281 research outputs found
Comparison of 30 THz impulsive burst time development to microwaves, H-alpha, EUV, and GOES soft X-rays
The recent discovery of impulsive solar burst emission in the 30 THz band is
raising new interpretation challenges. One event associated with a GOES M2
class flare has been observed simultaneously in microwaves, H-alpha, EUV, and
soft X-ray bands. Although these new observations confirm some features found
in the two prior known events, they exhibit time profile structure
discrepancies between 30 THz, microwaves, and hard X-rays (as inferred from the
Neupert effect). These results suggest a more complex relationship between 30
THz emission and radiation produced at other wavelength ranges. The multiple
frequency emissions in the impulsive phase are likely to be produced at a
common flaring site lower in the chromosphere. The 30 THz burst emission may be
either part of a nonthermal radiation mechanism or due to the rapid thermal
response to a beam of high-energy particles bombarding the dense solar
atmosphere.Comment: accepted to Astronomy and Astrophysic
Observed flux density enhancement at submillimeter wavelengths during an X-class flare
We analyse the 30 October, 2004, X1.2/SF solar event that occurred in AR
10691 (N13 W18) at around 11:44 UT. Observations at 212 and 405 GHz of the
Solar Submillimeter Telescope (SST), with high time resolution (5 ms), show an
intense impulsive burst followed by a long-lasting thermal phase. EUV images
from the Extreme Ultraviolet Imaging Telescope (SOHO/EIT) are used to identify
the possible emitting sources. Data from the Radio Solar Telescope Network
(RSTN) complement our spectral observations below 15 GHz. During the impulsive
phase the turnover frequency is above 15.4 GHz. The long-lasting phase is
analysed in terms of thermal emission and compared with GOES observations. From
the ratio between the two GOES soft X-ray bands, we derive the temperature and
emission measure, which is used to estimate the free-free submillimeter flux
density. Good temporal agreement is found between the estimated and observed
profiles, however the former is larger than the latter.Comment: 13 pages, 7 figure
Morc1 knockout evokes a depression-like phenotype in mice
Morc1 gene has recently been identified by a DNA methylation and genome-wide association study as a candidate gene for major depressive disorder related to early life stress in rodents, primates and humans. So far, no transgenic animal model has been established to validate these findings on a behavioral level. In the present study, we examined the effects of a Morc1 loss of function mutation in female C57BL/6N mice on behavioral correlates of mood disorders like the Forced Swim Test, the Learned Helplessness Paradigm, O-Maze and Dark-Light-Box. We could show that Morc1(-/-) mice display increased depressive-like behavior whereas no behavioral abnormalities regarding locomotor activity or anxiety-like behavior were detectable. CORT plasma levels did not differ significantly between Morc1(-/-) mice and their wildtype littermates, yet - surprisingly - total Bdnf mRNA-levels in the hippocampus were up-regulated in Morc1(-/-) animals. Although further work would be clarifying, Morc1(-/-) mice seem to be a promising epigenetically validated mouse model for depression associated with early life stress
The structural bases for agonist diversity in an Arabidopsis thaliana glutamate receptor-like channel
Arabidopsis thaliana glutamate receptor-like (GLR) channels are amino acid-gated ion channels involved in physiological processes including wound signaling, stomatal regulation, and pollen tube growth. Here, fluorescence microscopy and genetics were used to confirm the central role of GLR3.3 in the amino acid-elicited cytosolic Ca2+ increase in Arabidopsis seedling roots. To elucidate the binding properties of the receptor, we biochemically reconstituted the GLR3.3 ligand-binding domain (LBD) and analyzed its selectivity profile; our binding experiments revealed the LBD preference for L-Glu but also for sulfur-containing amino acids. Furthermore, we solved the crystal structures of the GLR3.3 LBD in complex with 4 different amino acid ligands, providing a rationale for how the LBD binding site evolved to accommodate diverse amino acids, thus laying the grounds for rational mutagenesis. Last, we inspected the structures of LBDs from nonplant species and generated homology models for other GLR isoforms. Our results establish that GLR3.3 is a receptor endowed with a unique amino acid ligand profile and provide a structural framework for engineering this and other GLR isoforms to investigate their physiology
Bright 30 THz Impulsive Solar Bursts
Impulsive 30 THz continuum bursts have been recently observed in solar
flares, utilizing small telescopes with a unique and relatively simple optical
setup concept. The most intense burst was observed together with a GOES X2
class event on October 27, 2014, also detected at two sub-THz frequencies,
RHESSI X-rays and SDO/HMI and EUV. It exhibits strikingly good correlation in
time and in space with white light flare emission. It is likely that this
association may prove to be very common. All three 30 THz events recently
observed exhibited intense fluxes in the range of 104 solar flux units,
considerably larger than those measured for the same events at microwave and
sub-mm wavelengths. The 30 THz burst emission might be part of the same
spectral burst component found at sub-THz frequencies. The 30 THz solar bursts
