216 research outputs found
TERAPIA RACIONAL EMOTIVA PARA REESTRUCTURAR LAS CREENCIAS IRRACIONALES EN PACIENTES DROGODEPENDIENTES DE UNA CLÍNICA EN HUARAL LIMA 2019
La presente investigación tiene como objetivo proponer un modelo de
intervención psicológica llamada Terapia Racional Emotiva (TRE) que ayude a
reestructurar las creencias irracionales en los pacientes de un centro para
drogodependientes de la ciudad de Huaral en el año 2019. La investigación
cuantitativa, contó con un diseño no experimental transversal descriptiva y una
muestra dirigida de 19 residentes del centro de rehabilitación. Se utilizó el Inventario
de Creencias Irracionales de Ellis, para medir creencias irracionales y se determinó
la confiabilidad de dicha variable con el alfa de Cronbach obteniendo como
resultado 0.504, así mismo la creencia 9 “Determinismo del pasado” fue la más
frecuente en la muestra alcanzando un 42,1 % del total de la muestra. Estos
resultados encontrados en la investigación nos reafirman la iniciativa de proponer
un programa de tratamiento creyendo que resulte eficiente en la práctica de
reestructurar las creencias irracionales encontradas en los pacientes de la clínica
en la ciudad de Huaral Lima en el año 2019, de este modo validamos nuestra
hipótesis de nuestro estudio.Tesi
Monográfico sobre Europa
23 páginas.Capítulo incluido en el libro: Estudios contemporáneos sobre geopolítica, conflictos armados y cooperación internacional. Libia Arenal Lora (Dirección) ; Francisco Antonio Domínguez Díaz (Edición). Sevilla: Universidad Internacional de Andalucía, 2020. ISBN 978-84-7993-360-9. Enlace: http://hdl.handle.net/10334/5599
Role of wild rabbits as reservoirs of leishmaniasis in a non-epidemic Mediterranean hot spot in Spain
We would like to thank the hunters of the municipality of Montefrio for their support in the study. This study was funded by the Project, Ministry of Economy and Competitiveness, Instituto de Salud Carlos III, Madrid and Feder Funds for Regional Development from the European Union, "One way to make Europe". Funding for open access charge: Universidad de Granada/CBVA.There is limited information regarding the role of wild mammals in the transmission dynamics of Leishmania
infantum. A potential human leishmaniasis hot spot was detected in southern Spain that could not be explained
solely by canine leishmaniasis prevalence. The aim of this work was to analyse the involvement of wild rabbits as
the main factor affecting this Mediterranean hot spot. A survey of wild rabbits, dogs and sand flies was conducted
in the human cases environment. A nearby region without clinical leishmaniasis cases was used as reference
control. 51 wild rabbits shot by hunters were analysed by molecular techniques. 1100 sand flies were captured
and morphologically identified. Blood collected from patients’ relatives/ neighbours (n = 9) and dogs (n = 66)
was used for molecular analysis and serology. In Mediterranean leishmaniasis hot spots such as Montefrío municipality
(average incidence of 16.8 human cases per 100,000 inhabitants/year), wild rabbits (n = 40) support
high L. infantum infection rates (100%) and heavy parasite burdens (average value: 503 parasites/mg) in
apparently normal ear skin directly accessible to sand flies, enabling the existence of heavily parasitized Phlebotomus
perniciosus females (12.5% prevalence). The prevalence of infection and median parasite load were very
low among rabbits captured in Hu´escar (n = 11), a human clinical leishmaniasis-free area for the last 18 years.
