Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study

Background Maternal metabolism during pregnancy is a major determinant of the intra-uterine environment and fetal outcomes. Herein, we characterize the maternal urinary metabolome throughout pregnancy to identify maternal metabolic signatures of fetal growth in two subcohorts and explain potential sources of variation in metabolic profiles based on lifestyle and clinical data. Methods We used 1H nuclear magnetic resonance (NMR) spectroscopy to characterize maternal urine samples collected in the INMA birth cohort at the first (n = 412 and n = 394, respectively, in Gipuzkoa and Sabadell cohorts) and third trimesters of gestation (n = 417 and 469). Metabolic phenotypes that reflected longitudinal intra- and inter-individual variation were used to predict measures of fetal growth and birth weight. Results A metabolic shift between the first and third trimesters of gestation was characterized by 1H NMR signals arising predominantly from steroid by-products. We identified 10 significant and reproducible metabolic associations in the third trimester with estimated fetal, birth, and placental weight in two independent subcohorts. These included branched-chain amino acids; isoleucine, valine, leucine, alanine and 3 hydroxyisobutyrate (metabolite of valine), which were associated with a significant fetal weight increase at week 34 of up to 2.4 % in Gipuzkoa (P < 0.005) and 1 % in Sabadell (P < 0.05). Other metabolites included pregnancy-related hormone by-products of estrogens and progesterone, and the methyl donor choline. We could explain a total of 48–53 % of the total variance in birth weight of which urine metabolites had an independent predictive power of 12 % adjusting for all other lifestyle/clinical factors. First trimester metabolic phenotypes could not predict reproducibly weight at later stages of development. Physical activity, as well as other modifiable lifestyle/clinical factors, such as coffee consumption, vitamin D intake, and smoking, were identified as potential sources of metabolic variation during pregnancy. Conclusions Significant reproducible maternal urinary metabolic signatures of fetal growth and birth weight are identified for the first time and linked to modifiable lifestyle factors. This novel approach to prenatal screening, combining multiple risk factors, present a great opportunity to personalize pregnancy management and reduce newborn disease risk in later life

Parametric Self-Oscillation via Resonantly Enhanced Multiwave Mixing

We demonstrate an efficient nonlinear process in which Stokes and anti-Stokes components are generated spontaneously in a Raman-like, near resonant media driven by low power counter-propagating fields. Oscillation of this kind does not require optical cavity and can be viewed as a spontaneous formation of atomic coherence grating

Modelling excited species and their role on kinetic pathways in the non-oxidative coupling of methane by dielectric barrier discharge

Acknowledgments We acknowledge and greatly appreciate the assistance from Dr. Mihailova from Plasma Matters B.V. in working with the software Plasimo and from Dr Marcus Campbell Bannerman from the University of Aberdeen for providing access to the computational cluster used for carrying out the simulations in this work. The work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC) New Investigator Award, grant no. EP/R031800/1.Peer reviewedPostprin

Alien plant invasions in South Africa: Driving forces and the human dimension

Invasive alien plants pose a substantial threat to the rich biodiversity of South Africa, and to the sustained delivery of a wide range of ecosystem services. Biological invasions are driven by human activities and mediated by culturally shaped values and ethics. This paper explores the human dimensions of alien plant invasions in South Africa. We consider four primary forces, those which directly influence the likelihood and rate of invasion — arrival of propagules; changes in disturbance regimes; changes in the availability of limiting factors; and fragmentation of the landscape — and the roles of 22 secondary driving forces in shaping the outcomes of the four primary driving forces. Human societies and their dynamics and activities are an integral part of each of the secondary driving forces. A map of the interactions between and among the primary and secondary driving forces shows how they are interlinked and influence each other — either positively or negatively, or switching between the two. There are two key points for intervention: prevention of the introduction of propagules of potentially invasive species and developing collaborative initiatives with enterprises that rely largely on alien species (for example, horticulture, agriculture and forestry, including community forestry) to minimize the introduction and use of potentially invasive species. An example of the first type of intervention would be to implement more effective inspection systems at international border and customs posts. This type of intervention can only be effective if those who are directly affected — whether businessmen, tourists or migrants — understand the requirement for these measures, and collaborate. The need to build public awareness of the critical importance of the human dimension of invasions emerges as a key theme from this analysis and is the basis for better-informed decisions, more effective control programmes and a reduction of further invasions

Indexing of mid-resolution satellite images with structural attributes.

