Lunar Surface Navigation for a Roving Vehicle (MOLAB)

This paper presents an examination of the guidance and navigation requirements for NASA\u27s MOLAB vehicle (Mobile Lunar Lab.). The functions and capabilities necessary to guide and navigate a roving vehicle over the area of the lunar surface for exploration and experimental investigations are considered. A mission profile is afforded — providing a general outline of environmental, navigation and guidance, and survey requirements. The fact that the moon will eventually be explored by man is a foregone conclusion. Aside from the central fact that it exists and can be reached, which in the context of the entire history of the human race implies that it will someday be explored, there are other, more practical and compelling reasons. The moon should supply information on comparative planetology and the evolution of the solar system; it has potential as a way station enroute to other space destinations; it may prove to be a source of valuable minerals and raw materials. When the moon exploration will take place is more of an open question. The idea of exploring the moon is, of course, not new. Earthbound explorations have been in progress for several centuries via the media of the telescope, the camera, and, more recently, radar. The last few years, however, have witnessed the first successful attempts at viewing the moon close-up. Ranger VII provided photographs of the lunar surface with detail which was, until then, unobtainable. The next step, Surveyor, will permit sampling the surface of the moon. Other lunar exploration programs now in the preparatory stage include the lunar orbiter system, which is scheduled for its first flight in 1966. But all of these programs have restrictions of one sort or another. Either they do not provide a means of sampling the surface or they provide limited coverage. What will ultimately be required is an integrated overall program to obtain information on the total moon

Gluon fusion into Higgs pairs at NLO QCD and the top mass scheme

We present the calculation of the full next-to-leading order (NLO) QCD corrections to Higgs boson pair production via gluon fusion at the LHC, including the exact top-mass dependence in the two-loop virtual and one-loop real corrections. This is the first independent cross-check of the NLO QCD corrections presented in the literature before. Our calculation relies on numerical integrations of Feynman integrals, stabilised with integration-by-parts and a Richardson extrapolation to the narrow width approximation. We present results for the total cross section as well as for the invariant Higgs-pair-mass distribution at the LHC, including for the first time a study of the uncertainty due to the scheme and scale choice for the top mass in the loops

Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids

Most clinically used opioids are thought to induce analgesia through activation of the mu opioid receptor (MOR). However, disparities have been observed between the efficacy of opioids in activating the MOR in vitro and in inducing analgesia in vivo. In addition, some clinically used opioids do not produce cross-tolerance with each other, and desensitization produced in vitro does not match tolerance produced in vivo. These disparities suggest that some opioids could be acting through other targets in vivo, but this has not been comprehensively tested. We thus screened 9 clinically relevant opioids (buprenorphine, hydrocodone, hydromorphone, morphine, 0-desmethyl-tramadol, oxycodone, oxymorphone, tapentadol, tramadol) against 9 pain-related receptor targets (MOR, delta opioid receptor [DOR], kappa opioid receptor [KOR], nociceptin receptor [NOP], cannabinoid receptor type 1 [CB1], sigma-1 receptor [al R], and the monoamine transporters [NET/SERT/DAT]) expressed in cells using radioligand binding and functional activity assays. We found several novel interactions, including monoamine transporter activation by buprenorphine and al R binding by hydrocodone and tapentadol. Tail flick anti-nociception experiments with CD-1 mice demonstrated that the monoamine transporter inhibitor duloxetine selectively promoted buprenorphine anti-nociception while producing no effects by itself or in combination with the most MOR-selective drug oxymorphone, providing evidence that these novel interactions could be relevant in vivo. Our findings provide a comprehensive picture of the receptor interaction profiles of clinically relevant opioids, which has not previously been performed. Our findings also suggest novel receptor interactions for future investigation that could explain some of the disparities observed between opioid performance in vitro and in vivo.Depomed, Inc.; University of ArizonaOpen access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

A simple low-SAR technique for chemical-shift selection with high-field spin-echo imaging

We have discovered a simple and highly robust method for removal of chemical shift artifact in spin-echo MR images, which simultaneously decreases the radiofrequency power deposition (specific absorption rate). The method is demonstrated in spin-echo echo-planar imaging brain images acquired at 7 T, with complete suppression of scalp fat signal. When excitation and refocusing pulses are sufficiently different in duration, and thus also different in the amplitude of their slice-select gradients, a spatial mismatch is produced between the fat slices excited and refocused, with no overlap. Because no additional radiofrequency pulse is used to suppress fat, the specific absorption rate is significantly reduced compared with conventional approaches. This enables greater volume coverage per unit time, well suited for functional and diffusion studies using spin-echo echo-planar imaging. Moreover, the method can be generally applied to any sequence involving slice-selective excitation and at least one slice-selective refocusing pulse at high magnetic field strengths. The method is more efficient than gradient reversal methods and more robust against inhomogeneities of the static (polarizing) field (B0)

First Application of Pulse-Shape Analysis to Silicon Micro-Strip Detectors

The method of pulse-shape analysis (PSA) for particle identification (PID) was applied to a double-sided silicon strip detector (DSSD) with a strip pitch of 300 \{mu}m. We present the results of test measurements with particles from the reactions of a 70 MeV 12C beam impinging on a mylar target. Good separation between protons and alpha particles down to 3 MeV has been obtained when excluding the interstrip events of the DSSD from the analysis.Comment: 7 pages, 6 figures, submitted to Nuclear Inst. and Methods in Physics Research

Getting a Handle on Sales: Shopping Carts Affect Purchasing by Activating Arm Muscles

This research demonstrates that the physical properties of shopping carts influence purchasing and spending. Prior research on ergonomics indicates that standard shopping carts, which are pushed via a horizontal handlebar, are likely to activate arm extensor muscles. Prior research on arm muscle activation, in turn, suggests that arm extensor activation may elicit less purchasing than arm flexor activation. The authors thus deduce that standard shopping carts may be suboptimal for stimulating purchases. The authors predicted that shopping carts with parallel handles (i.e., like a wheelbarrow or “walker”) would instead activate the flexor muscles and thus increase purchasing. An electromyography (EMG) study revealed that both horizontal and vertical handles more strongly activate the extensor muscles of the upper arm (triceps), whereas parallel handles more strongly activate the flexor muscles (biceps). In a field experiment, parallel-handle shopping carts significantly and substantially increased sales across a broad range of categories, including both vice and virtue products. Finally, in a simulated shopping experiment, parallel handles increased purchasing and spending beyond both horizontal and vertical handles. These results were not attributable to the novelty of the shopping cart itself, participants’ mood, or purely ergonomic factors