GESTÃO DE CONHECIMENTO E ASSESSORIA EXECUTIVA: UMA PESQUISA COM OS PROFISSIONAIS DE SECRETARIADO EXECUTIVO ATUANTES NA UNIVERSIDADE FEDERAL DO PARÁ

This paper focuses on the use of knowledge management processes by executive secretariat professionals in a specific work environment, in this case the Universidade Federal do Pará (UFPA). For achieving the main goal, we built a theoretical framework linking Knowledge Management and Executive Assistance, the latter being directly related to the occupation of the Executive Secretariat. The research is of an applied nature and the technical procedures used were bibliographic, documental and survey research. To the stage of data collection, a questionnaire with closed questions was prepared and sended to a targeting audience, formed by actives executive secretaries at UFPA. Responses were treated by means of content analysis seeking to understand the current context and infer new knowledge about the topic in question. The results indicate that professionals working in the executive secretariat position in the UFPA known and frequently applied processes of Knowledge Management in their professional context and apply specific knowledge of the Executive Assistance, contributing to consolidation of KM in secretarial field and in public organizational management.O presente artigo visa compreender a utilização dos processos de Gestão do Conhecimento pelos profissionais de secretariado executivo em um ambiente específico de trabalho, no caso, a Universidade Federal do Pará (UFPA). Para o atingimento do objetivo, foi construído um referencial teórico interligando a Gestão do Conhecimento e a Assessoria Executiva, esta última sendo diretamente relacionada à profissão de Secretariado Executivo. A pesquisa é de natureza aplicada e os procedimentos técnicos utilizados foram a pesquisa bibliográfica, documental e levantamento. Para a fase de coleta de dados, foi elaborado um questionário com perguntas fechadas, tendo como público-alvo os secretários executivos atuantes na UFPA. As respostas foram tratadas por meio da análise de conteúdo buscando compreender o contexto atual e inferir novos conhecimentos sobre a temática em questão. Os resultados apontam que os profissionais de secretariado executivo atuantes na instituição participante conhecem e aplicam frequentemente os processos de Gestão de Conhecimento em seu contexto profissional, bem como aplicam conhecimentos específicos da Assessoria Executiva para a consolidação da GC no âmbito secretarial e na gestão organizacional pública

Semi-analytic galaxy formation in early dark energy cosmologies

We study the impact of early dark energy (EDE) cosmologies on galaxy properties by coupling high-resolution numerical simulations with semi-analytic modeling (SAM) of galaxy formation and evolution. EDE models are characterized by a non-vanishing high-redshift contribution of dark energy, producing an earlier growth of structures and a modification of large-scale structure evolution. They can be viewed as typical representatives of non-standard dark energy models in which only the expansion history is modified, and hence the impact on galaxy formation is indirect. We show that in EDE cosmologies the predicted space density of galaxies is enhanced at all scales with respect to the standard LCDM scenario, and the corresponding cosmic star formation history and stellar mass density is increased at high-redshift. We compare these results with a set of theoretical predictions obtained with alternative SAMs applied to our reference LCDM simulation, yielding a rough measure of the systematic uncertainty of the models. We find that the modifications in galaxy properties induced by EDE cosmologies are of the same order of magnitude as intra-SAM variations for a standard LCDM realization (unless rather extreme EDE models are considered), suggesting that is difficult to use such predictions alone to disentangle between different cosmological scenarios. However, when independent information on the underlying properties of host dark matter haloes is included, the SAM predictions on galaxy bias may provide important clues on the expansion history and the equation-of-state evolution.Comment: 7 pages; 4 figures, MNRAS submitte

DIREITO AO ESQUECIMENTO: UM IMPASSE ENTRE O INDIVÍDUO E A SOCIEDADE

     O Direito ao Esquecimento consubstancia-se no entendimento de não perturbar alguém por atos pretéritos, seja o reclamante estando na qualidade de vítima ou agressor. Com a recente decisão do STF em não reconhecer o direito de esquecimento, as discussões acerca do tema tornaram-se ainda mais acaloradas. No artigo será exposto alguns dos mais notáveis casos, assim como os fundamentos favoráveis e contrários à receptação do direito ao esquecimento, sejam constitucionais ou jurisprudências, estes, da esfera brasileira ou internacional.Além do mais, em determinado momento haverá proposta de pacificação da controvérsia analisada, tendo por escopo sanar eventual divergência sobre o grau de importância dos elementos constitutivos da aceitação e/ou negação do direito ao esquecimento

A critical evaluation of network and pathway based classifiers for outcome prediction in breast cancer

