Neoadjuvant endocrine therapy for luminal breast cancer treatment: a first-choice alternative in times of crisis such as the COVID-19 pandemic

The epidemiological emergency caused by CoV-2 (COVID-19) has changed priorities in breast cancer management. In those places where the pandemic has had the greatest effect, it is of paramount importance for most patients to be at home, reducing or postponing their attendance at clinics, as well as avoiding surgeries. In this scenario, neoadjuvant endocrine treatment could be an appropriate alternative treatment for hormone receptor positive breast cancer (luminal-like tumours) in order to minimise hospital admissions and to delay elective surgeries. Accordingly, we present a simple protocol that can be applied to most cases of luminal-like breast cancer and is appropriate for the majority of secondary or tertiary medical centres, or even primary car

Design of one-dimensional Lambertian diffusers of light

We describe a method for designing a one-dimensional random surface that acts as a Lambertian diffuser. The method is tested by means of rigorous computer simulations and is shown to yield the desired scattering pattern.Comment: 6 pages, 2 figure

Nonadiabatic Quantum Dynamics Predissociation of H2O+(B 2B2)

This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in The Journal of of Physical Chemistry Letters, copyright © American Chemical Society after peer review. To access the final edited and published work, see DOI: http://dx.doi.org/10.1021/jz5022894A quantum-mechanical study of the predissociation of H2O+(B˜ 2B2) is carried out by using wave packet propagations on ab initio potential energy surfaces connected by nonadiabatic couplings. The simulations show that within the first 30 fs, 80% of the initial wave packet is transferred from the B 2B2 to the A˜ 2A1 electronic state through a conical intersection. A much slower transfer (in the ps timescale) from the A˜ 2A1 to the X˜2B1 state due to a Renner-Teller coupling determines the fragmentation branching ratios, which are in accordance with the experimental measurementsThis work has been partially supported by projects ENE2007-62934 and ENE2011-28200 (Secretaría de Estado de I+D+i, Spain) and the European COST actions CM1204 (XLIC) and MP1002 (Nano-IBCT). The calculations have been performed at the Centro de Computación Científica of the UAM

Nonadiabatic fragmentation of H2O+ and isotopomers. Wave packet propagation using ab initio wavefunctions

The fragmentation of the water cation from its B 2B2 electronic state, allowing the participation of the X 2B1, Ã 2A1 and C 2B1 states in the process, is simulated using the extended capabilities of the collocation GridTDSE code to account for the nonadiabatic propagation of wave packets in several potential energy surfaces connected by nonadiabatic couplings. Molecular data are calculated ab initio. Two initial wave packets are considered to reproduce two different experiments. The isotopic effect in the fragmentation of D2O+ and HDO+ is also studied and the results show very good agreement with the experimental cleavage preference in the fragmentation of HDO+This work has been partially supported by Ministerio de Economía and Competitividad (Spain), project ENE2014-52432-

Factores que inciden en el aprendizaje colaborativo en un entorno de formación superior mediado por tecnologías

La presente comunicación describe el análisis de un proceso de aprendizaje colaborativo en un entorno de educación superior mediado por tecnologías desde la perspectiva del estudiante. Partimos de la hipótesis que en un proceso educativo de estas características, el tipo de intervención y orientación docente incide en la respuesta del alumnado, de manera que una orientación estructurada y pautada permite enfatizar tanto la dimensión académica como la social del aprendizaje, y determina una mejor comprensión y realización de la actividad por parte de los estudiantes. Con esta investigación se pretende llegar a una comprensión de los principales parámetros e indicadores que se reflejan en una situación de aprendizaje colaborativo en entornos mediados por tecnologías, con el objeto de determinar el conjunto de estrategias orientadas a la colaboración que resultan eficaces para promover el aprendizaje. El estudio se enmarca en la teoría sociocultural inspirada por Vigotski, que enfatiza la interacción social que se relaciona con el cambio cognitivo. Gros (2005) señala algunas cuestiones que han centrado los estudios en este ámbito y que orientan nuestro trabajo: la interacción, la intervención del profesorado, la construcción colaborativa del conocimiento y las herramientas mediadoras