Baseline MxA mRNA expression predicts interferon beta response in multiple sclerosis patients

Background Myxovirus resistance protein A (MxA) is a molecule induced after interferon-beta injection, mostly used to evaluate its bioactivity. There is little available data on clinical utility of baseline MxA mRNA status. The objective of the study is to investigate whether baseline MxA mRNA expression can predict relapse and disease progression in multiple sclerosis patients treated with interferon-beta. Methods Baseline blood samples were obtained before the first interferon-beta dose was administered to evaluate MxA mRNA expression using real-time polymerase chain reaction (PCR). Demographic and clinical variables were prospectively recorded to define treatment responder and non responder groups. Results 104 patients were included in the study. Baseline MxA mRNA expression was significantly lower in the group of patients who met the definition of responders (1.07 vs 1.95, Student t test, p<0.0001). A threshold of 1.096 was established using Receiver Operating Characteristic analysis to differentiate between responders and non-responders (sensitivity 73.9%, specificity 69.0%). Survival analysis using this threshold showed that time to next relapse (p<0.0001) and to EDSS progression (p = 0.01) were significantly higher in patients with lower MxA titers. Conclusion The results suggest that baseline MxA mRNA levels may be useful for predicting whether multiple sclerosis patients will respond or not to interferon-beta treatment

Spectropolarimetric multi line analysis of stellar magnetic fields

In this paper we study the feasibility of inferring the magnetic field from polarized multi-line spectra using two methods: The pseudo line approach and The PCA-ZDI approach. We use multi-line techniques, meaning that all the lines of a stellar spectrum contribute to obtain a polarization signature. The use of multiple lines dramatically increases the signal to noise ratio of these polarizations signatures. Using one technique, the pseudo-line approach, we construct the pseudo-line as the mean profile of all the individual lines. The other technique, the PCA-ZDI approach proposed recently by Semel et al. (2006) for the detection of polarized signals, combines Principle Components Analysis (PCA) and the Zeeman Do ppler Imaging technique (ZDI). This new method has a main advantage: the polarized signature is extracted using cross correlations between the stellar spectra nd functions containing the polarization properties of each line. These functions are the principal components of a database of synthetic spectra. The synthesis of the spectra of the database are obtained using the radiative transfer equations in LTE. The profiles built with the PCA-ZDI technique are denominated Multi-Zeeman-Signatures. The construction of the pseudo line as well as the Multi-Zeeman-Signatures is a powerful tool in the study of stellar and solar magnetic fields. The information of the physical parameters that governs the line formation is contained in the final polarized profiles. In particular, using inversion codes, we have shown that the magnetic field vector can be properly inferred with both approaches despite the magnetic field regime.Comment: Accepted for publication in Astronomy and Astrophysic

Surface waves in solar granulation observed with {\sc Sunrise}

Solar oscillations are expected to be excited by turbulent flows in the intergranular lanes near the solar surface. Time series recorded by the IMaX instrument aboard the {\sc Sunrise} observatory reveal solar oscillations at high resolution, which allow studying the properties of oscillations with short wavelengths. We analyze two times series with synchronous recordings of Doppler velocity and continuum intensity images with durations of 32\thinspace min and 23\thinspace min, resp., recorded close to the disk center of the Sun to study the propagation and excitation of solar acoustic oscillations. In the Doppler velocity data, both the standing acoustic waves and the short-lived, high-degree running waves are visible. The standing waves are visible as temporary enhancements of the amplitudes of the large-scale velocity field due to the stochastic superposition of the acoustic waves. We focus on the high-degree small-scale waves by suitable filtering in the Fourier domain. Investigating the propagation and excitation of $f$- and $p_1$-modes with wave numbers $k > 1.4$\thinspace 1/Mm we find that also exploding granules contribute to the excitation of solar $p$-modes in addition to the contribution of intergranular lanes.Comment: 12 pages, 4 figures, to appear in a special volume on Sunrise in Astrophysical Journal Letter

