The Work That Place Does: The London Landed Estates and a Curatorial Approach to Estate Management

Writings on urban development and planning in Europe have been dominated by a combination of technical studies of the real estate sector and more structural political economy approaches on land expropriation and financialisation. In this paper we draw on the example of the London Landed Estates, to critically assess how land-owning real estate companies, that we call cityowners, perform their roles and what models and knowledge sources they draw upon in managing and carefully curating urban spaces and places. Data sources include interviews with Estate Managers, others involved in, or affected by their management, and other corporate public information. Our theoretical framing draws on performativity theory that we see as a valuable addition to existing research approaches. We describe and analyse the ways these agencies construct narratives and practices of socially responsible and historically established forms of performance, that they label ‘place-stewardship’, and the specific mechanisms they use to bring places into existence. Collectively, the discussion calls for an increased focus on how models abstracted from local context and politics can be ‘localised’, in the study of the governance of the built environment. Greater attention also needs to be paid to the work that place does in influencing the strategies, tactics, and activities of property owners

Human lectins, their carbohydrate affinities and where to find them

POCI-01-0145-FEDER-007265Lectins are a class of proteins responsible for several biological roles such as cell-cell interactions, signaling pathways, and several innate immune responses against pathogens. Since lectins are able to bind to carbohydrates, they can be a viable target for targeted drug delivery systems. In fact, several lectins were approved by Food and Drug Administration for that purpose. Information about specific carbohydrate recognition by lectin receptors was gathered herein, plus the specific organs where those lectins can be found within the human body.publishersversionpublishe

The FuGas 2.5 updated for the effects of surface turbulence on the transfer velocity of gases at the atmosphere–ocean interface

Accurately estimating air–water gas exchanges requires considering other factors besides wind speed. These are particularly useful for coastal ocean applications, where the sea-state varies at fine spatial and temporal resolutions. We upgrade FuGas 2.5 with improved formulations of the gas transfer velocity parametrized based on friction velocity, kinetic energy dissipation, roughness length, air-flow conditions, drift current and wave field. We then test the algorithm with field survey data collected in the Baltic Sea during spring–summer of 2014 and 2015. Collapsing turbulence was observed when gravity waves were the roughness elements on the sea-surface, travelling at a speed identical to the wind. In such cases, the turbulence driven transfer velocities (from surface renewal and micro-scale wave breaking) could be reduced from 20 cm h1 to 5 cm h1. However, when peak gravity waves were too flat, they were presumably replaced by capillary-gravity waves as roughness elements. Then, a substantial increase in the turbulence and roughness length was observed, despite the low and moderate winds, leading to transfer velocities up to twice as large as those predicted by empirical u10-based formulations.FCT/MCTES (PIDDAC) through project LARSyS: FCT Pluriannual funding 2020-2023 UIDB/EEA/50009/2020; FCT: DL57/2016/CP [1361]/CT[0008].info:eu-repo/semantics/publishedVersio

Análise Retrospetiva Sobre a Utilização em Contexto Real do Ranibizumab em Doentes com Degenerescência Macular da Idade Exsudativa em Portugal

INTRODUCTION: Anti-vascular endothelial growth factor therapy has revolutionized the treatment of wet age-related macular degeneration; however, it is important to monitor actual use of ranibizumab and related treatment outcomes in routine practice. MATERIAL AND METHODS: This was a retrospective, observational study to monitor the 2-year outcomes following ranibizumab treatment for wet age-related macular degeneration in Portugal. Patients treated between January 2009 and December 2009 were retrospectively evaluated. All decisions were made by the treating physician in accordance with their usual routine clinical practice. The primary assessment was mean change in visual acuity score using Early Treatment Diabetic Retinopathy Study or Snellen equivalent. RESULTS: A total of 128 patients with wet age-related macular degeneration were analyzed (mean age 79.4 years; mean visual acuity score 54.2 letters). Mean change in visual acuity score from baseline was -1.6 letters (n = 82) at year one and -5.1 letters (n = 72) at year two. The mean number of ranibizumab injections was 3.8 (year one) and 1.6 (year two). On average, patients attended 8.6 and 5.0 visits and optical coherence tomography was used in 75.0% of patients in year one and in 56.3% of patients in year two, respectively. DISCUSSION: Despite a relatively high number of visits, including monitoring visits and use of optical coherence tomography - guided therapy, few injections were administered and visual acuity was not improved. CONCLUSION: These findings indicate that as-needed treatment resulted in under-dosing in a real-life setting in Portugal. Such limitations may also be related to increasing numbers of patients, resulting in clinic saturation.info:eu-repo/semantics/publishedVersio

Spectroscopy characterization of humic acids isolated from Amazonian dark earth soils (Terra Preta De Índio).

Description and morphologic characterization; Extraction, chemical fractionation and purification of the humic material; DRIFT Spectroscopy analysis

Top-Down Particle Fabrication: Control of Size and Shape for Diagnostic Imaging and Drug Delivery

This review discusses rational design of particles for use as therapeutic vectors and diagnostic imaging agent carriers. The emerging importance of both particle size and shape is considered, and the adaptation and modification of soft lithography methods to produce nanoparticles is highlighted. To this end, studies utilizing particles made via a process called Particle Replication In Non-wetting Templates (PRINT™) are discussed. In addition, insights gained into therapeutic cargo and imaging agent delivery from related types of polymer-based carriers are considered

PAPULO-NODULES LOCATED TO BOTH LOWER EXTREMITIES

As doenças perfurantes caracterizam-se por eliminação transepidérmica de queratina ou de componentes do tecido conjuntivo dérmico. A dermatose perfurante adquirida atinge sobretudo doentes com diabetes mellitus (DM) e insuficiência renal crónica (IRC), especialmente sob diálise. Um doente do sexo masculino de 86 anos de idade, com antecedentes de DM2, é observado com múltiplas lesões pruriginosas, papulosas e papulo-nodulares, de coloração eritemato-violácea, com crosta central. As lesões localizavam-se a ambos os membros inferiores e tinham 2 meses de evolução. A biópsia realizada mostrou solução de continuidade epidérmica preenchida por material fibroso e células picnóticas, com eliminação de feixes de fibras de colagénio verticalizadas (coloração de Van-Gieson). O doente foi medicado com retinóide tópico, com melhoria das lesões cutâneas.Perforating diseases are characterized by transepidermal elimination of degenerated material, including collagen or elastic fibers. Acquired perforating dermatosis affects patients with diabetes mellitus or renal disease, especially under dialysis. An 86-year-old diabetic patient presents with very pruritic erythematous-violaceus papules and papulo-nodules, with a central crust. Lesions were evoluting for 2 months and were located to both lower extremities. The biopsy revealed a depression with fibrinous material and picnotic cells. Van-Gieson coloration showed elimination of vertical collagen bundles. The patient was treated with topical retinoid, with complete resolution