Information Architecture for a Chemical Modeling Knowledge Graph

Machine learning models for chemical property predictions are high dimension design challenges spanning multiple disciplines. Free and open-source software libraries have streamlined the model implementation process, but the design complexity remains. In order better navigate and understand the machine learning design space, model information needs to be organized and contextualized. In this work, instances of chemical property models and their associated parameters were stored in a Neo4j property graph database. Machine learning model instances were created with permutations of dataset, learning algorithm, molecular featurization, data scaling, data splitting, hyperparameters, and hyperparameter optimization techniques. The resulting graph contains over 83,000 nodes and 4 million edges and can be explored with interactive visualization software. The structure of the property graph is centered around models and molecules which enables efficient and intuitive inter- and intra-model evaluation. We use a curated lipophilicity dataset to demonstrate graph use cases. Difficult to predict molecules were identified across multiple models simultaneously. Powerful and expressive graph queries were implemented to identify molecular fragments that were both prevalent and associated with high lipophilicity prediction error

Interference between postural control and mental task performance in patients with vestibular disorder and healthy controls

OBJECTIVES - To determine whether interference between postural control and mental task performance in patients with balance system impairment and healthy subjects is due to general capacity limitations, motor control interference, competition for spatial processing resources, or a combination of these.METHOD - Postural stability was assessed in 48 patients with vestibular disorder and 24 healthy controls while they were standing with eyes closed on (a) a stable and (b) a moving platform. Mental task performance was measured by accuracy and reaction time on mental tasks, comprising high and low load, spatial and non-spatial tasks. Interference between balancing and performing mental tasks was assessed by comparing baseline (single task) levels of sway and mental task performance with levels while concurrently balancing and carrying out mental tasks.RESULTS - As the balancing task increased in difficulty, reaction times on both low load mental tasks grew progressively longer and accuracy on both high load tasks declined in patients and controls. Postural sway was essentially unaffected by mental activity in patients and controls.CONCLUSIONS - It is unlikely that dual task interference between balancing and mental activity is due to competition for spatial processing resources, as levels of interference were similar in patients with vestibular disorder and healthy controls, and were also similar for spatial and non-spatial tasks. Moreover, the finding that accuracy declined on the high load tasks when balancing cannot be attributed to motor control interference, as no motor control processing is involved in maintaining accuracy of responses. Therefore, interference between mental activity and postural control can be attributed principally to general capacity limitations, and is hence proportional to the attentional demands of both tasks

Oda Elt Project in Nicaragua. A Case Study in Project Design

The following is a description of the aims and activities of the ODA ELT Project: Nicaragua. It will describe the research into English Language Teaching which took place in the secondary schools of Nicaragua, how this research was conducted,and what the most significant findings were. From there, it will look at how project plans and activities were developed and the rationale for those plans. Finally, it will consider the implementation of these plans and the implications for future development within the área of ELT in Nicaragua

Oda Elt Project in Nicaragua. A Case Study in Project Design

The following is a description of the aims and activities of the ODA ELT Project: Nicaragua. It will describe the research into English Language Teaching which took place in the secondary schools of Nicaragua, how this research was conducted,and what the most significant findings were. From there, it will look at how project plans and activities were developed and the rationale for those plans. Finally, it will consider the implementation of these plans and the implications for future development within the área of ELT in Nicaragua

Use of mealtime advice mats in special schools for children with learning disabilities

Aim Eating, drinking and swallowing difficulties can have serious outcomes for children and adults with learning disabilities. Carers must adhere to management guidelines about mealtime support, and multidisciplinary teams must ensure this happens. A one-page point of care tool summarising the guidelines for a specific client, sometimes termed a ‘mealtime advice mat’ (MAM), is one method. The aim of this study was to determine whether MAMs are used in special schools, gain an understanding of their format and use and identify other methods of supporting adherence such as training. Methods Questionnaires were given to 14 speech and language therapists (SLTs) who work in special schools, and 13 members of staff of one London special school. Results The results suggest that SLTs use MAMS as common practice, and that there is agreement on their content and format, but not on the name of the resource. School staff also use this type of tool, but not directly at mealtimes. Conclusion Written, simplified guidelines to support children at mealtimes are used in special schools, however, although they contain similar information they vary in title and the way they are used. MAMs are simple and potentially cost-effective point-of-care tools that can reinforce eating and drinking guidelines, and can be used to measure adherence. Ensuring they are understood by and useful to carers requires further investigation