In search of a suitable way to deploy Triple-A capabilities through assessment of AAA models’ competitive advantage predictive capacity

Purpose – To determine how to best deploy the Triple-A supply chain (SC) capabilities (AAA-agility, adaptability and alignment) to improve competitive advantage (CA) by identifying the Triple-A SC model with the highest CA predictive capability. Design/methodology/approach – Assessment of in-sample and out-of-sample predictive capacity of Triple-ACA models (considering AAA as individual constructs) to find which has the highest CA predictive capacity. BIC, BIC-Akaike weights and PLSpredict are used in a multi-country, multi-informant, multi-sector 304 plant sample. Findings – Greater direct relationship model (DRM) in-sample and out-of-sample CA predictive capacity suggests DRM’s greater likelihood of achieving a higher CA predictive capacity than mediated relationship model (MRM). So, DRM can be considered a benchmark for research/practice and the Triple-A SC capabilities as independent levers of performance/CA. Research limitations/implications – DRM emerges as a reference for analysing how to trigger the three Triple-A SC levers for better performance/CA predictive capacity. Therefore, MRM proposals should be compared to DRM to determine whether their performance is significantly better considering the study’s aim. Practical implications – Results with our sample justify how managers can suitably deploy the Triple-A SC capabilities to improve CA by implementing AAA as independent levers. Single capability deployment does not require levels to be reached in others. Originality/value – First research considering Triple-A SC capability deployment to better improve performance/CA focusing on model’s predictive capability (essential for decision-making), further highlighting the lack of theory and contrasted models for Lee’s Triple-A framework.Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033Consejería de Transformación Económica, Industria, Conocimiento y Universidades PY20_0120

Climatic and land use changes on the NW of Iberian Peninsula recorded in a 1500-year record from Lake Sanabria

L'estudi de diversos descriptors paleoambientals com ara el pol·len, les diatomees i la sedimentologia, realitzat en sediments procedents del llac de Sanabria (NO de la península Ibèrica), ha aportat informació sobre les oscil·lacions climàtiques atribuïdes als períodes càlids tardoromà i medieval, així com a la petita edat del gel. Entre els anys 440 i 950 dC, el clima es caracteritzà per temperatures suaus i un règim de precipitacions mediterrani, malgrat l'existència de pulsacions més fredes vers els anys 530 i 700 dC. Les evidències pol·líniques dels usos del sòl indiquen l'extensió d'activitats ramaderes i agrícoles. Aquesta fase correspon al final del període càlid romà i al període càlid medieval. El canvi de condicions climàtiques es produeix entre els anys 950 i 1100 dC, moment en què els valors mínims de matèria orgànica, pol·len arbori, concentració de diatomees, nitrogen total (TN) i mida del gra indiquen temperatures més baixes i un règim de precipitacions més regular. Aquest període correspon a la petita edat del gel, que finalitzà vers l'any 1590 dC. Posteriorment, la productivitat del llac tendeix a recuperar els valors previs, malgrat que es produeixen episodis freds i curts. Els valors de carbó orgànic total, TN i diatomees covarien amb els índexs de temperatura del NO de la península Ibèrica i posarien de manifest que, amb anterioritat a l'era industrial, el sistema lacustre de Sanabria estava controlat principalment per les condicions climàtiques. Des de l'any 1920 dC, la productivitat del llac està influenciada per l'activitat humana.This multi-proxy paleoenvironmental study from Lake Sanabria (NW Iberian Peninsula), based on pollen, diatom, and sedimentology, provides evidences of climatic oscillations attributed to the Late Roman and Medieval Warm Periods as well as the Little Ice Age (LIA). From 440 to 950 AD, the climate was characterized by mild temperatures and a Mediterranean rainfall regime, although climatic cold periods were recorded at ca. 530 and 700. Evidence from pollen indicators of land-use suggests that grazing and farming were widespread activities. This period corresponds to the end of the Roman Warm Period and the Medieval Warm Period. The onset of new climate conditions occurred between 950 and 1100 AD, as minimum values of organic matter, arboreal pollen, diatom concentration, total nitrogen (TN), and grain size indicate low temperatures and a more regular rainfall regime. This period corresponds to the LIA and ended at 1590 AD, when lake productivity tended to recover to previous values in spite of the occurrence of cool events. Total organic carbon, TN, and diatom content covary with the temperature index for the NW Iberia, suggesting that Lake Sanabria was mainly controlled by climate before the industrial period. Since 1920 AD, lake productivity has been mainly influenced by human activity

