Development of a high-performance W-band duplexer for plasma diagnosis using a single band with dual circular polarization

Discrepancia entre la información que aparece en el artículo que indica que el copyright es de Elsevier, y la información que aparece en la página de la revista y en el Copyright Clearance Center que indican © 2019 The Authors. Published by Elsevier B.V., así como que el artículo está publicado en Open Access under a Creative Commons licenceThis work presents the design and experimental validation of a high performance, compact, waveguide duplexer operating from 91.5 to 96.5 GHz for its integration in diverse W-band microwave equipment as in plasma diagnosis applications. It uses a single frequency band, with two signals discriminated by different orthogonal circular polarization, which is generated by means of a septum orthomode transducer (OMT) polarizer. Moreover, this component is optimized loaded with the horn antenna for improving the overall system performance. It is explained how these two components are integrated into a very compact duplexer, designed using efficient numerical algorithms. The manufacturing process by mean of high precision milling, and including electrical discharge machining (EDM) has led to excellent performances. The measured return loss level and isolation are higher than 30 dB, and the insertion loss level is below 0.3 dB. Finally, the key parameter in this device, which reflects the symmetry in the manufacturing process, i.e., the axial ratio, is lower than 0.6 dB for both polarizations, an excellent result showing the potential of the presented designThis work was supported by the Spanish government under grants (ADDMATE) TEC2016-76070-C3-1/2-R (Agencia Estatal de Investigación, Spain, Fondo Europeo de Desarrollo Regional: AEI/FEDER/UE) and the program of Comunidad de Madrid, Spain S2013/ICE-3000 (SPADERADARCM

Luzula mendocina Barros

Precordillera, Cerro de las PiedraspublishedVersio

Use of deoxycorticosterone pivalate by veterinarians: A western european survey

open9siThis research was supported by FCT—Fundação para a Ciência e Tecnologia IP, grant UIDB/00276/2020This study aims to gather knowledge about the use of deoxycorticosterone pivalate (DOCP) by Western European Veterinarians (WEV) in dogs with typical hypoadrenocorticism. An observa-tional cross-sectional study was conducted using an online survey, translated into four languages and disseminated to veterinary affiliates and mailing lists in six countries of Western Continental Europe. Respondents were tasked to share their therapeutic approach to hypoadrenocorticism, whether they preferred DOCP or fludrocortisone and the specific practical use of DOCP. One-hundred and eighty-four responses were included. Of these, 79.9% indicated that they preferred prescribing DOCP over fludrocortisone as a first-line treatment for mineralocorticoid supplementation. A total of 154 respondents had used DOCP at least once. Eighty percent of those who reported their initial dosage prescribed 2.2 mg/kg. After starting DOCP, 68.2% of the respondents assess electrolytes 10 and 25 days after administration following manufacturer instructions. In stable dogs, electrolytes are monitored quarterly, monthly, semi-annually, and annually by 44.2%, 34.4%, 16.9%, and 4.6% of respondents respectively. When treatment adjustment is required, 53% prefer to reduce dosage while 47% increase the interval between doses. Overall, DOCP is the preferred mineralocorticoid supple-mentation among WEV. Reported variability underlies the need to investigate the best strategies for DOCP use and therapeutic adjustments.openRebocho R.; Dominguez-Ruiz M.; Englar R.E.; Arenas C.; Perez-Alenza M.D.; Corsini A.; Fracassi F.; Bennaim M.; Leal R.O.Rebocho R.; Dominguez-Ruiz M.; Englar R.E.; Arenas C.; Perez-Alenza M.D.; Corsini A.; Fracassi F.; Bennaim M.; Leal R.O

Early transformation of the Mediterranean Outflow Water (MOW) in the Gulf Of Cádiz, SW Iberian Peninsula: pathways, mixing and temporal variability.

