Cavus foot in soccer players : increased prevalence in experienced players and risk factor for injury

Background: Foot type, especially cavus foot, is associated with foot and ankle soccer injuries, such as ankle sprains, ankle instability, and foot and ankle lateral injuries. The aim of this study was to identify risk factors for foot and ankle injuries among soccer players. Methods: Male and female soccer players, from beginners to semiprofessionals, aged between 10 and 40 years were enrolled in this cross-sectional study. Players filled in questionnaires about their training and injury history. Clinical measurements included foot length, Foot Posture Index-6, and arch height flexibility. Each variable was dichotomized: age (<18 years versus $18 years), level of play (AA and below versus AAA and above), foot type (cavus or not), and injury. Injury occurrence was analyzed using x2 tests between each group of variables, and significance was set at P < .05. Results: A total of 277 players, including 81 females, volunteered; 147 were younger than 18 years and 180 were AA level or below. Cavus foot prevalence was 30%. In the cavus foot group, 51.8% of players had reached at least an AAA level compared with 27.8% in the normal-arched group (P < .001 [x2 ]). Injuries were associated with a cavus foot type (P < .01 [x2 ]) and with sex, age, or highest level played (P < .001 [x2 ]). Conclusions: This study identified a high prevalence of cavus foot among soccer players of all ages, with an increased prevalence among higher-level players. The injury risk factors were female sex, older age, playing at a higher level, and cavus feet. (J Am Podiatr Med Assoc 113(6), 2023

A track of the clones: new developments in cellular barcoding.

International experts from multiple disciplines gathered at Homerton College in Cambridge, UK from September 12-14, 2018 to consider recent advances and emerging opportunities in the clonal tracking of hematopoiesis in one of a series of StemCellMathLab workshops. The group included 35 participants with experience in the fields of theoretical and experimental aspects of clonal tracking, and ranged from doctoral students to senior professors. Data from a variety of model systems and from clinical gene therapy trials were discussed, along with strategies for data analysis and sharing and challenges arising due to underlying assumptions in data interpretation and communication. Recognizing the power of this technology underpinned a group consensus of a need for improved mechanisms for sharing data and analytical protocols to maintain reproducibility and rigor in its application to complex tissues.We thank the BBSRC (BB/R021465/1), the German Stem Cell Network, the Wellcome-MRC Cambridge Stem Cell Institute and the Labex CelTisPhyBio (No. ANR-10-LBX-0038) for funds to support this workshop and the conference staff at Homerton Colleg

Plantar pressure analysis : identifying risk of foot and ankle injury in soccer players

The aim of this study was to determine whether risk factors for foot or ankle injuries could be identified using quantitative foot measurements. Male and female soccer players of all levels from 9 to 40 years old were included in this cross-sectional study. Soccer history, foot and ankle function and injury history were investigated. Foot symmetry, length and arch height flexibility and plantar pressure captured with a mat were measured. All variables showing a significant correlation (P ≤ .05) and the presence of at least one foot or ankle injury were integrated into a multivariate logistic regression model using forward stepwise selection. We recruited 277 players (196 males), and 79 participants had sustained at least one foot or ankle soccer-related injury. The significant variables were as follows: age, gender, pressure on the lateral heel and on the fourth and fifth metatarsals. Based on the model, the area under the ROC curve was 81.2%. To achieve a specificity of 80%, the corresponding sensitivity was 72.2%. Plantar pressure measurements can objectively assess foot alignment. Increased pressure on the lateral heel and fourth and fifth metatarsal cavovarus foot type represent a risk factor for foot and ankle injuries in soccer. Level of evidence: IV

Numérique : impact sur le cycle de vie du document (Le)

Actes du colloque "Le numérique : impact sur le cycle de vie du document" organisé à l\u27université de Montréal par l\u27EBSI et l\u27ENSSIB du 13 au 15 octobre 2004. Son objectif était de traiter de façon interdisciplinaire la problématique suivante : « La numérisation, la diffusion des formats numériques originaux, les nouvelles méthodes d\u27indexation et d\u27analyse du document ainsi que le fonctionnement en réseau changent les données de base de la vie du document qui devient une sorte de phénix incessamment renaissant » (programme du colloque)

Validation of the Body Concealment Scale for Scleroderma (BCSS): Replication in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort

© 2016 Elsevier Ltd Body concealment is an important component of appearance distress for individuals with disfiguring conditions, including scleroderma. The objective was to replicate the validation study of the Body Concealment Scale for Scleroderma (BCSS) among 897 scleroderma patients. The factor structure of the BCSS was evaluated using confirmatory factor analysis and the Multiple-Indicator Multiple-Cause model examined differential item functioning of SWAP items for sex and age. Internal consistency reliability was assessed via Cronbach's alpha. Construct validity was assessed by comparing the BCSS with a measure of body image distress and measures of mental health and pain intensity. Results replicated the original validation study, where a bifactor model provided the best fit. The BCSS demonstrated strong internal consistency reliability and construct validity. Findings further support the BCSS as a valid measure of body concealment in scleroderma and provide new evidence that scores can be compared and combined across sexes and ages

On Russian Roulette Estimates for Bayesian Inference with Doubly-Intractable Likelihoods

A large number of statistical models are "doubly-intractable": the likelihood normalising term, which is a function of the model parameters, is intractable, as well as the marginal likelihood (model evidence). This means that standard inference techniques to sample from the posterior, such as Markov chain Monte Carlo (MCMC), cannot be used. Examples include, but are not confined to, massive Gaussian Markov random fields, autologistic models and Exponential random graph models. A number of approximate schemes based on MCMC techniques, Approximate Bayesian computation (ABC) or analytic approximations to the posterior have been suggested, and these are reviewed here. Exact MCMC schemes, which can be applied to a subset of doubly-intractable distributions, have also been developed and are described in this paper. As yet, no general method exists which can be applied to all classes of models with doubly-intractable posteriors. In addition, taking inspiration from the Physics literature, we study an alternative method based on representing the intractable likelihood as an infinite series. Unbiased estimates of the likelihood can then be obtained by finite time stochastic truncation of the series via Russian Roulette sampling, although the estimates are not necessarily positive. Results from the Quantum Chromodynamics literature are exploited to allow the use of possibly negative estimates in a pseudo-marginal MCMC scheme such that expectations with respect to the posterior distribution are preserved. The methodology is reviewed on well-known examples such as the parameters in Ising models, the posterior for Fisher-Bingham distributions on the $d$-Sphere and a large-scale Gaussian Markov Random Field model describing the Ozone Column data. This leads to a critical assessment of the strengths and weaknesses of the methodology with pointers to ongoing research

To portray clonal evolution in blood cancer, count your stem cells

International audienc