"FORESIGHT": Catawba County, North Carolina Planning Its Economic Future

Catawba County has successfully implemented an innovative strategic planning process. Drawing wide support from both the public and private sectors, this initiative has brought community leaders together to provide guidance for the future economic development of the county. This article outlines that process

Nearly sign-nonsingular matrices

AbstractA real matrix A is nearly sign-nonsingular if every term in the expansion of det A but one has the same sign. We show such matrices can be put into a normal form in which all diagonal entries are negative, all other nonzero entries are positive, and the directed graph of the matrix is intercyclic. With the help of recent results of Metzlar, McCuaig, and Thomassen on intercyclic digraphs, we are able to separate the nearly sign-nonsingular matrices into five classes and to characterize each of these classes. We also obtain two results showing where real matrices having intercyclic digraphs can or cannot be signed in such a way as to belong both to the class of sign-nonsingular matrices and the class of nearly sign-nonsingular matrices

Supermarkets and Rural Livelihoods: A Research Method

This document presents a research method to analyze the access of small and medium farmers to the supermarket market, and the effect of such access on the producers' decisions and net incomes. The method was developed for and used in a study carried out in 2004 in three Central American countries.Labor and Human Capital, Marketing,

Spectra and inverse sign patterns of nearly sign-nonsingular matrices

AbstractA nearly sign-nonsingular (NSNS) matrix is a real n × n matrix having at least two nonzero terms in the expansion of its determinant with precisely one of these terms having opposite sign to all the other terms. Using graph-theoretic techniques, we study the spectra of irreducible NSNS matrices in normal form. Specifically, we show that such a matrix can have at most one nonnegative eigenvalue, and can have no nonreal eigenvalue z in the sector {z: |arg z| ⩽ κ(n − 1)}. We also derive results concerning the sign pattern of inverses of these matrices

Screening for Low Energy Availability in Male Athletes: Attempted Validation of LEAM-Q

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Range expansion in an invasive small mammal: influence of life-history and habitat quality

Invasive species pose a major threat to biodiversity but provide an opportunity to describe the processes that lead to changes in a species' range. The bank vole (Myodes glareolus) is an invasive rodent that was introduced to Ireland in the early twentieth century. Given its continuing range expansion, the substantial empirical data on its spread thus far, and the absence of any eradication program, the bank vole in Ireland represents a unique model system for studying the mechanisms influencing the rate of range expansion in invasive small mammals. We described the invasion using a reaction-diffusion model informed by empirical data on life history traits and demographic parameters. We subsequently modelled the processes involved in its range expansion using a rule-based spatially explicit simulation. Habitat suitability interacted with density-dependent parameters to influence dispersal, most notably the density at which local populations started to donate emigrating individuals, the number of dispersing individuals and the direction of dispersal. Whilst local habitat variability influenced the rate of spread, on a larger scale the invasion resembled a simple reaction-diffusion process. Our results suggest a Type 1 range expansion where the rate of expansion is generally constant over time, but with some evidence for a lag period following introduction. We demonstrate that a two-parameter empirical model and a rule-based spatially explicit simulation are sufficient to accurately describe the invasion history of a species that exhibits a complex, density-dependent pattern of dispersa

Screening for low energy availability in male athletes : Attempted validation of LEAM-Q

A questionnaire-based screening tool for male athletes at risk of low energy availability (LEA) could facilitate both research and clinical practice. The present options rely on proxies for LEA such screening tools for disordered eating, exercise dependence, or those validated in female athlete populations. in which the female-specific sections are excluded. To overcome these limitations and support progress in understanding LEA in males, centres in Australia, Norway, Denmark, and Sweden collaborated to develop a screening tool (LEAM-Q) based on clinical investigations of elite and sub-elite male athletes from multiple countries and ethnicities, and a variety of endurance and weight-sensitive sports. A bank of questions was developed from previously validated questionnaires and expert opinion on various clinical markers of LEA in athletic or eating disorder populations, dizziness, thermoregulation, gastrointestinal symptoms, injury, illness, wellbeing, recovery, sleep and sex drive. The validation process covered reliability, content validity, a multivariate analysis of associations between variable responses and clinical markers, and Receiver Operating Characteristics (ROC) curve analysis of variables, with the inclusion threshold being set at 60% sensitivity. Comparison of the scores of the retained questionnaire variables between subjects classified as cases or controls based on clinical markers of LEA revealed an internal consistency and reliability of 0.71. Scores for sleep and thermoregulation were not associated with any clinical marker and were excluded from any further analysis. Of the remaining variables, dizziness, illness, fatigue, and sex drive had sufficient sensitivity to be retained in the questionnaire, but only low sex drive was able to distinguish between LEA cases and controls and was associated with perturbations in key clinical markers and questionnaire responses. In summary, in this large and international cohort, low sex drive was the most effective self-reported symptom in identifying male athletes requiring further clinical assessment for LEA

Biodentine Reduces Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells

International audienceIntroduction: The transient receptor potential (TRP) ion channels have emerged as important cellular sensors in both neuronal and non-neuronal cells, with TRPA1 playing a central role in nociception and neurogenic inflammation. The functionality of TRP channels has been shown to be modulated by inflammatory cytokines. The aim of this study was to investigate the effect of inflammation on odontoblast TRPA1 expression and to determine the effect of Biodentine (Septodent, Paris, France) on inflammatory-induced TRPA1 expression. Methods: Immunohistochemistry was used to study TRPA1 expression in pulp tissue from healthy and carious human teeth. Pulp cells were differentiated to odontoblastlike cells in the presence of 2 mmol/L beta-glycerophosphate, and these cells were used in quantitative polymerase chain reaction, Western blotting, calcium imaging, and patch clamp studies. Results: Immunofluorescent staining revealed. TRPA1 expression in odontoblast cell bodies and odontoblast processes, which was more intense in carious versus healthy teeth. TRPA1 gene expression was induced in cultured odontoblastlike cells by tumor necrosis factor alpha, and this expression was significantly reduced in the presence of Biodentine. The functionality of the TRPA1 channel was shown by calcium microfluorimetry and patch clamp recording, and our results showed a significant reduction in tumor necrosis factor alpha induced TRPA1 responses after Biodentine treatment. Conclusions: In conclusion, this study showed TRPA1 to be modulated by caries-induced inflammation and that Biodentine reduced TRPA1 expression and functional responses