Ant colony system for a VRP with multiple time windows and multiple visits

The vehicle routing problem with time windows is frequently found in literature, while multiple time windows are not often considered. In this paper a mathematical formulation of the vehicle routing problem with multiple time windows is presented, taking into account periodic constraints. A meta-heuristic based on Ant Colony System is proposed and implemented. Computational results related to a purpose-built benchmark are finally reported

The acceptability of intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in southern Tanzania

BACKGROUND\ud \ud Intermittent preventive treatment of malaria in infants (IPTi) reduces the incidence of clinical malaria. However, before making decisions about implementation, it is essential to ensure that IPTi is acceptable, that it does not adversely affect attitudes to immunization or existing health seeking behaviour. This paper reports on the reception of IPTi during the first implementation study of IPTi in southern Tanzania.\ud \ud METHODS\ud \ud Data were collected through in-depth interviews, focus group discussions and participant observation carried out by a central team of social scientists and a network of key informants/interviewers who resided permanently in the study sites.\ud \ud RESULTS\ud \ud IPTi was generally acceptable. This was related to routinization of immunization and resonance with traditional practices. Promoting "health" was considered more important than preventing specific diseases. Many women thought that immunization was obligatory and that health staff might be unwilling to assist in the future if they were non-adherent. Weighing and socialising were important reasons for clinic attendance. Non-adherence was due largely to practical, social and structural factors, many of which could be overcome. Reasons for non-adherence were sometimes interlinked. Health staff and "road to child health" cards were the main source of information on the intervention, rather than the specially designed posters. Women did not generally discuss child health matters outside the clinic, and information about the intervention percolated slowly through the community. Although there were some rumours about sulphadoxine pyrimethamine (SP), it was generally acceptable as a drug for IPTi, although mothers did not like the way tablets were administered. There is no evidence that IPTi had a negative effect on attitudes or adherence to the expanded programme on immunisation (EPI) or treatment seeking or existing malaria prevention.\ud \ud CONCLUSION\ud \ud In order to improve adherence to both EPI and IPTi local priorities should be taken into account. For example, local women are often more interested in weighing than in immunization, and they view vaccination and IPTi as vaguely "healthy" rather preventing specific diseases. There should be more emphasis on these factors and more critical consideration by policy makers of how much local knowledge and understanding is minimally necessary in order to make interventions successful

Fear and rumours regarding placental biopsies in a malaria-in-pregnancy trial in Benin.

BACKGROUND: A multi-country, community-based trial on scheduled screening and treatment for malaria in pregnancy was conducted in Benin, The Gambia and Burkina Faso. Despite standardized procedures and outcomes, the study became subject to rumours and accusations of placenta being sold for mystical and financial gain by trial staff, leading to drop-out rates of 30% and the consequent halting of placental biopsy sampling in Benin. This paper explores the role of socio-cultural beliefs related to placenta and identified additional factors contributing these rumours. METHODS: A qualitative comparative emergent-theory design was used to assess social factors related to trial implementation and uptake in the three countries. Data from participant observation, informal conversations, group discussions and interviews were triangulated and analysed with NVivo Qualitative Analysis software. RESULTS: Despite similar sociocultural beliefs about the sacred nature of the placenta in all three study countries, these beliefs did not affect participation rates in Burkina Faso and The Gambia and placenta-related rumours only emerged in Benin. Therefore, the presence of beliefs is not a sufficient condition to have generated placenta-selling fears. The rumours in Benin reflected the confluence of placenta-related beliefs and factors related to the implementation of the trial (including a catalysing adverse event and miscommunication during the informed consent procedure). Furthermore, distinct socio-political factors contributed to the emergence of rumours, including the historical distrust in governmental organizations and the tense relationship between some of the actors involved in the trial. CONCLUSION: Transdisciplinary social science research designs should accompany the implementation of the trial. The integration of multiple stakeholders' knowledge and involvement is required to define and solve upcoming barriers

False Starts, Wrong Turns and Dead Ends: Reflections on Recent Developments in Criminology

The nature and direction of criminology has changed significantly over the past two decades. The subject area has also grown exponentially and become more diverse. New fields of inquiry are opening up as new issues are added to the criminological agenda. However, at the same time there are some unwelcome developments in the discipline that impact on the orientation of the subject and which detract from its overall viability and standing. The aim of this paper is to identify these unwelcome trends in order to contribute to the development of a more critical and coherent criminology

A Dutch Version of the Reiss Screen of Maladaptive Behavior

Contains fulltext : 28639.pdf (publisher's version ) (Open Access)The Reiss Screen for Maladaptive Behavior, an instrument used to identify mentally retarded persons with mental health problems, was evaluated with 89 mentally retarded adults. Reliability and validity of the Reiss Screen, as well as the relationship with subject characteristics, is reported for a Dutch population. Internal consistency on the total score was good and modest on most subscales. The subscale autism had inadequate internal consistency. Interrater reliability was low to modest. Further, the Reiss Screen had good criterion validity. Last, few relationships were found between Reiss Screen scores and subject characteristics

Gaschromatographische Untersuchung der globalen und regionalen Verteilung von leichtfluechtigen Kohlenwasserstoffen und Chlormethan in der Atmosphaere

Available from the library of Darmstadt Technische Hochschule (DE) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman