Digital Integration: Understanding the Concept and its Environmental Predictors

This study investigates the impact of environmental factors on the decision to electronically integrate operations with international customers and/or suppliers. The following research question motivates the study: How does the environmental context affect the level of electronic integration of an organization with its international partners? This study elaborates on the concept of electronic integration. Studies on integration in general and electronic integration in particular adopt a loose definition of integration: they all agree in that integration is the opposite of markets, but they define this opposite in different terms: relationship contracting, long-term contracting, coordination, etc. Finally, the study also responds to Wathne and Heide’s (2004) call for a more comprehensive study of governance mechanisms in B2B, with emphasis on monitoring mechanisms

The Effect of Multigrade Classes on Cognitive and non- Cognitive Skills. Causal Evidence Exploiting Minimum Class Size Rules in Italy

We analyse how schooling in multigrade classes affects the formation of student cognitive and non-cognitive skills. Our identification strategy is based on some institutional features of the Italian educational system establishing a minimum number of students per class. Classes that do not reach the minimum number of pupils are organized in multigrade classes. In addition, the Italian law also establishes a maximum number of students for multigrade classes, which implies that class size in multigrade classes is very similar to class size in small single grade classes with a number of students just above the minimum size. Using census data on 5th grade Italian students, we find that pupils in multigrade classrooms obtain worse test scores both in literacy and numeracy standardised tests compared to comparable pupils in single grade classroom. While the effect is small and not always statistically significant for the literacy score, we find a large and highly statistically significant effect on the numeracy score. We also find that pupils placed in multigrade classes tend to have a more external centred locus of control. Our results are robust to different specifications including controls for class size and a number of student and school characteristics

Caenorhabditis elegans Histone Methyltransferase MET-2 Shields the Male X Chromosome from Checkpoint Machinery and Mediates Meiotic Sex Chromosome Inactivation

Meiosis is a specialized form of cellular division that results in the precise halving of the genome to produce gametes for sexual reproduction. Checkpoints function during meiosis to detect errors and subsequently to activate a signaling cascade that prevents the formation of aneuploid gametes. Indeed, asynapsis of a homologous chromosome pair elicits a checkpoint response that can in turn trigger germline apoptosis. In a heterogametic germ line, however, sex chromosomes proceed through meiosis with unsynapsed regions and are not recognized by checkpoint machinery. We conducted a directed RNAi screen in Caenorhabditis elegans to identify regulatory factors that prevent recognition of heteromorphic sex chromosomes as unpaired and uncovered a role for the SET domain histone H3 lysine 9 histone methyltransferase (HMTase) MET-2 and two additional HMTases in shielding the male X from checkpoint machinery. We found that MET-2 also mediates the transcriptional silencing program of meiotic sex chromosome inactivation (MSCI) but not meiotic silencing of unsynapsed chromatin (MSUC), suggesting that these processes are distinct. Further, MSCI and checkpoint shielding can be uncoupled, as double-strand breaks targeted to an unpaired, transcriptionally silenced extra-chromosomal array induce checkpoint activation in germ lines depleted for met-2. In summary, our data uncover a mechanism by which repressive chromatin architecture enables checkpoint proteins to distinguish between the partnerless male X chromosome and asynapsed chromosomes thereby shielding the lone X from inappropriate activation of an apoptotic program

Recognition and treatment of peri-implant mucositis: Do we have the right perception? A structured review

Peri-implant mucositis is a common inflammatory lesion of the soft tissues surrounding endosseous implants, with no loss of the supporting bone. Its prevention or early diagnosis are vital for dental implant success.The aim of this review was to investigate knowledge strengths and gaps in clinicians' perceptions of periimplant mucositis prevalence and evidence for successful treatment.A literature search for articles published until 2020, reporting on the prevalence of peri-implant mucositis and its treatment was performed in standard online databases. The inclusion criteria were as follows: studies in English; studies with an available abstract; studies on humans with at least 1 dental implant; and studies reporting on the prevalence and/or treatment of peri-implant mucositis. Sixty-five studies fulfilled the inclusion criteria. The included papers were analyzed to identify data on the prevalence and treatment of peri-implant mucositis. The prevalence statistics for peri-implant mucositis had wide ranges in both the patient-based (PB) analysis and the implant-based (IB) analysis; the possible reasons for these wide ranges are discussed. Treatment methods for peri-implant mucositis were analyzed individually and compared to the management of gingivitis.It was determined that the currently available information on the prevalence rates and the standardized therapeutic protocols for peri-implant mucositis are insufficient. Since the mean gingivitis and peri-implant mucositis prevalence rates in the PB analysis were similar, it is possible that peri-implant mucositis is underestimated due to variables related to implant rehabilitation itself

Death rates from malaria epidemics, Burundi and Ethiopia.

