Effects of Experimental Brood Size Manipulation and Gender on Carotenoid Levels of Eurasian Kestrels Falco tinnunculus

Animals use carotenoid-pigments for coloration, as antioxidants and as enhancers of the immune system. Carotenoid-dependent colours can thus signal individual quality and carotenoids have also been suggested to mediate life-history trade-offs.

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

dentification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 x 10(-8)) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.Peer reviewe

Technical Education in Jeopardy? Assessing the Interdisciplinary Faculty Structure in a University Merger

The social responsibility of universities is to contribute to solving the ‘wicked problems’ facing humanity, including climate change, poverty, conflicts and the lack of energy resources. Interdisciplinarity is an approach that enables solving these problems and helps higher education institutions become more socially responsible while meeting the requirements of their stakeholders. In this chapter, we analyse a multidisciplinary and sector-breaking merger of three higher education institutions in Finland, where the merger is justified by its contribution to solving wicked problems through increased structural interdisciplinarity. We examine the suggested faculty structures and views of staff and students to understand how interdisciplinarity and addressing the needs of stakeholders are seen from the perspective of technical education. The interdisciplinary faculty structure is heavily criticised by the internal stakeholders, who claim that it does not meet the needs of the university’s external stakeholders. However, there is debate on whose interests and identities are at risk when the disciplinary boundaries of technical education are transgressed.peerReviewe

Postmenopausal hormone therapy: risks and benefits.

Postmenopausal hormone therapy (PMHT) is used for the relief of menopausal symptoms, but the dosage has varied greatly throughout its existence. By the end of the 1990s, PMHT was mainly used to prevent chronic diseases such as osteoporosis, coronary heart disease and dementia, and large prevention trials were undertaken in this context. Following the initial negative reports of these trials, use of PMHT dramatically decreased. These reports noted surprisingly increased risks, notably of coronary heart disease, stroke and breast cancer, in people who used PMHT. Nowadays, considering the currently available data, it seems that an important distinction should be made between the treatment of climacteric symptoms in young, generally healthy, postmenopausal women and the prevention of chronic diseases in elderly women. PMHT seems to be beneficial and safe for postmenopausal symptomatic women aged 70 years old) owing to the increased risk of stroke and breast cancer in these patients.Journal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: re.jinfo:eu-repo/semantics/publishe