Layout level design for testability strategy applied to a CMOS cell library

The layout level design for testability (LLDFT) rules used here allow to avoid some hard to detect faults or even undetectable faults on a cell library by modifying the cell layout without changing their behavior and achieving a good level of reliability. These rules avoid some open faults or reduce their appearance probability. The main purpose has been to apply that set of LLDFT rules on the cells of the library designed at the Centre Nacional de Microelectronica (CNM) in order to obtain a highly testable cell library. The authors summarize the main results (area overhead and performance degradation) of the application of the LLDFT rules on the cell

The Visual Exploration of Insurance Data in Google Earth

Visualisation and geovisualisation techniques can both complement and help communicate the results of GIS and other analyses in the exploration of multivariate datasets and may provide insights and solutions for managing exposure and potential loss. Graphical techniques and the use of geobrowsers such as Google Earth are also being used in a communicative role to engage a variety of different audiences within insurance companies with information about policies, exposure and potential losses. In this paper, we focus on one particular geo-browser, Google Earth, which provides access to a rich array of datasets including aerial imagery, roads, administrative boundaries and photographs and, importantly, allows additional data to be added through the welldocumented KML format

On the Nature of MeV-blazars

Broad-band spectra of the FSRQ (flat-spectrum-radio quasars) detected in the high energy gamma-ray band imply that there may be two types of such objects: those with steep gamma-ray spectra, hereafter called MeV-blazars, and those with flat gamma-ray spectra, GeV-blazars. We demonstrate that this difference can be explained in the context of the ERC (external-radiation-Compton) model using the same electron injection function. A satisfactory unification is reachable, provided that: (a) spectra of GeV-blazars are produced by internal shocks formed at the distances where cooling of relativistic electrons in a jet is dominated by Comptonization of broad emission lines, whereas spectra of MeV-blazars are produced at the distances where cooling of relativistic electrons is dominated by Comptonization of near-IR radiation from hot dust; (b) electrons are accelerated via a two step process and their injection function takes the form of a double power-law, with the break corresponding to the threshold energy for the diffusive shock acceleration. Direct predictions of our model are that, on average, variability time scales of the MeV-blazars should be longer than variability time scales of the GeV-blazars, and that both types of the blazar phenomenon can appear in the same object.Comment: Accepted for publication in the Astrophysical Journa

A functional central limit theorem for a Markov-modulated infinite-server queue

The production of molecules in a chemical reaction network is modelled as a Poisson process with a Markov-modulated arrival rate and an exponential decay rate. We analyze the distributional properties of $M$, the number of molecules, under specific time-scaling; the background process is sped up by $N^{\alpha}$, the arrival rates are scaled by $N$, for $N$ large. A functional central limit theorem is derived for $M$, which after centering and scaling, converges to an Ornstein-Uhlenbeck process. A dichotomy depending on $\alpha$ is observed. For $\alpha\leq1$ the parameters of the limiting process contain the deviation matrix associated with the background process.Comment: 4 figure

Comprehensive Pain Management Using Opioids for Children and Adolescents: Still a Wild Goose to Chase?

Children and adolescents treated for acute and chronic pain represent particular vulnerable patients with distinct and unmet medical and psychosocial needs that continue even beyond the complexity of treating the diseases they suffer [...

Monitoring of Cell Layer Integrity with a Current-Driven Organic Electrochemical Transistor

The integrity of CaCo-2 cell barriers is investigated by organic electrochemical transistors (OECTs) in a current-driven configuration. Ion transport through cellular barriers via the paracellular pathway is modulated by tight junctions between adjacent cells. Rupturing its integrity by H2O2 is monitored by the change of the output voltage in the transfer characteristics. It is demonstrated that by operating the OECT in a current-driven configuration, the sensitive and temporal resolution for monitoring the cell barrier integrity is strongly enhanced as compared to the OECT transient response measurement. As a result, current-driven OECTs are useful tools to assess dynamic and critical changes in tight junctions, relevant for clinical applications as drug targeting and screening

Perspectief op een schone ruit

Deze notitie gaat over de introductie van landschapselementen rond de Ruit van Rotterdam. Planten verwijderen vervuiling uit lucht, water en bodem, geven restruimten een bestemming en verhogen de kwaliteit van de leefomgevin

Landbouw, water en extremen

Bij de effecten van klimaatverandering wordt vaak onderscheid gemaakt tussen primaire en secundaire effecten. Onder primaire effecten worden verstaan veranderingen in zeespiegel, neerslag, temperatuur en wind. Secundaire effecten zoals verzilting, wateroverschot en -tekort, overstromingsrisico en hittestress ontstaan afhankelijk fysisch-geografische aspecten in een gebied, zoals hoogteligging, bodemtype en hydrologische eigenschappen. Voor het beschrijven en begrijpen van klimaatverandering is een onderscheid in de verschillende primaire en secundaire effecten belangrijk. Wanneer gekeken wordt naar de effecten op verschillende typen landbouw lopen deze effecten door elkaar en hebben een interactie. Voor enkele signaalgewassen zijn door Alterra en KNMI kwantitatief relevante grenswaarden in relatie tot de verschillende klimaatscenario’s beschreven. Is onderdeel van klimaateffectatla

THE ECONOMIC IMPACT OF SERIOUS FLUOROQUINOLONE-RELATED ADVERSE EVENTS

Peer reviewe