Method of planetary atmospheric investigation using a split-trajectory dual flyby mode Patent

Planetary atmospheric investigation using split trajectory dual flyby mod

Identification of the High-Risk Gravida

In the past, there has been considerable pessimism about our ability to identify the pregnant patient at risk. However, with the development of sophisticated diagnostic techniques these patients can be identified and with appropriate treatment their outcome can be improved. This paper presents the overall benefit of categorizing obstetrical patients, the method that has been developed at the Medical College of Virginia (MCV), and certain categories of high-risk obstetrical patients who continue to present problems and have unacceptably high complication rates

Vitamin and Mineral Intake Relative to the DRIs in Young Adults

INTRODUCTION: In general, most college-aged students live highly, and newly, independent lives. Although campuses offer wide varieties of food choices, most choices do not meet the standards set by the RDA or DRIs, per NHANES 1999-2000. METHODS: In order to document these eating patterns, 1001 male (n=379) and female (n=622) college-aged students quantified dietary intake for three consecutive days using the food log method. Assessment reports were generated and analyzed in order to determine the percentage of the DRI in both males and females, and groups with a BMI of less than 20 and greater than 30. Tests for correlation of micronutrient intake between gender and BMI was performed. RESULTS: Results show that a majority of this population do not meet the DRI standards in most categories of vitamins and minerals. Results also show that BMI has little to no relationship with optimal micronutrient intake. Food choices negatively impacted micronutrient levels

Big Maggots Dig Deeper: Size-Dependent Larval Dispersal in Flies

The ability of individual animals to select habitats optimal for development and survival can be constrained by the costs of moving through the environment. Animals that seek overwintering sites underground, for example, may be constrained by the energy required to burrow into the soil. We conducted field and laboratory studies to determine the relationship between individual size and overwintering site selection in the tephritid flies, Rhagoletis juglandis and Rhagoletis suavis. We also explored the effect of site selection on pupal mortality, parasitism, and the ability to emerge from overwintering sites after eclosion. In both species, and in both lab and field tests, larger pupae were found at deeper soil depths. In addition, marginally non-significant trends indicated pupae in deeper sites were 48 % more likely to survive the overwintering period. Finally, larger individuals were more likely to eclose and emerge from the soil at a given depth, but flies in deep overwintering sites were less likely to emerge from those sites than flies in shallow sites. Our data indicate that overwintering site selection represents a trade-off between avoiding predators and parasites that occur at shallow sites, and the energetic and mortality costs of burrowing to, overwintering in, and emerging from, deeper sites. The size-dependent overwintering site selection demonstrated here has implications for population dynamics and pest control strategies. Some fly control measures, such as the introduction of parasites or predators, will be mitigated when the deepest and least accessible overwintering pupae represent a disproportionately large amount of the population\u27s reproductive capacity

Analysis of mode choice for intercity travel: Application of a hybrid choice model to two distinct US corridors

With growing concerns about greenhouse gas emissions and traffic congestion, there is an emphasis on encouraging shifts to public transport, for both short and long distance travel. Major differences exist across countries in how successful these efforts are, and the United States is often used as the key example of a country with a strong resistance to shifting away from private car use. Even within the United States however, there is strong heterogeneity across regions and across different types of travellers. This paper seeks to add empirical evidence to understand the drivers of mode choice for intercity travel, using stated choice data from two major US intercity corridors: the Northeast Corridor (NEC) and the Cascade Corridor. We develop a hybrid choice model that allows for deterministic and random variations across travellers in their preferences, some of which can be linked to underlying attitudinal constructs. Our results highlight extensive heterogeneity and provide interesting insights into the drivers of behaviour, and the relationship between attitudes and actual choices. As an example, we see that for some groups, notably West Coast respondents, a stronger anti-car attitude is counter-acted by a reduced utility for non-car modes when making choices, possibly due quality of public transport provision. Similarly, for other groups, such as older and female travellers, a reduced concern for privacy, which would benefit public transport, is counter-acted by a stronger pro-car attitude. These findings highlight the complex way in which attitudes can influence choices and provide insights for targeted policy interventions. Through scenario testing, we also show how future modal split might change depending on how these patterns of heterogeneity evolve over time, noting that the way this might happen is of course unknown at present