Recently, several classifiers that combine primary tumor data, like gene expression data, and secondary data sources, such as protein-protein interaction networks, have been proposed for predicting outcome in breast cancer. In these approaches, new composite features are typically constructed by aggregating the expression levels of several genes. The secondary data sources are employed to guide this aggregation. Although many studies claim that these approaches improve classification performance over single gene classifiers, the gain in performance is difficult to assess. This stems mainly from the fact that different breast cancer data sets and validation procedures are employed to assess the performance. Here we address these issues by employing a large cohort of six breast cancer data sets as benchmark set and by performing an unbiased evaluation of the classification accuracies of the different approaches. Contrary to previous claims, we find that composite feature classifiers do not outperform simple single gene classifiers. We investigate the effect of (1) the number of selected features; (2) the specific gene set from which features are selected; (3) the size of the training set and (4) the heterogeneity of the data set on the performance of composite feature and single gene classifiers. Strikingly, we find that randomization of secondary data sources, which destroys all biological information in these sources, does not result in a deterioration in performance of composite feature classifiers. Finally, we show that when a proper correction for gene set size is performed, the stability of single gene sets is similar to the stability of composite feature sets. Based on these results there is currently no reason to prefer prognostic classifiers based on composite features over single gene classifiers for predicting outcome in breast cancer

Use of Amniotic Membrane Transplant and Deep Anterior Keratoplasty in a Patient with Bilateral Acanthamoeba Infectious Keratitis: A Case Report

The aim of this study was to report a case with the use of amniotic membrane transplant and deep anterior keratoplasty in a patient with bilateral Acanthamoeba infectious keratitis as a treatment. A 20-year-old male presented with bilateral Acanthamoeba keratitis (AK) who was initially diagnosed with herpetic keratitis receiving full antiviral and corticosteroid topical treatment without any improvement. Corneal biopsy was performed to confirm the suspected diagnosis, and Acanthamoeba stromal cysts were identified in the sample. Treatment was initiated with 0.02% chlorhexidine, 0.1% propamidine isethionate, neomycin, and tropicamide/phenylephrine. Symptoms and clinical improvement were achieved between the 8th and 10th weeks, so corticosteroids were initiated. Treatment was continued until we observed a poor response in the left eye; therefore, an epithelial scraping and amniotic membrane placement were performed. Lately, the right eye underwent a deep anterior lamellar keratoplasty. A challenging case of bilateral AK managed with topical medications, amniotic membrane, and corneal keratoplasty. The earlier the disease is diagnosed, the better the outcome. If the diagnosis is delayed, the amoebas have penetrated deep into the corneal stroma, and successful therapy becomes difficult. A surgical option can be an early solution with a good prognosis for these cases

ClC-3 regulates the excitability of nociceptive neurons and is involved in inflammatory processes within the spinal sensory pathway

ClC-3 Cl–/H+ exchangers are expressed in multiple endosomal compartments and likely modify intra-endosomal pH and [Cl–] via the stoichiometrically coupled exchange of two Cl– ions and one H+. We studied pain perception in Clcn3–/– mice and found that ClC-3 not only modifies the electrical activity of peripheral nociceptors but is also involved in inflammatory processes in the spinal cord. We demonstrate that ClC-3 regulates the number of Nav and Kv ion channels in the plasma membrane of dorsal root ganglion (DRG) neurons and that these changes impair the age-dependent decline in excitability of sensory neurons. To distinguish the role of ClC-3 in Cl–/H+ exchange from its other functions in pain perception, we used mice homozygous for the E281Q ClC-3 point mutation (Clcn3E281Q/E281Q), which completely eliminates transport activity. Since ClC-3 forms heterodimers with ClC-4, we crossed these animals with Clcn4–/– to obtain mice completely lacking in ClC-3-associated endosomal chloride–proton transport. The electrical properties of Clcn3E281Q/E281Q/Clcn4–/– DRG neurons were similar to those of wild-type cells, indicating that the age-dependent adjustment of neuronal excitability is independent of ClC-3 transport activity. Both Clcn3–/– and Clcn3E281Q/E281Q/Clcn4–/– animals exhibited microglial activation in the spinal cord, demonstrating that competent ClC-3 transport is needed to maintain glial cell homeostasis. Our findings illustrate how reduced Cl–/H+ exchange contributes to inflammatory responses and demonstrate a role for ClC-3 in the homeostatic regulation of neuronal excitability beyond its function in endosomal ion balance

Análise interpretativa das dermatoses mais frequentes em Porto Alegre - Rio Grande do Sul - Brasil

Análise interpretativa das dermatoses mais frequentes em Porto Alegre - Rio Grande do Sul - Brasi

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO