ADOPTION ASSESSMENT OF NUTRITIONAL TECHNOLOGIES BY DAIRY CATTLE SMALLHOLDERS

This study aimed at characterizing nutritional packages adoption by the small dairy farmers under crop-livestock production system. The study is based on quantitative and qualitative statistical analysis. A cross-sectional random survey covered a total of 200 farmers located in 4 governorates Sharqia, Monufia, El-Fayoum, and Minya (50 each). The socio-economic analysis indicated that the illiteracy level was higher (42%) in Minya governorate as compared to others. about half of the households (49%) have been working full time in their farms as farmer this means that they earn their living from agriculture. Family labor represented the highest percentage being 88%, 92%, 80%, and 86% for Sharqia, Monufia, El-Fayoum, and Minya respectively. The results further indicated that farmers who used silage, hay, and green forages, have the highest animal numbers, either from indigenous cows, crossbred cows, buffaloes, sheep, goat, and donkey compared to those who do not use the nutritional packages (non-adopters). The highest percentage of dairy, heifer, fattening, and growing for crossbred cows and buffaloes was detected under silage, hay, and untraditional green forages adopters comparable to those detected under non-adopters. Sharqia governorate had the highest number and consequently percentage of animals followed by El-Fayoum governorate. Silage adopters recorded the highest significant (P<0.05) value of daily milk yield (DMY) and total milk yield (TMY) for indigenous cow, crossbred cow and buffalo as compared to non-adopters. Calving interval significantly (P<0.05) increased for all dairy animals (indigenous cows, crossbred cows, and buffaloes) under non-adopters of nutritional packages being 387, 388.57, and 402 days for the aforementioned animals, respectively. Dairy animals reared under the Nile Delta had the highest significant DMY versus those under the Middle Egypt, where it was 4.05, 8.52, and 7.29 kg vs 3.76, 7.74, and 6.48 kg per day for indigenous cows, crossbred cows, and buffaloes, respectively. In conclusion, adopters of nutritional packages had the highest animal percent and recorded the highest productivity compared to non-adopters

Farnesol attenuates cadmium-induced kidney injury by mitigating oxidative stress, inflammation and necroptosis and upregulating cytoglobin and PPARγ in rats

Heavy metals are environmental pollutants that can harm animals and humans even at low concentrations. Cadmium (Cd) is known for its serious health effects on different organs and its toxicity is associated with oxidative stress (OS) and inflammation. Farnesol (FAR), a sesquiterpene alcohol found in many vegetables and fruits, possesses promising anti-inflammatory and antioxidant activities. This study evaluated the effect of FAR on Cd-induced kidney injury, pinpointing its effect of the redox status, inflammation, fibrosis and necroptosis. Rats in this study received FAR for 14 days and Cd on day 7. Elevated serum creatinine, urea and uric acid, and several kidney histopathological alterations were observed in Cd-administered rats. Cd increased MDA, decreased antioxidants, downregulated PPARγ and upregulated NF-κB p65, IL-6, TNF-α, and IL-1β. Necroptosis mediators (RIP1, RIP3, MLKL, and caspase-8) and α-SMA were upregulated, and collagen deposition was increased in Cd-administered rats. FAR ameliorated kidney injury markers and tissue damage, attenuated OS, suppressed NF-κB and inflammatory mediators, and enhanced antioxidants. In addition, FAR suppressed RIP1, RIP3, MLKL, caspase-8, and α-SMA, and enhanced kidney cytoglobin and PPARγ. In conclusion, FAR protects against Cd nephrotoxicity by suppressing OS, inflammatory response and necroptosis, effects associated with enhanced antioxidants, cytoglobin, and PPARγ

Vascular Endothelial Growth Factor gene polymorphism (rs2010963) in ST- Segment Elevation Myocardial Infarction: An Egyptian Pilot Study

