The voice of patients with laryngeal carcinoma after oncosurgery

The voice of patients indicated for surgical procedures in treating of dysphonia is already damaged before the operation. The problem, which exists at the level of glottis patients usually try to solve by compensative mechanisms. The quality of voice after the interventions in larynx depends on the type and width of resection, disturbance of physiological phonation mechanisms, and ability to establish optimal phonation automatism. The damage of laryngeal structure, especially its glottic part and vocal cords as its central part, no matter if they are just fibrous or they are partially or totally absent, leads into the development of substitutive phonation mechanisms. The most frequent substitutive mechanisms are: vestibular, ventricular, and chordoventricular phonation. There are some variations of these phonation mechanisms, which are conditioned not only by applied surgical technique, but as they are also individual characteristics, they can be the consequence of applied rehabilitation methods. The diagnosis of voice condition before and after the oncosurgical procedure is done by: laryngostroboscopy, subjective acoustic analysis of voice, and objective acoustic analysis of voice (sonography or computer analysis of acoustic signal). The most of laryngeal carcinomas appear in glottic region, so the function of phonation imposes itself as the objective parameter to measure the quality of life after the oncosurgery of larynx. That is the reason why according to the priority, it is just behind the principle of "oncologic radicalism". Phonation as the most complex laryngeal function seems to have secondary importance. All known operative techniques, especially partial resections, have the preservation of phonation as their goal

Gamma ray production in inelastic scattering of neutrons produced by cosmic muons in 56^{56}Fe

We report on the study of the intensities of several gamma lines emitted after the inelastic scattering of neutrons in $^{56}$Fe. Neutrons were produced by cosmic muons passing the 20t massive iron cube placed at the Earth's surface and used as a passive shield for the HPGe detector. Relative intensities of detected gamma lines are compared with the results collected in the same iron shield by the use of $^{252}$Cf neutrons. Assessment against the published data from neutron scattering experiments at energies up to 14 MeV is also provided

Uticaj lokaliteta i sorte na prinos zrna ekološki uzgajane heljde (Fagopyrum esculentum)

U radu su prikazani rezultati za prinos zrna sorti heljde gajene na području dva lokaliteta (Pašića Polje i Laholo) u opštini Bijelo Polje, Crna Gora. Istraživanje je izvedeno u mikroogledima, koji su urađeni po slučajnom blok sistemu u četiri ponavljanja tokom 2010. godine. Heljda je gajena po principima ekološke proizvodnje. U ogledu je bilo zastupljeno 11 sorti (Novosadska, Heljda 2, Bamby, Češka, Darja, Prekmurska, Čebelica, Francuska, Heljda1, Spacinska i Godijevo). Kao standardna sorta korišćen je tip Godijevo. Ustanovljene su statistički značajne razlike u prinosu izmedju ispitivanih sorti i lokaliteta. Na lokalitetu „Pašića Polje“ prosječan prinos zrna iznosio je 511,86 kg  ili ha-1 za 54,14 kg manje od standarda-tipa Godijevo. Na ovom oglednom polju najviši prinos ostvarila je sorta Heljda 2  (619,25 kg haֿ¹), sa 53,25 kg više u odnosu na standardnu sortu Godijevo  (566,00 kg ha-1). Najniži prinos  ostvarila je sorta Heljda 1  (308,75 kg ha-1) sa 257,25 kg manje od standardne sorte. Na ovom oglednom polju („Pašića Polje“) ostvareni su znatno niži prinosi zrna u poređenju sa oglednim poljem „Laholo“. Na lokalitetu „Laholo“ prosječan prinos zrna izosio je 784,70 kg ha-1 ili za 134,30 kg manje od standarda-tipa Godijevo. Na ovom oglednom polju najviši prinos ostvarila je sorta Francuska (964,75 kg ha-1) sa 45,75 kg više u odnosu na standardnu sortu Godijevo (919,00 kg ha-1). Najniži prinos  ostvarila je sorta Heljda 1  (455,25 kg ha-1), što je čak za 463,75 kg manje od standardne sorte. Na ovom oglednom polju („Laholo“) ostvareni su znatno veći prinosi u poređenju sa oglednim poljem „Pašića Polje“.  Ustanovljena je značajna razlika u prinosu zrna izmedju ispitivanih lokaliteta. Najveća razlika utvrđena je kod sorti Francuska, Prekmurska i Godijevo, a najmanja kod sorte Heljda 1

