Veterinary Arsenicals

Feed medication and other forms of chemotherapy in our meat-producing animals have caused heated controversies. Some of this confusion is due to both a distortion of and a lack of information. Arsenicals are some of the oldest compounds whose use in agriculture has been questioned. An attempt will be made to trace the historical use of arsenicals and to discuss their metabolism and side effects from a veterinarian\u27s point of view

Sirolimus Ointment for Facial Angiofibromas in Individuals with Tuberous Sclerosis Complex.

BACKGROUND: Facial angiofibromas affect most patients with tuberous sclerosis complex. They tend to progress, can cause recurrent bleeding and facial disfigurement, and have significant psychological effects. We reviewed the effectiveness and safety of topical sirolimus ointment 0.1%. We also assessed the effect of treatment on quality of life. METHODS: We report our experience in using sirolimus ointment in 14 patients with TSC (9 children and 5 adults). The impact of sirolimus ointment was monitored with digital photography, dermatological review using a validated Facial Angiofibroma Severity Index (FASI), and quality of life assessments using the questionnaires PedsQL for children and SF36 for adults. RESULTS: The FASI scores were improved in 12/14 cases after six months' treatment, and improvement was more likely in children (median FASI scores of improvement after treatment were 3 points for children and 1 for adults). Proxy-reported PedsQL scores for the total psychosocial domain improved significantly in the children in the cohort with treatment. CONCLUSIONS: Sirolimus ointment 0.1% administered once a day was effective in treating facial angiofibromas. It appears to be safe and well tolerated and to have a positive impact on patients' quality of life. It appeared to be most beneficial when started in childhood

Patterns in high-frequency FX data: Discovery of 12 empirical scaling laws

We have discovered 12 independent new empirical scaling laws in foreign exchange data-series that hold for close to three orders of magnitude and across 13 currency exchange rates. Our statistical analysis crucially depends on an event-based approach that measures the relationship between different types of events. The scaling laws give an accurate estimation of the length of the price-curve coastline, which turns out to be surprisingly long. The new laws substantially extend the catalogue of stylised facts and sharply constrain the space of possible theoretical explanations of the market mechanisms.Comment: 26 pages, 3 figures, 23 tables,2nd version (text made more concise and readable, algorithm pseudocode, results unchanged), 5-year datasets (USD-JPY, EUR-USD) provided at http://www.olsen.ch/more/datasets

Agents Play Mix-game

In mix-game which is an extension of minority game, there are two groups of agents; group1 plays the majority game, but the group2 plays the minority game. This paper studies the change of the average winnings of agents and volatilities vs. the change of mixture of agents in mix-game model. It finds that the correlations between the average winnings of agents and the mean of local volatilities are different with different combinations of agent memory length when the proportion of agents in group 1 increases. This study result suggests that memory length of agents in group1 be smaller than that of agent in group2 when mix-game model is used to simulate the financial markets.Comment: 8 pages, 6 figures, 3 table

Unveiling the corona of the Milky Way via ram-pressure stripping of dwarf satellites

<p>The spatial segregation between dwarf spheroidal (dSph) and dwarf irregular galaxies in the Local Group has long been regarded as evidence of an interaction with their host galaxies. In this paper, we assume that ram-pressure stripping is the dominant mechanism that removed gas from the dSphs and we use this to derive a lower bound on the density of the corona of the Milky Way at large distances (R similar to 50-90 kpc) from the Galactic Centre. At the same time, we derive an upper bound by demanding that the interstellar medium of the dSphs is in pressure equilibrium with the hot corona. We consider two dwarfs (Sextans and Carina) with well-determined orbits and star formation histories. Our approach introduces several novel features: (i) we use the measured star formation histories of the dwarfs to derive the time at which they last lost their gas and (via a modified version of the Kennicutt-Schmidt relation) their internal gas density at that time; (ii) we use a large suite of 2D hydrodynamical simulations to model the gas stripping; and (iii) we include supernova feedback tied to the gas content. Despite having very different orbits and star formation histories, we find results for the two dSphs that are in excellent agreement with one another. We derive an average particle density of the corona of the Milky Way at R = 50-90 kpc in the range n(cor) = 1.3-3.6 x 10(-4) cm(-3). Including additional constraints from X-ray emission limits and pulsar dispersion measurements (that strengthen our upper bound), we derive Galactic coronal density profiles. Extrapolating these to large radii, we estimate the fraction of baryons (missing baryons) that can exist within the virial radius of the Milky Way. For an isothermal corona (T-cor = 1.8 x 10(6) K), this is small - just 10-20 per cent of the expected missing baryon fraction, assuming a virial mass of 1-2 x 10(12) M-circle dot. Only a hot (T-cor = 3 x 10(6) K) and adiabatic corona can contain all of the Galaxy's missing baryons. Models for the Milky Way must explain why its corona is in a hot adiabatic thermal state; or why a large fraction of its baryons lie beyond the virial radius.</p>

