Guiding Testing Activities by Predicting Defect-prone Parts Using Product and Inspection Metrics

Product metrics, such as size or complexity, are often used to identify defect-prone parts or to focus quality assurance activities. In contrast, quality information that is available early, such as information provided by inspections, is usually not used. Currently, only little experience is documented in the literature on whether data from early defect detection activities can support the identification of defect-prone parts later in the development process. This article compares selected product and inspection metrics commonly used to predict defect-prone parts. Based on initial experience from two case studies performed in different environments, the suitability of different metrics for predicting defect-prone parts is illustrated. These studies revealed that inspection defect data seems to be a suitable predictor, and a combination of certain inspection and product metrics led to the best prioritizations in our contexts.Comment: 8 pages. The final publication is available at http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=632818

Interface morphologies in liquid/liquid dewetting

The dynamics and morphology of a liquid polystyrene (PS) film on the scale of a hundred nanometer dewetting from a liquid polymethylmethacrylate (PMMA) film is investigated experimentally and theoretically. The polymers considered here are both below their entanglement lengths and have negligible elastic properties. A theoretical model based on viscous Newtonian flow for both polymers is set up from which a system of coupled lubrication equations is derived and solved numerically. A direct comparison of the numerical solution with the experimental findings for the characteristic signatures of the cross-sections of liquid/air and liquid/liquid phase boundaries of the dewetting rims as well as the dewetting rates is performed and discussed for various viscosity ratios of the PS and PMMA layers

Not all who are bots are evil: A cross-platform analysis of automated agent governance

The growth of online platforms is accompanied by the increasing use of automated agents. Despite being discussed primarily in the context of opinion manipulation, agents play diverse roles within platform ecosystems that raises the need for governance approaches that go beyond policing agents’ unwanted behaviour. To provide a more nuanced assessment of agent governance, we introduce an analytical framework that distinguishes between different aspects and forms of governance. We then apply it to explore how agents are governed across nine platforms. Our observations show that despite acknowledging diverse roles of agents, platforms tend to focus on governing selected forms of their misuse. We also observe differences in governance approaches used by platforms, in particular when it comes to the agent rights/obligations and transparency of policing mechanisms. These observations highlight the necessity of advancing the algorithmic governance research agenda and developing a generalizable normative framework for agent governance

Not all who are bots are evil: A cross-platform analysis of automated agent governance

The growth of online platforms is accompanied by the increasing use of automated agents. Despite being discussed primarily in the context of opinion manipulation, agents play diverse roles within platform ecosystems that raises the need for governance approaches that go beyond policing agents’ unwanted behaviour. To provide a more nuanced assessment of agent governance, we introduce an analytical framework that distinguishes between different aspects and forms of governance. We then apply it to explore how agents are governed across nine platforms. Our observations show that despite acknowledging diverse roles of agents, platforms tend to focus on governing selected forms of their misuse. We also observe differences in governance approaches used by platforms, in particular when it comes to the agent rights/obligations and transparency of policing mechanisms. These observations highlight the necessity of advancing the algorithmic governance research agenda and developing a generalizable normative framework for agent governance

Focusing Testing by Using Inspection and Product Metrics

A well-known approach for identifying defect-prone parts of software in order to focus testing is to use different kinds of product metrics such as size or complexity. Although this approach has been evaluated in many contexts, the question remains if there are further opportunities to improve test focusing. One idea is to identify other types of information that may indicate the location of defect- prone software parts. Data from software inspections, in particular, appear to be promising. This kind of data might already lead to software parts that have inherent difficulties or programming challenges, and in consequence might be defect-prone. This article first explains how inspection and product metrics can be used to focus testing activities. Second, we compare selected product and inspection metrics commonly used to predict defect-prone parts. Based on initial experience from two case studies performed in different environments, the suitability of different metrics for predicting defect-prone parts is illustrated. The studies revealed that inspection defect data seems to be a suitable predictor, and a combination of certain inspection and product metrics led to the best prioritizations in our contexts. In addition, qualitative experience is presented.Peer reviewe

