6,270 research outputs found
Power Brokers: Middlemen in Legislative Bargaining
We consider a model of decentralized bargaining among three parties. Parties meet one-on-one after being randomly matched, and can sell or buy votes to one another. The party with a majority of the votes can decide to implement its preferred policy or extend negotiations to capture additional rents. We provide necessary and sufficient conditions for the existence of an equilibrium in which a party acts as an intermediary, transferring resources and voting rights among parties that wouldn't negotiate directly with one another. These conditions are generic, do not require special frictions, and include `well-behaved' (i.e., single-peaked) preference profiles
Pattern formation in a predator-prey system characterized by a spatial scale of interaction
We describe pattern formation in ecological systems using a version of the
classical Lotka-Volterra model characterized by a spatial scale which controls
the predator-prey interaction range. Analytical and simulational results show
that patterns can emerge in some regions of the parameters space where the
instability is driven by the range of the interaction. The individual-based
implementation captures realistic ecological features. In fact, spatial
structures emerge in an erratic oscillatory regime which can contemplate
predators' extinction.Comment: 5 pages, 4 figure
The 2010 August 01 type II burst: A CME-CME Interaction, and its radio and white-light manifestations
We present observational results of a type II burst associated with a CME-CME
interaction observed in the radio and white-light wavelength range. We applied
radio direction-finding techniques to observations from the STEREO and Wind
spacecraft, the results of which were interpreted using white-light
coronagraphic measurements for context. The results of the multiple
radio-direction finding techniques applied were found to be consistent both
with each other and with those derived from the white-light observations of
coronal mass ejections (CMEs). The results suggest that the Type II burst radio
emission is causally related to the CMEs interaction.Comment: 7 pages, 6 figures, Accepted to ApJ: January 16, 201
An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response.
Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, interferon (IFN)-dependent upregulation of IFN-stimulated genes (ISGs), and the activity of various ISG products; the multifunctional NS1 protein is responsible for most of these activities. To determine the importance of other viral genes in the interplay between the virus and the host IFN response, we characterized populations and selected mutants of wild-type viruses selected by passage through non-IFN-responsive cells. We reasoned that, by allowing replication to occur in the absence of the selection pressure exerted by IFN, the virus could mutate at positions that would normally be restricted and could thus find new optimal sequence solutions. Deep sequencing of selected virus populations and individual virus mutants indicated that nonsynonymous mutations occurred at many phylogenetically conserved positions in nearly all virus genes. Most individual mutants selected for further characterization induced IFN and ISGs and were unable to counteract the effects of exogenous IFN, yet only one contained a mutation in NS1. The relevance of these mutations for the virus phenotype was verified by reverse genetics. Of note, several virus mutants expressing intact NS1 proteins exhibited alterations in the M1/M2 proteins and accumulated large amounts of deleted genomic RNAs but nonetheless replicated to high titers. This suggests that the overproduction of IFN inducers by these viruses can override NS1-mediated IFN modulation. Altogether, the results suggest that influenza viruses replicating in IFN-competent cells have tuned their complete genomes to evade the cellular innate immune system and that serial replication in non-IFN-responsive cells allows the virus to relax from these constraints and find a new genome consensus within its sequence space.
IMPORTANCE In natural virus infections, the production of interferons leads to an antiviral state in cells that effectively limits virus replication. The interferon response places considerable selection pressure on viruses, and they have evolved a variety of ways to evade it. Although the influenza virus NS1 protein is a powerful interferon antagonist, the contributions of other viral genes to interferon evasion have not been well characterized. Here, we examined the effects of alleviating the selection pressure exerted by interferon by serially passaging influenza viruses in cells unable to respond to interferon. Viruses that grew to high titers had mutations at many normally conserved positions in nearly all genes and were not restricted to the NS1 gene. Our results demonstrate that influenza viruses have fine-tuned their entire genomes to evade the interferon response, and by removing interferon-mediated constraints, viruses can mutate at genome positions normally restricted by the interferon response
Seismic Emissions from a Highly Impulsive M6.7 Solar Flare
On 10 March 2001 the active region NOAA 9368 produced an unusually impulsive
solar flare in close proximity to the solar limb. This flare has previously
been studied in great detail, with observations classifying it as a type 1
white-light flare with a very hard spectrum in hard X-rays. The flare was also
associated with a type II radio burst and coronal mass ejection. The flare
emission characteristics appeared to closely correspond with previous instances
of seismic emission from acoustically active flares. Using standard local
helioseismic methods, we identified the seismic signatures produced by the
flare that, to date, is the least energetic (in soft X-rays) of the flares
known to have generated a detectable acoustic transient. Holographic analysis
of the flare shows a compact acoustic source strongly correlated with the
impulsive hard X-ray, visible continuum, and radio emission. Time-distance
diagrams of the seismic waves emanating from the flare region also show faint
signatures, mainly in the eastern sector of the active region. The strong
spatial coincidence between the seismic source and the impulsive visible
continuum emission reinforces the theory that a substantial component of the
seismic emission seen is a result of sudden heating of the low photosphere
associated with the observed visible continuum emission. Furthermore, the
low-altitude magnetic loop structure inferred from potential--field
extrapolations in the flaring region suggests that there is a significant
inverse correlation between the seismicity of a flare and the height of the
magnetic loops that conduct the particle beams from the corona.Comment: 16 pages, 7 figures, Solar Physics Topical Issue: SOHO 19/GONG 2007
"Seismology of Magnetic Activity", Accepte
An analysis of interplanetary solar radio emissions associated with a coronal mass ejection
Coronal mass ejections (CMEs) are large-scale eruptions of magnetized plasma
that may cause severe geomagnetic storms if Earth-directed. Here we report a
rare instance with comprehensive in situ and remote sensing observa- tions of a
CME combining white-light, radio, and plasma measurements from four different
vantage points. For the first time, we have successfully applied a radio
direction-finding technique to an interplanetary type II burst detected by two
identical widely separated radio receivers. The derived locations of the type
II and type III bursts are in general agreement with the white light CME recon-
struction. We find that the radio emission arises from the flanks of the CME,
and are most likely associated with the CME-driven shock. Our work demon-
strates the complementarity between radio triangulation and 3D reconstruction
techniques for space weather applications
Role of mitochondria and reactive oxygen species in dendritic cell differentiation and functions.
Merit, Tenure, and Bureaucratic Behavior: Evidence From a Conjoint Experiment in the Dominican Republic
Bureaucratic behavior in developing countries remains poorly understood. Why do some
public servants – yet not others – work hard to deliver public services, misuse state
resources, and/or participate in electoral mobilization? A classic answer comes from Weber:
bureaucratic structures shift behavior towards integrity, neutrality, and commitment to
public service. Our paper conducts the first survey experimental test of the effects of
bureaucratic structures. It does so through a conjoint experiment with public servants in the
Dominican Republic. Looking at merit examinations and job stability, we find that Weber
was right – but only partially. Recruitment by examination curbs corruption and political
services by bureaucrats, while enhancing work motivation. Job stability, by contrast, only
decreases political services: tenured bureaucrats are less likely to participate in electoral
mobilization. Examinations thus enhance the quality of bureaucracy (motivation and lower
corruption) and democracy (electoral competition); job stability only enhances the quality
of democracy
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