Di-μ-oxido-bis-[(1,4,8,11-tetra-aza-cyclo-tetra-decane-κN,N',N'',N''')dimangan-ese(III,IV)] bis-(tetra-phenyl-borate) chloride acetonitrile disolvate.

The title compound, [Mn(2)O(2)(C(10)H(24)N(4))(2)](C(24)H(20)B)(2)Cl·2CH(3)CN, is a mixed-valent Mn(III)/Mn(IV) oxide-bridged mangan-ese dimer with one chloride and two tetra-phenyl-borate counter-anions. There are two non-coordinated mol-ecules of acetonitrile in the formula unit. A center of inversion is present between the two metal atoms, and, consequently, there is no distinction between Mn(III) and Mn(IV) metal centers. In the Mn(2)O(2) core, the Mn-O distances are 1.817 (3) and 1.821 (3) Å. The cyclam ligand is in the cis configuration. The chloride counter-anion resides on a center of symmetry, whereas the tetra-phenyl-borate counter-anion is in a general position. The cyclam ligand is hydrogen bonded to the acetonitrile as well as to the chloride anion. One of the phenyl rings of the anion and the acetonitrile solvent molecule are each disordered over two sets of sites

A SIMPLE WAY TO MEASURE THE DYNAMIC VISCOSITY OF A FLUID

In this paper, we measured the viscosity of different fluids, including edible oils and soaps, at a constant temperature, using two experimental methods. Namely, the falling ball and the oscillation of the mass-spring system inside a fluid. Three different masses were used to evaluate the viscosity obtained by the falling ball method. The results were very similar. More precision of the viscosity value is done using a calibration curve. The results are compared with those measured by the mass-spring system and they show good agreement. This simple way of viscosity measurement using mechanical physics concepts can be used for educational purposes such as the practical work of a bachelor

PENERAPAN MODEL MULTIMEDIA SEBAGAI MEDIA PEMBELAJARAN ALTERNATIF UNTUK MENINGKATKAN SELF MOTIVATED LEARNING DAN SELF REGULATED LEARNING

Teknologi multimedia merupakan Salah satu teknologi yang ditawarkan dalam media pembelajaran alternatif untuk dimanfaatkan dalam dunia pendidikan saat ini. Hardcopy yang digunakan dalam Proses Belajar Mengajar terkadang menyulitkan pelaku pendidikan dalam hal mengakses dan menerima informasi secara cepat dan realtime, sehingga memunculkan ide untuk mengembangkan materi pelajaran dalam bentuk multimedia, yang akan memudahkan pendidik dan peserta didik dalam menjalankan aktivitas dalam PMB. Kejenuhan belajar akan muncul Apabila pendidik selalu menggunakan metode yang konvensional secara terus menerus dan tanpa ada variasi, karena tidak ada warna baru dalam PBM. Implikasi dari metode belajar secara konvensional yang digunakan oleh tenaga pendidik, menunjukkan bahwa 20% atau lebih peserta didik kurang antusias dan berminat mempelajari materi, 35% atau lebih peserta didik kurang mempunyai inisiatif untuk mencari atau memperdalam wawasan melalui referensi lain selain yang diberikan oleh tenaga pendidik. Permasalahan lain adalah, ketersediaan sumber belajar di perpustakaan sangat minim, sehingga materi yang didapat pun kurang up to date. Hal ini semakin memperkuat permasalahan kurang berminat dan rendahnya inisiatif peserta didik dalam proses belajar mengajar.Pada penelitian ini,dikembangkan multimedia dan pemodelan multimedia yang dapat meningkatkan Self Motivated Learning dan Self Regulated Learning dengan menggunakan metode penelitian pengembangan research and development, dan analisi akhir dilakukan pengujian dengan bantuan SPSS.Model digitalisasi media pembelajaran ini mampu membuat peserta didik menjadi tertarik untuk belajar secara aktif dan mandiri

