GPU Concurrency: Weak Behaviours and Programming Assumptions

Concurrency is pervasive and perplexing, particularly on graphics processing units (GPUs). Current specifications of languages and hardware are inconclusive; thus programmers often rely on folklore assumptions when writing software. To remedy this state of affairs, we conducted a large empirical study of the concurrent behaviour of deployed GPUs. Armed with litmus tests (i.e. short concurrent programs), we questioned the assumptions in programming guides and vendor documentation about the guarantees provided by hardware. We developed a tool to generate thousands of litmus tests and run them under stressful workloads. We observed a litany of previously elusive weak behaviours, and exposed folklore beliefs about GPU programming---often supported by official tutorials---as false. As a way forward, we propose a model of Nvidia GPU hardware, which correctly models every behaviour witnessed in our experiments. The model is a variant of SPARC Relaxed Memory Order (RMO), structured following the GPU concurrency hierarchy

Interactions of inert confiners with explosives

The deformation of an inert confiner by a steady detonation wave in an adjacent explosive is investigated for cases where the confiner is suciently strong (or the explosive suciently weak) such that the overall change in the sound speed of the inert is small. A coupling condition which relates the pressure to the deflection angle along the explosive-inert interface is determined. This includes its dependence on the thickness of the inert, for cases where the initial sound speed of the inert is less than or greater than the detonation speed in the explosive (supersonic and subsonic inert ows, respectively). The deformation of the inert is then solved by prescribing the pressure along the interface. In the supersonic case, the detonation drives a shock into the inert, subsequent to which the ow in the inert consists of alternating regions of compression and tension. In this case reverberations or `ringing' occurs along both the deflected interface and outer edge of the inert. For the subsonic case, the flow in the interior of the inert is smooth and shockless. The detonation in the explosive initially defl ects the smooth interface towards the explosive. For sufficiently thick inerts in such cases, it appears that the deflection of the confiner would either drive the detonation speed in the explosive up to the sound speed of the inert or drive a precursor wave ahead of the detonation in the explosive. Transonic cases, where the inert sound speed is close to the detonation speed, are also considered. It is shown that the confinement affect of the inert on the detonation is enhanced as sonic conditions are approached from either side

P–042 Impact of semen parameters, sperm DNA fragmentation and sperm aneuploidy in male infertility

Study question. Should sperm aneuploidies and sperm DNA fragmentation (sDNAfrag) be included as valid tests in the routine investigation of male infertility? Summary answer. Sperm DNA fragmentation was associated with male age, oligozoospermia (OZ), oligoteratozoospermia (OT), astenoteratozoospermia (AT) and oligoastenoteratozoospermia (OAT). Sperm aneuploidies were associated with OT and OAT. What is known already. Semen parameters assist male infertility diagnosis and treatment, but sDNAfrag and aneuploidy analysis could add useful information, as abnormal values compromise fertility. To include these tests in the routine diagnosis it should be determined if behave as informative parameter and add information regarding the fertility status. For that, further studies comparing these tests to semen parameters are needed, since previous results are not consensual. Additionally, standardization of a sDNAfrag cut-off is needed, as different sample sizes and techniques originate distinct results. Also, until a standardization of the protocol is missing, a cut-off value should be defined for each laboratory. Study design, size, duration. A retrospective and prospective investigation was performed, within a 12 years period (April 2007-December 2019). A total of 835 infertile males with a normal karyotype (46,XY) were included. Karyotyping and evaluation of sDNAfrag and sperm aneuploidies were made at a public Genetic unit. All normozoospermic (NZ) patients with a born child and patients whose infertility treatments were done due to female factors were selected from our database and used as controls (60 individuals). Participants/materials, setting, methods. Semen analysis followed WHO–2010 guidelines. sDNAfrag was evaluated using the TUNEL assay. Sperm aneuploidies were detected using FISH (chromosomes 13, 18, 21, X, Y). Several tests were applied: correlations for linear associations between numerical variables, ANOVA for comparisons between means, Dunn-test for post-hoc comparisons. To determine the sDNAfrag cut-off value, the area under the ROC curve, sensitivity and specificity, were calculated, with the Youden-Index used to find a threshold that maximizes both sensitivity and specificity. Main results and the role of chance. Regarding male age, it was observed a positive correlation with sperm concentration, a negative correlation with sperm vitality (VT) and hypoosmolality, and a positive correlation with sDNAfrag. Regarding sDNAfrag, it was observed negative correlation with sperm concentration, total progressive motility (TPM), morphology, VT and hypoosmolality. Regarding sperm aneuploidies, both total sperm aneuploidy and total sperm disomy exhibited a negative association with sperm concentration, TPM and morphology. It was also investigated whose groups of individuals could be indicated for sDNAfrag or sperm aneuploidy testing. The NZ group evidenced significant lower sDNAfrag, total sperm aneuploidy and total sperm disomy in relation to the non-NZ group. In the NZ group, sDNAfrag was significantly lower in relation to the OZ, OT, AT and OAT groups. The NZ group presented significant lower percentages of sperm aneuploidy in relation to the OT and OAT groups, and significant lower percentages of sperm disomy in relation to the OAT group. Additionally, sDNAfrag was positively correlated with total sperm aneuploidy and total sperm disomy. From the present large population, ROC curve analysis allowed estimating a cut-off value of 18.8% for the TUNEL-assay (sDNAfrag), with 0.658 of area under the curve, 53.9% sensitivity and 76.7% specificity. Limitations, reasons for caution. Although presenting a high number of cases and strict controls, the present study was unable to include as controls healthy men with proven fertility. Additionally, the present study did not take into account life-style factors and male associated pathologies besides infertility. Wider implications of the findings: Semen parameters were shown to be negatively correlated with sDNAfrag and sperm aneuploidies. As sDNAfrag testing and sperm aneuploidy testing were associated with semen abnormalities and male age, it is suggested their inclusion in the routine evaluation of infertile men, thus adding important complementary information about the fertility status

