Undernutrition and stage of gestation influence fetal adipose tissue gene expression

Funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS), including the Strategic Partnership for Animal Science Excellence (SPASE) and the U.S. National Institutes of Health (HD045784). None of the authors had any financial or personal conflicts of interest.Peer reviewedPostprin

Robust Conditional Wald Inference for Over-Identified IV

For the over-identified linear instrumental variables model, researchers commonly report the 2SLS estimate along with the robust standard error and seek to conduct inference with these quantities. If errors are homoskedastic, one can control the degree of inferential distortion using the first-stage F critical values from Stock and Yogo (2005), or use the robust-to-weak instruments Conditional Wald critical values of Moreira (2003). If errors are non-homoskedastic, these methods do not apply. We derive the generalization of Conditional Wald critical values that is robust to non-homoskedastic errors (e.g., heteroskedasticity or clustered variance structures), which can also be applied to nonlinear weakly-identified models (e.g. weakly-identified GMM)

Wikum: Bridging Discussion Forums and Wikis Using Recursive Summarization

Large-scale discussions between many participants abound on the internet today, on topics ranging from political arguments to group coordination. But as these discussions grow to tens of thousands of posts, they become ever more difficult for a reader to digest. In this article, we describe a workflow called recursive summarization, implemented in our Wikum prototype, that enables a large population of readers or editors to work in small doses to refine out the main points of the discussion. More than just a single summary, our workflow produces a summary tree that enables a reader to explore distinct subtopics at multiple levels of detail based on their interests. We describe lab evaluations showing that (i) Wikum can be used more effectively than a control to quickly construct a summary tree and (ii) the summary tree is more effective than the original discussion in helping readers identify and explore the main topics

Extended Dualization: a method for the Bosonization of Anomalous Fermion Systems in Arbitrary Dimension

The technique of extended dualization developed in this paper is used to bosonize quantized fermion systems in arbitrary dimension $D$ in the low energy regime. In its original (minimal) form, dualization is restricted to models wherein it is possible to define a dynamical quantized conserved charge. We generalize the usual dualization prescription to include systems with dynamical non--conserved quantum currents. Bosonization based on this extended dualization requires the introduction of an additional rank $0$ (scalar) field together with the usual antisymmetric tensor field of rank $(D-2)$. Our generalized dualization prescription permits one to clearly distinguish the arbitrariness in the bosonization from the arbitrariness in the quantization of the system. We study the bosonization of four--fermion interactions with large mass in arbitrary dimension. First, we observe that dualization permits one to formally bosonize these models by invoking the bosonization of the free massive Dirac fermion and adding some extra model--dependent bosonic terms. Secondly, we explore the potential of extended dualization by considering the particular case of \underbar{chiral} four--fermion interactions. Here minimal dualization is inadequate for calculating the extra bosonic terms. We demonstrate the utility of extended dualization by successfully completing the bosonization of this chiral model. Finally, we consider two examples in two dimensions which illuminate the utility of using extended dualization by showing how quantization ambiguities in a fermionic theory propagate into the bosonized version. An explicit parametrization of the quantization ambiguities of the chiral current in the Chiral Schwinger model is obtained. Similarly, for the sine--Gordon interaction in the massive Thirring model the quantizationComment: Revised version including major changes in section 3, to be published in Phys. Rev.

The eight-vertex model and lattice supersymmetry

We show that the XYZ spin chain along the special line of couplings J_xJ_y+J_xJ_z+J_yJ_z=0 possesses a hidden N=(2,2) supersymmetry. This lattice supersymmetry is non-local and changes the number of sites. It extends to the full transfer matrix of the corresponding eight-vertex model. In particular, it is shown how to derive the supercharges from Baxter's Bethe ansatz. This analysis leads to new conjectures concerning the ground state for chains of odd length. We also discuss a correspondence between the spectrum of this XYZ chain and that of a manifestly supersymmetric staggered fermion chain.Comment: 40 pages, 6 figures, Tik

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p  90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care

Aqueous alteration processes in Jezero crater, Mars—implications for organic geochemistry

The Perseverance rover landed in Jezero crater, Mars, in February 2021. We used the Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals (SHERLOC) instrument to perform deep-ultraviolet Raman and fluorescence spectroscopy of three rocks within the crater. We identify evidence for two distinct ancient aqueous environments at different times. Reactions with liquid water formed carbonates in an olivine-rich igneous rock. A sulfate-perchlorate mixture is present in the rocks, which probably formed by later modifications of the rocks by brine. Fluorescence signatures consistent with aromatic organic compounds occur throughout these rocks and are preserved in minerals related to both aqueous environments

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Determining crystal structures through crowdsourcing and coursework

We show here that computer game players can build high-quality crystal structures. Introduction of a new feature into the computer game Foldit allows players to build and real-space refine structures into electron density maps. To assess the usefulness of this feature, we held a crystallographic model-building competition between trained crystallographers, undergraduate students, Foldit players and automatic model-building algorithms. After removal of disordered residues, a team of Foldit players achieved the most accurate structure. Analysing the target protein of the competition, YPL067C, uncovered a new family of histidine triad proteins apparently involved in the prevention of amyloid toxicity. From this study, we conclude that crystallographers can utilize crowdsourcing to interpret electron density information and to produce structure solutions of the highest quality