602 research outputs found
GESTĂO DE CONHECIMENTO E ASSESSORIA EXECUTIVA: UMA PESQUISA COM OS PROFISSIONAIS DE SECRETARIADO EXECUTIVO ATUANTES NA UNIVERSIDADE FEDERAL DO PARĂ
This paper focuses on the use of knowledge management processes by executive secretariat professionals in a specific work environment, in this case the Universidade Federal do Pará (UFPA). For achieving the main goal, we built a theoretical framework linking Knowledge Management and Executive Assistance, the latter being directly related to the occupation of the Executive Secretariat. The research is of an applied nature and the technical procedures used were bibliographic, documental and survey research. To the stage of data collection, a questionnaire with closed questions was prepared and sended to a targeting audience, formed by actives executive secretaries at UFPA. Responses were treated by means of content analysis seeking to understand the current context and infer new knowledge about the topic in question. The results indicate that professionals working in the executive secretariat position in the UFPA known and frequently applied processes of Knowledge Management in their professional context and apply specific knowledge of the Executive Assistance, contributing to consolidation of KM in secretarial field and in public organizational management.O presente artigo visa compreender a utilização dos processos de Gestão do Conhecimento pelos profissionais de secretariado executivo em um ambiente específico de trabalho, no caso, a Universidade Federal do Pará (UFPA). Para o atingimento do objetivo, foi construído um referencial teórico interligando a Gestão do Conhecimento e a Assessoria Executiva, esta última sendo diretamente relacionada à profissão de Secretariado Executivo. A pesquisa é de natureza aplicada e os procedimentos técnicos utilizados foram a pesquisa bibliográfica, documental e levantamento. Para a fase de coleta de dados, foi elaborado um questionário com perguntas fechadas, tendo como público-alvo os secretários executivos atuantes na UFPA. As respostas foram tratadas por meio da análise de conteúdo buscando compreender o contexto atual e inferir novos conhecimentos sobre a temática em questão. Os resultados apontam que os profissionais de secretariado executivo atuantes na instituição participante conhecem e aplicam frequentemente os processos de Gestão de Conhecimento em seu contexto profissional, bem como aplicam conhecimentos específicos da Assessoria Executiva para a consolidação da GC no âmbito secretarial e na gestão organizacional pública
Semi-analytic galaxy formation in early dark energy cosmologies
We study the impact of early dark energy (EDE) cosmologies on galaxy
properties by coupling high-resolution numerical simulations with semi-analytic
modeling (SAM) of galaxy formation and evolution. EDE models are characterized
by a non-vanishing high-redshift contribution of dark energy, producing an
earlier growth of structures and a modification of large-scale structure
evolution. They can be viewed as typical representatives of non-standard dark
energy models in which only the expansion history is modified, and hence the
impact on galaxy formation is indirect. We show that in EDE cosmologies the
predicted space density of galaxies is enhanced at all scales with respect to
the standard LCDM scenario, and the corresponding cosmic star formation history
and stellar mass density is increased at high-redshift. We compare these
results with a set of theoretical predictions obtained with alternative SAMs
applied to our reference LCDM simulation, yielding a rough measure of the
systematic uncertainty of the models. We find that the modifications in galaxy
properties induced by EDE cosmologies are of the same order of magnitude as
intra-SAM variations for a standard LCDM realization (unless rather extreme EDE
models are considered), suggesting that is difficult to use such predictions
alone to disentangle between different cosmological scenarios. However, when
independent information on the underlying properties of host dark matter haloes
is included, the SAM predictions on galaxy bias may provide important clues on
the expansion history and the equation-of-state evolution.Comment: 7 pages; 4 figures, MNRAS submitte
DIREITO AO ESQUECIMENTO: UM IMPASSE ENTRE O INDIVĂDUO E A SOCIEDADE
O Direito ao Esquecimento consubstancia-se no entendimento de nĂŁo perturbar alguĂ©m por atos pretĂ©ritos, seja o reclamante estando na qualidade de vĂtima ou agressor. Com a recente decisĂŁo do STF em nĂŁo reconhecer o direito de esquecimento, as discussĂ”es acerca do tema tornaram-se ainda mais acaloradas. No artigo serĂĄ exposto alguns dos mais notĂĄveis casos, assim como os fundamentos favorĂĄveis e contrĂĄrios Ă receptação do direito ao esquecimento, sejam constitucionais ou jurisprudĂȘncias, estes, da esfera brasileira ou internacional.AlĂ©m do mais, em determinado momento haverĂĄ proposta de pacificação da controvĂ©rsia analisada, tendo por escopo sanar eventual divergĂȘncia sobre o grau de importĂąncia dos elementos constitutivos da aceitação e/ou negação do direito ao esquecimento
A critical evaluation of network and pathway based classifiers for outcome prediction in breast cancer
Recently, several classifiers that combine primary tumor data, like gene
expression data, and secondary data sources, such as protein-protein
interaction networks, have been proposed for predicting outcome in breast
cancer. In these approaches, new composite features are typically constructed
by aggregating the expression levels of several genes. The secondary data
sources are employed to guide this aggregation. Although many studies claim
that these approaches improve classification performance over single gene