Blunt traumatic aortic injury: Initial experience with endovascular repair

ObjectivesEndovascular treatment of traumatic aortic injury (TAI) is an alternative to open repair (OR) in patients with blunt trauma. We report our initial experience after integration of endovascular repair using thoracic devices.MethodsA retrospective review of a prospectively collected institutional trauma registry was performed. Between September 2005 and November 2008, 71 patients with TAI presented to our institution. Based on imaging, TAIs were classified into grade 1-4 in severity. These included: grade 1, intimal tear; grade 2, intramural hematoma; grade 3, aortic pseudoaneurysm; and grade 4, free rupture. Initial management included resuscitation, blood pressure control, and treatment of associated injuries. After stabilization, all patients were considered for thoracic endovascular aortic repair (TEVAR) using a thoracic device. If contraindicated, candidates underwent OR. Outcome measures were mortality, stroke, paraplegia, intensive care unit (ICU), and hospital stay.ResultsThe mean age was 39.8 years, with 50 males. The mean injury severity score (ISS) was 42.6. Nineteen (27%) patients with a mean ISS of 60 died shortly after arrival prior to any vascular intervention. Ten (14%) patients with grade 1 injuries were managed medically. The remaining 42 (59%) patients with grade 2 and 3 injuries underwent repair. Median interval between admission and repair was 4.3 days (range, 0-109 days). Fifteen (21%) patients with a mean ISS of 34.4 underwent OR with no mortality, stroke, or paraplegia. Twenty-seven (38%) patients with a mean ISS of 36.7 underwent TEVAR with no mortality or paraplegia. One TEVAR patient suffered a perioperative stroke. Twenty-two patients had a TAG (W.L. Gore & Associates, Flagstaff, Ariz) device. Four patients had a Talent Thoracic (Medtronic Vascular, Santa Rosa, Calif), and 1 patient had an Excluder (W.L. Gore) device. The left subclavian artery was covered in 13 (48%) patients. Patients who underwent TEVAR were older than those who had OR (47.8 vs 31.1 years, P < .006). The aortic diameter proximal to the injury was larger in the TEVAR group (24.4 vs 19.6 mm, P < .0001). There was no difference in the mean ICU or hospital length of stay between the two groups. Mortality correlated with the ISS score (P < .0001). Median follow-up time was 19.4 months (range, 0-27). Only 56% of the TEVAR patients were fully compliant with their surveillance imaging protocol.ConclusionIn this initial experience, the results of TEVAR did not differ from OR. Long-term follow-up is required to determine the effectiveness of this treatment strategy. Adherence to follow-up imaging protocols is challenging in this patient population. Next generation devices will make TEVAR applicable to a wider range of patients

Postoperative renal function preservation with nonischemic femoral arterial cannulation for thoracoabdominal aortic repair.

BACKGROUND: Renal failure after thoracoabdominal aortic repair is a significant clinical problem. Distal aortic perfusion for organ and spinal cord protection requires cannulation of the left femoral artery. In 2006, we reported the finding that direct cannulation led to leg ischemia in some patients and was associated with increased renal failure. After this finding, we modified our perfusion technique to eliminate leg ischemia from cannulation. In this article, we present the effects of this change on postoperative renal function. METHODS: Between February 1991 and July 2008, we repaired 1464 thoracoabdominal aortic aneurysms. Distal aortic perfusion was used in 1088, and these were studied. Median patient age was 68 years, and 378 (35%) were women. In September 2006, we began to adopt a sidearm femoral cannulation technique that provides distal aortic perfusion while maintaining downstream flow to the leg. This was used in 167 patients (15%). We measured the joint effects of preoperative glomerular filtration rate (GFR) and cannulation technique on the highest postoperative creatinine level, postoperative renal failure, and death. Analysis was by multiple linear or logistic regression with interaction. RESULTS: The preoperative GFR was the strongest predictor of postoperative renal dysfunction and death. No significant main effects of sidearm cannulation were noted. For peak creatinine level and postoperative renal failure, however, strong interactions between preoperative GFR and sidearm cannulation were present, resulting in reductions of postoperative renal complications of 15% to 20% when GFR was \u3c60 mL\u3e/min/1.73 m(2). For normal GFR, the effect was negated or even reversed at very high levels of GFR. Mortality, although not significantly affected by sidearm cannulation, showed a similar trend to the renal outcomes. CONCLUSION: Use of sidearm cannulation is associated with a clinically important and highly statistically significant reduction in postoperative renal complications in patients with a low GFR. Reduced renal effect of skeletal muscle ischemia is the proposed mechanism. Effects among patients with good preoperative renal function are less clear. A randomized trial is needed