ST- segment elevation myocardial infarction (STEMI) is the most severe form of coronary artery disease. Vascular endothelial growth factor (VEGF-A) is critical in post- Myocardial Infarction (MI) angiogenesis. VEGF-A (rs2010963) gene polymorphism hasn’t been explored in Egyptian ethnicity. This study aimed to explore the role of the VEGF-A gene (rs2010963) polymorphism in STEMI and its outcome. It was carried out on 50 STEMI patients and 50 controls who gave blood samples for VEGF-A level estimation by ELISA and VEGF-A gene(rs2010963) polymorphism by real-time PCR. We revealed that VEGF-A level was higher in STEMI cases vs. control at baseline and in STEMI cases at 2-weeks vs. baseline. At a cut off value &gt; 20 pg/ml was a statistically significant discriminator of STEMI vs. control [AUC (95% CI) = 0.785 (0.692-0.861), sensitivity 82%, specificity 72%]. Participants with C/G-G/G genotypes of VEGF-A (rs2010963) had 2.8-times higher odds vs. those with C/C genotype to exhibit STEMI. C/G genotype was associated with highest VEGF-A level. STEMI participants with C/G genotype had 4.3-times higher odds vs. those with C/C-G/G genotype to exhibit poor outcome. In conclusions, VEGF-A level can discriminate STEMI cases from control. VEGF-A (rs2010963) gene polymorphism affects VEGF-A level, associated with risk of developing STEMI and affects clinical outcome

Propagation of Plane Waves in Generalized Piezo-thermoelastic Medium: Comparison Of Different Theories

ABSTRACT: In this paper, a general solution for the propagation of plane waves in generalized piezo-thermoelastic medium for two-dimensional problem under the different thermoelastic theories is investigated. We have included Coupled theory (CT), Lord-Schulman (L-S) and Green-Lindsay (G-L) theories. The normal mode analysis is used to obtain the exact expressions for the considered variables. The results of the physical quantities have been illustrated graphically by comparison between (CT), (L-S) and (G-L) theories. KEYWORDS: Piezo-thermoelastic, Relaxation time, Normal mode analysis, Generalized thermoelasticity. I INTRODUCTION Piezoelectric is considered one of the basic properties of crystals, ceramics, polymers, liquid crystals and some biological tissues (e.g. bone and tendon). Recent interest in the piezoelectric materials stems from their potential applications in intelligent structural systems, and piezoelectric is currently enjoying a greatest resurgence in both fundamental research and technical applications. The theory of thermo-piezoelectric was first proposed by Mindlin Thermoelasticity theories that predict a finite speed for the propagation of thermal signals have aroused much interest in the last three decades. These theories are known as generalized thermoelasticity theories. The first generalization of the thermoelasticity theory is due to Lord and Shulman [8] who introduced the theory of generalized thermoelasticity with one relaxation time through postulating a new law of heat conduction to replace the classical Fourier&apos; law. This law contains the heat flux vector as well as its time derivative. It contains also a new constant that acts as a relaxation time. The heat equation of this theory is of the wave-type which ensuring finite speeds of propagation of heat and elastic waves. The remaining, governing equations for this theory, namely, the equations of motion and the constitutive relations remain the same as those for the coupled and the uncoupled theories. This theory was extended by Dhaliwal and Sherief [9] to general anisotropic media in the presence of heat sources. Othman [10] studied the Lord

Pathways to paediatric urology subspecialisation:a study of casemix, incumbent attitudes and opinions

Objective: To identify any self-reported differences or attitudes towards certification, publication, or practice patterns between adult urology and paediatric general surgery-trained paediatric urology providers. There are no known published differences in clinical/operative/research outcomes in either group. Methods: An 18-item cross-sectional survey was compiled through the EAU Young Academic Urologists (YAU) office and disseminated to a trans-Atlantic convenience sample of current practising paediatric urologists. This was created using a mini-Delphi method to provide current semi-quantitative data relating to current opinions and attitudes of this cohort. Results: A total of 228 respondents completed the survey, with female respondents representing 37% and 34% for urology and paediatric general surgery, respectively. Nearly 90% overall respondents felt that a full 2-year paediatric fellowship program was very important and 94% endorsed a collaborative dedicated paediatric urology on call service, with 92% supporting the joint development of transitional care. Urology managed higher numbers of bedwetting (p = 0.04), bladder bowel dysfunction (p = 0.02), endourological procedures (p = 0.04), and robotics (p = 0.04). Paediatric general surgery managed higher numbers of laparoscopic reconstruction (p = 0.03), and posterior urethral valve ablation (p = 0.002). Conclusion: This study represents the first time that a cross-sectional cohort of paediatric urologists from different training backgrounds were compared to assess their productivity, practice patterns and attitudes. Paediatric urology is in a unique position to have two contributing specialities, with the ability to provide optimal transitional and lifelong care. We believe that there should be a strong emphasis on collaboration and to remove any historically-created barriers under policies of equity, diversity and inclusivity.</p

Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration

Periodontitis is an inflammation-related condition, caused by an infectious microbiome and host defense that causes damage to periodontium. The natural processes of the mouth, like saliva production and eating, significantly diminish therapeutic medication residency in the region of periodontal disease. Furthermore, the complexity and diversity of pathological mechanisms make successful periodontitis treatment challenging. As a result, developing enhanced local drug delivery technologies and logical therapy procedures provides the foundation for effective periodontitis treatment. Being biocompatible, biodegradable, and easily administered to the periodontal tissues, hydrogels have sparked substantial an intense curiosity in the discipline of periodontal therapy. The primary objective of hydrogel research has changed in recent years to intelligent thermosensitive hydrogels, that involve local adjustable sol-gel transformations and regulate medication release in reaction to temperature, we present a thorough introduction to the creation and efficient construction of new intelligent thermosensitive hydrogels for periodontal regeneration. We also address cutting-edge smart hydrogel treatment options based on periodontitis pathophysiology. Furthermore, the problems and prospective study objectives are reviewed, with a focus on establishing effective hydrogel delivery methods and prospective clinical applications

Fibroblast cell-based therapy prevents induction of alopecia areata in an experimental model

YesAlopecia areata (AA) is an autoimmune hair loss disease with infiltration of proinflammatory cells into hair follicles. Current therapeutic regimens are unsatisfactory mainly because of the potential for side effects and/or limited efficacy. Here we report that cultured, transduced fibroblasts, which express the immunomodulatory molecule indoleamine 2,3-dioxygenase (IDO), can be applied to prevent hair loss in an experimental AA model. A single intraperitoneal (IP) injection of IDO-expressing primary dermal fibroblasts was given to C3H/HeJ mice at the time of AA induction. While 60–70% of mice that received either control fibroblasts or vehicle injections developed extensive AA, none of the IDO-expressing fibroblast-treated mice showed new hair loss up to 20 weeks post injection. IDO cell therapy significantly reduced infiltration of CD4+ and CD8+ T cells into hair follicles and resulted in decreased expression of TNF-α, IFN-γ and IL-17 in the skin. Skin draining lymph nodes of IDO fibroblast-treated mice were significantly smaller, with more CD4+ CD25+ FoxP3+ regulatory T cells and fewer Th17 cells than those of control fibroblast and vehicle-injected mice. These findings indicate that IP injected IDO-expressing dermal fibroblasts can control inflammation and thereby prevent AA hair loss.Canadian Institutes of Health Researches (Funding Reference Number: 134214 and 136945)

Biodeterioration Assessment of a Unique Old Pharaonic Kingdom Wooden Statue Using Advanced Diagnostic Techniques

A recently discovered Egyptian wooden statue of King Djedefre was studied together with some surrounding burial soil samples for assessing the statue biodeterioration. The wooden morphological characterisation identified the hardwood Acacia nilotica as the wood type. X-ray diffraction, micro-FT-IR spectroscopy, and scanning electron microscopy with an X-ray spectrometer were used to evaluate the wood deterioration degree and the soil contribution in wood biodeterioration. Microbiological analyses (fluorescent in situ hybridisation and polymerase chain reaction) were also performed to detect the microbial attack on the statue. The prolonged interaction of the statue with the burial environment caused a strong wood decay due to biotic (fungi and bacteria) and abiotic factors (e.g., humidity fluctuations of the burial environment), which caused the severe cracking and collapsing of the wood structures. The analyses of the burial soil mineral composition were relevant for obtaining an overall picture of the statue deterioration. The results are useful for planning the right conservation procedures for this very particular and important wooden statue. Furthermore, analysis of the woody cell wall will help in the selection of appropriate consolidation and recovery treatments. Because the statue is a unique single piece of wood, and the morphological observations indicated that it is a bald woman in a sitting position, this statue will provide new and interesting knowledge of Egyptian culture