Comparison of the Influence of Oxygen Groups Introduced by Graphene Oxide on the Activity of Carbon Felt in Vanadium and Anthraquinone Flow Batteries

An increasing number of studies focus on organic flow batteries (OFBs) as possible substitutes for the vanadium flow battery (VFB), featuring anthraquinone derivatives, such as anthraquinone-2,7-disulfonic acid (2,7-AQDS). VFBs have been postulated as a promising energy storage technology. However, the fluctuating cost of vanadium minerals and risky supply chains have hampered their implementation, while OFBs could be prepared from renewable raw materials. A critical component of flow batteries is the electrode material, which can determine the power density and energy efficiency. Yet, and in contrast to VFBs, studies on electrodes tailored for OFBs are scarce. Hence, in this work, we propose the modification of commercial carbon felts with reduced graphene oxide (rGO) and poly(ethylene glycol) for the 2,7-AQDS redox couple and to preliminarily assess its effects on the efficiency of a 2,7-AQDS/ferrocyanide flow battery. Results are compared to those of a VFB to evaluate if the benefits of the modification are transferable to OFBs. The modification of carbon felts with surface oxygen groups introduced by the presence of rGO enhanced both its hydrophilicity and surface area, favoring the catalytic activity toward VFB and OFB reactions. The results are promising, given the improved behavior of the modified electrodes. Parallels are established between the electrodes of both FB technologies.CSIC, MICINN, and AEI (MCIN/AEI/10.13039/501100011033), alongside the European Union − NextGenerationEU for funding the PTITRANSENER projectMinisterio de Universidades of the Government of Spain for granting his predoctoral fellowship contract (FPU20/04400)Clausthal University of Technology through a stay at the Research Center for Energy Storage Technologies (EST) in Goslar, GermanyAlexander von Humboldt Foundation (Germany) for sponsoring a research fellowship at Clausthal University of Technolog

Periotrónico: XML en un periódico electrónico a la carta. Resultados y perspectivas

El Periotrónico es un periódico electrónico a medida. Se fundamenta por una parte en el empleo de JML, un lenguaje basado en XML, para la descripción de noticias, y por otra en un modelo de personalización de contenidos basado en el plegado (sólo se muestran a priori aquellas noticias cuya temática es de interés expreso para el usuario). Parte de la tecnología de control de personalización se realiza en el cliente lo que reduce la sobrecarga tanto del servidor utilizado como de las redes de transmisión necesarias. A partir de los resultados obtenidos, se pretende, en una segunda fase, el desarrollo de cuatro objetivos: utilizar un lenguaje estándar de marcas periodísticas, basado en XML, para la generación de noticias; fomentar la difusión inmediata de unos mismos contenidos periodísticos en diferentes soportes (PC, TV, etc.), mediante el uso de tecnologías como MHEG; favorecer la creación de comunidades virtuales, basándose en las preferencias aportadas por los clientes, que permitan el envío de contenidos periodísticos y publicitarios comunes; por último, mejorar la relación entre los diferentes contenidos informativos y las posibilidades de recuperación de información incluida en éstos. Tales factores configurarían este producto como un modelo rentable apto para el comercio electrónico.Resultados parciales del proyecto "El Periotrónico: Concepción y Desarrollo de un Periódico Electrónico Personalizado", financiado por la CICYT (Programa Nacional de Aplicaciones y Servicios Telemáticos, Ref. TEL97-0788

Prensa en XML: el negocio de la personalización y la conquista de nuevos medios

Los periódicos electrónicos no han encontrado aún la forma de aprovechar completamente las posibilidades que les ofrecen los lenguajes de marcado, y en especial XML, así como la posibilidad de usar diversos medios de salida, con el fin de difundir a través de ellos una misma información (adaptando la profundidad de la misma a las posibilidades de cada soporte) consiguiendo que el producto sea rentable. El proyecto InfoMedia, que lleva a cabo un grupo de investigadores de la Universidad Carlos III de Madrid, se desarrolla sobre esta idea. Este texto expone los conceptos básicos (y algunas iniciativas ya desarrolladas) sobre los que gira el proyecto: la necesidad de contemplar los diversos medios (ordenadores, televisión, teléfono móvil...) accesibles mediante un mismo lenguaje, basado en XML; la posibilidad de establecer diferentes tipos de productos y, por tanto, diferentes formas de financiación y pago de los mismos; finalmente, la necesidad de determinar qué públicos distintos pueden existir y qué información necesitan.CICYT. Proyecto TEL99-020

Groundwater origin and recharge in the hyperarid Cordillera de la Costa, Atacama Desert, northern Chile.