MTOR cross-talk in cancer and potential for combination therapy

The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions. mTOR functions through two functionally and structurally distinct multi-component complexes, mTORC1 and mTORC2, which interact with each other and with several elements of other signaling pathways. In the past few years, many new insights into mTOR function and regulation have been gained and extensive genetic and pharmacological studies in mice have enhanced our understanding of how mTOR dysfunction contributes to several diseases, including cancer. Single-agent mTOR targeting, mostly using rapalogs, has so far met limited clinical success; however, due to the extensive cross-talk between mTOR and other pathways, combined approaches are the most promising avenues to improve clinical efficacy of available therapeutics and overcome drug resistance. This review provides a brief and up-to-date narrative on the regulation of mTOR function, the relative contributions of mTORC1 and mTORC2 complexes to cancer development and progression, and prospects for mTOR inhibition as a therapeutic strategy

PENGARUH PENGGUNAAN BERBAGAI LEVEL KONSENTRAT MENGANDUNG ZnSO4 dan Zn-Cu ISOLEUSINAT TERHADAP PENGGUNAAN ENERGI KAMBING KACANG YANG MENGKONSUMSI SILASE SORGHUM–Clitoria ternatea (The effect of different level of concentrate additioncontaining ZnSo4....

The aim of this research was to measure the effect of different level of concentrate addition containing znso4 and zn-cu isoleusinat on energy utilization of kacang goats fed mixed silage of sorghum-clitoria ternatea. Twelve male kacang goats with average body weight 14.4 kg and 14.93 % coefficient of variation was used in this research. Experiment methode was used with research design was block randomised design consist of 4 treatments and 3 replications. The treatments were: T1: mixed silage of sorghum-Clitoriaternatea without concentgrate; T2; T3 and T4 was mixed silage of sorghum-Clitoriaternatea added by 10, 20 and 30 % of concentrate containg of 150 mg ZnSO4  and 2 % of Zn-Cu isoleusinat respectively. Parameter measured was consumnption and digestibility of anergy and blood glucose concentration. The result showed that addition of different level of concentrate containing ZnSO4 and Zn-Cu isoleusinatfollowed by increase of consumption and digestibility of energy and blood glucose concentration. It can be concluded the amount of concentrate providing containing of ZnSO4 and Zn-Cu isoleusinathad effect on  energy consumption while no effect on digestibility of energy and blood glucose concentration. Further more 20 % of concentrate containg of ZnSO4 and Zn-Cu isoleusinat was the greatest level

Role of mTOR signaling in tumor microenvironment. An overview

The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME). In recent years, it has been well recognized that cancer cells co-exist and co-evolve with their TME, which is often involved in drug resistance. The mTOR pathway modulates the interactions between the stroma and the tumor, thereby affecting both the tumor immunity and angiogenesis. The activation of mTOR signaling is associated with these pro-oncogenic cellular processes, making mTOR a promising target for new combination therapies. This review highlights the role of mTOR signaling in the characterization and the activity of the TME’s elements and their implications in cancer immunotherapy

First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer

AIM: To investigate activity, toxicity, and prognostic factors for survival of erlotinib and fixed dose-rate gemcitabine (FDR-Gem) in advanced pancreatic cancer. METHODS: We designed a single-arm prospective, multicentre, open-label phase II study to evaluate the combination of erlotinib (100 mg/d, orally) and weekly FDR-Gem (1000 mg/m2, infused at 10 mg/m2per minute) in a population of previously untreated patients with locally advanced, inoperable, or metastatic pancreatic cancer. Primary endpoint was the rate of progression-free survival at 6 mo (PFS-6); secondary endpoints were overall response rate (ORR), response duration, tolerability, overall survival (OS), and clinical benefit. Treatment was not considered to be of further interest if the PFS-6 was < 20% (p0 = 20%), while a PFS-6 > 40% would be of considerable interest (p1 = 40%); with a 5% rejection error (α = 5%) and a power of 80%, 35 fully evaluable patients with metastatic disease were required to be enrolled in order to complete the study. Analysis of prognostic factors for survival was also carried out. RESULTS: From May 2007 to September 2009, 46 patients were enrolled (male/female: 25/21; median age: 64 years; median baseline carbohydrate antigen 19-9 (CA 19-9): 897 U/mL; locally advanced/metastatic disease: 5/41). PFS-6 and median PFS were 30.4% and 14 wk (95%CI: 10-19), respectively; 1-year and median OS were 20.2% and 26 wk (95%CI: 8-43). Five patients achieved an objective response (ORR: 10.9%, 95%CI: 1.9-19.9); disease control rate was 56.5% (95%CI: 42.2-70.8); clinical benefit rate was 43.5% (95%CI: 29.1-57.8). CA 19-9 serum levels were decreased by > 25% as compared to baseline in 14/23 evaluable patients (63.6%). Treatment was well-tolerated, with skin rash being the most powerful predictor of both longer PFS (P < 0.0001) and OS (P = 0.01) at multivariate analysis (median OS for patients with or without rash: 42 wk vs 15 wk, respectively, Log-rank P = 0.03). Additional predictors of better outcome were: CA 19-9 reduction, female sex (for PFS), and good performance status (for OS). CONCLUSION: Primary study endpoint was not met. However, skin rash strongly predicted erlotinib efficacy, suggesting that a pharmacodynamic-based strategy for patient selection deserves further investigation

