Regional Analysis of Potentials of Flexibility Options in the ElectricitySystem for the Study Regions Prignitz in Brandenburg and Anhalt-Bitterfeld-Wittenberg in Saxony-Anhalt

The electricity system is changing. Due to the climate targets, the share of fluctuating renewable energy will continue to rise in the next few years, and conventional, fossil fuels will increasingly take a back seat. This creates the challenge of balancing supply and demand in the power system and increases the need for flexibility in the electricity system. In this article flexibility in energy systems is introduced, flexibility options are categorised along existing literature and a method is explained to approach the estimation of flexibility potential by means of two example regions. Therefore, 13 flexibility options in the electricity system in four categories are analysed: flexible generators, demand side management, storage, and power-to-X. By means of the two study regions Prignitz in Brandenburg and Anhalt-Bitterfeld-Wittenberg in Saxony-Anhalt, a practicable, transferable method to quantify and compare the technical potentials of the flexibility options at a high regional level is developed

Whole body magnetic resonance imaging in healthy children and adolescents: Bone marrow appearances of the appendicular skeleton

Objective: To describe the appearances of bone marrow in the appendicular skeleton on fat-suppressed T2- weighted sequences as assessed by whole-body MRI in healthy and asymptomatic children and adolescents. Material and methods: Following ethical approval, we assessed the bone marrow of the extremities on water-only Dixon T2-weighted images as part of a whole-body MRI in 196 healthy and asymptomatic children aged 5–19 years. Based on a newly devised and validated scoring system, we graded intensity (0–2 scale) and extension (1–4 scale) of focal high signal bone marrow areas, and divided them into minor or major findings, based on intensity and extension, reflecting their potential conspicuousness in a clinical setting. Results: In the upper extremity, we registered 366 areas with increased signal whereof 79 were major findings. In the lower extremities there were 675 areas of increased signal of which 340 were major findings. Hundred-andfifteen (58.79%) individuals had at least one major finding, mainly located in the hand and proximal humerus, and the feet and knees. We found no differences according to gender, reported hours of sports activity, handedness, or age group, except for more minor findings in the upper extremities amongst 15–18-year-olds as compared to those aged 5–8 years. Conclusion: Focal areas of high signal intensity on whole-body MRI, T2-weighted fat suppressed images that, in a clinical setting could cause concern, were seen in more than half of healthy, asymptomatic children and adolescents. Awareness of this is important when interpreting whole-body MRI in this age group, particularly in the assessment of clinically silent lesions

Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer

In our previous work we showed that NGAL, a protein involved in the regulation of proliferation and differentiation, is overexpressed in human breast cancer (BC) and predicts poor prognosis. In neoadjuvant chemotherapy (NACT) pathological complete response (pCR) is a predictor for outcome. The aim of this study was to evaluate NGAL as a predictor of response to NACT and to validate NGAL as a prognostic factor for clinical outcome in patients with primary BC. Immunohistochemistry was performed on tissue microarrays from 652 core biopsies from BC patients, who underwent NACT in the GeparTrio trial. NGAL expression and intensity was evaluated separately. NGAL was detected in 42.2% of the breast carcinomas in the cytoplasm. NGAL expression correlated with negative hormone receptor (HR) status, but not with other baseline parameters. NGAL expression did not correlate with pCR in the full population, however, NGAL expression and staining intensity were significantly associated with higher pCR rates in patients with positive HR status. In addition, strong NGAL expression correlated with higher pCR rates in node negative patients, patients with histological grade 1 or 2 tumors and a tumor size <40 mm. In univariate survival analysis, positive NGAL expression and strong staining intensity correlated with decreased disease-free survival (DFS) in the entire cohort and different subgroups, including HR positive patients. Similar correlations were found for intense staining and decreased overall survival (OS). In multivariate analysis, NGAL expression remained an independent prognostic factor for DFS. The results show that in low-risk subgroups, NGAL was found to be a predictive marker for pCR after NACT. Furthermore, NGAL could be validated as an independent prognostic factor for decreased DFS in primary human BC

Co-exposure to UV radiation and crude oil increases acute embryotoxicity and sublethal malformations in the early life stages of Atlantic haddock (Melanogrammus aeglefinus)

