The palaeoweatherings on the iberian hercynian basernent: approach to a regional interpretation from sorne spanish profiles

The Hercynian basement of the Iberian Peninsula has undergone different stages of supergenic weathering which has given rise to a superposition of several «weathering mantles». Remnants ofan old weathering mantle, Mesozoic in age, and related to a planation surface older than the Alpine tectonic phases, have been found. Nowadays the fragments of this old surface appear unleveled and/or fossilized by younger sediments. likewise, related to the «Raña» sediments ofUpper Neogene-lower Pleistocene age, appears a weathering mantle, probably active today, which is rich in kaolinite and with strong hydromorphic features

Deterioro de monumentos graníticos por cristalización de sales en ambiente urbano con baja contaminación

The effect of salt crystallization on granite (s.l) rocks used as building material in an urban environment with low atmospheric pollution was studied. The manners of salt crystallization and the subsequent deterioration caused were analyzed in unweathered granite and other fades which had undergone strong transformations in quarries before being used as stone materials, "alterites".Se estudia el efecto de la cristalización de sales solubles en rocas graníticas s.l empleadas como materiales de construcción, en ambiente urbano con baja contaminación atmosférica. Las formas en que cristalizan las sales y el deterioro asociado a su presencia son analizados en granitos sanos y en otras facies que han sufrido fuertes transformaciones en cantera previas a su empleo como materiales de construcción ("alteritas")

New polymorphisms associated with response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis

Anti-tumor necrosis factor (anti-TNF) drugs are effective against psoriasis, although 20–30% of patients are nonresponders. Few pharmacogenomic studies have been performed to predict the response to anti-TNF drugs in psoriasis. We studied 173 polymorphisms to establish an association with the response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis (N=144). We evaluated the response using PASI75 at 3, 6 and 12 months. The results of the multivariate analysis showed an association between polymorphisms in PGLYR4, ZNF816A, CTNNA2, IL12B, MAP3K1 and HLA-C genes and the response at 3 months. Besides, the results for polymorphisms in IL12B and MAP3K1 were replicated at 6 months. We also obtained significant results for IL12B polymorphism at 1 year. Moreover, polymorphisms in FCGR2A, HTR2A and CDKAL1 were significant at 6 months. This is the first study to show an association with these polymorphisms. However, these biomarkers should be validated in large-scale studies before implementation in clinical practiceThis study was supported by Instituto de Salud Carlos III (FIS PI10/01740), Fundación Teófilo Hernando, and AbbVie. RPP has a grant from Universidad Autónoma de Madrid (FPI program 2013

Importance of porosity and transfer of matter in the rock weathering processes: two examples in Central Spain.

14 p.Some physical properties (bulk and free porosity, pore size distribution), and the chemical composition and mass balance of two deeply weathered profiles one developed on Hercynian granodiorite and the other on pre-Cambrian slates were studied. Hydric and mercury porosimetry, nitrogen adsorption techniques, chemical analyses and XRD techniques were used. On granodiorite, weathering has created increased porosity with a pore diameter \5 lm, whereas on slates the weathering has produced of ca. 1 lm in diameter. These pore sizes have played an important role in the weathering processes. Assuming that weathering preserves volumes, except in the uppermost part of the profiles, it brought about a loss of matter of more than 12% (*300 kg/m3) on granodiorite and ca. 30% (*800 kg/m3) on slates. These changes are related to shifts in the mineralogical evolution, with the appearance of new 2:1 and 1:1 phyllosilicates and Fe oxyhydroxides as the main authigenic minerals. The release of matter, at least since the upper Neogene until the present, has led to the lowering of relief in a more or less homogeneous way, giving rise to gentle hillsides and flat surfaces below which the current river networks are incised. Porosity studies have the potential to explain several specific landforms as well as affecting landscape development in general.The authors acknowledged the interesting suggestions of Prof. C. R. TWIDALE. We also thank the Ministerio de Educacio´n y Ciencia of Spain and the Junta de Castilla y Leo´n for financial support under Projects CGL2007-62168/BTE (funds FEDER) and Project SA024A07, respectively.10261/35212Peer reviewe

Carcaterización mineralógica de las lutitas del pérmico y triásico en Pina (Castellón).

2 p

Las paleoalteraciones sobre el Zócalo Hercínico Ibérico. Aproximación a una interpretación regional a partir de perfiles españoles.

Universidad de la Coruña. Area de Xeoloxía e Minería.Peer reviewe