Comparison of effectiveness between a conventional catheter and a manual commercial catheter: randomized trial of simulation of intraosseous access in a biological model

Introduction: In the emergency services an action of paramount importance in critically ill patients is to obtain an early vascular access. When vascular access is not established, an intraosseous route should be obtained; otherwise, the mortality of these critically ill patients is almost 100%. In Colombia, the intraosseous access is not used because of the high costs of the devices and the lack of training of the healthcare staff to conduct the procedure.Objective: To determine the efficacy of a low-cost device to establish intraosseous access.Materials and methods: Quantitative approach, experimental design in a simulated environment with chicken tarsus and metatarsus. An analysis was conducted using frequency tables and central tendency measurements. Likewise, further analyses were done using Fisher's exact test, Chi2, and Mann-Whitney test.Results: A total of 99% of the procedures were successful with both catheters. The average time for intraosseous access was 6.6 seconds with Insyte 14 catheter and 4.7 seconds with Din 1515x Illinois Desch device (P=0.001). There were no significant differences in the number of attempts to secure a successful intraosseous access using any of the 2 devices (P=0.56).Conclusion: There was no significant difference between the Ci 14 and the Si 14 catheter to establish a successful intraosseous access in the chicken tarsus and metatarsus in a simulated environment. © 2019 Sociedad Colombiana de Anestesiología y Reanimación (S.C.A.R.E.)

SISTEMA INFORMÁTICO PARA ESTIMAR EL RIESGO DE CÁNCER DE MAMA APLICANDO TÉCNICAS DE APRENDIZAJE AUTOMÁTICO / COMPUTER SYSTEM TO ESTIMATE THE RISK OF BREAST CANCER BY APPLYING MACHINE LEARNING TECHNIQUES

El cáncer de mama es una enfermedad que afecta a las personas de todo el mundo, con mayores tasas de incidencia en el sexo femenino, aunque no excluye al sexo masculino. Se encuentra entre los cinco tipos de cáncer más mortíferos, teniendo mayor afluencia en los países menos desarrollados donde el acceso a los programas de salud es más deficiente. Las altas cifras de afectación y muerte son alarmantes, en la mayoría de los casos porque se detecta en etapas tardías. Se conoce clínicamente que en pacientes donde se logra detectar la enfermedad en etapas I y II se aumenta considerablemente el pronóstico de vida y las tasas de supervivencia. En el presente trabajo se propone el desarrollo de un sistema informático de carácter preventivo como proceso hospitalario orientado a Latinoamérica y el Caribe basado en factores de riesgo característicos de la población a fin de estimar la posibilidad de que las personas sean propensas a tener la enfermedad y así contribuir al diagnóstico clínico de la enfermedad en etapas iniciales. Como punto de partida se tienen los modelos estadísticos basados en cálculos sobre factores de riesgos, donde en 1989 Gail creó un modelo específicamente en la población blanca norteamericana utilizando cinco factores. Para la estimación se utilizan técnicas de aprendizaje automático que confluyen en la elaboración de un modelo computacional que permite calcular las estimaciones y arrojar dichos resultados nutriéndose de los factores de riesgos característicos para poblaciones latinas específicamente los definidos en la norma mexicana NOM-041-SSA2-2011

Carbonatación de un hormigón hibrido con alto contenido de escoria siderurgica de alto horno y su impacto en la corrosión del acero estructural

The aim of this research was to study the carbonation resistance of a blast furnace slag concrete (80% GBFS/20%OPC), with and without alkaline activation, and its influence on the corrosion of structural reinforcement. An OPC-based concrete produced under the same specifications was used as a reference material. To do this, the material was subjected to an accelerated carbonation process under controlled conditions (65% relative humidity, 1% CO2, 25°C). The half-cell potential (Ecorr), linear polarization resistance (LPR) tests showed that both concretes based on GBFS led to depassivation of the reinforcing steel at approximately 99 days, which is the time required for full carbonation of the evaluated concretes.El objetivo de esta investigación fue estudiar la resistencia a la carbonatación de un hormigón a base de escoria granulada de alto horno (80% GBFS/20%OPC), con y sin activación alcalina, y su influencia sobre la corrosión del acero estructural. Un hormigón basado en cemento portland producido con las mismas especificaciones fue usado como material de referencia. Para ello, el material fue sometido a un proceso de carbonatación acelerada bajo condiciones controladas (Humedad Relativa 65 %, 1% CO2, 25 °C). Los ensayos de potencial de media celda (Ecorr) y Resistencia a la polarización lineal (LPR) mostraron que los aceros estructurales aproximadamente a los 99 días alcanzan la despasivación en los hormigones basados en escoria, coincide este tiempo con el requerido para la completa carbonatación de los hormigones evaluados

