Le traitement conservateur dans le cadre d’une pubalgie de surcharge chez l’athlète, une revue systématique de revues systématiques

La pubalgie de surcharge touche de nombreux athlètes et engendre d’importantes conséquences, tant musculo-squelettiques que financières. De nombreux facteurs de risque ont été identifiés mais cette pathologie reste complexe et il n’existe aucun consensus concernant le traitement conservateur. L’objectif de cette étude est de répertorier les différents traitements conservateurs dans le cadre de pubalgies de surcharge chez les athlètes et d’en évaluer l’efficacité pour émettre des recommandations thérapeutiques pratiques (GRADE) pour le physiothérapeute

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis

Rheumatoid arthritis is characterised by synovial inflammation and proliferation of fibroblast-like synoviocytes. The induction of apoptosis has long been proposed as a target for proliferative autoimmune diseases, and has further been shown to act as a successful treatment of experimental models of arthritis, such as collagen-induced arthritis. Here we examined the effects of specific oral small-molecule inhibitors of the transcription regulating cyclin-dependent kinase 9 on the development and progression of collagen-induced arthritis. DBA/1 mice were immunised with bovine collagen type II and treated orally with specific CDK9 inhibitors. The effects of CDK9 inhibition on RNA levels and protein expression, apoptosis induction, caspase activation and lymphocyte phenotype were further analysed. Mice showed a significant delay in disease onset and a reduction in disease severity following treatment with CDK9 inhibitors. Inhibiting CDK9 activity in peripheral blood mononuclear cells resulted in the loss of Mcl-1 expression at both the protein and RNA levels, along with a subsequent increase in apoptosis. CDK9 specific inhibitors may be a potential alternative treatment not only of cancer, but also for autoimmune- and inflammatory diseases. Taken together, these results show that transient inhibition of CDK9 induces apoptosis in leukocyte subsets and modulates the immune response

The Grizzly, January 26, 1999

A Work in Progress • Area Congressmen Discuss Leadership in the 21st Century • Montco Welcomes Clintons, Gores • Classes Held Martin Luther King Day • The Message of Dr. King Remembered • Students Honored for Fundraising • Spring/Summer Internships • Collegeville Squares is a Hit • Opinion: State of Surreality; Impeachment: Democracy on Trial? • Film Society: New & Improved! • Ursinus Gymnastics Back in Full Swing • First Conference Win for UC Swimming • Winter Sports Wrap-uphttps://digitalcommons.ursinus.edu/grizzlynews/1431/thumbnail.jp

The Grizzly, September 22, 1998

Ursinus Gears Up for Family Day • Dr. Fouts Gives Lecture on Chimpanzee Research • Freshman Class Election Results • Opinion: Ursinus\u27 Movement Towards Diversity; In Response to Has America Sunk to the Level of Terrorists? • Presentations on Family Day • Help is out There • Old Dogs Don\u27t Need New Tricks • Big, Big Band: Big, Big Success • Theater Life • Field Hockey Wrap-Up • UC Volleyball Evens Out at 2-2 • Bears Recognized in Centennial Conference Honor Roll • Lady Bears Suffer Conference Losses • Men\u27s Soccer Split Games • Football Falls in Conference Opener • Flo Jo Dies at 38 • Ripken Ends Streakhttps://digitalcommons.ursinus.edu/grizzlynews/1424/thumbnail.jp

The Grizzly, September 29, 1998

Construction Begins for New Bookstore • Ursinus Students Named Smith Scholars • Econ. Students Apply Classroom Knowledge • Opinion: Terrorist Debate Continues; Ursinus Keeps up With the Times; Students Vote Two Thumbs up for Co-ed Living • Is Home the way you Left it? • Students Spending Weekends Differently • Hugs Help Pottstown Hospital • Family Day \u2798 = Success • Kelley on Photography • Berman Exhibits Not Well Attended • Volleyball Hit With Key Injury • UC Football Gets Terrorized • Men\u27s Soccer Drops Two • Women\u27s Soccer Shuts-Out Dickinson • Who\u27s in Charge Here? • Women\u27s Rugby Overpowered by Lock Haven University • Centennial Conference Newshttps://digitalcommons.ursinus.edu/grizzlynews/1425/thumbnail.jp

Persistent tachypnea of infancy: Follow up at school age.