Crude oil causes severe abnormalities in developing fish. Photomodification of constituents in crude oil increases its toxicity several fold. We report on the effect of crude oil, in combination with ultraviolet (UV) radiation, on Atlantic haddock (Melanogrammus aeglefinus) embryos. Accumulation of crude oil on the eggshell makes haddock embryos particularly susceptible to exposure. At high latitudes, they can be exposed to UV radiation many hours a day. Haddock embryos were exposed to crude oil (5–300 μg oil/L nominal loading concentrations) for three days in the presence and absence of UV radiation (290–400 nm). UV radiation partly degraded the eggs' outer membrane resulting in less accumulation of oil droplets in the treatment with highest oil concentration (300 μg oil/L). The co-exposure treatments resulted in acute toxicity, manifested by massive tissue necrosis and subsequent mortality, reducing LC50 at hatching stage by 60 % to 0.24 μg totPAH/L compared to 0.62 μg totPAH/L in crude oil only. In the treatment with nominal low oil concentrations (5–30 μg oil/L), only co-exposure to UV led to sublethal morphological heart defects. Including phototoxicity as a parameter in risk assessments of accidental oil spills is recommended.publishedVersio

Vascular CXCR4 Expression – a Novel Antiangiogenic Target in Gastric Cancer?

BACKGROUND: G-protein-coupled receptors (GPCRs) are prime candidates for novel cancer prevention and treatment strategies. We searched for differentially expressed GPCRs in node positive gastric carcinomas. METHODOLOGY/PRINCIPAL FINDINGS: Differential expression of GPCRs in three node positive vs. three node negative intestinal type gastric carcinomas was analyzed by gene array technology. The candidate genes CXCL12 and its receptor CXCR4 were validated by real-time reverse-transcription polymerase chain reaction in an independent set of 37 gastric carcinomas. Translation was studied by immunohistochemistry in 347 gastric carcinomas using tissue microarrays as well as in 61 matching lymph node metastases. Protein expression was correlated with clinicopathological patient characteristics and survival. 52 GPCRs and GPCR-related genes were up- or down-regulated in node positive gastric cancer, including CXCL12. Differential expression of CXCL12 was confirmed by RT-PCR and correlated with local tumour growth. CXCL12 immunopositivity was negatively associated with distant metastases and tumour grade. Only 17% of gastric carcinomas showed CXCR4 immunopositive tumour cells, which was associated with higher local tumour extent. 29% of gastric carcinomas showed CXCR4 positive tumour microvessels. Vascular CXCR4 expression was significantly associated with higher local tumour extent as well as higher UICC-stages. When expressing both, CXCL12 in tumour cells and CXCR4 in tumour microvessels, these tumours also were highly significantly associated with higher T- and UICC-stages. Three lymph node metastases revealed vascular CXCR4 expression while tumour cells completely lacked CXCR4 in all cases. The expression of CXCL12 and CXCR4 had no impact on patient survival. CONCLUSIONS/SIGNIFICANCE: Our results substantiate the significance of GPCRs on the biology of gastric carcinomas and provide evidence that the CXCL12-CXCR4 pathway might be a novel promising antiangiogenic target for the treatment of gastric carcinomas

Identification of biology-based breast cancer types with distinct predictive and prognostic features: role of steroid hormone and HER2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapy

Introduction: Reliable predictive and prognostic markers for routine diagnostic purposes are needed for breast cancer patients treated with neoadjuvant chemotherapy. We evaluated protein biomarkers in a cohort of 116 participants of the GeparDuo study on anthracycline/taxane-based neoadjuvant chemotherapy for operable breast cancer to test for associations with pathological complete response (pCR) and disease-free survival (DFS). Particularly, we evaluated if interactions between hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) expression might lead to a different clinical behavior of HR+/HER2+ coexpressing and HR+/HER2- tumors and whether subgroups of triple negative tumors might be identified by the help of Ki67 labeling index, cytokeratin 5/6 (CK5/6), as well as cyclooxygenase-2 (COX-2), and Y-box binding protein 1 (YB-1) expression. Methods: Expression analysis was performed using immunohistochemistry and silver-enhanced in situ hybridization on tissue microarrays (TMAs) of pretherapeutic core biopsies. Results: pCR rates were significantly different between the biology-based tumor types (P = 0.044) with HR+/HER2+ and HR-/HER2- tumors having higher pCR rates than HR+/HER2-tumors. Ki67 labeling index, confirmed as significant predictor of pCR in the whole cohort (P = 0.001), identified HR-/HER- (triple negative) carcinomas with a higher chance for a pCR (P = 0.006). Biology-based tumor type (P = 0.046 for HR+/HER2+vs. HR+/HER2-), Ki67 labeling index (P = 0.028), and treatment arm (P = 0.036) were independent predictors of pCR in a multivariate model. DFS was different in the biology-based tumor types (P < 0.0001) with HR+/HER2- and HR+/HER2+ tumors having the best prognosis and HR-/HER2+ tumors showing the worst outcome. Biology-based tumor type was an independent prognostic factor for DFS in multivariate analysis (P < 0.001). Conclusions: Our data demonstrate that a biology-based breast cancer classification using estrogen receptor (ER), progesterone receptor (PgR), and HER2 bears independent predictive and prognostic potential. The HR+/HER2+ coexpressing carcinomas emerged as a group of tumors with a good response rate to neoadjuvant chemotherapy and a favorable prognosis. HR+/HER2- tumors had a good prognosis irrespective of a pCR, whereas patients with HR-/HER- and HR-/HER+ tumors, especially if they had not achieved a pCR, had an unfavorable prognosis and are in need of additional treatment options. Trial registration ClinicalTrials.gov identifier: NCT0079337