NIPA Defines an SCF-Type Mammalian E3 Ligase that Regulates Mitotic Entry

SummaryThe regulated oscillation of protein expression is an essential mechanism of cell cycle control. The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core. Here we identify NIPA (nuclear interaction partner of ALK) as a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry. Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, which restricts substrate ubiquitination activity to interphase. We show nuclear cyclin B1 to be a substrate of SCFNIPA. Inactivation of NIPA by RNAi results in nuclear accumulation of cyclin B1 in interphase, activation of cyclin B1-Cdk1 kinase activity, and premature mitotic entry. Thus, SCFNIPA-based ubiquitination may regulate S-phase completion and mitotic entry in the mammalian cell cycle

A Peptoid Delivers CoQ-derivative to Plant Mitochondria via Endocytosis

Controlled delivery of molecules interfering specifically with target activities in a cell of interest can be a powerful tool for experimental manipulation, because it can be administered at a defined time point and does not require genetic transformation, which in some systems is difficult and time consuming. Peptides as versatile tools that can be tailored for binding numerous binding partners, are of special interest. However, their passage through membranes, their intracellular targeting, and their sensitivity to proteases is limiting. The use of peptoids, where cationic amino-acid side chains are linked to nitrogen (rather than to carbon) of the peptide bond, can circumvent these limitations, because they are not cleavable by proteases. In the current work, we provide a proof-of-concept that such Trojan Peptoids, the plant PeptoQ, can be used to target a functional cargo (i.e. a rhodamine-labelled peptoid and a coenzyme Q10 derivative) into mitochondria of tobacco BY-2 cells as experimental model. We show that the uptake is specific for mitochondria, rapid, dose-dependent, and requires clathrin-mediated endocytosis, as well as actin filaments, while microtubules seem to be dispensable. Viability of the treated cells is not affected, and they show better survival under salt stress, a condition that perturbs oxidative homeostasis in mitochondria. In congruence with improved homeostasis, we observe that the salt induced accumulation of superoxide is mitigated and even inverted by pretreatment with PeptoQ. Using double labelling with appropriate fluorescent markers, we show that targeting of this Trojan Peptoid to the mitochondria is not based on a passage through the plasma membrane (as thought hitherto), but on import via endocytotic vesicles and subsequent accumulation in the mitochondrial intermembrane space, from where it can enter the matrix, e.g. when the permeability of the inner membrane is increased under salt stress

Budesonide as induction therapy for incomplete microscopic colitis: A randomised, placebo‐controlled multicentre trial

Background and aims: Incomplete microscopic colitis (MCi) is a subtype of microscopic colitis (MC). Budesonide is recommended as a first-line treatment for MC. However, randomised trials on efficacy of treatment in MCi are missing. We therefore performed a randomised, placebo-controlled trial to evaluate budesonide as induction therapy for MCi. Methods: Patients with active MCi were randomly assigned to either budesonide 9 mg once daily or placebo for 8 weeks in a double-blind, double-dummy design. The primary endpoint was clinical remission, defined as a mean of <3 stools/day and a mean of <1 watery stool/day in the 7 days before week 8. Results: Due to insufficient patient recruitment, the trial was discontinued prematurely. The intention-to-treat analysis included 44 patients (21 budesonide and 23 placebo). The primary endpoint of clinical remission at week 8 was obtained by 71.4% on budesonide and 43.5% on placebo (p = 0.0582). All clinical secondary endpoints were in favour of budesonide. Budesonide decreased the number of soft or watery stools (16.3 vs. 7.7, p = 0.0186) and improved health-related quality of life for all four dimensions of the short health scale. Adverse events with a suspected relation to study drug were reported in one patient in the budesonide group and two patients in the placebo group. Neither serious nor severe adverse events occurred during the double-blind phase. Conclusions: Budesonide decreased the frequency of soft or watery stools and improved the patients' quality of life significantly in MCi, but the primary endpoint was not met due to the low sample size (type 2 error). Budesonide was safe and well tolerated during the 8-weeks treatment course