AbstractBackgroundPersistent tachypnea of infancy (PTI) is a rare pediatric lung disease of unknown origin. The diagnosis can be made by clinical presentation and chest high resolution computed tomography after exclusion of other causes. Clinical courses beyond infancy have rarely been assessed.MethodsPatients included in the Kids Lung Register diagnosed with PTI as infants and now older than 5 years were identified. Initial presentation, extrapulmonary comorbidities, spirometry and clinical outcome were analyzed.ResultsThirty‐five children older than 5 years with PTI diagnosed as infants were analyzed. At the age of 5 years, 74% of the patients were reported as asymptomatic and did not develope new symptoms during the observational period at school‐age (mean, 3.9 years; range, 0.3‐6.3). At the age of about 10 years, none of the symptomatic children had abnormal oxygen saturation during sleep or exercise anymore. Lung function tests and breathing frequency were within normal values throughout the entire observational period.ConclusionsPTI is a pulmonary disease that can lead to respiratory insufficiency in infancy. As at school age most of the previously chronically affected children became asymptomatic and did not develop new symptoms. We conclude that the overall clinical course is favorable

Fertility education for adolescent cancer patients: Gaps in current clinical practice in Europe

Objective: As adolescent cancer patients may suffer from infertility following treatment, fertility counselling is essential. Our aim was to explore the current situation in four European countries in terms of (I) education about the risk for infertility, (II) counselling on fertility preservation, (III) patients' knowledge on fertility, (IV) sufficiency of information and (V) uptake of cryopreservation. Methods: In total, 113 patients (13–20 years) at 11 study centres completed a self-report questionnaire three and six months after cancer diagnosis. Multivariate logistic regression was used to estimate odds ratios (OR) with 95% confidence intervals (CI). Results: As many as 80.2% of participants reported having received education about the risk for infertility prior to treatment, 73.2% recalled counselling on fertility preservation. Only 52.3% stated they felt sufficiently informed to make a decision. Inability to recall counselling on fertility preservation (OR = 0.03, CI: 0.00–0.47) and female gender (OR = 0.11, CI: 0.03–0.48) was associated with lower use of cryopreservation, whereas older age was associated with higher use. Conclusion: Fertility counselling was available to a relatively high proportion of patients, and it did influence the utilisation of cryopreservation. However, many patients did not feel sufficiently informed. Further improvement is needed to enable adolescent cancer patients to make an informed decision on fertility preservation

The Grizzly, September 15, 1998

Where\u27s Your Money Going? • Kenneth Starr\u27s XXX-Files • Pfahler Hall Renovations: The Sound of Progress • Opinion: Has America Sunk to the Level of Terrorists?; Academic Computing: Beneficial or Detrimental?; How Efficient Will the New Mail System Be? • Poets in Our Midst • RLO = One Big Happy Family • The Man from La Mancha has Gone Home • Addition Made to the History Department • Statues Breathe Life into Ursinus • Elyssa Rundle: The Spirit of the Paint • Big Big Band at UC • New Addition to Ursinus Training Staff • Men\u27s Soccer Plagued by Injuries • Football Back on Track • Women\u27s Soccer Shuts Out Washington • Field Hockey Drops Two Close Ones • Hinkle Named Player of the Week • UC Cross Country • UC Volleyball Improves to 7-1https://digitalcommons.ursinus.edu/grizzlynews/1423/thumbnail.jp

Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review

BACKGROUND AND OBJECTIVE The 30-day expected mortality rate is frequently used as a metric to determine which patients benefit from palliative radiation treatment (RT). We conducted a narrative review to examine whether its use as a metric might be appropriate for patient selection. METHODS A literature review was conducted to identify relevant studies that highlight the benefits of palliative RT in timely symptom management among patients with a poor performance status, the accuracy of predicting survival near the end of life and ways to speed up the process of RT administration through rapid response clinics. KEY CONTENT AND FINDINGS Several trials have demonstrated substantial response rates for pain and/or bleeding by four weeks and sometimes within the first two weeks after RT. Models of patient survival have limited accuracy, particularly for predicting whether patients will die within the next 30 days. Dedicated Rapid Access Palliative RT (RAPRT) clinics, in which patients are assessed, simulated and treated on the same day, reduce the number of patient visits to the radiation oncology department and hence the burden on the patient as well as costs. CONCLUSIONS Single-fraction palliative RT should be offered to eligible patients if they are able to attend treatment and could potentially benefit from symptom palliation, irrespective of predicted life expectancy. We discourage the routine use of the 30-day mortality as the only metric to decide whether to offer RT. More common implementation of RAPRT clinics could result in a significant benefit for patients of all life expectancies, but particularly those having short ones