Pendapatan Pengrajin Tenun Ikat “Ina Ndao” Di Kelurahan Naikoten I Kecamatan Kota Raja Kupang

Rumah Tenun Ikat “INA NDAO” telah menghasilkan produk kerajinan berupa kain tenun dengan bentuk yang beragam. Bentuk-bentuk yang dimaksud misalnya, motif Buna, Sotis dan Motif ikat. Harga jual dari masing-masing motif bervariasi. Selain dalam bentuk kain  ikat juga dimodifikasi menjadi baju, topi, rompi dan tas yang dapat langsung di pasarkan. Terdapat 20 orang tenaga kerja yang menghasilkan kerajinan tenun ikat. Untuk 14 orang tenaga kerja memiliki penghasilan di atas Upah Minimum Provinsi karena mereka telah mampu menghasilkan produk kerajinan dalam jumlah banyak dan motif yang bervariasi dalam sebulan sedangkan untuk empat orang tenaga kerja memiliki pendapatan di bawah dari UMP. Hal ini disebabkan oleh kerajinan yang dihasilkan dalam jumlah yang terbatas. Pemerintah dan swasta diharapkan memberikan perhatian dan dukungan terhadap pengembangan usaha yang bersifat promosi hasil kerajinan yang bernuansa budaya

Improving the capacity of the Head of the sub civil service in regional apparatus organisation of the government in Malaka district

Purpose: The purpose of this study was to examine the human resource capacity of the Head of Personnel Subdivision in the Organization of the Scope of the Malaka Regency Government, to find out supporting factors and constraints of the Human Resources Capacity its function and to find out the efforts taken by the Organization of the Regional Government of the Malaka Regency in increasing the capacity of Human Resources Head of Personnel Sub Division. Research methodology: The research method used in research was qualitative research methods with the type of case studies. Results: This study’s results are that human resource capacity is inadequate due to the low educational qualifications held by the Head of Personnel Sub-division within the scope of the Malaka district government. Limitation: This study’s limitation is that this research only focuses on the phenomena in the Malaka Regency so that the results of similar research can produce different findings if carried out on other research objects. Contribution: This research’s contribution is that it can provide scientific information for students of public administration programs and can be a scientific reference in the formulation and development of civil service innovations within the local government of Malaka Regency. Keywords: Capacity, Regional apparatus organizatio

Constructing Agency: The Role of Language

Is agency a straightforward and universal feature of human experience? Or is the construction of agency (including attention to and memory for people involved in events) guided by patterns in culture? In this paper we focus on one aspect of cultural experience: patterns in language. We examined English and Japanese speakers’ descriptions of intentional and accidental events. English and Japanese speakers described intentional events similarly, using mostly agentive language (e.g., “She broke the vase”). However, when it came to accidental events English speakers used more agentive language than did Japanese speakers. We then tested whether these different patterns found in language may also manifest in cross-cultural differences in attention and memory. Results from a non-linguistic memory task showed that English and Japanese speakers remembered the agents of intentional events equally well. However, English speakers remembered the agents of accidents better than did Japanese speakers, as predicted from patterns in language. Further, directly manipulating agency in language during another laboratory task changed people’s eye-witness memory, confirming a possible causal role for language. Patterns in one’s linguistic environment may promote and support how people instantiate agency in context