Convective motions and net circular polarization in sunspot penumbrae

We have employed a penumbral model, that includes the Evershed flow and convective motions inside penumbral filaments, to reproduce the azimuthal variation of the net circular polarization (NCP) in sunspot penumbrae at different heliocentric angles for two different spectral lines. The theoretical net circular polarization fits the observations as satisfactorily as penumbral models based on flux-tubes. The reason for this is that the effect of convective motions on the NCP is very small compared to the effect of the Evershed flow. In addition, the NCP generated by convective upflows cancels out the NCP generated by the downflows. We have also found that, in order to fit the observed NCP, the strength of the magnetic field inside penumbral filaments must be very close to 1000 G. In particular, field-free or weak-field filaments fail to reproduce both the correct sign of the net circular polarization, as well as its dependence on the azimuthal and heliocentric angles.Comment: Accepted for publication in the Astrophysical Journal. 10 pages, 7 figures (3 in color). Uses emulatedap

Temporal evolution of the Evershed flow in sunspots. II. Physical properties and nature of Evershed clouds

Context: Evershed clouds (ECs) represent the most conspicuous variation of the Evershed flow in sunspot penumbrae. Aims: We determine the physical properties of ECs from high spatial and temporal resolution spectropolarimetric measurements. Methods: The Stokes profiles of four visible and three infrared spectral lines are subject to inversions based on simple one-component models as well as more sophisticated realizations of penumbral flux tubes embedded in a static ambient field (uncombed models). Results: According to the one-component inversions, the EC phenomenon can be understood as a perturbation of the magnetic and dynamic configuration of the penumbral filaments along which these structures move. The uncombed inversions, on the other hand, suggest that ECs are the result of enhancements in the visibility of penumbral flux tubes. We conjecture that the enhancements are caused by a perturbation of the thermodynamic properties of the tubes, rather than by changes in the vector magnetic field. The feasibility of this mechanism is investigated performing numerical experiments of thick penumbral tubes in mechanical equilibrium with a background field. Conclusions: While the one-component inversions confirm many of the properties indicated by a simple line parameter analysis (Paper I of this series), we tend to give more credit to the results of the uncombed inversions because they take into account, at least in an approximate manner, the fine structure of the penumbra.Comment: Accepted for publication in A&

Bright points in the quiet Sun as observed in the visible and near-UV by the balloon-borne observatory Sunrise

Bright points (BPs) are manifestations of small magnetic elements in the solar photosphere. Their brightness contrast not only gives insight into the thermal state of the photosphere (and chromosphere) in magnetic elements, but also plays an important role in modulating the solar total and spectral irradiance. Here we report on simultaneous high-resolution imaging and spectropolarimetric observations of BPs using Sunrise balloon-borne observatory data of the quiet Sun at disk center. BP contrasts have been measured between 214 nm and 525 nm, including the first measurements at wavelengths below 388 nm. The histograms of the BP peak brightness show a clear trend toward broader contrast distributions and higher mean contrasts at shorter wavelengths. At 214 nm we observe a peak brightness of up to five times the mean quiet-Sun value, the highest BP contrast so far observed. All BPs are associated with a magnetic signal, although in a number of cases it is surprisingly weak. Most of the BPs show only weak downflows, the mean value being 240 m/s, but some display strong down- or upflows reaching a few km/s.Comment: Accepted for publication in The Astrophysical Journal Letters on September 08 201

Maximum Entropy Limit of Small-scale Magnetic Field Fluctuations in the Quiet Sun

The observed magnetic field on the solar surface is characterized by a very complex spatial and temporal behavior. Although feature-tracking algorithms have allowed us to deepen our understanding of this behavior, subjectivity plays an important role in the identification and tracking of such features. In this paper, we continue studies Gorobets, A. Y., Borrero, J. M., & Berdyugina, S. 2016, ApJL, 825, L18 of the temporal stochasticity of the magnetic field on the solar surface without relying either on the concept of magnetic features or on subjective assumptions about their identification and interaction. We propose a data analysis method to quantify fluctuations of the line-of-sight magnetic field by means of reducing the temporal field's evolution to the regular Markov process. We build a representative model of fluctuations converging to the unique stationary (equilibrium) distribution in the long time limit with maximum entropy. We obtained different rates of convergence to the equilibrium at fixed noise cutoff for two sets of data. This indicates a strong influence of the data spatial resolution and mixing-polarity fluctuations on the relaxation process. The analysis is applied to observations of magnetic fields of the relatively quiet areas around an active region carried out during the second flight of the Sunrise/IMaX and quiet Sun areas at the disk center from the Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory satellite.Comment: 11 pages, 5 figures, The Astrophysical Journal Supplement Series (accepted

