Fitting Rasch Model using Appropriateness Measure Statistics

El objetivo de este trabajo fue estudiar la potencia y propiedades distribucionales de tres estadísticos de medida de la adecuación cuando se utilizan como estadísticos de ajuste de los ítems. Los estadísticos sometidos a comparación fueron: Lz, Eci2z y Eci4z. Los resultados obtenidos se compararon con los estadísticos T-outfit y T-infit. Se seleccionaron cuatro tamaños muestrales: 100, 250, 500 y 1000 sujetos. Se sometieron a estudio distintas distribuciones de habilidad: uniforme y normal, con media 0 y desviación típica 1, y uniforme y normal con media –1 y desviación típica 1. El parámetro de pseudo-azar fue fijado en .25. Para los parámetros de dificultad se utilizaron dos distribuciones uniformes de ±1 logits y ±2 logits. Por ultimo, se consideraron dos longitudes de tests: 15 y 30 ítems. Los resultados mostraron que los estadísticos Lz, T-outfit y T-infit no tienden a los valores esperados cuando se calculan con parámetros estimados, mientras que los estadísticos Eci2z y Eci4z mantuvieron mejor las propiedades de sus distribuciones teóricas. Además, la potencia de estos dos últimos estadísticos para detectar ítems no ajustados al modelo de Rasch estuvo entre un 5% y un 10% más que la potencia de los estadísticos Lz, T-outfit y T-infitIn this paper, the distributional properties and power rates of the Lz, Eci2z, and Eci4z statistics when they are used as item fit statistics were explored. The results were compare to t-transformation of Outfit and Infit mean square. Four sample sizes were selected: 100, 250, 500, and 1000 examinees. The abilities were uniform and normal with mean 0 and standard deviation 1, and uniform and normal with mean –1 and standard deviation 1. The pseudo-guessing parameter was fixed at .25. Two ranges of difficulty parameters were selected: ±1 logits and ±2 logits. Two test lengths were selected: 15 and 30 items. The results showed important differences between the T-infit, T-outfit, Lz, Eci2z, and Eci4z statistics. The T-oufit, T-infit, and Lz statistics showed poor standardization with estimated parameters because their distributional properties were not close to the expected values. However, the Eci2z and Eci4z statistics showed satisfactory standardization on all conditions. Further, the power rates of Eci2z and Eci4z were 5% to 10% higher than the power rates of Lz, T-outfit, and T-infit to detect items that do not fit Rasch model

Informe de seguimiento de la actividad de los Ministerios en relación con los Programas del Marco General para la Mejora de la Calidad de la Administración General del Estado durante 2011: Real Decreto 951/2005, de 29 de julio, por el que se establece el Marco General para la Mejora de la Calidad en la AGE

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Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID

Background and purposeThe coronavirus disease 2019 (COVID-19) has been associated with olfactory dysfunction. The persistent symptoms of anosmia or hyposmia were associated in previous studies with the development of memory impairment and mood disturbances. We aimed to investigate the association between the chronicity of reported olfactory dysfunction and subjective and objective cognitive performance in long-COVID patients and to explore whether their emotional symptoms are related to their cognition.MethodsOne hundred twenty-eight long-COVID participants were recruited. Reported symptomatology, subjective memory complaints, anxiety and depression symptomatology, and trait-anxiety were assessed. Subjective memory complaints and mood disturbances were compared among groups of participants with olfactory dysfunction as an acute (AOD), persistent (POD), or nonexistent (NOD) symptom. Seventy-six of the volunteers also participated in a face-to-face session to assess their objective performance on tests of general cognitive function and verbal declarative memory. Objective cognitive performance and mood disturbances were compared among the AOD, POD, and NOD groups.ResultsThe subjective memory complaints and the anxiety and depression symptoms were similar among the groups, but the score in general cognitive function was lower in the participants with symptoms of acute olfactory dysfunction than in those with no olfactory symptoms at any time. Participants’ memory complaints were positively related to their emotional symptoms. The relationship between depressive symptomatology and memory complaints interacted with the olfactory dysfunction, as it only occurred in the participants without symptoms of olfactory dysfunction. Depressive symptomatology and acute olfactory symptoms were negatively associated with general cognitive function and delayed memory performance. The months elapsed from diagnosis to assessment also predicted delayed memory performance. Anxious symptomatology was negatively associated with the immediate ability to recall verbal information in participants who did not present olfactory dysfunction in the acute phase of the infection.ConclusionOlfactory dysfunction in the acute phase of the infection by COVID-19 is related to cognitive deficits in objective tests, and mood disturbances are associated with self-reported and objective memory. These findings may contribute to further understanding the neuropsychological and emotional aspects of long-COVID