Age of the Peach Springs Tuff, Southeastern California and Western Arizona

Sanidine separates from pumice of the early Miocene Peach Springs Tuff are concordantly dated at 18.5 ± 0.2 Ma by two isotopic techniques. The Peach Springs Tuff is the only known unit that can be correlated between isolated outcrops of Miocene strata from the central Mojave Desert of southeastern California to the western Colorado Plateau in Arizona, across five structural provinces, a distance of 350 km. Thus the age of the Peach Springs Tuff is important to structural and paleogeographic reconstructions of a large region. Biotite and sanidine separates from bulk samples of the Peach Springs Tuff from zones of welding and vapor-phase alteration have not produced consistent ages by the K-Ar method. Published ages of mineral separates from 17 localities ranged from 16.2 to 20.5 Ma. Discordant 40Ar/39Ar incremental release spectra were obtained for one biotite and two of the sanidine separates. Ages that correspond to the last gas increments are as old as 27 Ma. The 40Ar/39Ar incremental release determinations on sanidine separated from blocks of Peach Springs Tuff pumice yield ages of 18.3 ± 0.3 and 18.6 ± 0.4 Ma. Laser fusion measurements yield a mean age of 18.51 ± 0.10. The results suggest that sanidine and biotite K-Ar ages older than about 18.5 Ma are due to inherited Ar from pre-Tertiary contaminants, which likely were incorporated into the tuff during deposition. Sanidine K-Ar ages younger than 18 Ma probably indicate incomplete extraction of radiogenic 40Ar, whereas laser fusion dates of biotite and hornblende younger than 18 Ma likely are due to postdepositional alteration. Laser fusion ages as high as 19.01 Ma on biotite grains from pumice suggest that minerals from pre-Tertiary country rocks also were incorporated in the magma chamber

Scaling of the distribution of fluctuations of financial market indices

We study the distribution of fluctuations over a time scale $\Delta t$ (i.e., the returns) of the S&P 500 index by analyzing three distinct databases. Database (i) contains approximately 1 million records sampled at 1 min intervals for the 13-year period 1984-1996, database (ii) contains 8686 daily records for the 35-year period 1962-1996, and database (iii) contains 852 monthly records for the 71-year period 1926-1996. We compute the probability distributions of returns over a time scale $\Delta t$, where $\Delta t$ varies approximately over a factor of 10^4 - from 1 min up to more than 1 month. We find that the distributions for $\Delta t \leq$ 4 days (1560 mins) are consistent with a power-law asymptotic behavior, characterized by an exponent $\alpha \approx 3$, well outside the stable L\'evy regime $0 < \alpha < 2$. To test the robustness of the S&P result, we perform a parallel analysis on two other financial market indices. Database (iv) contains 3560 daily records of the NIKKEI index for the 14-year period 1984-97, and database (v) contains 4649 daily records of the Hang-Seng index for the 18-year period 1980-97. We find estimates of $\alpha$ consistent with those describing the distribution of S&P 500 daily-returns. One possible reason for the scaling of these distributions is the long persistence of the autocorrelation function of the volatility. For time scales longer than $(\Delta t)_{\times} \approx 4$ days, our results are consistent with slow convergence to Gaussian behavior.Comment: 12 pages in multicol LaTeX format with 27 postscript figures (Submitted to PRE May 20, 1999). See http://polymer.bu.edu/~amaral/Professional.html for more of our work on this are

Zn(O, S) layers for chalcoyprite solar cells sputtered from a single target

A simplified Cu(In, Ga)(S, Se)2/Zn(O, S)/ZnO:Al stack for chalcopyrite thin- film solar cells is proposed. In this stack the Zn(O, S) layer combines the roles of the traditional CdS buffer and undoped ZnO layers. It will be shown that Zn(O, S) films can be sputtered in argon atmosphere from a single mixed target without substrate heating. The photovoltaic performance of the simplified stack matches that of the conventional approach. Replacing the ZnO target with a ZnO/ZnS target may therefore be sufficient to omit the CdS buffer layer and avoid the associated complexity, safety and recycling issues, and to lower production cost

Signal yields, energy resolution, and recombination fluctuations in liquid xenon

This work presents an analysis of monoenergetic electronic recoil peaks in the dark-matter-search and calibration data from the first underground science run of the Large Underground Xenon (LUX) detector. Liquid xenon charge and light yields for electronic recoil energies between 5.2 and 661.7 keV are measured, as well as the energy resolution for the LUX detector at those same energies. Additionally, there is an interpretation of existing measurements and descriptions of electron-ion recombination fluctuations in liquid xenon as limiting cases of a more general liquid xenon recombination fluctuation model. Measurements of the standard deviation of these fluctuations at monoenergetic electronic recoil peaks exhibit a linear dependence on the number of ions for energy deposits up to 661.7 keV, consistent with previous LUX measurements between 2 and 16 keV with H3. We highlight similarities in liquid xenon recombination for electronic and nuclear recoils with a comparison of recombination fluctuations measured with low-energy calibration data.Peer Reviewe