Death rates exceeded emergency thresholds at 4 sites during epidemics of Plasmodium falciparum malaria in Burundi (2000-2001) and in Ethiopia (2003-2004). Deaths likely from malaria ranged from 1,000 to 8,900, depending on site, and accounted for 52% to 78% of total deaths. Earlier detection of malaria and better case management are needed

Public IT Policies in Less Developed Countries: A Critical Assessment of the Literature and a Reference Framework for Future Work

How well do extant diffusion models originating in developed countries explain adoption of information technologies in less developed countries? m a t is the current status of the literature with respect to public IT policies? The authors explore the literature on public IT policies to answer these questions. Findings indicate that, due to differences in environmental factors, existing models may not be readily applicable to less developed countries without careful consideration of the structural differences between developed countries -where most models originated- and less developed countries. Within extant studies of public IT policies, this article identifies typical research characteristics - e.g., case study methodologies, single country selection, single project scope, and little theory development. Finally, an integrative framework for the rationalization of existing models is proposed

Conscientisation and Communities of Compost: Rethinking management pedagogy in an age of climate crises

The unprecedented scale of the climate crisis has led to a questioning of conventional approaches to sustainability in management education, centred around business case for sustainability narratives. Such critique gives rise to serious questions around how we approach teaching the universality of the climate crisis, species extinction and biodiversity loss differently. Working with Freire’s stress on the political role of the educator, action rooted in the concrete, and the interconnections he establishes between pedagogy and political organization, our contribution is to connect these interventions with Haraway’s (2016) call to stay ‘with the trouble’ and generate Communities of Compost - that is, collective more than human communities of multi-species flourishing. In doing so, we propose threading together ecocentric and political economy approaches in management education, to present an alternative to corporate sustainability solutionism and to politically rethink scalar mismatches - that is when problems and proposed ‘solutions’ to the climate crisis apply to different sets of relations. As a way of addressing this, we develop pedagogical practices around Haraway’s multi-species Communities of Compost and combine this with the political movement of La Via Campesina - focusing on its campaigns for agroecology and food sovereignty

Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes.

This paper describes the effectiveness of first-line regimens for stage 2 human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense infection in nine Médecins Sans Frontières HAT treatment programmes in Angola, Republic of Congo, Sudan and Uganda. Regimens included eflornithine and standard- and short-course melarsoprol. Outcomes for 10461 naïve stage 2 patients fitting a standardised case definition and allocated to one of the above regimens were analysed by intention-to-treat analysis. Effectiveness was quantified by the case fatality rate (CFR) during treatment, the proportion probably and definitely cured and the Kaplan-Meier probability of relapse-free survival at 12 months and 24 months post admission. The CFR was similar for the standard- and short-course melarsoprol regimens (4.9% and 4.2%, respectively). The CFR for eflornithine was 1.2%. Kaplan-Meier survival probabilities varied from 71.4-91.8% at 1 year and 56.5-87.9% at 2 years for standard-course melarsoprol, to 73.0-91.1% at 1 year for short-course melarsoprol, and 79.9-97.4% at 1 year and 68.6-93.7% at 2 years for eflornithine. With the exception of one programme, survival at 12 months was >90% for eflornithine, whilst for melarsoprol it was <90% except in two sites. Eflornithine is recommended where feasible, especially in areas with low melarsoprol effectiveness

Closing the Gender Gap ? Life Competences and Social Environment

This paper investigates whether adult proficiency formation is affected by social environments. Using the Italian sample of the ALL survey conducted in 2003, which includes cohorts born between 1938 and 1988, we exploit temporal and regional variations in indicators of women empowerment to assess whether more progressive environments favour the reduction dynamics of the gender gap. Results suggest that environmental factors matter but they do not have a gender differential effect. Adult proficiency is higher for individuals grown in more progressive societies in terms of female labour market participation, women political empowerment, female sexual emancipation and laity

Re-testing PISA Students One Year Later: On School Value Added Estimation Using OECD-PISA

Thanks to the effort of two local educational authorities, in two regions of North Italy (Valle d\u2019Aosta and the autonomous province of Trento) the PISA 2009 test was re-administered to the same students one year later. This paper is the first to analyse in the OECD-PISA context the potential advantages of re-testing the same students in order to provide better measures of schools\u2019 contributions to student achievement. We show that while cross-sectional measures of school value added based on PISA student literacy, which measures \u201cknowledge for life\u201d, tend to be very volatile over time whenever there is a high year-to-year attrition in the student population, longitudinal measures of school value added are very robust to student attrition (even without controlling for sample selection). Moreover, persistence in individual test scores tends to be higher in highly \u201cselective\u201d (i.e. high drop-out) school environments