 1259-1266. doi:10.1016/s0957-4166(01)00209-9Wang, H., Yang, K.-F., Li, L., Bai, Y., Zheng, Z.-J., Zhang, W.-Q., … Xu, L.-W. (2013). Modulation of Silver-Titania Nanoparticles on Polymethylhydrosiloxane-based Semi-Interpenetrating Networks for Catalytic Alkynylation of Trifluoromethyl Ketones and Aromatic Aldehydes in Water. ChemCatChem, 6(2), 580-591. doi:10.1002/cctc.20130087