Percepción de la demanda y necesidades de formación en salud mental de los médicos de atención primaria

ResumenObjetivoConocer la opinión de los médicos de atención primaria (AP) sobre la demanda asistencial en salud mental (SM), sus necesidades de formación y sus actitudes ante dichos trastornos.DiseñoEstudio observacional transversal.EmplazamientoAtención primaria.ParticipantesLos sujetos de estudio fueron médicos de AP. De un total de 1.191 médicos de AP en Castilla-La Mancha se seleccionó a 301 mediante muestreo aleatorio estratificado.Mediciones principalesSe elaboró un cuestionario autorrellenable y se indentificaron las siguientes variables: características profesionales y sociodemográficas, demanda percibida de problemas de SM y dificultades percibidas en su resolución, formación en SM, conocimientos sobre recursos especializados y actitudes hacia dichos trastornos.ResultadosLa mayoría (63,5%, intervalo de confianza [IC] del 95%, 57,6-69,4) consideró que los problemas mentales están relacionados con, al menos, el 20% de las consultas. Los problemas señalados como motivos de consulta muy frecuentes fueron: trastornos de ansiedad (75,9%), del estado de ánimo (73,5%) y somatomorfos (40,5%). La proporción que consideró suficiente el nivel de información sobre recursos especializados ascendió hasta el 63,6% (IC del 95%, 57,8-69,6). En cuanto a las actitudes, el 43,7% (IC del 95%, 37,7-49,8) opinó que los equipos de AP no pueden hacerse cargo de la demanda existente. Dicha opinión fue significativamente más frecuente en los médicos con más pacientes asignados, mayor presión asistencial, sin formación MIR, con menor demanda percibida, sin formación en SM y peor conocimiento de los recursos especializados.ConclusionesEn opinión de la mayoría de los médicos, los problemas mentales están relacionados con, al menos, una de cada 5 consultas. Una elevada proporción considera que los equipos de AP no pueden hacerse cargo de la demanda existente, sobre todo cuando la presión asistencia les elevada. La mayoría opina que debería haber mayor formación específica en SM y mayor coordinación con los servicios especializados.AbstractObjectiveTo know the opinion of the primary health care (PHC) physicians on the assistance demand in mental health (MH), their training necessities and their attitudes about this disorders.DesignObservational and transversal study.SettingPrimary care.ParticipantsThe subjects of the study were PHC physicians. From a total of 1191 PHC physicians in Castilla-La Mancha region, 301 were selected by random stratified sampling.Main measurementsA self-complimented questionnaire was elaborated, being identified the following variables: professional and sociodemographics characteristics, their perceived demands of MH problems, perceived difficulties in resolution, training in MH, knowledge about specialized resources and their attitudes about mental disorders.Results63.5% (95% confidence interval [CI], 57.6-69.4) considered that the mental problems are related with, at least, 20% of the consultations. Very frequent consulted problems were: anxiety disorders (75.9%), affective disorders (73.5%), and somatoform disorders (40.5%). 63.6% (95% CI; 57.8-69.6) considered to have enough information about specialized resources. About attitudes, 43.7% (95% CI; 37.7-49.8) said the PHC physicians cannot be taken charge of the existent demand. This opinion as significantly more frequents in physicians with more patient assigned, more assistance pressure, without postgraduate assistance formation (Spanish MIR system), with less perceived demand, without training in MH and worse knowledge of the specialized resources.ConclusionsIn opinion of most of the physicians the mental disorders are related with, at least, 1 of each 5 consultations. A high proportion considers that the teams of PHC cannot be taken charge of the existent demand, mainly when it is high the assistance pressure.Most says that more specific training should exist in MH and more coordination with the specialized services

Research in Mathematics Education in Spain: SEIEM Symposia

Spain produces a large amount of research in mathematics education and its results are presented in the symposia of the Spanish Society for Research in Mathematics Education (SEIEM). This paper presents a study of the proceedings of these symposia. Its aim is to identify some bibliometric indicators and networks of institutional collaboration and co-authorship. The analysis was performed with 268 SEIEM documents. We found a low level of scientific collaboration between researchers in the field. Similar results are obtained for international cooperationEn España se realizan un gran número de investigaciones en Educación Matemática y se presentan avances de sus resultados en los simposios de la Sociedad Española de Investigación en Educación Matemática (SEIEM). En este artículo se presenta un estudio de las actas de dichos simposios. El objetivo de este trabajo es identificar algunos indicadores bibliométricos así como las redes de colaboración institucional y de coautoría. El análisis se realizó con 268 documentos de las actas SEIEM, observándose un bajo porcentaje de colaboración científica entre los investigadores del área. También se obtienen similares resultados en la cooperación internaciona

