Characteristics Of Nurse Entrepreneurs In Established Practice

The purpose of this study was to assess business knowledge/skills and characteristics of nurse entrepreneurs

Development of a simulator for studying simplified lunar escape systems

Design and development of lunar escape system simulator for investigation of lunar escape problems and simplified manual guidance and control for lunar escape vehicle

Description and flight tests of an oculometer

A remote sensing oculometer was successfully operated during flight tests with a NASA experimental Twin Otter aircraft at the Langley Research Center. Although the oculometer was designed primarily for the laboratory, it was able to track the pilot's eye-point-of-regard (lookpoint) consistently and unobtrusively in the flight environment. The instantaneous position of the lookpoint was determined to within approximately 1 deg. Data were recorded on both analog and video tape. The video data consisted of continuous scenes of the aircraft's instrument display and a superimposed white dot (simulating the lookpoint) dwelling on an instrument or moving from instrument to instrument as the pilot monitored the display information during landing approaches

Barriers to reporting non-motor symptoms to health-care providers in people with Parkinson's

Background: Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress. A high rate of non-declaration of NMS by patients to healthcare providers (HCP) means that many NMS remain untreated. Current understanding of the factors preventing disclosure of NMS to HCPs is limited. The present study aimed to i) further assess the prevalence of NMS and associated distress, ii) establish current rates of NMS reporting across a range of sources, and iii) explore overall and any symptom specific barriers to help-seeking for NMS. Methods: 358 PD patients completed a cross-sectional survey of NMS severity, reporting and barriers to help-seeking. A series of Generalised Estimating Equations were used to determine whether barriers were symptom specific. Results: A mean of 10.5 NMS were reported by each patient. Rates of non-reporting of NMS ranged from 15 to 72% of those experiencing distressing symptoms. The most commonly reported barriers to help-seeking were acceptance of symptoms; lack of awareness that a symptom was associated with PD, and belief that no effective treatments were available. Symptom specific barriers were found for sexual dysfunction (embarrassment), unexplained pain and urinary problems (belief about lack of treatment availability). Conclusion: A diverse range of barriers prevent PD patients reporting NMS to HCPs and these barriers differ between NMS. The study provides the foundations for developing interventions to increase reporting by targeting individual NMS. Increasing rates of help-seeking for NMS by patients to their Parkinson's healthcare providers will increase appropriate clinical care which may improve quality of life and well-being

Preliminary flight tests of an oculometer

A remote sensing oculometer has been successfully operated during flight tests. This device was able to track the pilot's eye-point-of-regard (lookpoint) consistently and unobtrusively in the flight environment. The instantaneous position of the lookpoint was determined to within approximately 1 degree. Data were recorded on both analog and video tape. The video data consisted of continuous scenes of the aircraft's instrument display and a superimposed white dot (simulating the lookpoint) dwelling or moving from instrument to instrument as the pilot monitored the display information during landing approaches

Extended Molecular Gas in the Nearby Starburst Galaxy Maffei 2

We present a 9'x9' fully-sampled map of the CO J=1-0 emission in the nearby starburst galaxy Maffei 2 obtained at the Five College Radio Astronomy Observatory. The map reveals previously known strong CO emission in the central starburst region as well as an extended asymmetric distribution with bright CO lines at the ends of the bar and in a feature at the north-east edge of the molecular disk. This northern feature, proposed previously to be an interacting companion galaxy, could be a dwarf irregular galaxy, although the CO data are also consistent with the feature being simply an extension of one of the spiral arms. We estimate the total molecular gas mass of Maffei 2 to be (1.4-1.7)x10^9 Mo or ~3-4% of its dynamical mass. Adopting the recently determined lower value for the CO-to-H2 conversion factor in the central region, our data lead to the surprising result that the largest concentrations of molecular gas in Maffei 2 lie at the bar ends and in the putative dwarf companion rather than in the central starburst. A gravitational stability analysis reveals that the extended disk of Maffei 2 lies above the critical density for star formation; however, whether the central region is also gravitationally unstable depends both on the details of the rotation curve and the precise value of the CO-to-H2 conversion factor in this region.Comment: accepted to ApJ (Sept 10 2004 issue

Clinical significance of Polycomb gene expression in brain tumors

Polycomb group (PcG) proteins are crucial for neural cancer stem cell (NCSC) self-renewal. However, the relative expression levels of PcG genes in different subtypes of brain tumors, their prognostic role and their effects on cellular pathways have not been investigated. For this purpose, we queried the Oncomine database and found that 4 PcG genes (EZH2, RBBP7, SUZ12, YY1) are specifically expressed in brain tumors. EZH2 expression increases with tumor grade in adult and pediatric brain tumors, and is a poor prognostic factor. In glioblastoma, EZH2 inhibits differentiation, and activates cancer-, cell cycle- and cellular movement-related genes. In keeping with previously published data, our results suggest that EZH2 is both a prognostic factor and a promising therapy target in brain tumors

Mineralogy and provenance of the TiO₂ - ilmenite heavy mineral sand deposit of Nataka

The Nataka heavy mineral sand deposit occurs along the northeast Mozambique coastline. It comprises a regional Pleistocene elliptical structure extending from Somalia, passing through Kenya, Tanzania, Madagascar and Mozambique, to Richards Bay in South Africa. The deposit consists of fine- to medium- grained, unconsolidated red sediments, hosting heavy minerals. The deposit mineral assemblage is made up of non-valuable phases comprising mostly magnetite, hematite, chromite, monazite, and the valuable phases dominated by ilmenite (50.91 wt. %), with additional zircon and rutile (9.96 and 3.52 wt. % respectively). The total heavy minerals comprise about 5% volume, of which 2 % are valuable heavy minerals making up about 445 Mt (million tonnes) probable resources. This study focuses on the mineralogical characterization of ilmenite from the Nataka deposit, alongside with sediment provenance. Mineralogical and chemical characterisation of ilmenite undertaken on 32 samples from 16 selected drill holes using a combination of QEMSCAN and EPMA revealed that the ilmenite has undergone different stages of alteration, at distinct environment conditions, yielding products spanning from hydrated ilmenite to leucoxene. The alteration dominantly involved groundwater, which was oxidizing and acidic, hence the predominance of ilmenite-pseudorutile alteration. Long exposure to direct sunshine has been hypothesized as a different process that might have favoured the direct alteration of ilmenite to leucoxene and of pseudorutile to leucoxene, on a smaller scale. The major impurities in the ilmenite are Al and Si, which are enriched in the advanced ilmenite alteration products (leucoxene), where they fill pores and cracks. Chromium impurities occur as discrete grains of chrome spinel. The compositional variety of magnetite, Cr-spinel, tourmaline, zircon and rutile indicate major contribution from granitoid terranes, subjected to granulite metamorphic facies (750 to 1000 :C), and minor contribution from mafic plutonic intrusions. The granitoid field as a sediment source area if analysed in conjunction with zircon ages (1100 – 900 Ma, 900 – 700 Ma, and 650 – 500 Ma), and zircon δ¹⁸O (7.07 ‰) is consistent with preferential sourcing from the proximal Mesoproterozoic Nampula Complex, with some contribution from igneous plutonic rocks from Xixano, Lalamo and Montepuez Complexes