P. perniciosus was the most abundant Phlebotomus species in all the domestic/peridomestic microhabitats
sampled, both indoors and outdoors. Accordingly, leishmaniasis is clustering in space and time at this local scale
represented by Montefrío due to the proximity of two competent host reservoirs (dogs and heavily parasitized
wild rabbits) associated with overlapping sylvatic and domestic transmission cycles through the main vector,
P. perniciosus. We highlight the usefulness of determining the prevalence of infection and parasite burden in wild
rabbits as a control leishmaniasis measure with the advantage that the use of the ear offers.Ministry of Economy and Competitiveness, Instituto de Salud Carlos III, MadridFeder Funds for Regional Development from the European Union, "One way to make Europe"Universidad de Granada/CBV
Stabilization of the Virulence Plasmid pSLT of Salmonella Typhimurium by Three Maintenance Systems and Its Evaluation by Using a New Stability Test
Certain Salmonella enterica serovars belonging to subspecies I carry low-copy-number virulence plasmids of variable size (50–90 kb). All of these plasmids share the spv operon, which is important for systemic infection. Virulence plasmids are present at low copy numbers. Few copies reduce metabolic burden but suppose a risk of plasmid loss during bacterial division. This drawback is counterbalanced by maintenance modules that ensure plasmid stability, including partition systems and toxin-antitoxin (TA) loci. The low-copy number virulence pSLT plasmid of Salmonella enterica serovar Typhimurium encodes three auxiliary maintenance systems: one partition system (parAB) and two TA systems (ccdABST and vapBC2ST). The TA module ccdABST has previously been shown to contribute to pSLT plasmid stability and vapBC2ST to bacterial virulence. Here we describe a novel assay to measure plasmid stability based on the selection of plasmid-free cells following elimination of plasmid-containing cells by ParE toxin, a DNA gyrase inhibitor. Using this new maintenance assay we confirmed a crucial role of parAB in pSLT maintenance. We also showed that vapBC2ST, in addition to contribute to bacterial virulence, is important for plasmid stability. We have previously shown that ccdABST encodes an inactive CcdBST toxin. Using our new stability assay we monitored the contribution to plasmid stability of a ccdABST variant containing a single mutation (R99W) that restores the toxicity of CcdBST. The “activation” of CcdBST (R99W) did not increase pSLT stability by ccdABST. In contrast, ccdABST behaves as a canonical type II TA system in terms of transcriptional regulation. Of interest, ccdABST was shown to control the expression of a polycistronic operon in the pSLT plasmid. Collectively, these results show that the contribution of the CcdBST toxin to pSLT plasmid stability may depend on its role as a co-repressor in coordination with CcdAST antitoxin more than on its toxic activity.The work in RD and FG's laboratories is supported by grants BFU2011-25939 (RD), CSD2008-00013 (RD and FG), and BIO2013-46281-P/BIO2015-69085-REDC (FG) from the Spanish Ministry of Economy and Competitiveness.Peer reviewedPeer Reviewe
Effectiveness of an O-Alkyl Hydroxamate in Dogs with Naturally Acquired Canine Leishmaniosis: An Exploratory Clinical Trial
Canine leishmaniosis is a challenge in veterinary medicine and no drug to date has achieved
parasite clearance in dogs. Histone deacetylase inhibitors are a drug class widely used in cancer
chemotherapy. We have successfully used O-alkyl hydroxamates (vorinostat derivatives) in the
treatment of a laboratory model of visceral leishmaniasis without showing toxicity. In order to
test the effectiveness of a particular compound, MTC-305, a parallel-group, randomized, singlecentre,
exploratory study was designed in naturally infected dogs. In this clinical trial, 18 dogs
were allocated into 3 groups and were treated with either meglumine antimoniate (104 mg SbV/kg),
MTC-305 (3.75 mg/kg) or a combination of both using a lower MTC-305 dose (1.5 mg/kg) through
a subcutaneous route for 2 treatment courses of 30 days, separated by a 30-day rest period. After
treatment, a follow-up time of 4 months was established. Parasite burden in bone marrow, lymph
node and peripheral blood were quantified through qPCR. Antibody titres were determined through
an immunofluorescence antibody test, and cytokine expression values were calculated through RTqPCR.