Moving Magnetic Features around a Pore

Spectropolarimetric observations from Sunrise II/IMaX obtained in June 2013 are used for a statistical analysis to determine the physical properties of moving magnetic features (MMFs) observed near a pore. MMFs of the same and opposite polarity with respect to the pore are found to stream from its border at an average speed of 1.3 km s$^{-1}$ and 1.2 km s$^{-1}$ respectively, with mainly same-polarity MMFs found further away from the pore. MMFs of both polarities are found to harbor rather weak, inclined magnetic fields. Opposite-polarity MMFs are blue-shifted, while same-polarity MMFs do not show any preference for up- or downflows. Most of the MMFs are found to be of sub-arcsecond size and carry a mean flux of $\sim$ 1.2$\times 10^{17}$ Mx.Comment: 8 pages, 4 figures, accepted for publication in ApJ

Sunrise: instrument, mission, data and first results

The Sunrise balloon-borne solar observatory consists of a 1m aperture Gregory telescope, a UV filter imager, an imaging vector polarimeter, an image stabilization system and further infrastructure. The first science flight of Sunrise yielded high-quality data that reveal the structure, dynamics and evolution of solar convection, oscillations and magnetic fields at a resolution of around 100 km in the quiet Sun. After a brief description of instruments and data, first qualitative results are presented. In contrast to earlier observations, we clearly see granulation at 214 nm. Images in Ca II H display narrow, short-lived dark intergranular lanes between the bright edges of granules. The very small-scale, mixed-polarity internetwork fields are found to be highly dynamic. A significant increase in detectable magnetic flux is found after phase-diversity-related reconstruction of polarization maps, indicating that the polarities are mixed right down to the spatial resolution limit, and probably beyond.Comment: accepted by ApJ

Light-triggered carotenogenesis in myxococcus xanthus: New paradigms in photosensory signaling, transduction and gene regulation

22 pags., 6 figs. -- This article belongs to the Special Issue Myxobacteria: Physiology and RegulationMyxobacteria are Gram-negative δ-proteobacteria found predominantly in terrestrial habitats and often brightly colored due to the biosynthesis of carotenoids. Carotenoids are lipophilic isoprenoid pigments that protect cells from damage and death by quenching highly reactive and toxic oxidative species, like singlet oxygen, generated upon growth under light. The model myxobacterium Myxococcus xanthus turns from yellow in the dark to red upon exposure to light because of the photoinduction of carotenoid biosynthesis. How light is sensed and transduced to bring about regulated carotenogenesis in order to combat photooxidative stress has been extensively investigated in M. xanthus using genetic, biochemical and high-resolution structural methods. These studies have unearthed new paradigms in bacterial light sensing, signal transduction and gene regulation, and have led to the discovery of prototypical members of widely distributed protein families with novel functions. Major advances have been made over the last decade in elucidating the molecular mechanisms underlying the light-dependent signaling and regulation of the transcriptional response leading to carotenogenesis in M. xanthus. This review aims to provide an up-to-date overview of these findings and their significance.This research was funded by grants PGC2018-094635-B-C21 (to M.E.-A.) and PGC2018- 094635-B-C22 (to S.P) from the Agencia Estatal de Investigación (AEI)-Spain and European Regional Development Fund (FEDER), and by grant 20992/PI/18 (to M.E.-A.) from Fundación Séneca (Murcia)- Spain. The Ministerio de Educación y Cultura-Spain funded Ph.D. fellowships to A.J.M.-G, E.P.-M. and E.B.-M., and AEI-Spain funded that to R.P.-C