Role of mTOR-regulated autophagy in spine pruning defects and memory impairments induced by binge-like ethanol treatment in adolescent mice

Adolescence is a brain maturation developmental period during which remodeling and changes in synaptic plasticity and neural connectivity take place in some brain regions. Different mechanism participates in adolescent brain maturation, including autophagy that plays a role in synaptic development and plasticity. Alcohol is a neurotoxic compound and its abuse in adolescence induces neuroinflammation, synaptic and myelin alterations, neural damage and behavioral impairments. Changes in synaptic plasticity and its regulation by mTOR have also been suggested to play a role in the behavioral dysfunction of binge ethanol drinking in adolescence. Therefore, by considering the critical role of mTOR in both autophagy and synaptic plasticity in the developing brain, the present study aims to evaluate whether binge ethanol treatment in adolescence would induce dysfunctions in synaptic plasticity and cognitive functions and if mTOR inhibition with rapamycin is capable of restoring both effects. Using C57BL/6 adolescent female and male mice (PND30) treated with ethanol (3 g/kg) on two consecutive days at 48-hour intervals over 2 weeks, we show that binge ethanol treatment alters the density and morphology of dendritic spines, effects that are associated with learning and memory impairments and changes in the levels of both transcription factor CREB phosphorylation and miRNAs. Rapamycin administration (3 mg/kg) prior to ethanol administration restores ethanol-induced changes in both plasticity and behavior dysfunctions in adolescent mice. These results support the critical role of mTOR/autophagy dysfunctions in the dendritic spines alterations and cognitive alterations induced by binge alcohol in adolescence

Kinetic and functional properties of human mitochondrial phosphoenolpyruvate carboxykinase

The cytosolic form of phosphoenolpyruvate carboxykinase (PCK1) plays a regulatory role in gluconeogenesis and glyceroneogenesis. The role of the mitochondrial isoform (PCK2) remains unclear. We report the partial purification and kinetic and functional characterization of human PCK2. Kinetic properties of the enzyme are very similar to those of the cytosolic enzyme. PCK2 has an absolute requirement for Mn2+ ions for activity; Mg2+ ions reduce the Km for Mn2+ by about 60 fold. Its specificity constant is 100 fold larger for oxaloacetate than for phosphoenolpyruvate suggesting that oxaloacetate phosphorylation is the favored reaction in vivo. The enzyme possesses weak pyruvate kinase-like activity (kcat=2.7 s-1). When overexpressed in HEK293T cells it enhances strongly glucose and lipid production showing that it can play, as the cytosolic isoenzyme, an active role in glyceroneogenesis and gluconeogenesis

Resilience dynamics and productivity-driven shifts in the marine communities of the Western Mediterranean Sea

Ecological resilience has become a conceptual cornerstone bridging ecological processes to conservation needs. Global change is increasingly associated with local changes in environmental conditions that can cause abrupt ecosystem reorganizations attending to system-specific resilience fluctuations with time (i.e. resilience dynamics). Here we assess resilience dynamics associated with climate-driven ecosystems transitions, expressed as changes in the relevant contribution of species with different life-history strategies, in two benthopelagic systems. We analysed data from 1994 to 2019 coming from a scientific bottom trawl survey in two environmentally contrasting ecosystems in the Western Mediterranean Sea—Northern Spain and Alboran Sea. Benthopelagic species were categorized according to their life-history strategies (opportunistic, periodic and equilibrium), ecosystem functions and habitats. We implemented an Integrated Resilience Assessment (IRA) to elucidate the response mechanism of the studied ecosystems to several candidate environmental stressors and quantify the ecosystems’ resilience. We demonstrate that both ecosystems responded discontinuously to changes in chlorophyll-a concentration more than any other stressor. The response in Northern Spain indicated a more overarching regime shift than in the Alboran Sea. Opportunistic fish were unfavoured in both ecosystems in the recent periods, while invertebrate species of short life cycle were generally favoured, particularly benthic species in the Alboran Sea. The study illustrates that the resilience dynamics of the two ecosystems were mostly associated with fluctuating productivity, but subtle and long-term effects from sea warming and fishing reduction were also discernible. Such dynamics are typical of systems with wide environmental gradient such as the Northern Spain, as well as systems with highly hydrodynamic and of biogeographical complexity such as the Alboran Sea. We stress that management should become more adaptive by utilizing the knowledge on the systems’ productivity thresholds and underlying shifts to help anticipate both short-term/less predictable events and long-term/expected effects of climate change.En prensa2,27