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Informe del Comité Científico de la Agencia Española de Seguridad Alimentaria y Nutrición (AESAN) sobre la prospección de peligros químicos de interés en seguridad alimentaria en España

A lo largo de la cadena alimentaria pueden estar presentes, incorporarse o producirse distintos peligros de tipo químico que podrían suponer un riesgo para el consumidor.El Comité Científico ha realizado una revisión de los peligros químicos de mayor interés para la seguridad alimentaria en España que no cuentan con una regulación específica, identificándolos y señalando aquellos alimentos o condiciones que, a priori, podrían implicar un mayor riesgo para el consumidor, con el fin de realizar, eventualmente, estudios prospectivos.En el informe se han contemplado los siguientes peligros químicos y matrices: Cilindrospermop-sina (toxina de cianobacterias) en agua de bebida (no envasada), Cloropropanoles y Glicidol en alimentos infantiles, Furano y derivados en alimentos procesados en general y alimentos infantiles en particular, Hidrocarburos de aceites minerales, Micotoxinas producidas por hongos del género Claviceps en cereales y alimentos derivados, Toxinas de Alternaria en frutas, hortalizas, cereales y tomate, Micotoxinas de Fusarium (Eniatinas, Nivalenol) en cereales y Alcaloides de la pirrolizidina en alimentos infantiles, complementos alimenticios, miel, polen, té, infusiones y cereales.De cada uno de ellos se describe su identificación y caracterización, la evaluación de la exposición, y se incluyen así mismo recomendaciones y consideraciones futuras.Por otro lado, la identificación de nuevos peligros para los que puede producirse una exposición significativa, o la evaluación del riesgo derivado de una exposición o susceptibilidad nuevas o incrementadas significativamente a un peligro conocido es importante, no solo a efectos de un eventual control de estos peligros emergentes, sino también de promover la investigación y mejorar su conocimiento por parte de los consumidores y de la comunidad científica

IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals

AbstractThe IFNL4 ss469415590 polymorphism, in high linkage disequilibrium with the IL28B rs12979860 variant, has been associated with hepatitis C virus clearance. We evaluated whether ss469415590 is associated with clinical and immunovirological parameters in human immunodeficiency virus-infected subjects. We found an independent association of the IFNL4 ss469415590 polymorphism with higher prevalence of AIDS-defining illnesses and lower CD4 T cell numbers. These results suggest the existence of common host defence mechanisms against different viral infections

Effect of the aniline fragment in Pt(II) and Pt(IV) complexes as anti-proliferative agents. Standard reduction potential as a more reliable parameter for Pt(IV) compounds than peak reduction potential

The problems of resistance and side effects associated with cisplatin and other chemotherapeutic drugs have boosted research aimed at finding new compounds with improved properties. The use of platinum(IV) prodrugs is one alternative, although there is some controversy regarding the predictive ability of the peak reduction potentials. In the work described here a series of fourteen chloride Pt(II) and Pt(IV) compounds was synthesised and fully characterised. The compounds contain different bidentate arylazole heterocyclic ligands. Their cytotoxic properties against human lung carcinoma (A549), human breast carcinoma (MCF7) and human colon carcinoma (HCT116 and HT29) cell lines were studied. A clear relationship between the type of ligand and the anti-proliferative properties was found, with the best results obtained for the Pt(II) compound that contains an aniline fragment, (13), thus evidencing a positive effect of the NH2 group. Stability and aquation studies in DMSO, DMF and DMSO/water mixtures were carried out on the active complexes and an in-depth analysis of the two aquation processes, including DFT analysis, of 13 was undertaken. It was verified that DNA was the target and that cell death occurred by apoptosis in the case of 13. Furthermore, the cytotoxic derivatives did not exhibit haemolytic activity. The reduction of the Pt(IV) compounds whose Pt(II) congeners were active was studied by several techniques. It was concluded that the peak reduction potential was not useful to predict the ability for reduction. However, a correlation between the cytotoxic activity and the standard reduction potential was found.This work has been funded by the Spanish Ministerio de Ciencia, Innovación y Universidades (MCIU), Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) (RTI2018-100709-B-C21 to BRM, RTI2018-100709-B-C22 to AM, RTI2018-094093-B-I00 to RSP), Junta de Comunidades de Castilla-La Mancha-FEDER (JCCM) (grant SBPLY/19/180501/000260 to BRM), Ministerio de Economía y Competitividad (Project PID2019-104381GB-I00 to GC), Fundación Leticia Castillejo Castillo to MJRH, Junta de Castilla y León, Consejería de Educación y Cultura y Fondo Social Europeo (Projects BU263P18 and BU087G19 to JVC) as well as UCLM-FEDER (grants 2019-GRIN-27183 and 2019-GRIN-27209 to BRM) and University of Girona (MPCUdG2016/076 to AM)