Satellite image classification has been a major research field for many years with its varied applications in the field of Geography, Geology, Archaeology, Environmental Sciences and Military purposes. Many different techniques have been proposed to classify satellite images with color, shape and texture features. Complex indices like Vegetation index (NDVI), Brightness index (BI) or Urban index (ISU) are used for multi-spectral or hyper-spectral satellite images. In this paper we will show the efficiency of structural features describing man-made objects in mid-resolution satellite images to describe image content. We will then show the state-of-the-art to classify large satellite images with structural features computed from road networks and urban regions extracted on small image patches cut in the large image. Fisher Linear Discriminant (FLD) analysis is used for feature selection and a one-vsrest probabilistic Gaussian kernel Support Vector Machines (SVM) classification method is used to classify the images. The classification probabilities associated with each subimage of the large image provide an estimate of the geographical class coverage

Autofeedback scheme for preservation of macroscopic coherence in microwave cavities

We present a scheme for controlling the decoherence of a linear superposition of two coherent states with opposite phases in a high-Q microwave cavity, based on the injection of appropriately prepared ``probe'' and ``feedback'' Rydberg atoms, improving the one presented in [D. Vitali et al., Phys. Rev. Lett. 79, 2442 (1997)]. In the present scheme, the information transmission from the probe to the feedback atom is directly mediated by a second auxiliary cavity. The detection efficiency for the probe atom is no longer a critical parameter, and the decoherence time of the superposition state can be significantly increased using presently available technology.Comment: revtex, 15 pages, 4 eps figure

Sources of Stress, Family Functioning, and Needs of Families With a Chronic Critically Ill Child: A Qualitative Study.

PICU hospitalization is particularly stressful for families. When it is prolonged and the prognostic is uncertain, it can significantly and negatively affect the whole family. To date, little is known on how families with a chronic critically ill (CCI) child are affected. This national study explored the specific PICU-related sources of stress, family functioning and needs of families of CCI patients during a PICU hospitalization. This descriptive qualitative study was conducted in the eight pediatric intensive care units in Switzerland. Thirty-one families with a child meeting the CCI criteria participated in semi-structured interviews. Interviews, including mothers only (n = 12), fathers only (n = 8), or mother and father dyads (n = 11), were conducted in German, French, or English by two trained researchers/clinical nurses specialists. Interviews were recorded, transcribed verbatim, and analyzed using deductive and inductive content analyses. Five overarching themes emerged: (1) high emotional intensity, (2) PICU-related sources of stress, (3) evolving family needs, (4) multi-faceted family functioning, and (5) implemented coping strategies. Our study highlighted the importance of caring for families with CCI children. Parents reported high negative emotional responses that affect their family functioning. Families experience was highly dependent on how HCPs were able to meet the parental needs, provide emotional support, reinforce parental empowerment, and allow high quality of care coordination

Secondary transfer of organic gunshot residues: Empirical data to assist the evaluation of three scenarios.

The present study aimed at providing data to assess the secondary transfer of organic gunshot residues (OGSR). Three scenarios were evaluated in controlled conditions, namely displacing a firearm from point A to point B, a simple handshake and an arrest involving handcuffing on the ground. Specimens were collected from the firearm, the hands of the shooter and the non-shooter undergoing the secondary transfer in order to compare the amounts detected. Secondary transfer was observed for the three scenarios, but to a different extent. It was found that displacing a firearm resulted in secondary transfer in &lt;50% of the experiments. The firearm also had an influence, as contrary to the pistol, no secondary OGSR were detected using the revolver. Shaking the hand of the shooter also transferred OGSR to the non-shooter's hand. In that case, the amount of OGSR was generally higher on the shooter than on the non-shooter. Finally, the largest secondary transfer was observed after the arrest with handcuffing with positive results in all cases using the pistol. In that scenario, the amounts on the shooter and the non-shooter were in the same range. This study highlights that the secondary transfer must be taken into account in the interpretation of OGSR. Indeed, an individual's hands might be contaminated by handling a firearm or having physical contact with a shooter