Are Successive Generations Getting Wealthier, and If So, Why?

This paper examines the wealth of successive birth cohorts in the United States using data from the 1989-2001 Surveys of Consumer Finances. We find that older households (those aged 55-64, 65-74 or 75-84) in 2001 had more wealth than households of similar age in 1989, but that the same was not true of younger households. We also find that changes in standard demographic characteristics (marital status, educational attainment, years in the labor force, and health status) can explain most of the divergent trends across age groups. Given the historically large capital gains that accrued during the 1990s, these results raise some intriguing questions about the nature of saving and wealth accumulation during that decade.wealth, macroeconomics, generations, birth cohorts, capital gains

Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence.

BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S. aureus Newman for susceptibility to cathelicidin antimicrobial peptide, we discovered BlaI as a novel cathelicidin resistance factor. Additionally, through integrational mutagenesis in S. aureus Newman and MRSA Sanger 252 strains, we confirmed the role of BlaI in resistance to human and murine cathelidicin and showed that it contributes to virulence in human whole blood and murine infection models. We further demonstrated that BlaI could be a target for innate immune-based antimicrobial therapies; by removing BlaI through subinhibitory concentrations of 6-aminopenicillanic acid, we were able to sensitize S. aureus to LL-37 killing

Duplex specific nuclease-amplified detection of microRNA using compact quantum dot-DNA conjugates

Advances in nanotechnology have provided new opportunities for the design of next-generation nucleic acid biosensors and diagnostics. Indeed, combining advances in functional nanoparticles, DNA nanotechnology, and nuclease-enzyme-based amplification can give rise to new assays with advantageous properties. In this work, we developed a microRNA (miRNA) assay using bright fluorescent quantum dots (QDs), simple DNA probes, and the enzyme duplex-specific nuclease. We employed an isothermal target-recycling mechanism, where a single miRNA target triggers the cleavage of many DNA signal probes. The incorporation of DNA-functionalized QDs enabled a quantitative fluorescent readout, mediated by Förster resonance energy transfer (FRET)-based interaction with the DNA signal probes. Our approach splits the reaction in two, performing the enzyme-mediated amplification and QD-based detection steps separately such that each reaction could be optimized for performance of the active components. Target recycling gave ca. 3 orders of magnitude amplification, yielding highly sensitive detection with a limit of 42 fM (or 1.2 amol) of miR-148, with excellent selectivity versus mismatched sequences and other miRNAs. Furthermore, we used an alternative target (miR-21) and FRET pair for direct and absolute quantification of miR-21 in RNA extracts from human cancer and normal cell lines

What Can Philosophers Really Learn from Science Journals?

Philosophers of science regularly use scientific publications in their research. To make their analyses of the literature more thorough, some have begun to use computational methods from the digital humanities (DH). Yet this creates a tension: it’s become a truism in science studies that the contents of scientific publications do not accurately reflect the complex realities of scientific investigation. In this paper, we outline existing views on how scientific publications fit into the broader picture of science as a system of practices, and find that none of these views exclude articles as valuable sources for philosophical inquiry. Far from ignoring the gap between texts and practice, proper use of DH tools requires, and can even contribute to, our understanding of that gap and its implications

ROSAT implementation of a proposed multi-mission x ray data format

Until recently little effort has been made to ensure that data from X-ray telescopes are delivered in a format that reflects the common characteristics that most X-ray datasets share. Instrument-specific data-product design hampers the comparison of X-ray measurements made by different detectors and should be avoided whenever possible. The ROSAT project and the High Energy Astrophysics Science Archive Research Center (HEASARC) have defined a set of X-ray data products ('rationalized files') for ROSAT data that can be used for distribution and archiving of data from other X-ray missions. This set of 'rationalized files' has been defined to isolate instrument-independent and instrument-specific quantities using standards FITS constructs to ensure portability. We discuss the usage of the 'rationalized files' by ROSAT for data distribution and archiving, with particular emphasis on discrimination between instrument-independent and instrument-specific quantities, and discuss application of this format to data from other X-ray missions

Helminth Community Dynamics in Populations of Blue-Winged Teal (Anas discors) Using Two Distinct Migratory Corridors

The influence of spatially distinct host subpopulations on helminth community structure and pattern was examined in a migratory avian host species. Forty helminth species represented by 24,082 individuals were collected from 184 blue-winged teal (Anas discors; BWT) from 2 primary migratory corridors in Florida (eastern migratory corridor; EMC) and Louisiana and Texas (western migratory corridor; WMC). Mean species richness was greater in BWT from the WMC (x̅±SE = 10.2 ± 0.3 species) than the EMC (8.6 ± 0.2). The helminth community from the WMC had higher abundances of 6 common/intermediate species. Corridor helminth communities were similar in species composition but less similar when incorporating abundances of those species. Overlapping distributions of phylogenetically related host species that share generalist helminth species across ecologically similar habitats seem to mitigate the isolating mechanisms that are necessary for the distinct coevolutionary pathways to develop between adjacent corridors

PHOTZIP: A Lossy FITS Image Compression Algorithm that Protects User-Defined Levels of Photometric Integrity

A lossy compression algorithm is presented for astronomical images that protects photometric integrity for detected point sources at a user-defined level of statistical tolerance. PHOTZIP works by modeling, smoothing, and then compressing the astronomical background behind self-detected point sources, while completely preserving values in and around those sources. The algorithm also guaranties a maximum absolute difference (in terms of $\sigma$) between each compressed and original background pixel, allowing users to control quality and lossiness. For present purposes, PHOTZIP has been tailored to FITS format and is freely available over the web. PHOTOZIP has been tested over a broad range of astronomical imagery and is in routine use by the Night Sky Live (NSL) project for compression of all-sky FITS images. Compression factors depend on source densities, but for the canonical NSL implementation, a PHOTZIP (and subsequently GZIP or BZIP2) compressed file is typically 20% of its uncompressed size.Comment: 10 pages, 3 figures. Accepted for publication in A

Differentiating patterns of violence in the family

The feasibility and prevalence of Reciprocal, Hierarchical and Paternal patterns of family aggression hypothesised by Dixon and Browne (2003) were explored within a sample of maltreating families. The psychological reports of 67 families referred to services for alleged child maltreatment that evidenced concurrent physical intimate partner violence and child maltreatment were investigated. Of these, 29 (43.3%) cases were characterised by hierarchical; 28 (41.8%) Reciprocal and 10 (14.9%) Paternal patterns. Significant differences in the form of child maltreatment perpetrated by mothers and fathers and parent dyads living in different patterns were found. In Hierarchical sub-patterns, fathers were significantly more likely to have been convicted for a violent and/or sexual offence than mothers and were significantly less likely to be biologically related to the child. The findings demonstrate the existence of the different patterns in a sample of families involved in the Child Care Protection process in England and Wales, supporting the utility of a holistic approach to understanding aggression in the family