Interactions of Hermitian and non-Hermitian Hamiltonians

The coupling of non-Hermitian PT-symmetric Hamiltonians to standard Hermitian Hamiltonians, each of which individually has a real energy spectrum, is explored by means of a number of soluble models. It is found that in all cases the energy remains real for small values of the coupling constant, but becomes complex if the coupling becomes stronger than some critical value. For a quadratic non-Hermitian PT-symmetric Hamiltonian coupled to an arbitrary real Hermitian PT-symmetric Hamiltonian, the reality of the ground-state energy for small enough coupling constant is established up to second order in perturbation theory.Comment: 9 pages, 0 figure

Management of wet age-related macular degeneration in Spain: Challenges for treat and extend implementation in routine clinical practice

Purpose. To ascertain wet AMD (wAMD) management patterns in Spain. Methods. A two-round Delphi study conducted through a questionnaire-based survey designed from literature review and validated by an independent Steering Committee. Results. Forty-nine retina specialists experienced in wAMD participated by answering the two-round study questionnaire. Retina specialists are the main responsible for wAMD diagnosis and monitoring, including visits and associated procedures, with a median time per visit of 15 minutes. Standard treatment strategies are based on anti-VEGF administration, including standard loading dose administration followed by maintenance with aflibercept or ranibizumab (81% of patients). Although treat and extend (T&E) dosing strategy is considered as optimal for wAMD management (78% of the panelists), the main routine healthcare limitations (i.e., visits overload, reduced staff, short visit time, coordination issues, lack of facilities) conduct to self-defined “flexible” strategies, based on T&E and pro-re-nata (PRN) protocols. Conclusion. Proactive treatment patterns (T&E) are the preferred ones by the retina specialists in Spain. However, their proper implementation is difficult due to healthcare resource limitations, as well as organisation and logistic issues. .e use of anti-VEGF agents with longer duration of action could facilitate the use of strict T&E approaches according to routine clinical practicesThe study has been sponsored by Bayer Hispania S.L. Logistic

Integrable su(3) spin chain combining different representations

The general expression for the local matrix $t(\theta)$ of a quantum chain with the site space in any representation of su(3) is obtained. This is made by generalizing $t(\theta)$ from the fundamental representation and imposing the fulfillment of the Yang-Baxter equation. Then, a non-homogeneous spin chain combining different representations of su(3) is solved by developing a method inspired in the nested Bethe ansatz. The solution for the eigenvalues of the trace of the monodromy matrix is given as two coupled Bethe equations. A conjecture about the solution of a chain with the site states in different representations of su(n) is presented. The thermodynamic limit of the ground state is calculated.Comment: PlainTex harvmac, 30 pages, 7 figures, to appear in Journal of Physics

Effect of metformin on all-cause mortality and major adverse cardiovascular events: An updated meta-analysis of randomized controlled trials.

