217 research outputs found
On Bergman completeness of non-hyperconvex domains
We study the problem of the boundary behaviour of the Bergman kernel and the
Bergman completeness in some classes of bounded pseudoconvex domains, which
contain also non-hyperconvex domains. Among the classes for which we prove the
Bergman completeness and the convergence of the Bergman kernel to infinity
while tending to the boundary are all bounded pseudoconvex balanced domains,
all bounded Hartogs domains with balanced fibers over regular domains and some
bounded Laurent-Hartogs domains.Comment: 13 page
Families of strictly pseudoconvex domains and peak functions
We prove that given a family of strictly pseudoconvex domains varying
in topology on domains, there exists a continuously varying
family of peak functions for all at every $\zeta\in\partial
G_t.
Entire curves avoiding given sets in C^n
Let be a proper closed subset of and
at most countable (). We give conditions
of and , under which there exists a holomorphic immersion (or a proper
holomorphic embedding) with .Comment: 10 page
Regularity of Kobayashi metric
We review some recent results on existence and regularity of Monge-Amp\`ere
exhaustions on the smoothly bounded strongly pseudoconvex domains, which admit
at least one such exhaustion of sufficiently high regularity. A main
consequence of our results is the fact that the Kobayashi pseudo-metric k on an
appropriare open subset of each of the above domains is actually a smooth
Finsler metric. The class of domains to which our result apply is very large.
It includes for instance all smoothly bounded strongly pseudoconvex complete
circular domains and all their sufficiently small deformations.Comment: 14 pages, 8 figures - The previously announced main result had a gap.
In this new version the corrected statement is given. To appear on the volume
"Geometric Complex Analysis - Proceedings of KSCV 12 Symposium
Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung
© 2015 Tay et al. Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directly regulating anti-microbial machinery of the innate immune system may boost host defence responses. Here we demonstrate that miR-328 is a key element of the host response to pulmonary infection with non-typeable haemophilus influenzae and pharmacological inhibition in mouse and human macrophages augments phagocytosis, the production of reactive oxygen species, and microbicidal activity. Moreover, inhibition of miR-328 in respiratory models of infection, steroid-induced immunosuppression, and smoke-induced emphysema enhances bacterial clearance. Thus, miRNA pathways can be targeted in the lung to enhance host defence against a clinically relevant microbial infection and offer a potential new anti-microbial approach for the treatment of respiratory diseases
Correction: Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung
[This corrects the article DOI: 10.1371/journal.ppat.1004549.]
Invariant Distances
In this chapter we shall define the (invariant) distance we are going to use, and collect some of its main properties we shall need later on
A remark on the dimension of the Bergman space of some Hartogs domains
Let D be a Hartogs domain of the form D={(z,w) \in CxC^N : |w| < e^{-u(z)}}
where u is a subharmonic function on C. We prove that the Bergman space of
holomorphic and square integrable functions on D is either trivial or infinite
dimensional.Comment: 12 page
Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract (GIT). Cigarette smoke (CS) exposure and chronic obstructive pulmonary disease (COPD) are risk factors for CD, although the mechanisms involved are poorly understood. We employed a mouse model of CS-induced experimental COPD and clinical studies to examine these mechanisms. Concurrent with the development of pulmonary pathology and impaired gas exchange, CS-exposed mice developed CD-associated pathology in the colon and ileum, including gut mucosal tissue hypoxia, HIF-2 stabilization, inflammation, increased microvasculature, epithelial cell turnover, and decreased intestinal barrier function. Subsequent smoking cessation reduced GIT pathology, particularly in the ileum. Dimethyloxaloylglycine, a pan-prolyl hydroxylase inhibitor, ameliorated CS-induced GIT pathology independently of pulmonary pathology. Prior smoke exposure exacerbated intestinal pathology in 2,4,6-trinitrobenzenesulfonic acid-induced (TNBS-induced) colitis. Circulating vascular endothelial growth factor, a marker of systemic hypoxia, correlated with CS exposure and CD in mice and humans. Increased mucosal vascularisation was evident in ileum biopsies from CD patients who smoke compared with nonsmokers, supporting our preclinical data. We provide strong evidence that chronic CS exposure and, for the first time to our knowledge, associated impaired gas exchange cause systemic and intestinal ischemia, driving angiogenesis and GIT epithelial barrier dysfunction, resulting in increased risk and severity of CD
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