807 research outputs found
POEMMA: Probe Of Extreme Multi-Messenger Astrophysics
The Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) mission is being
designed to establish charged-particle astronomy with ultra-high energy cosmic
rays (UHECRs) and to observe cosmogenic tau neutrinos (CTNs). The study of
UHECRs and CTNs from space will yield orders-of-magnitude increase in
statistics of observed UHECRs at the highest energies, and the observation of
the cosmogenic flux of neutrinos for a range of UHECR models. These
observations should solve the long-standing puzzle of the origin of the highest
energy particles ever observed, providing a new window onto the most energetic
environments and events in the Universe, while studying particle interactions
well beyond accelerator energies. The discovery of CTNs will help solve the
puzzle of the origin of UHECRs and begin a new field of Astroparticle Physics
with the study of neutrino properties at ultra-high energies.Comment: 8 pages, in the Proceedings of the 35th International Cosmic Ray
Conference, ICRC217, Busan, Kore
The POEMMA (Probe of Extreme Multi-Messenger Astrophysics) mission
The Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) is designed to
observe cosmic neutrinos (CNs) above 20 PeV and ultra-high energy cosmic rays
(UHECRs) above 20 EeV over the full sky. The POEMMA mission calls for two
identical satellites flying in loose formation, each comprised of a 4-meter
wide field-of-view (45 degrees) Schmidt photometer. The hybrid focal surface
includes a fast (1 s) ultraviolet camera for fluorescence observations
and an ultrafast (10 ns) optical camera for Cherenkov observations. POEMMA will
provide new multi-messenger windows onto the most energetic events in the
universe, enabling the study of new astrophysics and particle physics at these
otherwise inaccessible energies.Comment: 8 pages, 6 figures, presented in 36th International Cosmic Ray
Conference (Madison). arXiv admin note: substantial text overlap with
arXiv:1907.0621
Low back pain in 17 year olds has substantial impact and represents an important public health disorder: a cross-sectional study
<p>Abstract</p> <p>Background</p> <p>Prevalence of low back pain (LBP) rises rapidly during adolescence, reaching adult levels by the age of 18. It has been suggested that adolescent LBP is benign with minimal impact, despite limited evidence.</p> <p>Methods</p> <p>The aim of this study was to investigate the impact of LBP and the influence of chronicity, gender and presence of other spinal pain comorbidities at age 17. Subjects (n = 1283) were categorised according to experiencing current and chronic LBP, gender and presence of other areas of spinal pain. LBP impact was ascertained via questions regarding seeking professional assistance, using medication, missing school/work, limited normal or recreational physical activity and health related quality of life (HRQOL).</p> <p>Results</p> <p>12.3% of participants reported current but not chronic LBP, while 19.9% reported current chronic LBP. LBP was more commonly reported by females than males. Other spinal pain comorbidities were common in the LBP groups. Impact was greater in subjects with chronic LBP, in females and in those with other spinal pain comorbidities.</p> <p>Conclusion</p> <p>LBP, and particularly chronic LBP, has a significant negative impact at 17 years. It is commonly associated with care seeking, medication use, school absenteeism, and reduced HRQOL. These findings support that adolescent LBP is an important public health issue that requires attention.</p
The Roadmap to the POEMMA mission
The Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) is designed to observe ultrahigh-energy cosmic rays (UHECRs) and cosmic neutrinos from space with sensitivity over the full celestial sky. Developed as a NASA Astrophysics Probe-class mission, POEMMA consists of two identical telescopes orbiting the Earth in a loose formation designed to observe extensive air showers (EAS) via air fluorescence and Cherenkov emissions. UHECRs and UHE neutrinos above 20 EeV are observed with the stereo fluorescence technique, while tau neutrinos above 20 PeV are observed via the optical Cherenkov signals produced by up-going EAS generated by the decay of Earth-emerging tau-leptons. The POEMMA satellites are designed to quickly re-orientate to follow up transient cosmic neutrino candidate sources and obtain unparalleled neutrino flux sensitivity. Both observation techniques and the instrument design are being validated by current and upcoming missions, such as Mini-EUSO and EUSO-SPB as part of the JEM-EUSO program, and the Terzina instrument onboard the NUSES SmallSat mission. We discuss the POEMMA science performance and the current roadmap to the POEMMA mission
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A preliminary investigation to explore the cognitive resources of physicians experiencing difficulty in training
Background
Treating patients is complex, and research shows that there are differences in cognitive resources between physicians who experience difficulties, and those who do not. It is possible that differences in some cognitive resources could explain the difficulties faced by some physicians. In this study, we explore differences in cognitive resources between different groups of physicians (that is, between native (UK) physicians and International Medical Graduates (IMG); those who continue with training versus those who were subsequently removed from the training programme); and also between physicians experiencing difficulties compared with the general population.
Methods
A secondary evaluation was conducted on an anonymised dataset provided by the East Midlands Professional Support Unit (PSU). One hundred and twenty one postgraduate trainee physicians took part in an Educational Psychology assessment through PSU. Referrals to the PSU were mainly on the basis of problems with exam progression and difficulties in communication skills, organisation and confidence. Cognitive resources were assessed using the Wechsler Adult Intelligence Scale (WAIS-IV). Physicians were categorised into three PSU outcomes: ‘Continued in training’, ‘Removed from training’ and ‘Active’ (currently accessing the PSU).
Results
Using a one-sample Z test, we compared the referred physician sample to a UK general population sample on the WAIS-IV and found the referred sample significantly higher in Verbal Comprehension (VCI; z = 8.78) and significantly lower in Working Memory (WMI; z = −4.59). In addition, the native sample were significantly higher in Verbal Comprehension than the UK general population sample (VCI; native physicians: z = 9.95, p < .001, d = 1.25), whilst there was a lesser effect for the difference between the IMG sample and the UK general population (z = 2.13, p = .03, d = 0.29). Findings also showed a significant difference in VCI scores between those physicians who were ‘Removed from training’ and those who ‘Continued in training’.
Conclusions
Our results suggest it is important to understand the cognitive resources of physicians to provide a more focussed explanation of those who experience difficulties in training. This will help to implement more targeted interventions to help physicians develop compensatory strategies
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
Protein/DNA interactions in complex DNA topologies: expect the unexpected
DNA supercoiling results in compacted DNA structures that can bring distal sites into close proximity. It also changes the local structure of the DNA, which can in turn influence the way it is recognised by drugs, other nucleic acids and proteins. Here, we discuss how DNA supercoiling and the formation of complex DNA topologies can affect the thermodynamics of DNA recognition. We then speculate on the implications for transcriptional control and the three-dimensional organisation of the genetic material, using examples from our own simulations and from the literature. We introduce and discuss the concept of coupling between the multiple length-scales associated with hierarchical nuclear structural organisation through DNA supercoiling and topology
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