875 research outputs found
Measurement of a side wall permeability effect in soil columns using fibre-optics sensing
Side-wall leakage - the preferential flow of water or pollutants near the wall of a side column - has been studied using in-situ fibre optical detection of a dye solution at the boundary and in the centre of a soil column
Isospin Effects in Nuclear Multifragmentation
We develop an improved Statistical Multifragmentation Model that provides the
capability to calculate calorimetric and isotopic observables with precision.
With this new model we examine the influence of nuclear isospin on the fragment
elemental and isotopic distributions. We show that the proposed improvements on
the model are essential for studying isospin effects in nuclear
multifragmentation. In particular, these calculations show that accurate
comparisons to experimental data require that the nuclear masses, free energies
and secondary decay must be handled with higher precision than many current
models accord.Comment: 46 pages, 16 figure
DXA-derived hip shape is related to osteoarthritis:findings from in the MrOS cohort
BF conducted this research whilst on a clinical research primer fellowship awarded by the Elizabeth Blackwell Institute, University of Bristol, UK. This study was funded by Arthritis Research UK project grant ref 20244. CG is funded by Arthritis Research UK grant ref 20000. The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research under the following grant numbers: R01 AR052000, K24 AR048841, U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128.Peer reviewedPostprin
Disruption of a structurally important extracellular element in the Glycine Receptor leads to decreased synaptic integration and signaling resulting in Severe Startle Disease
Functional impairments or trafficking defects of inhibitory glycine receptors (GlyRs) have been linked to human hyperekplexia/startle disease and autism spectrum disorders. We found that a lack of synaptic integration of GlyRs, together with disrupted receptor function, is responsible for a lethal startle phenotype in a novel spontaneous mouse mutant shaky, caused by a missense mutation, Q177K, located in the extracellular ÎČ8âÎČ9 loop of the GlyR α1 subunit. Recently, structural data provided evidence that the flexibility of the ÎČ8âÎČ9 loop is crucial for conformational transitions during opening and closing of the ion channel and represents a novel allosteric binding site in Cys-loop receptors. We identified the underlying neuropathological mechanisms in male and female shaky mice through a combination of protein biochemistry, immunocytochemistry, and both in vivo and in vitro electrophysiology. Increased expression of the mutant GlyR α1Q177K subunit in vivo was not sufficient to compensate for a decrease in synaptic integration of α1Q177KÎČ GlyRs. The remaining synaptic heteromeric α1Q177KÎČ GlyRs had decreased current amplitudes with significantly faster decay times. This functional disruption reveals an important role for the GlyR α1 subunit ÎČ8âÎČ9 loop in initiating rearrangements within the extracellularâtransmembrane GlyR interface and that this structural element is vital for inhibitory GlyR function, signaling, and synaptic clustering
Fragment Production in Non-central Collisions of Intermediate Energy Heavy Ions
The defining characteristics of fragment emission resulting from the
non-central collision of 114Cd ions with 92Mo target nuclei at E/A = 50 MeV are
presented. Charge correlations and average relative velocities for mid-velocity
fragment emission exhibit significant differences when compared to standard
statistical decay. These differences associated with similar velocity
dissipation are indicative of the influence of the entrance channel dynamics on
the fragment production process
Education inequalities in adult all-cause mortality: first national data for Australia using linked census and mortality data
BACKGROUND: National linked mortality and census data have not previously been available for Australia. We estimated education-based mortality inequalities from linked census and mortality data that are suitable for international comparisons. METHODS: We used the Australian Bureau of Statistics Death Registrations to Census file, with data on deaths (2011-2012) linked probabilistically to census data (linkage rate 81%). To assess validity, we compared mortality rates by age group (25-44, 45-64, 65-84âyears), sex and area-inequality measures to those based on complete death registration data. We used negative binomial regression to quantify inequalities in all-cause mortality in relation to five levels of education ['Bachelor degree or higher' (highest) to 'no Year 12 and no post-secondary qualification' (lowest)], separately by sex and age group, adjusting for single year of age and correcting for linkage bias and missing education data. RESULTS: Mortality rates and area-based inequality estimates were comparable to published national estimates. Men aged 25-84âyears with the lowest education had age-adjusted mortality rates 2.20 [95% confidence interval (CI): 2.08â2.33] times those of men with the highest education. Among women, the rate ratio was 1.64 (1.55â1.74). Rate ratios were 3.87 (3.38â4.44) in men and 2.57 (2.15â3.07) in women aged 25-44âyears, decreasing to 1.68 (1.60â1.76) in men and 1.44 (1.36â1.53) in women aged 65-84âyears. Absolute education inequalities increased with age. One in three to four deaths (31%) was associated with less than Bachelor level education. CONCLUSIONS: These linked national data enabled valid estimates of education inequality in mortality suitable for international comparisons. The magnitude of relative inequality is substantial and similar to that reported for other high-income countries.Rosemary J Korda, Nicholas Biddle, John Lynch, James Eynstone-Hinkins, Kay Soga, Emily Banks ... et al
Non-Thermal Behavior in Multifragment Decay
This research was sponsored by the National Science Foundation Grant NSF PHY-931478
A Helicity-Based Method to Infer the CME Magnetic Field Magnitude in Sun and Geospace: Generalization and Extension to Sun-Like and M-Dwarf Stars and Implications for Exoplanet Habitability
Patsourakos et al. (Astrophys. J. 817, 14, 2016) and Patsourakos and
Georgoulis (Astron. Astrophys. 595, A121, 2016) introduced a method to infer
the axial magnetic field in flux-rope coronal mass ejections (CMEs) in the
solar corona and farther away in the interplanetary medium. The method, based
on the conservation principle of magnetic helicity, uses the relative magnetic
helicity of the solar source region as input estimates, along with the radius
and length of the corresponding CME flux rope. The method was initially applied
to cylindrical force-free flux ropes, with encouraging results. We hereby
extend our framework along two distinct lines. First, we generalize our
formalism to several possible flux-rope configurations (linear and nonlinear
force-free, non-force-free, spheromak, and torus) to investigate the dependence
of the resulting CME axial magnetic field on input parameters and the employed
flux-rope configuration. Second, we generalize our framework to both Sun-like
and active M-dwarf stars hosting superflares. In a qualitative sense, we find
that Earth may not experience severe atmosphere-eroding magnetospheric
compression even for eruptive solar superflares with energies ~ 10^4 times
higher than those of the largest Geostationary Operational Environmental
Satellite (GOES) X-class flares currently observed. In addition, the two
recently discovered exoplanets with the highest Earth-similarity index, Kepler
438b and Proxima b, seem to lie in the prohibitive zone of atmospheric erosion
due to interplanetary CMEs (ICMEs), except when they possess planetary magnetic
fields that are much higher than that of Earth.Comment: http://adsabs.harvard.edu/abs/2017SoPh..292...89
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