The role of a pharmacist in pharmacovigilance system

Introduction: Although they represent an important mediator between patients and National Pharmacovigilance Centre, pharmacists still don't participate enough in system of reporting adverse drug reactions (ADR). By reporting ADR both quality of therapy and quality of patient's life are improving, and pharmaceutical industry is also encouraged to invent and produce new formulations which will be better beared and whose use will significantly improve risk-benefi t ratio. Aim: The aim of this work is that by collecting information about ADRs, based on direct contact of a pharmacist and patients, explain and improve the role of a pharmacist in pharmacovigilance system. Subjects and Methods: Information about adverse reactions were being collected in three private pharmacies in Inđija and in one private pharmacy in Sombor. In period from 20.12.2017.-10.01.2018. pharmacists collected data about adverse reactions of medicines. In period from 11.01.-01.02.2018. patients were additionally informed about unexpected and adverse drug reactions. The standard form for reporting an adverse reaction, which was taken from the site of Medicines and Medical Devices Agency of Serbia (ALIMS), was fi lled for each reported case and sent to National Pharmacovigilance Center (NPC). Suspect drugs were classified in categories according to Anatomical-Therapeutic-Chemical classification (ATC). Results: In first period, there were 19 reported reactions. After additional information given to patients, there were 33 reported adverse reactions. The most numerous adverse drug reactions were reported for the group of cardiovascular drugs (32.7%), the group of anti-infective drugs with systemic effects (15.4%) and for group of drugs which affect nervous system (13.5%). After analyzing reported reactions, according to NPC all of reactions were expected (52), but 3 of them fulfilled criteria of seriousness. Conclusions: Thanks to additional information and direct communication between a pharmacist and patients, reporting unexpected and adverse drug reactions is significantly improving

Neutron-induced fission cross section of 242

Accurate nuclear-data needs in the fast-neutron-energy region have been recently addressed for the development of next generation nuclear power plants (GEN-IV) by the OECD Nuclear Energy Agency (NEA). This sensitivity study has shown that of particular interest is the 242Pu(n,f) cross section for fast reactor systems. Measurements have been performed with quasi-monoenergetic neutrons in the energy range from 15 MeV to 20 MeV produced by the Van de Graaff accelerator of the JRC-Geel. A twin Frisch-grid ionization chamber has been used in a back-to-back configuration as fission fragment detector. The 242Pu(n,f) cross section has been normalized to 238U(n,f) cross section data. The results were compared with existing literature data and show acceptable agreement within 5%

Narrow resonances in the continuum of the unbound nucleus 15^{15}F

The structure of the unbound $^{15}$F nucleus is investigated using the inverse kinematics resonant scattering of a radioactive $^{14}$O beam impinging on a CH$_2$ target. The analysis of $^{1}$H($^{14}$O,p)$^{14}$O and $^{1}$H($^{14}$O,2p)$^{13}$N reactions allowed the confirmation of the previously observed narrow $1/2^{-}$ resonance, near the two-proton decay threshold, and the identification of two new narrow 5/2$^{-}$ and 3/2$^{-}$ resonances. The newly observed levels decay by 1p emission to the ground of $^{14}$O, and by sequential 2p emission to the ground state (g.s.) of $^{13}$N via the $1^-$ resonance of $^{14}$O. Gamow shell model (GSM) analysis of the experimental data suggests that the wave functions of the 5/2$^{-}$ and 3/2$^{-}$ resonances may be collectivized by the continuum coupling to nearby 2p- and 1p- decay channels. The observed excitation function $^{1}$H($^{14}$O,p)$^{14}$O and resonance spectrum in $^{15}$F are well reproduced in the unified framework of the GSM

The ν\nu -ball Campaign at ALTO

International audienceIn 2017–2018, the ALTO facility hosted an experimental campaign using a γ spectrometer called ν-ball. This device is an hybrid array combining the excellent energy resolution of high purity germanium detectors with the excellent time resolution of new generation of scintillators LaBr3. Despite the short duration of the campaign, 3 200 hours of beam time distributed over eight experimental project have been provided. In this paper, a description of the progress of the campaign as a short description of the ν-ball array will be given