open a promising new window for the study of flares at their originComment: 11 pages, 4 Figures J. Geophys. Res - Space Physics, accepted, May
21, 201
Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome
Dravet syndrome is a severe epileptic encephalopathy caused primarily by haploinsufficiency of the SCN1A gene. Repetitive seizures can lead to endurable and untreatable neurological deficits. Whether this severe pathology is reversible after symptom onset remains unknown. To address this question, we generated a Scn1a conditional knock-in mouse model (Scn1a Stop/+) in which Scn1a expression can be re-activated on-demand during the mouse lifetime. Scn1a gene disruption leads to the development of seizures, often associated with sudden unexpected death in epilepsy (SUDEP) and behavioral alterations including hyperactivity, social interaction deficits and cognitive impairment starting from the second/third week of age. However, we showed that Scn1a gene re-activation when symptoms were already manifested (P30) led to a complete rescue of both spontaneous and thermic inducible seizures, marked amelioration of behavioral abnormalities and normalization of hippocampal fast-spiking interneuron firing. We also identified dramatic gene expression alterations, including those associated with astrogliosis in Dravet syndrome mice, that, accordingly, were rescued by Scn1a gene expression normalization at P30. Interestingly, regaining of Nav1.1 physiological level rescued seizures also in adult Dravet syndrome mice (P90) after months of repetitive attacks. Overall, these findings represent a solid proof-of-concept highlighting that disease phenotype reversibility can be achieved when Scn1a gene activity is efficiently reconstituted in brain cells
Characteristics associated with quality of life among people with drug-resistant epilepsy
Quality of Life (QoL) is the preferred outcome in non-pharmacological trials, but there is little UK population evidence of QoL in epilepsy. In advance of evaluating an epilepsy self-management course we aimed to describe, among UK participants, what clinical and psycho-social characteristics are associated with QoL. We recruited 404 adults attending specialist clinics, with at least two seizures in the prior year and measured their self-reported seizure frequency, co-morbidity, psychological distress, social characteristics, including self-mastery and stigma, and epilepsy-specific QoL (QOLIE-31-P). Mean age was 42 years, 54% were female, and 75% white. Median time since diagnosis was 18 years, and 69% experienced ≥10 seizures in the prior year. Nearly half (46%) reported additional medical or psychiatric conditions, 54% reported current anxiety and 28% reported current depression symptoms at borderline or case level, with 63% reporting felt stigma. While a maximum QOLIE-31-P score is 100, participants’ mean score was 66, with a wide range (25–99). In order of large to small magnitude: depression, low self-mastery, anxiety, felt stigma, a history of medical and psychiatric comorbidity, low self-reported medication adherence, and greater seizure frequency were associated with low QOLIE-31-P scores. Despite specialist care, UK people with epilepsy and persistent seizures experience low QoL. If QoL is the main outcome in epilepsy trials, developing and evaluating ways to reduce psychological and social disadvantage are likely to be of primary importance. Educational courses may not change QoL, but be one component supporting self-management for people with long-term conditions, like epilepsy
The Horizontal Component of Photospheric Plasma Flows During the Emergence of Active Regions on the Sun
The dynamics of horizontal plasma flows during the first hours of the
emergence of active region magnetic flux in the solar photosphere have been
analyzed using SOHO/MDI data. Four active regions emerging near the solar limb
have been considered. It has been found that extended regions of Doppler
velocities with different signs are formed in the first hours of the magnetic
flux emergence in the horizontal velocity field. The flows observed are
directly connected with the emerging magnetic flux; they form at the beginning
of the emergence of active regions and are present for a few hours. The Doppler
velocities of flows observed increase gradually and reach their peak values
4-12 hours after the start of the magnetic flux emergence. The peak values of
the mean (inside the +/-500 m/s isolines) and maximum Doppler velocities are
800-970 m/s and 1410-1700 m/s, respectively. The Doppler velocities observed
substantially exceed the separation velocities of the photospheric magnetic
flux outer boundaries. The asymmetry was detected between velocity structures
of leading and following polarities. Doppler velocity structures located in a
region of leading magnetic polarity are more powerful and exist longer than
those in regions of following polarity. The Doppler velocity asymmetry between
the velocity structures of opposite sign reaches its peak values soon after the
emergence begins and then gradually drops within 7-12 hours. The peak values of
asymmetry for the mean and maximal Doppler velocities reach 240-460 m/s and
710-940 m/s, respectively. An interpretation of the observable flow of
photospheric plasma is given.Comment: 20 pages, 10 figures, 3 tables. The results of article were presented
at the ESPM-13 (12-16 September 2011, Rhodes, Greece, Abstract Book p. 102,
P.4.12,
http://astro.academyofathens.gr/espm13/documents/ESPM13_abstract_programme_book.pdf
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