Immune-mediated hookworm clearance and survival of a marine mammal decrease with warmer ocean temperatures

Indexación: Scopus.We appreciate the logistical support of the Chilean Navy, Artisanal fishermen of Quellon (Vessel crews Marimar II and Nautylus V), and the crews of the Chilean Navy lighthouse. We thank Amanda Hooper, Eugene DeRango, Elvira Vergara, Ignacio Silva, Dr. Lorraine Barbosa, Emma Milner, Sian Tarrant, Emily Morris, Suzette Miller, and Piero Becker for dedicated field assistance. We thank Dr. Vanesa Ezenwa for comments and insights in earlier versions of the manuscript. This work was supported by The Rufford Small Grant Foundation (Grant N 18815–1), Morris Animal Foundation (Grant N D16ZO-413), and the Society for Marine Mammalogy Small Grants in aid awards 2015 and 2016.Increases in ocean temperature are associated with changes in the distribution of fish stocks, and the foraging regimes and maternal attendance patterns of marine mammals. However, it is not well understood how these changes affect offspring health and survival. The maternal attendance patterns and immunity of South American fur seals were assessed in a rookery where hookworm disease is the main cause of pup mortality. Pups receiving higher levels of maternal attendance had a positive energy balance and a more reactive immune system. These pups were able to expel hookworms through a specific immune mediated mechanism and survived the infection. Maternal attendance was higher in years with low sea surface temperature, therefore, the mean hookworm burden and mortality increased with sea surface temperature over a 10-year period. We provide a mechanistic explanation regarding how changes in ocean temperature and maternal care affect infectious diseases dynamics in a marine mammal. © Seguel et al.https://elifesciences.org/articles/3843

Estilos de vida saludable y calidad de vida en estudiantes de Biología durante la Pandemia-Covid-19-2021

Quality of life is a criterion that incorporates a diversity of dimensions related to physical strength, psychological aspect, level of autonomy, social relations and religious beliefs. There is evidence of a gap in relation to styles and quality of life, in university education, considering remote educational activities due to the COVID 19 pandemic; The correlation between healthy lifestyles and quality of life in biology students of the pre-professional practice of the Biology-Natural Sciences Career of the Enrique Guzmán y Valle National University was studied. The research followed the descriptive quantitative method. An intentional census sampling was carried out. Between healthy lifestyles and quality of life in students there is a perfect and positive linear correlation; likewise, there is a direct correlation between the sports activities dimension and quality of life, where 83.3% state that they carry out sports activities more than three times a week. In addition, the relationship between sleep, rest and quality of life. It presents a direct and positive correlation, all the students affirm to carry out relaxation activities.Calidad de vida, es un criterio que incorpora una diversidad de dimensiones relacionadas con la fortaleza física, aspecto psicológico, nivel de autonomía, relaciones sociales y las creencias religiosas. Se evidencia la existencia de un vacío en relación a los estilos y calidad de vida, en la educación universitaria, considerando las actividades educativas remotas a causa de la pandemia COVID 19; se estudió la correlación entre los estilos de vida saludable y la calidad de vida en estudiantes de biología de la práctica preprofesional de la Carrera de Biología -Ciencias Naturales de la Universidad Nacional Enrique Guzmán y Valle. La investigación siguió el método cuantitativo de tipo descriptivo. Se realizó un muestreo censal, de tipo intencional. Entre los estilos de vida saludable y la calidad de vida en los estudiantes existe una correlación lineal perfecta y positiva; así mismo, entre la dimensión actividades deportivas y la calidad de vida hay una correlación directa, en donde el 83.3% afirma realizar actividades deportivas más de tres veces a la semana. Además, la relación que existe entre el sueño, reposo y la calidad de vida. Presenta una correlación directa y positiva, la totalidad de estudiantes afirma realizar actividades de relajación

Measurements in two bases are sufficient for certifying high-dimensional entanglement

High-dimensional encoding of quantum information provides a promising method of transcending current limitations in quantum communication. One of the central challenges in the pursuit of such an approach is the certification of high-dimensional entanglement. In particular, it is desirable to do so without resorting to inefficient full state tomography. Here, we show how carefully constructed measurements in two bases (one of which is not orthonormal) can be used to faithfully and efficiently certify bipartite high-dimensional states and their entanglement for any physical platform. To showcase the practicality of this approach under realistic conditions, we put it to the test for photons entangled in their orbital angular momentum. In our experimental setup, we are able to verify 9-dimensional entanglement for a pair of photons on a 11-dimensional subspace each, at present the highest amount certified without any assumptions on the state.Comment: 11+14 pages, 2+7 figure

Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia

Q3Q1Pacientes embarazadas hipertensasObjective: We sought to determine if soluble levels of C5b-9, the terminal complement complex, correlate with end-organ injury in preeclampsia. Study Design: Project COPA (Complement and Preeclampsia in the Americas), a multi-center observational study in Colombia from 2015 to 2016, enrolled hypertensive pregnant women into four groups: chronic hypertension, gestational hypertension, preeclampsia, and preeclampsia with severe features. Trained coordinators collected clinical data, blood and urine. End-organ injury was defined by serum creatinine ≥ 1.0 mg/dl, aspartate transaminase ≥ 70U/L, platelet count < 150,000/µl, or lactate dehydrogenase ≥ 500 U/L. Data were analyzed by χ2 or Fisher’s exact test with significance at P < 0.05. Main Outcome Measure: C5b-9 concentrations in plasma and urine, using enzyme linked immunosorbent assays. Results: In total, 298 hypertensive participants were enrolled. Plasma and urine C5b-9 levels were measured in all participants and stratified by quartile (Q1-4), from lowest to highest C5b-9 concentration. Participants with low plasma C5b-9 levels (Q1) were more likely to have end-organ injury compared to those with higher levels (Q2-Q4) [platelet count < 150,000/μl (20.8% vs. 8.4%, P = 0.01); elevated serum creatinine ≥ 1.0 mg/dl (14.9% vs. 4.5%, P = 0.009)]. In contrast, participants with high urinary C5b-9 levels (Q4) were more likely to have end-organ injury compared to those with lower levels (Q1-Q3) [platelet count < 150,000/μl (19.7% vs. 7.4%, P = 0.003); elevated serum creatinine ≥ 1.0 mg/dl (12.3% vs. 4.4%, P = 0.025)]. Conclusion: We identified a pattern of increased urine and low plasma C5b-9 levels in patients with preeclampsia and end-organ injury. Soluble C5b-9 levels may be used to identify complement-mediated end-organ injury in preeclampsia.https://orcid.org/0000-0001-6822-0374Revista Internacional - IndexadaA1N

Empirical leucine-to-carbon conversion factors for estimating heterothrophic bacterial production in surface waters of the world oceans

Comunicación oralBacterial biomass production is a key parameter for evaluating the role of bacterioplankton in ocean carbon cycling. However, bacterial production cannot be directly measured and is typically estimated from the incorporation rates of radiolabelled leucine. The conversion of leucine uptake rates into bacterial carbon production rates requires the use of conversion factors (CFs) which must be empirically determined. Despite the empirical leucine-to-carbon CFs vary widely across environments very little is known about its potential controlling factors. We conducted a set of 10 surface seawater cultures experiments where the growth of the natural bacterial assemblage was promoted by filtration (removal of grazers) or by both filtration and dilution. Sampling stations were located between 30 ºN and 30 ºS, including the Atlantic, Pacific and Indian oceans. CFs varied from 0.13 to 1.47 Kg C mol Leu-1, being higher in the filtrated than in the filtrated and diluted treatment. The abundance of picocyanobacteria explained 60% of the observed variability. Our results further suggest that the composition of bacterioplankton, as assessed by ARISA fingerprinting, may partially explain the observed variation in CFs

Sample dilution and bacterial community composition influence empirical leucine-to-carbon conversion factors in surface waters of the world's oceans

Research articleThe transformation of leucine incorporation into prokaryotic carbon production rates requires the use of either theoretical or empirically determined conversion factors. Empirical leucine-to-carbon conversion factors (eCFs) vary widely across environments, and little is known about their potential controlling factors. We conducted 10 surface seawater manipulation experiments across the world’s oceans, where the growth of the natural prokaryotic assemblages was promoted by filtration (i.e. removal of grazers; F treatment) or filtration combined with dilution (i.e. relieving also resource competition; FD treatment). The impact of sunlight exposure was also evaluated in the FD treatments, and we did not find a significant effect on the eCFs. The eCFs varied from 0.09 to 1.47 kg C mol Leu-1 and were significantly lower in the filtered and diluted (FD) than in the filtered (F) treatments. Also, changes in bacterial community composition during the incubations, as assessed by Automated Ribosomal Intergenic Spacer Analysis (ARISA), were stronger in the FD than in the F treatments, as compared to unmanipulated controls. Thus, we discourage the common procedure of diluting samples (in addition to filtration) for eCFs determination. The eCFs in the filtered treatment were negatively correlated with the initial chlorophyll a concentration, picocyanobacterial abundance (mostly Prochlorococcus) and the percentage of heterotrophic prokaryotes with high nucleic acid content (%HNA). The latter two variables explained 80% of the eCFs variability in the F treatment, supporting the view that both Prochlorococcus and HNA prokaryotes incorporate leucine in substantial amounts although resulting into relatively low carbon production rates in the oligotrophic ocean.En prensa3,829