363 research outputs found
An introduction to the theory and practice of MOVE progression accords.
MOVE progression accords identify specific vocational progression routes from both further
education and the workplace to and through higher education. This includes the provision of
guaranteed places on higher education programmes of study and other agreed collaborative
activities designed to support and prepare learners for progression to higher education.
MOVE progression accords are designed to promote vocational progression opportunities
and to encourage the engagement of employers in supporting progression to higher level
learning in collaboration with MOVE and its partner institutions in the region. In signing the
accord, partners are also committing to implementing an agreed set of ârequiredâ activities
designed to ensure that the accords are seen as a supported, collaborative process between
the practitioners and the learners involved. There is also a list of optional ârecommendedâ
activities. Our approach is predicated on the belief that this shared professional learning will
help to effect behavioural and culture changes that will underpin the continuing success and
sustainability of the accords
Fiscaal overgangsbeleid : een raamwerk voor het vormgeven en beoordelen van het overgangsbeleid van de fiscale wetgever
In the Netherlands amendments to fiscal legislation are almost a daily routine. Exemptions or deductible items applicable today might be abolished next year. The legislator faces two questions with each legislative amendment: when to enact new rules, and whether they should apply to everybody or whether exceptions should apply in certain cases. Miscellaneous factors affect the solution to these questions. A major factor is the trust that civilians may have as regards the continuance of the former rule. Another regards the taxpayersâ reaction to the announcement of a legislative amendment. To date, the factors affecting aforementioned decisions have not yet been systematically listed. The goal of this research is to develop a framework for fiscal transition policy. Firstly, the framework comprises an assessment framework for fiscal transitional law. The assessment framework provides concrete guidelines for both drafting transitional law and assessing existing transitional regimes. It is a product of the framework for fiscal transition policy, as it incorporates both the policy-related actions of the legislator and taxpayersâ behaviour. Secondly, the framework contains rules of thumb for the legislator for pursuing a fiscal transition policy.Grenzen van fiscale soevereinitei
Evolving a DSL implementation
Domain Specific Languages (DSLs) are small languages designed for use in a specific domain. DSLs typically evolve quite radically throughout their lifetime, but current DSL implementation approaches are often clumsy in the face of such evolution. In this paper I present a case study of an DSL evolving in its syntax, semantics, and robustness, implemented in the Converge language. This shows how real-world DSL implementations can evolve along with changing requirements
Psoas abscess: report of a series and review of the literature
We describe a series of twelve patients with a psoas abscess seen in a
three-year period in a university hospital and a large teaching hospital
in the Netherlands. In our series, five of the 12 patients had a primary
psoas abscess. The predisposing conditions were intravenous drug use,
diabetes mellitus, prostate carcinoma and haematoma in the psoas muscle in
a patient with haemophilia A. Seven of the 12 patients had a secondary
psoas abscess. Five cases were due to vertebral osteomyelitis including
two cases of tuberculosis. In the other two cases it was due to colitis
and urinary tract infection. It is remarkable that in our series there was
only one patient with a psoas abscess secondary to a disease of the
digestive tract, while this is the most common cause of a secondary psoas
abscess in the literature. There were two cases of tuberculosis which is
an emerging disease again
Sawja: Static Analysis Workshop for Java
Static analysis is a powerful technique for automatic verification of
programs but raises major engineering challenges when developing a full-fledged
analyzer for a realistic language such as Java. This paper describes the Sawja
library: a static analysis framework fully compliant with Java 6 which provides
OCaml modules for efficiently manipulating Java bytecode programs. We present
the main features of the library, including (i) efficient functional
data-structures for representing program with implicit sharing and lazy
parsing, (ii) an intermediate stack-less representation, and (iii) fast
computation and manipulation of complete programs
Ground reaction forces during walking with different load and slope combinations in rats
BACKGROUND: Treadmill animal models are commonly used to study effects of exercise on bone. Since mechanical loading induces bone strain, resulting in bone formation, exercise that induces higher strains is likely to cause more bone formation. Our aim was to investigate the effect of slope and additional load on limb bone strain. METHODS: Horizontal and vertical ground reaction forces on left fore-limb (FL) and hind-limb (HL) of twenty 23-week old female Wistar rats (weight 279 ± 26 g) were measured for six combinations of SLOPE (-10°, 0°, +10°) and LOAD (0 to 23% of body mass). Peak force (Fmax), rate of force rise (RC), stance time (Tstance) and impulse (Fint) on FLs and HLs were analyzed. RESULTS: For the FL, peak ground reaction forces and rate of force rise were highest when walking downward -10° with load (Fmax = 2.09±0.05 N, FLRC = 34±2 N/s) For the HL, ground reaction forces and rate of force rise were highest when walking upward +10°, without load (Fmax = 2.20±0.05 N, HLRC = 34±1 N/s). Load increased stance time. Without additional load, estimates for the highest FL loading (slope is -10°) were larger than for the highest HL loading (slope is +10°) relative to level walking. CONCLUSIONS: Thus, walking downward has a higher impact on FL bones, while walking upward is a more optimal HL exercise. Additional load may have a small effect on FL loading
In Vivo Mechanical Loading Modulates Insulin-Like Growth Factor Binding Protein-2 Gene Expression in Rat Osteocytes
Mechanical stimulation is essential for maintaining skeletal integrity. Mechanosensitive osteocytes are important during the osteogenic response. The growth hormone-insulin-like growth factor (GH-IGF) axis plays a key role during regulation of bone formation and remodeling. Insulin-like growth factor binding proteins (IGFBPs) are able to modulate IGF activity. The aim of this study was to characterize the role of IGFBP-2 in the translation of mechanical stimuli into bone formation locally in rat tibiae. Female Wistar rats were assigned to three groups (n = 5): load, sham, and control. The four-point bending model was used to induce a single period of mechanical loading on the tibial shaft. The effect on IGFBP-2 mRNA expression 6 hours after stimulation was determined with nonradioactive in situ hybridization on decalcified tibial sections. Endogenous IGFBP-2 mRNA was expressed in trabecular and cortical osteoblasts, some trabecular and subendocortical osteocytes, intracortical endothelial cells of blood vessels, and periosteum. Megakaryocytes, macrophages, and myeloid cells also expressed IGFBP-2 mRNA. Loading and sham loading did not affect IGFBP-2 mRNA expression in osteoblasts, bone marrow cells, and chondrocytes. An increase of IGFBP-2 mRNA-positive osteocytes was shown in loaded (1.68-fold) and sham-loaded (1.35-fold) endocortical tibial shaft. In conclusion, 6 hours after a single loading session, the number of IGFBP-2 mRNA-expressing osteocytes at the endosteal side of the shaft and inner lamellae was increased in squeezed and bended tibiae. Mechanical stimulation modulates IGFBP-2 mRNA expression in endocortical osteocytes. We suggest that IGFBP-2 plays a role in the lamellar bone formation process
Microalbuminuria and Cardiovascular Autonomic Dysfunction Are Independently Associated With Cardiovascular Mortality: Evidence for Distinct Pathways: The Hoorn Study
) or microalbuminuria (1.76 [1.05-2.94]), respectively. CONCLUSIONS: Both microalbuminuria and C-AD are independently associated with cardiovascular mortality, and the excess mortality attributable to microalbuminuria cannot be explained by C-A
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