Aims: The Italian Society of Diabetology and the Italian Association of Clinical Diabetologists are developing new guidelines for drug treatment of type 2 diabetes. The effects of anti-hyperglycaemic drugs on all-cause mortality and major adverse cardiovascular events (MACEs) were included among the critical clinical outcomes. We have therefore carried out an updated meta-analysis on the effects of metformin on these outcomes. Data synthesis: A MEDLINE and EMBASE search was performed to identify all randomized controlled trials (RCTs) with duration ≥52 weeks (published up to August 2020), in which metformin was compared with either placebo/no therapy or active comparators. MACEs (restricted for RCT reporting MACEs within their study endpoints) and all-cause mortality (irrespective of the inclusion of MACEs among the pre-specified endpoints) were considered as the primary endpoints. Mantel-Haenszel odds ratio (MH-OR) with 95% confidence interval was calculated for all endpoints considered. Metformin was associated with a nonsignificant reduction of all-cause mortality (n = 13 RCTs; MH-OR 0.80 [95% CI 0.60, 1.07]). However, this association became statistically significant after excluding RCTs comparing metformin with sulfonylureas, SGLT-2 inhibitors or GLP-1 analogues (MH-OR 0.71 [0.51, 0.99]). Metformin was associated with a lower risk of MACEs compared with comparator treatments (n = 2 RCTs; MH-OR 0.52 [0.37, 0.73]), p < 0.001. Similar results were obtained in a post-hoc analysis including all RCTs fulfilling criteria for inclusion in the analysis (MH-OR: 0.57 [0.42, 0.76]). Conclusions: This updated meta-analysis suggests that metfomin is significantly associated with lower risk of MACEs and tendentially lower all-cause mortality compared to placebo or other anti-hyperglycaemic drugs

Effect of insulin secretagogues on major cardiovascular events and all-cause mortality: A meta-analysis of randomized controlled trials.

Background and aim: In 2019, the Italian Society of Diabetology and the Italian Association of Clinical Diabetologists nominated an expert panel to develop guidelines for drug treatment of type 2 diabetes. This expert panel, after identifying the effects of glucose-lowering agents on major adverse cardiovascular events (MACEs) and all-cause mortality as critical outcomes, decided to perform a systematic review and meta-analysis on the effect of insulin secretagogues (sulfonylureas and glinides) with this respect. Methods and results: A MEDLINE database search was performed to identify all RCTs, up to January 1st, 2020, with duration≥52 weeks, in which insulin secretagogues (glibenclamide, gliclazide, glimepiride, glipizide, chlorpropamide, repaglinide, nateglinide) were compared with either placebo or active comparators. The principal endpoints were MACE (restricted for RCT reporting MACEs within their outcomes) and all-cause mortality (irrespective of the inclusion of MACEs among the pre-specified outcomes). Mantel-Haenszel odds ratio (MH-OR) with 95% Confidence Interval (95% CI) was calculated for all the endpoints considered. Fourteen RCTs were included in the analysis for MACEs (919 in insulin secretagogues and 1,087 in control group). Insulin secretagogues were not significantly associated with an increased risk of MACEs in comparison with controls (MH-OR 1.08 [95% CI 0.96, 1.22], p = 0.20). When considering the 48 RCTs fulfilling criteria for inclusion in the analysis on all-cause mortality, insulin secretagogues were associated with a significantly increased risk of all-cause mortality (MH-OR 1.11 [1.00, 1.23], p = 0.04). Conclusions: This meta-analysis suggests that insulin secretagogues are associated with an increased risk of all-cause mortality when compared with placebo or other anti-hyperglycaemic drugs

Large-scale latitude distortions of the inner Milky Way Disk from the Herschel/Hi-GAL Survey

We use the Herschel Hi-GAL survey data to study the spatial distribution in Galactic longitude and latitude of the interstellar medium and of dense, star-forming clumps in the inner Galaxy. The peak position and width of the latitude distribution of the dust column density as well as of number density of compact sources from the band-merged Hi-GAL photometric catalogues are analysed as a function of longitude. The width of the diffuse dust column density traced by the Hi-GAL 500 micron emission varies across the inner Galaxy, with a mean value of 1{\deg}.2-1{\deg}.3, similar to that of the 250um Hi-GAL sources. 70um Hi-GAL sources define a much thinner disk, with a mean FWHM of 0{\deg}.75, and an average latitude of b=0{\deg}.06, coincident with the results from ATLASGAL. The GLAT distribution as a function of GLON shows modulations, both for the diffuse emission and for the compact sources, with ~0{\deg}.2 displacements mostly toward negative latitudes at l~ +40{\deg}, +12{\deg}, -25{\deg} and -40{\deg}. No such modulations can be found in the MIPSGAL 24 or WISE 22 um data when the entire source samples are considered. The distortions revealed by Herschel are interpreted as large-scale bending modes of the Plane. The lack of similar distortions in tracers of more evolved YSOs or stars rules out gravitational instabilities or satellite-induced perturbations, as they should act on both the diffuse and stellar disk components. We propose that the observed bends are caused by incoming flows of extra-planar gas interacting with the gaseous disk. Stars decouple from the gaseous ISM and relax into the stellar disk potential. The time required for the disappearance of the distortions from the diffuse ISM to the relatively evolved YSO stages are compatible with star-formation timescales