Treatment safety was evaluated through the assessment of haematological and biochemical
parameters in blood, weight, and gastrointestinal alterations. Assessment was carried out before,
between and after treatment series. Treatment with MTC-305 was effective at reducing parasite
burdens and improving the animals’ clinical picture. Dogs treated with this compound did not
present significant toxicity signs. These results were superior to those obtained using the reference
drug, meglumine antimoniate, in monotherapy. These results would support a broader clinical trial,
optimised dosage, and an expanded follow-up stage to confirm the efficacy of this drug.University of GranadaAndalusian GovernmentEuropean Commission B-CTS-270UGR18
P20_0013
High Efficiency Power Amplifier Based on Envelope Elimination and Restoration Technique
Due to complex envelope and phase modulation employed in modern transmitters it is necessary to use power amplifiers that have high linearity. Linear power amplifiers (classes A, B and AB) are commonly used, but they suffer from low efficiency especially if the transmitted signal has high peak to average power ratio (PAPR). Kahn's technique based on envelope elimination and restoration (EER) is based on idea that high efficiency power supply (envelope amplifier) could be used to modulate the envelope of high efficient non linear power amplifiers (classes D or E). This paper presents solutions for power amplifier that performs envelope modulation and class E amplifier that is used as a non linear amplifier. The envelope amplifier is implemented as a multilevel converter in series with linear regulator and can provide up to 100 W of instantaneous power and reproduce 2 MHz sine wave. The implemented Class E amplifier can operate at 120 MHz with efficiency near to 85%. The envelope amplifier and class E amplifier have been integrated and efficiency and linearity of the implemented transmitter has been measured and presente
The variable geometry central receiver system concept. First results and comparison with conventional central receiver systems
In line with the global trend for improving efficiency of existing solar power plants, the CTAER has
developed and built a variable geometry central receiver facility, in which the solar field rotates around
the tower axis following the sun's position during the day. The goal of this new approach is to increase the
optical efficiency of the field by significantly reducing the angle of incidence of the Sun on the heliostats.
This paper presents the advantages of this new variable geometry design and describes the main features
of the experimental facility based on this approach as built by CTAER in Almeria. It also compares a
conventional solar central receiver plant (i.e., with stationary heliostats and receiver) and an equivalent
variable geometry power plant. For this study we employed published data from a real solar central
receiver plant with known production (Abengoa’s PS10). The results of the study show an increase in
annual energy collection and distribution by the variable geometry plant, leading to a potential reduction
in the number of heliostats required compared to a conventional central receiver plant for the same annual
energy collection
Circulating miR-320a as a Predictive Biomarker for Left Ventricular Remodelling in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention
Restoration of epicardial coronary blood flow, achieved by early reperfusion with primary
percutaneous coronary intervention (PPCI), is the guideline recommended to treat patients with
ST-segment-elevation myocardial infarction (STEMI). However, despite successful blood restoration,
increasing numbers of patients develop left ventricular adverse remodelling (LVAR) and heart failure.
Therefore, reliable prognostic biomarkers for LVAR in STEMI are urgently needed. Our aim was
to investigate the role of circulating microRNAs (miRNAs) and their association with LVAR in
STEMI patients following the PPCI procedure. We analysed the expression of circulating miRNAs
in blood samples of 56 patients collected at admission and after revascularization (at 3, 6, 12 and
24 h). The associations between miRNAs and left ventricular end diastolic volumes at 6 months were
estimated to detect LVAR. miRNAs were also analysed in samples isolated from peripheral blood
mononuclear cells (PBMCs) and human myocardium of failing hearts. Kinetic analysis of miRNAs
showed a fast time-dependent increase in miR-133a, miR-133b, miR-193b, miR-499, and miR-320a
in STEMI patients compared to controls. Moreover, the expression of miR-29a, miR-29b, miR-324,
miR-208, miR-423, miR-522, and miR-545 was differentially expressed even before PPCI in STEMI.
Furthermore, the increase in circulating miR-320a and the decrease in its expression in PBMCs were
significantly associated with LVAR and correlated with the expression of miR-320a in human failing
myocardium from ischaemic origin. In conclusion, we determined the time course expression of new
circulating miRNAs in patients with STEMI treated with PPCI and we showed that miR-320a was
positively associated with LVAR
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