classifiers, the gain in performance is difficult to assess. This stems mainly
from the fact that different breast cancer data sets and validation procedures
are employed to assess the performance. Here we address these issues by
employing a large cohort of six breast cancer data sets as benchmark set and by
performing an unbiased evaluation of the classification accuracies of the
different approaches. Contrary to previous claims, we find that composite
feature classifiers do not outperform simple single gene classifiers. We
investigate the effect of (1) the number of selected features; (2) the specific
gene set from which features are selected; (3) the size of the training set and
(4) the heterogeneity of the data set on the performance of composite feature
and single gene classifiers. Strikingly, we find that randomization of
secondary data sources, which destroys all biological information in these
sources, does not result in a deterioration in performance of composite feature
classifiers. Finally, we show that when a proper correction for gene set size
is performed, the stability of single gene sets is similar to the stability of
composite feature sets. Based on these results there is currently no reason to
prefer prognostic classifiers based on composite features over single gene
classifiers for predicting outcome in breast cancer
Use of Amniotic Membrane Transplant and Deep Anterior Keratoplasty in a Patient with Bilateral Acanthamoeba Infectious Keratitis: A Case Report
The aim of this study was to report a case with the use of amniotic membrane transplant and deep anterior keratoplasty in a patient with bilateral Acanthamoeba infectious keratitis as a treatment. A 20-year-old male presented with bilateral Acanthamoeba keratitis (AK) who was initially diagnosed with herpetic keratitis receiving full antiviral and corticosteroid topical treatment without any improvement. Corneal biopsy was performed to confirm the suspected diagnosis, and Acanthamoeba stromal cysts were identified in the sample. Treatment was initiated with 0.02% chlorhexidine, 0.1% propamidine isethionate, neomycin, and tropicamide/phenylephrine. Symptoms and clinical improvement were achieved between the 8th and 10th weeks, so corticosteroids were initiated. Treatment was continued until we observed a poor response in the left eye; therefore, an epithelial scraping and amniotic membrane placement were performed. Lately, the right eye underwent a deep anterior lamellar keratoplasty. A challenging case of bilateral AK managed with topical medications, amniotic membrane, and corneal keratoplasty. The earlier the disease is diagnosed, the better the outcome. If the diagnosis is delayed, the amoebas have penetrated deep into the corneal stroma, and successful therapy becomes difficult. A surgical option can be an early solution with a good prognosis for these cases
ClC-3 regulates the excitability of nociceptive neurons and is involved in inflammatory processes within the spinal sensory pathway
ClC-3 Clâ/H+ exchangers are expressed in multiple endosomal compartments and likely modify intra-endosomal pH and [Clâ] via the stoichiometrically coupled exchange of two Clâ ions and one H+. We studied pain perception in Clcn3â/â mice and found that ClC-3 not only modifies the electrical activity of peripheral nociceptors but is also involved in inflammatory processes in the spinal cord. We demonstrate that ClC-3 regulates the number of Nav and Kv ion channels in the plasma membrane of dorsal root ganglion (DRG) neurons and that these changes impair the age-dependent decline in excitability of sensory neurons. To distinguish the role of ClC-3 in Clâ/H+ exchange from its other functions in pain perception, we used mice homozygous for the E281Q ClC-3 point mutation (Clcn3E281Q/E281Q), which completely eliminates transport activity. Since ClC-3 forms heterodimers with ClC-4, we crossed these animals with Clcn4â/â to obtain mice completely lacking in ClC-3-associated endosomal chlorideâproton transport. The electrical properties of Clcn3E281Q/E281Q/Clcn4â/â DRG neurons were similar to those of wild-type cells, indicating that the age-dependent adjustment of neuronal excitability is independent of ClC-3 transport activity. Both Clcn3â/â and Clcn3E281Q/E281Q/Clcn4â/â animals exhibited microglial activation in the spinal cord, demonstrating that competent ClC-3 transport is needed to maintain glial cell homeostasis. Our findings illustrate how reduced Clâ/H+ exchange contributes to inflammatory responses and demonstrate a role for ClC-3 in the homeostatic regulation of neuronal excitability beyond its function in endosomal ion balance
Corrigendum: ClC-3 regulates the excitability of nociceptive neurons and is involved in inflammatory processes within the spinal sensory pathway
AnĂĄlise interpretativa das dermatoses mais frequentes em Porto Alegre - Rio Grande do Sul - Brasil
AnĂĄlise interpretativa das dermatoses mais frequentes em Porto Alegre - Rio Grande do Sul - Brasi
Measurement of the cosmic ray spectrum above eV using inclined events detected with the Pierre Auger Observatory
A measurement of the cosmic-ray spectrum for energies exceeding
eV is presented, which is based on the analysis of showers
with zenith angles greater than detected with the Pierre Auger
Observatory between 1 January 2004 and 31 December 2013. The measured spectrum
confirms a flux suppression at the highest energies. Above
eV, the "ankle", the flux can be described by a power law with
index followed by
a smooth suppression region. For the energy () at which the
spectral flux has fallen to one-half of its extrapolated value in the absence
of suppression, we find
eV.Comment: Replaced with published version. Added journal reference and DO
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