Beschluss für die Empfehlung der STIKO zum Wechsel von quadrivalenten zu trivalenten Influenza-Impfstoffen

Seit September 2023 empfiehlt die WHO den Wechsel von quadrivalenten zu trivalenten Influenza-Impfstoffen ohne B/Yamagata Linie. Die Verfügbarkeit eines trivalenten lebend-attenuierten Influenza-Impfstoffs (LAIV) in Deutschland wird ab der Saison 2024/2025 erwartet. Die Verfügbarkeit von trivalenten inaktivierten Influenza-Impfstoffen wird ab der Saison 2025/2026 erwartet. Daher passt die STIKO ihre Influenza-Impfempfehlung wie folgt an: Die STIKO empfiehlt eine jährliche Impfung im Herbst für Personen im Alter von ≥ 60 Jahren mit einem inaktivierten Influenza-Hochdosis-Impfstoff oder bei entsprechender Indikation im Alter von ≥ 6 Monaten mit einem inaktivierten Influenza-Impfstoff (Standarddosis) mit jeweils von der WHO empfohlener Antigenkombination. Kinder und Jugendliche im Alter von 2 - 17 Jahren können alternativ mit einem LAIV geimpft werden, sofern keine Kontraindikation besteht.Peer Reviewe

Advances in formal Slavic linguistics 2016

Advances in Formal Slavic Linguistics 2016&nbsp;initiates a new series of collective volumes on formal Slavic linguistics. It presents a selection of high quality papers authored by young and senior linguists from around the world and contains both empirically oriented work, underpinned by up-to-date experimental methods, as well as more theoretically grounded contributions. The volume covers all major linguistic areas, including morphosyntax, semantics, pragmatics, phonology, and their mutual interfaces. The particular topics discussed include argument structure, word order, case, agreement, tense, aspect, clausal left periphery, or segmental phonology. The topical breadth and analytical depth of the contributions reflect the vitality of the field of formal Slavic linguistics and prove its relevance to the global linguistic endeavour. Early versions of the papers included in this volume were presented at the conference on Formal Description of Slavic Languages 12 or at the satellite Workshop on Formal and Experimental Semantics and Pragmatics, which were held on December 7-10, 2016 in Berlin

Advances in formal Slavic linguistics 2016

Advances in Formal Slavic Linguistics 2016&nbsp;initiates a new series of collective volumes on formal Slavic linguistics. It presents a selection of high quality papers authored by young and senior linguists from around the world and contains both empirically oriented work, underpinned by up-to-date experimental methods, as well as more theoretically grounded contributions. The volume covers all major linguistic areas, including morphosyntax, semantics, pragmatics, phonology, and their mutual interfaces. The particular topics discussed include argument structure, word order, case, agreement, tense, aspect, clausal left periphery, or segmental phonology. The topical breadth and analytical depth of the contributions reflect the vitality of the field of formal Slavic linguistics and prove its relevance to the global linguistic endeavour. Early versions of the papers included in this volume were presented at the conference on Formal Description of Slavic Languages 12 or at the satellite Workshop on Formal and Experimental Semantics and Pragmatics, which were held on December 7-10, 2016 in Berlin