The Cordillera de la Costa is located along the coastline of northern Chile, in the hyperarid Atacama Desert area. Chemical and isotopic analyses of several small coastal springs and groundwater reservoirs between 22.5°S and 25.5°S allow understanding groundwater origin, renewal time and the probable timing of recharge. The aquifers are mostly in old volcanic rocks and alluvial deposits in small intra-mountain basins. All spring waters are brackish, of the sodium chloride type due to intensive concentration of precipitation due aridity and for deep groundwater to additional water-rock interaction in slowly renewed groundwater and mixing with deep seated brines. The heavy δ18O and δ2H values in spring water are explained by recharge by the arrival of moist air masses from the Pacific Ocean and the originally lighter values in the deep wells can be associated to past recharge by air masses coming from the Atlantic Ocean. Current recharge is assumed almost nil but it was significant in past wetter-than-present periods, increasing groundwater reserves, which are not yet exhausted. To explain the observed chloride content and radiocarbon (14C) activity, a well-mixed (exponential) flow model has been considered for aquifer recharge. The average residence time of groundwater feeding the springs has been estimated between 1 and 2 hyr, up to 5 hyr and between 7 and 13 hyr for deep well water, assuming that current recharge is much less than during the previous wetter period. The recharge period feeding the coastal springs could have been produced 2 to 5 hyr BP, when the area was already inhabited, and recharge in the Michilla mine was produced during the 10 to 14.5 hyr BP CAPE (Central Andean Pluvial Event) pluvial events of the central Andes). Age uncertainty cannot be solved with only radiocarbon data. The approximate coincidence of turnover time with the past wet periods, as revealed by paleoclimate data, points to significant recharge during them

Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE)

Aim: Patients with systemic sclerosis (SSc) are at increased risk of cancer, a growing cause of non-SSc-related death among these patients. We analyzed the increased cancer risk among Spanish patients with SSc using standardized incidence ratios (SIRs) and identified independent cancer risk factors in this population. Material and methods: Spanish Scleroderma Registry data were analyzed to determine the demographic characteristics of patients with SSc, and logistic regression was used to identify cancer risk factors. SIRs with 95% confidence intervals (CIs) relative to the general Spanish population were calculated. Results: Of 1930 patients with SSc, 206 had cancer, most commonly breast, lung, hematological, and colorectal cancers. Patients with SSc had increased risks of overall cancer (SIR 1.48, 95% CI 1.36-1.60; P < 0.001), and of lung (SIR 2.22, 95% CI 1.77-2.73; P < 0.001), breast (SIR 1.31, 95% CI 1.10-1.54; P = 0.003), and hematological (SIR 2.03, 95% CI 1.52-2.62; P < 0.001) cancers. Cancer was associated with older age at SSc onset (odds ratio [OR] 1.22, 95% CI 1.01-1.03; P < 0.001), the presence of primary biliary cholangitis (OR 2.35, 95% CI 1.18-4.68; P = 0.015) and forced vital capacity <70% (OR 1.8, 95% CI 1.24-2.70; P = 0.002). The presence of anticentromere antibodies lowered the risk of cancer (OR 0.66, 95% CI 0.45-0.97; P = 0.036). Conclusions: Spanish patients with SSc had an increased cancer risk compared with the general population. Some characteristics, including specific autoantibodies, may be related to this increased risk

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative

13 páginas,1 figura, 3 tablas, 1 apéndice. Se extraen los autores pertenecientes a The CIBERER network que trabajan en Centros del CSIC del Appendix ACIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research.This study has been funded by Instituto de Salud Carlos III (ISCIII) and Spanish Ministry of Science and InnovationPeer reviewe