3,274 research outputs found

    Elastic Correlations in Nucleosomal DNA Structure

    Full text link
    The structure of DNA in the nucleosome core particle is studied using an elastic model that incorporates anisotropy in the bending energetics and twist-bend coupling. Using the experimentally determined structure of nucleosomal DNA [T.J. Richmond and C.A. Davey, Nature {\bf 423}, 145 (2003)], it is shown that elastic correlations exist between twist, roll, tilt, and stretching of DNA, as well as the distance between phosphate groups. The twist-bend coupling term is shown to be able to capture these correlations to a large extent, and a fit to the experimental data yields a new estimate of G=25 nm for the value of the twist-bend coupling constant

    A Precision Angle Sensor using an Optical Lever inside a Sagnac Interferometer

    Full text link
    We built an ultra low noise angle sensor by combining a folded optical lever and a Sagnac interferometer. The instrument has a measured noise floor of 1.3 prad / Hz^(1/2) at 2.4 kHz. We achieve this record angle sensitivity using a proof-of-concept apparatus with a conservative N=11 bounces in the optical lever. This technique could be extended to reach sub-picoradian / Hz^(1/2) sensitivities with an optimized design.Comment: 3 pages, 4 figure

    The molecular origin of DNA-drug specificity in netropsin and distamycin.

    Full text link

    Microstructure and Phase Stability of Single Crystal NiAl Alloyed with Hf and Zr

    Get PDF
    Six near stoichiometric, NiAl single-crystal alloys, with 0.05-1.5 at.% of Hf and Zr additions plus Si impurities, were microstructurally analyzed in the as-cast, homogenized, and aged conditions. Hafnium-rich interdendritic regions, containing the Heusler phase (Ni2AlHf), were found in all the as-cast alloys containing Hf. Homogenization heat treatments partially reduced these interdendritic segregated regions. Transmission electron microscopy (TEM) observations of the as-cast and homogenized microstructures revealed the presence of a high density of fine Hf (or Zr) and Si-rich precipitates. These were identified as G-phase, Nil6X6Si7, or as an orthorhombic NiXSi phase, where X is Hf or Zr. Under these conditions the expected Heusler phase (beta') was almost completely absent. The Si responsible for the formation of the G and NiHfSi phases is the result of molten metal reacting with the Si-containing crucible used during the casting process. Varying the cooling rates after homogenization resulted in the refinement or complete suppression of the G and NiHfSi phases. In some of the alloys studied, long-term aging heat treatments resulted in the formation of Heusler precipitates, which were more stable at the aging temperature and coarsened at the expense of the G-phase. In other alloys, long-term aging resulted in the formation of the NiXSi phase. The stability of the Heusler or NiXSi phases can be traced to the reactive element (Hf or Zr) to silicon ratio. If the ratio is high, then the Heusler phase appears stable after long time aging. If the ratio is low, then the NiHfSi phase appears to be the stable phase

    Power-Based Droop Control in DC Microgrids Enabling Seamless Disconnection From Upstream Grids

    Get PDF
    This paper proposes a local power-based droop controller for distributed energy resource converters in dc microgrids that are connected to upstream grids by grid-interface converters. During normal operation, the grid-interface converter imposes the microgrid bus voltage, and the proposed controller allows power flow regulation at distributed energy resource converters\u2019 output. On the other hand, during abnormal operation of the grid-interface converter (e.g., due to faults in the upstream grid), the proposed controller allows bus voltage regulation by droop control. Notably, the controller can autonomously convert from power flow control to droop control, without any need of bus voltage variation detection schemes or communication with other microgrid components, which enables seamless transitions between these two modes of operation. Considering distributed energy resource converters employing the power-based droop control, the operation modes of a single converter and of the whole microgrid are defined and investigated herein. The controller design is also introduced. Furthermore, the power sharing performance of this control approach is analyzed and compared with that of classical droop control. The experimental results from a laboratory-scale dc microgrid prototype are reported to show the final performances of the proposed power-based droop control

    PENGARUH PENAMBAHAN LENSA NOZZLE DAN JUMLAH BLADE AIRFOIL TIPE NACA 4415 TERHADAP HASIL DAYA LISTRIK TURBIN ANGIN SUMBU HORISONTAL