Suppressed CO emission and high G/D ratios in z=2 galaxies with sub-solar gas-phase metallicity

We study a population of significantly sub-solar enrichment galaxies at z=1.99, to investigate how molecular gas, dust and star-formation relate in low-metallicity galaxies at the peak epoch of star-formation. We target our sample with several deep ALMA and VLA datasets, and find no individual detections of CO[4-3], CO[1-0] or dust, in stark contrast to the >60% detection rate expected for solar-enrichment galaxies with these MS Halpha SFRs. We find that both low and high density molecular gas (traced by CO[1-0] and CO[4-3] respectively) are affected by the low enrichment, showing sample average (stacked) luminosity deficits >0.5-0.7 dex below expectations. This is particularly pertinent for the use of high-J CO emission as a proxy of instantaneous star-formation rate. Our individual galaxy data and stacked constraints point to a strong inverse dependence ∝Zγ of gas-to-dust ratios (G/D) and CO-to-H2 conversion factors (aco) on metallicity at z∼2, with γG/D<-2.2 and γαCO<-0.8, respectively. We quantify the importance of comparing G/D and aco vs. metallicity trends from the literature on a common, suitably normalised metallicity scale. When accounting for systematic offsets between different metallicity scales, our z∼2 constraints on these scaling relations are consistent with the corresponding relations for local galaxies. However, among those local relations, we favour those with a steep/double power-law dependence of G/D on metallicity. Finally, we discuss the implications of these findings for (a) gas mass measurements for sub-M∗ galaxies, and (b) efforts to identify the characteristic galaxy mass scale contributing most to the comoving molecular gas density at z=2

The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens

Spironucleus vortens is a protozoan parasite associated with significant mortalities in the freshwater angelfish, Pterophyllum scalare. Control of this parasite is especially problematic due to restrictions on the use of the drug of choice, metronidazole (MTZ), on fish farms. Use of garlic (Allium sativum) is undergoing a renaissance following experimental validations of its antimicrobial efficiency. Ajoene ((E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide), is a stable transformation product of allicin, the primary biologically active component of garlic. In the current study, an ajoene oil crude extract had a minimum inhibitory concentration (MIC) of 40 μg/ml against S. vortens. GC-MS and NMR spectroscopy revealed this ajoene extract contained a mixture of the (E) and (Z)-ajoene isomers along with diallyl disulphide (DADS) and diallyl trisulphide (DATS). The only component of the ajoene crude oil found to substantially inhibit S. vortens growth by optical density monitoring (Bioscreen C Reader) was (Z)-ajoene (MIC 16 μg/ml). Ajoene oil acted in synergy with MTZ in vitro, reducing the individual MIC of this drug (4 μg/ml) by 16-fold, and that of ajoene oil by 200-fold with a fractional inhibitory concentration (FIC) index of 0.263. This synergistic interaction was confirmed in vivo. S. vortens-infected P. scalare angelfish dosed orally with 0.5% (v/w) MTZ combined with 0.05% (v/w) ajoene displayed a significant reduction in faecal trophozoite count, whilst those fed on 0.5% MTZ flakes (half the recommended oral dose) alone did not. This study demonstrates for the first time the synergistic interaction between the synthetic drug MTZ and natural ajoene oil both in vitro and in vivo. Future work should evaluate the potential synergy of ajoene and MTZ against MTZ-resistant bacteria and protists