    Get PDF
    Danur Lambang Pristiandaru. PENGARUH PENAMBAHAN LENSA NOZZLE TURBIN ANGIN DAN JUMLAH BLADE AIRFOIL TIPE NACA 4415 TERHADAP HASIL DAYA LISTRIK. Skripsi, Fakultas Keguruan dan Ilmu Pendidikan Universitas Sebelas Maret Surakarta. Januari 2016 Tujuan penelitian ini adalah: (1) Menyelidiki pengaruh jumlah blade pada turbin angin non-twisted blade tipe airfoil NACA 4415 terhadap daya listrik yang dihasilkan. (2) Menyelidiki pengaruh penambahan lensa nozzle pada turbin angin non-twisted blade tipe airfoil NACA 4415 terhadap daya listrik yang dihasilkan turbin angin. (3) Menyelidiki pengaruh bersama (interaksi) antara penambahan lensa nozzle dan jumlah blade terhadap daya listrik yang dihasilkan turbin angin. Penelitian ini menggunakan metode deskriptif kuantitatif. Sampel dalam penelitian ini adalah Turbin Angin Sumbu Horisontal (TASH) dengan desain blade airfoil NACA 4415 non-twisted. 3 desain lensa nozzle digunakan untuk mengetahui pengaruhnya terhadap peningkatan daya listrik TASH. Terdapat 3 variasi jumlah blade yaitu jumlah blade 2, jumlah blade 3, dan jumlah blade 4. Variasi kecepatan angin yang digunakan dalam penelitian ini adalah 2,5 m/s, 3,5 m/s, dan 4,5 m/s. Data diperoleh dengan melakukan pengujian TASH menggunakan angin rekayasa, daya listrik yang dihasilkan dibaca dan direkam oleh data logger. Data yang diperoleh dari hasil penelitian dimasukkan ke dalam tabel dan ditampilkan dalam bentuk grafik, kemudian dianalisis. Berdasarkan hasil penelitian dapat disimpulkan bahwa: (1) Adanya pengaruh variasi jumlah blade terhadap daya listrik turbin angin. TASH 3 blade menghasilkan daya listrik yang paling besar yaitu 0,7222 W pada kecepatan angin 4,5 m/s. (2) Adanya pengaruh penambahan lensa nozzle terhadap turbin angin. Lensa nozzle mampu meningkatkan hasil daya listrik turbin angin semua jenis variasi jumlah blade dibandingkan turbin angin tanpa lensa nozzle. (3) Ada pengaruh bersama yang signifikan antara variasi jumlah blade dan variasi jenis lensa terhadap daya listrik turbin angin. TASH 3 blade dengan lensa C pada kecepatan angin 4,5 m/s memiliki daya listrik tertinggi yaitu sebesar 0,82041 W. Daya listrik tersebut meningkat 13,60% dibanding TASH 3 blade tanpa penambahan lensa, yaitu 0,7222 W. Kata kunci: Turbin Angin, Lensa Nozzle, Daya Listrik, Data Logge

    Stress detection using wearable physiological sensors

    Get PDF
    As the population increases in the world, the ratio of health carers is rapidly decreasing. Therefore, there is an urgent need to create new technologies to monitor the physical and mental health of people during their daily life. In particular, negative mental states like depression and anxiety are big problems in modern societies, usually due to stressful situations during everyday activities including work. This paper presents a machine learning approach for stress detection on people using wearable physiological sensors with the �final aim of improving their quality of life. The presented technique can monitor the state of the subject continuously and classify it into "stressful" or "non-stressful" situations. Our classification results show that this method is a good starting point towards real-time stress detection

    Differences in estimates of size distribution of beryllium powder materials using phase contrast microscopy, scanning electron microscopy, and liquid suspension counter techniques

    Get PDF
    Accurate characterization of the physicochemical properties of aerosols generated for inhalation toxicology studies is essential for obtaining meaningful results. Great emphasis must also be placed on characterizing particle properties of materials as administered in inhalation studies. Thus, research is needed to identify a suite of techniques capable of characterizing the multiple particle properties (i.e., size, mass, surface area, number) of a material that may influence toxicity. The purpose of this study was to characterize the morphology and investigate the size distribution of a model toxicant, beryllium. Beryllium metal, oxides, and alloy particles were aerodynamically size-separated using an aerosol cyclone, imaged dry using scanning electron microscopy (SEM), then characterized using phase contrast microscopy (PCM), a liquid suspension particle counter (LPC), and computer-controlled SEM (CCSEM). Beryllium metal powder was compact with smaller sub-micrometer size particles attached to the surface of larger particles, whereas the beryllium oxides and alloy particles were clusters of primary particles. As expected, the geometric mean (GM) diameter of metal powder determined using PCM decreased with aerodynamic size, but when suspended in liquid for LPC or CCSEM analysis, the GM diameter decreased by a factor of two (p < 0.001). This observation suggested that the smaller submicrometer size particles attached to the surface of larger particles and/or particle agglomerates detach in liquid, thereby shifting the particle size distribution downward. The GM diameters of the oxide materials were similar regardless of sizing technique, but observed differences were generally significant (p < 0.001). For oxides, aerodynamic cluster size will dictate deposition in the lung, but primary particle size may influence biological activity. The GM diameter of alloy particles determined using PCM became smaller with decreasing aerodynamic size fraction; however, when suspended in liquid for CCSEM and LPC analyses, GM particle size decreased by a factor of two (p < 0.001) suggesting that alloy particles detach in liquid. Detachment of particles in liquid could have significance for the expected versus actual size (and number) distribution of aerosol delivered to an exposure subject. Thus, a suite of complimentary analytical techniques may be necessary for estimating size distribution. Consideration should be given to thoroughly understanding the influence of any liquid vehicle which may alter the expected aerosol size distribution

    Strain hardening of fcc metal surfaces induced by microploughing

    Get PDF
    Microploughing experiments were used as a method for better understanding the ploughing mechanism in gold and iridium single crystals. The plough depths ranged from 20 nm in iridium to 1,600 nm in gold. Yield stress profiles and TEM analyses indicate that both materials strain harden even when very small volumes of material are involved. Strain hardening theory, as applied to bulk material, is useful in analyzing the results
    • …
    corecore